- 関
- RAGE
WordNet
- put an end to; "The terrible news ended our hopes that he had survived"
- a final state; "he came to a bad end"; "the so-called glorious experiment came to an inglorious end" (同)destruction, death
- the point in time at which something ends; "the end of the year"; "the ending of warranty period" (同)ending
- bring to an end or halt; "She ended their friendship when she found out that he had once been convicted of a crime"; "The attack on Poland terminated the relatively peaceful period after WW I" (同)terminate
- a piece of cloth that is left over after the rest has been used or sold (同)remainder, remnant, oddment
- (American football) a position on the line of scrimmage; "no one wanted to play end"
- the part you are expected to play; "he held up his end"
- the concluding parts of an event or occurrence; "the end was exciting"; "I had to miss the last of the movie" (同)last, final_stage
- either extremity of something that has length; "the end of the pier"; "she knotted the end of the thread"; "they rode to the end of the line"; "the terminals of the anterior arches of the fornix" (同)terminal
- (football) the person who plays at one end of the line of scrimmage; "the end managed to hold onto the pass"
- a boundary marking the extremities of something; "the end of town"
- a final part or section; "we have given it at the end of the section since it involves the calculus"; "Start at the beginning and go on until you come to the end"
- one of two places from which people are communicating to each other; "the phone rang at the other end"; "both ends wrote at the same time"
- the surface at either extremity of a three-dimensional object; "one end of the box was marked `This side up"
- have an end, in a temporal, spatial, or quantitative sense; either spatial or metaphorical; "the bronchioles terminate in a capillary bed"; "Your rights stop where you infringe upon the rights of other"; "My property ends by the bushes"; "The symphony ends in a pianissimo" (同)stop, finish, terminate, cease
- be the end of; be the last or concluding part of; "This sad scene ended the movie" (同)terminate
- increase in price or value; "the news caused a general advance on the stock market" (同)rise
- an amount paid before it is earned (同)cash advance
- rise in rate or price; "The stock market gained 24 points today" (同)gain
- pay in advance; "Can you advance me some money?"
- situated ahead or going before; "an advance party"; "at that time the most advanced outpost was still east of the Rockies" (同)advanced, in advance
- being ahead of time or need; "gave advance warning"; "was beforehand with her report" (同)beforehand
- cause to move forward; "Can you move the car seat forward?" (同)bring forward
- move forward, also in the metaphorical sense; "Time marches on" (同)progress, pass_on, move on, march on, go_on
- move forward; "we have to advance clocks and watches when we travel eastward" (同)set ahead
- bring forward for consideration or acceptance; "advance an argument" (同)throw out
- develop further; "We are advancing technology every day"
- farther along in physical or mental development; "the childs skeletal age was classified as `advanced"; "children in the advanced classes in elementary school read far above grade average"
- ahead of the times; "the advanced teaching methods"; "had advanced views on the subject"; "a forward-looking corporation"; "is British industry innovative enough?" (同)forward-looking, innovative, modern
- far along in time; "a man of advanced age"; "advanced in years"; "a ripe old age"; "the ripe age of 90" (同)ripe
- ahead in development; complex or intricate; "advanced technology"; "a sophisticated electronic control system" (同)sophisticated
- (of societies) highly developed especially in technology or industry; "advanced societies"; "an advanced country technologically"
- at a higher level in training or knowledge or skill; "an advanced degree"; "an advanced text in physics"; "special seminars for small groups of advanced students at the University"
- comparatively late in a course of development; "the illness had reached an advanced stage"; "an advanced state of exhaustion"
- a chemical substance formed as a result of a chemical reaction; "a product of lime and nitric acid"
- a consequence of someones efforts or of a particular set of circumstances; "skill is the product of hours of practice"; "his reaction was the product of hunger and fatigue"
- an artifact that has been created by someone or some process; "they improve their product every year"; "they export most of their agricultural production" (同)production
- a quantity obtained by multiplication; "the product of 2 and 3 is 6" (同)mathematical product
PrepTutorEJDIC
