severe combined immunodeficiency syndrome

重症複合型免疫不全症

WordNet

1. very bad in degree or extent; "a severe worldwide depression"; "the house suffered severe damage"
2. unsparing and uncompromising in discipline or judgment; "a parent severe to the pitch of hostility"- H.G.Wells; "a hefty six-footer with a rather severe mien"; "a strict disciplinarian"; "a Spartan upbringing" (同)spartan
3. intensely or extremely bad or unpleasant in degree or quality; "severe pain"; "a severe case of flu"; "a terrible cough"; "under wicked fire from the enemys guns"; "a wicked cough" (同)terrible, wicked
4. join for a common purpose or in a common action; "These forces combined with others"
5. harvester that heads and threshes and cleans grain while moving across the field
6. add together from different sources; "combine resources"
7. set or keep apart; "sever a relationship" (同)break_up
8. a pattern of symptoms indicative of some disease
9. a complex of concurrent things; "every word has a syndrome of meanings"
10. immunological disorder in which some part of the bodys immune system is inadequate and resistance to infectious diseases is reduced

PrepTutorEJDIC

1. (人・法律などが)『厳しい』,厳格な / (態度・表情が)厳粛な,いかめしい / (病気などが)『重い』,危険な / (様式・趣味などが)簡素な,じみな,飾りのない / (人の体に)厳しくこたえる,激しい / (試験などが)難しい,厳しい
2. …'を'『結合する』,合同する / …'を'兼ね備える;(…と)…'を'兼ね合わさせる《+『名』+『with』+『名』》 / …'を'化合させる;(…と)…'を'化合させる《+『名』+『with』+『名』》 / 『結合する』,連合する,合同する / (…と)化合する《+『with』+『名』》 / 連合,合同;(特に)企業合同,政治連合 / (また『combine harvester』)(刈り取りと脱穀が同時にできる)複式収穫機,コンバイン
3. (全体から)…‘を'切断する《+『名』+『from』+『名』》 / (いくつかの部分に)…‘を'分ける《+『名』+『in』(『into』)+『名』》 / 〈関係など〉‘を'断つ / 切れる,分かれる,分裂する
4. (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

UpToDate Contents

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• 1. 重度複合型免疫不全（SCID）：概要 severe combined immunodeficiency scid an overview
• 2. 重度複合型免疫不全（SCID）：特定の欠損 severe combined immunodeficiency scid specific defects
• 3. ディジョージ症候群：臨床的特徴および診断 digeorge syndrome clinical features and diagnosis
• 4. T細胞陰性、B細胞陰性、NK細胞陽性の重度複合型免疫不全 t cell negative b cell negative nk cell positive severe combined immunodeficiency
• 5. X連鎖重度複合型免疫不全（SCID） x linked severe combined immunodeficiency scid

English Journal

• Establishing a peritoneal dissemination xenograft mouse model for survival outcome assessment of experimental gastric cancer.

• Zhang C, Awasthi N, Schwarz MA, Schwarz RE.SourceDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas; Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Gastrointestinopancreatic Surgery, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
• The Journal of surgical research.J Surg Res.2013 Jun 15;182(2):227-34. doi: 10.1016/j.jss.2012.10.052. Epub 2012 Nov 15.
• BACKGROUND: Peritoneal dissemination of gastric cancer is a common reason for unresectability, a frequent recurrence mechanism, and a common cause for death. The present study was performed to test peritoneal dissemination gastric cancer xenografts mouse models that would support survival outcome an
• PMID 23201270

• Mumps virus encephalomyelitis in a 19-year old male patient with an undefined severe combined immunodeficiency post-haematopoietic bone marrow transplantation: A rare fatal complication.

• Eyre TA, Pelosi E, McQuaid S, Richardson D, Newman J, Hill K, Veys P, Davies G, Orchard KH.SourceWessex Blood and Marrow Transplantation Programme, Department of Haematology, Southampton University Hospitals Trust, SO16 6YD, UK.
• Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.J Clin Virol.2013 Jun;57(2):165-8. doi: 10.1016/j.jcv.2013.02.003. Epub 2013 Feb 26.
• We describe a rare case of fatal mumps encephalomyelitis occurring in 19-year old male following matched unrelated donor peripheral blood haematopoietic stem cell transplantation (HSCT). The indication for HSCT was for an undefined form of severe combined immunodeficiency (SCID). Molecular typing of
• PMID 23485346

• Expression of a functional human adenosine deaminase in transgenic tobacco plants.

