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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/19 16:44:45」(JST)

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Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic (to temporarily paralyze accommodation), and as a mydriatic (to dilate the pupil). For Homatropine methylbromide see Methylhomatropine, this is a different medication. Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide salt.

Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administration.

Side effects

Blurred vision
Sensitivity to light

Complications

Untreated glaucoma
Myasthenia gravis
Severe heart failure
Thyrotoxicosis

References

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English Journal

Myomatous hepatic angiomyolipoma: imaging findings in 14 cases with radiological-pathological correlation and review of the literature.

Zhu Z1, Yang L, Zhao XM, Luo DQ, Zhang HT, Zhou CW.
The British journal of radiology.Br J Radiol.2014 May 8:20130712. [Epub ahead of print]
Objective: To display and analyse the imaging features of myomatous hepatic angiomyolipomas (MHAMLs). Methods: The imaging features (CT = 9; MRI = 10; ultrasound = 10; contrast-enhanced ultrasound = 4) of 14 patients with pathologically proven MHAMLs were reviewed retrospectively. Re
PMID 24670055

Development and validation of a LC-MS/MS method for homocysteine thiolactone in plasma and evaluation of its stability in plasma samples.

Arora B1, Narayanasamy A2, Nirmal J1, Halder N1, Patnaik S1, Ravi AK1, Velpandian T3.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2014 Jan 1;944:49-54. doi: 10.1016/j.jchromb.2013.11.011. Epub 2013 Nov 14.
The present study demonstrates the development and validation of a sensitive method for the quantification of homocysteine thiolactone (HCTL) in human plasma using the technique of LC-MS/MS. The gradient elution of HCTL was achieved within 5min using ZIC HILIC column having acetonitrile with 0.1% fo
PMID 24291720

Effects of different mydriatics on intraocular pressure, pupil diameter, and ruminal and intestinal motility in healthy sheep.

Ribeiro AP1, Crivelaro RM, Teixeira PP, Trujillo DY, Guimarães PJ, Vicente WR, Martins BD, Laus JL.
Veterinary ophthalmology.Vet Ophthalmol.2013 Nov 18. doi: 10.1111/vop.12121. [Epub ahead of print]
OBJECTIVE: To determine the effects of the administration of subconjunctival 1% atropine (SA), topical 1% atropine (A), 0.5% tropicamide (T), 1% homatropine (H), 10% phenylephrine (P), and 2% ibopamine (I) on intraocular pressure (IOP), pupil diameter (PD), ruminal motility (RM) and intestinal motil
PMID 24238072

Japanese Journal

Development and validation of a capillary zone electrophoresis method for the determination of atropine, homatropine and scopolamine in ophthalmic solutions

CHERKAOUI Samir,MATEUS Lidia,CHRISTEN Philippe,VEUTHEY Jean-Luc
Journal of chromatography. B, Biomedical sciences and applications 696(2), 283-290, 1997-08-29
NAID 10024519224

トロパンアルカロイドの二相間分配挙動

宮崎玉樹,四方田千佳子,岡田敏史
藥學雜誌 113(5), 376-384, 1993-05-25
… Values of pK_a and log P_0 for scopolamine were smaller than those for atropine or homatropine. …
NAID 110003649406

無水酢酸-氷酢酸溶液中における塩基の強酸塩の過塩素酸滴定(<特集>医薬品の分析)

朝日豊,田中正己,美馬和子
分析化学 35(3), 147-150, 1986-03-05
日本薬局方収載の塩化ベタネコール(I),塩酸ピロカルピン(II),臭化水素酸スコポラミン(III),臭化水素酸ホマトロピン(IV),塩酸キニーネ(V),塩酸ジブカイン(VI),塩酸プロカインアミド(VII),塩酸テトラカイン(VIII)の非水滴定法を検討した.いずれも酢酸第二水銀で前処理しなくても,無水酢酸-氷酢酸(9:1〜7:3)溶液中0.1M過塩素酸で電位差滴定しうる.第一,第二アミン(VII …
NAID 110002909302

Related Pictures

★リンクテーブル★

リンク元	「ムスカリン受容体拮抗薬」「ホマトロピン」
拡張検索	「homatropine methylbromide」「homatropine hydrobromide」

「ムスカリン受容体拮抗薬」

Homatropine
Systematic (IUPAC) name
	(N-methyl-8-azabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a601006
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	87-00-3
ATC code	A02BX03 S01FA05
PubChem	CID 6321423
DrugBank	DB00725
ChemSpider	16498795
UNII	8QS6WCL55Z
ChEMBL	CHEMBL1233442
Chemical data
Formula	C16H21NO3
Mol. mass	356.26 g/mol
	SMILES CN3[C@H]1CC[C@@H]3C[C@@H](C1)OC(=O)C(O)c2ccccc2;
	InChI InChI=1S/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18H,7-10H2,1H3/t12-,13+,14+,15? ; Key:ZTVIKZXZYLEVOL-MCOXGKPRSA-N ;
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