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Cycloplegia caused by Cyclopentolate 1% instilled into both eyes.

Cyclopentolate is a medication commonly used during pediatric eye examinations that dilates the eye (mydriatic), prevents accommodation of the eye to different distances (cycloplegic), and blocks specific receptors called muscarinic receptors (muscarinic antagonist).^[1] Cyclopentolate is also administered as an atropine substitute to reverse muscarinic and central nervous system effects of indirect cholinomimetic (anti-AChase) administration.

When used in eye drops in pediatric eye examinations, Cyclopentolate 0.5 percent and 1.0 percent is used to stop the eye focusing at near distance, enabling the ophthalmologist, optometrist, or orthoptist to obtain a more accurate reading of the focusing power of the eyes. Brand names include Cyclogyl, Cylate, & Pentolair.^[2]

The drops take around 30-60 minutes to work and less than 24 hours to wear off (with patients advised not to drive a vehicle or operate machinery for the first 12 hours). The pupils become wider when Cyclopentolate is administered, making the eyes more sensitive to light. Close objects (and possibly distant objects) will also appear blurred.

Side effects to Cyclopentolate are rare, but can include effects such as disorientation, incoherent speech or visual disturbances during the 24-hour period that the drug has an effect. The side effects are more common in children.

References

^ "Cyclopentolate". http://www.drugbank.ca/drugs/DB00979. Retrieved June 15, 2012.
^ "cyclopentolate hydrochloride solution - ophthalmic, Cyclogyl, Cylate, Pentolair". http://www.medicinenet.com/cyclopentolate_hydrochloride-eye_drops/article.htm. Retrieved June 15, 2012.
^ John P.Whitcher, Paul Riordan-Eva. Vaughan & Asbury's general ophthalmology. (17th ed. ed.). McGraw-Hill Medical. p. 63. ISBN 978-0071443142.

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English Journal

Botulinum Toxin as an Alternative to Treat the Spasm of the Near Reflex.

Laria C1, Merino-Suárez ML, Piñero DP, Gómez-Hurtado A, Pérez-Cambrodí RJ.
Seminars in ophthalmology.Semin Ophthalmol.2015 Aug 21:1-4. [Epub ahead of print]
We describe the case of an eight-year-old girl with complaints of headaches and blurred vision (uncorrected visual acuity: 0.1 decimal) that showed on examination miotic pupils, pseudomyopia, no ocular motility restrictions, and no associated neurological disease. After initial treatment with cyclop
PMID 24809739

Therapeutic effect of atropine 1% in children with low myopia.

Yi S1, Huang Y2, Yu SZ1, Chen XJ1, Yi H1, Zeng XL3.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus.J AAPOS.2015 Jul 27. pii: S1091-8531(15)00179-2. doi: 10.1016/j.jaapos.2015.04.006. [Epub ahead of print]
PURPOSE: To evaluate the efficacy of topical atropine 1% in promoting unaided visual acuity, reducing myopia, and slowing the progression of ocular axial elongation in Chinese children with low myopia.METHODS: Children with low myopia were randomly assigned to one of two groups, receiving either atr
PMID 26228967

Spectrophotometric Determination of Distigmine Bromide, Cyclopentolate HCl, Diaveridine HCl and Tetrahydrozoline HCl via Charge Transfer Complex Formation with TCNQ and TCNE Reagents.

Mohamed GG1, Rizk MS1, Zaky Frag EY1.
Iranian journal of pharmaceutical research : IJPR.Iran J Pharm Res.2015 Summer;14(3):701-14.
The purpose of this investigation was directed to propose sensitive, accurate and reproducible methods of analysis that can be applied to determine distigmine bromide (DTB), cyclopentolate hydrochloride (CPHC), diaveridine hydrochloride (DVHC) and tetrahydrozoline hydrochloride (THHC) drugs in pure
PMID 26330858

Japanese Journal

Prevalence of Eye Diseases and Causes of Visual Impairment in School-Aged Children in Western China

PI Lian-Hong,CHEN Lin,LIU Qin,KE Ning,FANG Jing,ZHANG Shu,XIAO Jun,YE Wei-Jiang,XIONG Yan,SHI Hui,ZHOU Xi-Yuan,YIN Zheng-Qin
Journal of epidemiology 22(1), 37-44, 2012-01-01
… We conducted door-to-door surveys and eye examinations including optometry, stereoscopic vision test, eye position and eye movement, slit lamp examination of the anterior segment, retinoscopy, and fundus examination after cycloplegia with 1% cyclopentolate.Results: Among 3469 children, data were available for 3079 (88.76%). …
NAID 10030213040

P-152 Cyclopentolate、Phenylephrine、Tropicamide を主成分とする 3 種点眼剤混合液の臨床への応用その 2 : 使用性の検討

宮松洋信,佐藤直子,細田順一,薄井紀夫,臼井正彦
日本病院薬学会年会講演要旨集 10, 230, 2000-09-01
NAID 110001788623

Related Pictures

★リンクテーブル★

リンク元	「ムスカリン受容体拮抗薬」「シクロペントラート」「シクロペントレート」
拡張検索	「cyclopentolate hydrochloride」

「ムスカリン受容体拮抗薬」

Cyclopentolate
Systematic (IUPAC) name
	2-(dimethylamino)ethyl (1-hydroxycyclopentyl)(phenyl)acetate
Clinical data
Pregnancy cat.	C
Legal status	?
Routes	Topic
Identifiers
CAS number	512-15-2
ATC code	S01FA04
PubChem	CID 2905
DrugBank	DB00979
ChemSpider	2802
UNII	I76F4SHP7J
KEGG	D07759
ChEBI	CHEBI:4024
ChEMBL	CHEMBL1200473
Chemical data
Formula	C17H25NO3
Mol. mass	291.385 g/mol
	SMILES O=C(OCCN(C)C)C(c1ccccc1)C2(O)CCCC2;
	InChI InChI=1S/C17H25NO3/c1-18(2)12-13-21-16(19)15(14-8-4-3-5-9-14)17(20)10-6-7-11-17/h3-5,8-9,15,20H,6-7,10-13H2,1-2H3 ; Key:SKYSRIRYMSLOIN-UHFFFAOYSA-N ;
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