• Singhabahu S, George J, Bringloe D.SourceSchool of Health, Sport and Bioscience, University of East London, Water Lane, London, E15 4LZ, UK.
• Transgenic research.Transgenic Res.2013 Jun;22(3):643-9. doi: 10.1007/s11248-012-9676-1. Epub 2012 Dec 21.
• An inherited disorder, adenosine deaminase deficiency is a form of severe combined immunodeficiency, which is ultimately caused by an absence of adenosine deaminase (ADA), a key enzyme of the purine salvage pathway. The absence of ADA-activity in sufferers eventually results in a dysfunctional immun
• PMID 23264022

Japanese Journal

• 原発性免疫不全症に対する遺伝子治療の現状と今後の展望

• 内山 徹,小野寺 雅史
• 日本臨床免疫学会会誌 36(3), 148-155, 2013
• …   原発性免疫不全症（primary immunodeficiency, PID）の根治的治療法として造血幹細胞移植が挙げられるが，至適ドナーがいない場合には移植関連合併症の危険が増大する．このような背景から1990年代よりレトロウイルスベクターを用いた遺伝子治療がアデノシンデアミナーゼ欠損症に対し開始され，続いてX連鎖重症複合免疫不全症，ウィスコット・アルドリッチ症候群，慢性肉芽腫症など様々なPIDにおいてその効果が確認 …
• NAID 130003364172

• Analysis of mutations and recombination activity in RAG-deficient patients

• Asai Erika,Wada Taizo,Sakakibara Yasuhisa,Toga Akiko,Toma Tomoko,Shimizu Takashi,Nampoothiri Sheela,Imai Kohsuke,Nonoyama Shigeaki,Morio Tomohiro,Muramatsu Hideki,Kamachi Yoshiro,Ohara Osamu,Yachie Akihiro
• Clinical Immunology 138(2), 172-177, 2011-02
• … Herein, we report 5 cases of RAG deficiency from 5 families: 3 of Omenn syndrome, 1 of severe combined immunodeficiency, and 1 of combined immunodeficiency with oligoclonal TCRγδ+ T cells, autoimmunity and cytomegalovirus infection. …
• NAID 120002772030

• Combined microdeletions and CHD7 mutation causing severe CHARGE/DiGeorge syndrome : clinical presentation and molecular investigation by array-CGH

• Kaliakatsos Marios,Giannakopoulos Aristeidis,Fryssira Helena [他],KANARIOU Maria,SKIATHITOU Anna-Venetia,SIAHANIDOU Tania,GIANNIKOU Krinio,MAKRYTHANASIS Periklis,KANAVAKIS Emmanuel,TZETIS Maria
• Journal of human genetics 55(11), 761-763, 2010-11-01
• NAID 10030737707

Related Links

• Severe combined immunodeficiency - Wikipedia, the free ...

Severe combined immunodeficiency (SCID), (also known as "Alymphocytosis," " Glanzmann–Riniker syndrome," "Severe mixed immunodeficiency syndrome," and "Thymic alymphoplasia") is a genetic disorder characterized by the absence of ...

• Severe Combined Immunodeficiency Syndrome (SCID)

SCID is a group of very rare-and potentially fatal-inherited disorders related to the immune system. The immune system normally fights off attacks from dangerous bacteria and viruses. People with SCID have a defect in their immune system ...

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★リンクテーブル★

関連記事	「combine」「severe」「sever」「immunodeficiency」「combined」

「combine」

　　[★]

• v.

• 併用する、組み合わせる、結合する、合併する

関

ally、associate、bind、binding、bond、bonding、combination、combined application、complicate、concomitant、concurrent、conjoin、conjugate、conjugation、conjunction、connect、connection、couple、dock、engage、engagement、join、ligate、linkage、merge、merger、symphysial、union

　 　 　 　

「severe」

　　[★]

• adj.

• 重篤な、重症の、重度の、激しい、苛酷な

• 1.

• 厳しい、厳格な。厳密な(⇔mild)。容赦しない、血も涙もない、痛烈な
• ひどい、猛烈な。骨の折れる。過酷な

• 2

• 簡素な、地味な、渋い。厳粛な

関

critically ill、grave、heavily、intense、life-threatening、rampant、serious、seriously、severe disease、severely、strenuous、severeness

　 　 　 　

「sever」

　　[★]

• v.

• 切断する

関

ablate、ablation、amputate、amputation、break、breakage、cleavage、cleave、scission、transection、truncate、truncation

　 　

「immunodeficiency」

　　[★] 免疫不全症 → 免疫不全症候群 　

「combined」

　　[★]

• adj.

• 混合性の

関

mixed