- (細いものの)『端』,先端《+『of』+『名』》 / (物語などの)『終り』,終結部《+『of』+『名』》 / (物事・期間の)『最後』《+『of』+『名』》;(…に)結末をつけるもの《+『to』+『名』》 / (…の)端の部分,末端部《『of』+『名』》 / 《しばしば複数形で》『目的』(purpose),目標(aim) / 《遠回しに》死,滅亡 / 《しばしば複数形で》切れ端,くず,残りもの / (事業などの)部門(part) / (フットボールで)エンド)前衛両端の選手または位置) / …‘を'『終わらせる』,終える / 〈物事が〉…‘の'終りとなる,‘を'締めくくる / 『終わる』,終了する(come to an end)
- …'を'『前進させる』,前に出す / 〈事〉'を'『進める』,促進する / (ある階級・地位などに)〈人〉'を'昇進させる《+『名』〈人〉+『to』+『名』》 / 《『advance』+『名』〈人〉+『名』〈金〉=『advance』+『名』〈金〉+『to』+『名』〈人〉》 〈人〉‘に'〈金〉'を'前払いする,融資する / 〈時間・期日〉'を'早める;〈時計〉‘の'時間を早める / (…に向かって)『前進する』,進む《+『on』(『upon, toward』)+『名』》 / (…に)昇進する《+『to』(『in』)+『名』》 / 〈事が〉進歩する,はかどる / 〈時が〉進む / 〈値段・価値が〉上がる / 〈U〉〈C〉『進むこと』,前進 / 〈U〉(…の)流れ,進行《+『of』+『名』》 / 〈U〉〈C〉(…の)進歩,発達《+『of』+『名』》 / 〈U〉〈C〉(…への)昇進,出世《+『to』+『名』》 / 〈C〉(…の)前払い,前払い金《+『on』+『名』》 / 《複数形で》(人に)言い寄ること,取り入ること《+『to』+『名』》 / 前進している / 前もっての
- 進出した,前進した / 進歩した / 上級の,高等の / (時が)進んだ,進行した
- 《時間・距離》『…の間』 / 《利益・貢献》『…のために』 / 《適応・用途》『…向きの(に);』…用の(に);…のための(に) / 《目的・意向》『…のために,』に / 《敬意・記念》『…のために;』…を記念して / 《獲得・追求》『…を得るために』,を求めて / 《行く先・方向》『…あてに;』…[方面]行きの,に向けて / 《交換・報償など》『…に対して』;…と引き換えに;…のお返しに / 《原因・理由》『…のために』,なので / 《代理・代表》『…の代わりに;』…を代表して / 《形容詞の後に用いて》『…にとって,』には / 《比較級の後に用いて》『…の結果として,』…のために / 《対比》『…としては,』のわりには / 《関連》『…について,』の点では / 《資格・属性》『…として』 / 《賛成・支持》…『に賛成して』,を支持して / 《傾向・好み》…『に対する』,には / 《模倣》《おもに米》《英文》…の名を取って(after) / 《割合》…に対して / 《『for』+『名』〈人〉+『to』 doの形で,〈人〉が不定詞to doの意味上の主語を表して》…が(…することは,…するために) / […というのは]…だから
- 『産物』;製品 / (…の)結果,帰結《+『of』+『名』(do『ing』)》 / (数の)積 / (化学の)生成物
UpToDate Contents
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- 1. 糖尿病性腎症の概要 overview of diabetic nephropathy
- 2. 糖尿病性網膜症：病因 diabetic retinopathy pathogenesis
- 3. 続発性（AA）アミロイドーシスの治療 treatment of secondary aa amyloidosis
- 4. 若年性特発性関節炎：疫学と免疫病態学 juvenile idiopathic arthritis epidemiology and immunopathogenesis
- 5. 糖尿病性多発性神経障害の病因および予防 pathogenesis and prevention of diabetic polyneuropathy
English Journal
- Collagen advanced glycation inhibits its Discoidin Domain Receptor 2 (DDR2)-mediated induction of lysyl oxidase in osteoblasts.
- Khosravi R, Sodek KL, Faibish M, Trackman PC.SourceDepartment of Molecular and Cell Biology, Division of Oral Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA 02118, USA. Electronic address: Roozbeh.kh@gmail.com.
- Bone.Bone.2014 Jan;58:33-41. doi: 10.1016/j.bone.2013.10.001. Epub 2013 Oct 10.
- Diabetes increases the risk of bone fracture. Organic and inorganic bone extracellular matrix components determine bone strength. Previous studies indicate that in diabetes, glycation of collagen causes abnormal arrangements of collagen molecules and fragile bones. Diabetic bone fragility is additio
- PMID 24120383
- Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling.
- Liu J, Huang K, Cai GY, Chen XM, Yang JR, Lin LR, Yang J, Huo BG, Zhan J, He YN.SourceDepartment of Nephrology, Daping Hospital, Third Military Medical University, Chongqing 400042, China; Kidney Center and Key Laboratory of the People's Liberation Army, Chinese PLA General Hospital and Military Medical Postgraduate College, Beijing 100853, China; Dazhou Military Hospital of Chinese PLA, Dazhou, Sichuan, China.
- Cellular signalling.Cell Signal.2014 Jan;26(1):110-21. doi: 10.1016/j.cellsig.2013.10.002. Epub 2013 Oct 7.
- Premature senescence is a key process in the progression of diabetic nephropathy (DN). In our study, we hypothesized that receptors for advanced glycation end-products (RAGE) mediate endoplasmic reticulum (ER) stress to induce premature senescence via p21 signaling activation in diabetic nephropathy
- PMID 24113348
- Potential of birds to serve as a pathology-free model of Type 2 Diabetes, 1: Is the apparent absence of the RAGE gene a factor in the resistance of avian organisms to chronic hyperglycemia?
- Szwergold BS, Miller CB.SourceDeglycation Research, West Lebanon, New Hampshire, United States ; szwerg115@gmail.com.
- Rejuvenation research.Rejuvenation Res.2013 Dec 9. [Epub ahead of print]
- ABSTRACT Diabetes mellitus has become a global pandemic that accounts for an ever-increasing rates of morbidity and mortality, and consumes a growing share of national health-care budgets. In spite of decades of effort, a solution to this problem has not yet been found. One reason for this situation
- PMID 24313337
Japanese Journal
- 動脈硬化とAGE/RAGE/ADMA system(<特集>動脈硬化とアフェレシス)
- 山岸 昌一
- 日本アフェレシス学会雑誌 32(1), 15-20, 2013-02-28
- … Among various biochemical pathways, the process of formation and accumulation of advanced glycation end products (AGE) and their mode of action are most compatible with the theory of 'metabolic memory'. … Furthermore, there is accumulating evidence that AGE, their receptor RAGE and asymmetric dimethylarginine (ADMA) system plays an important role in CVD in diabetes. …
- NAID 110009580162
- Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet
- SHIMOMOTO Takasumi,LUO Yi,OHMORI Hitoshi,CHIHARA Yoshitomo,FUJII Kiyomu,SASAHIRA Tomonori,DENDA Ayumi,KUNIYASU Hiroki
- Journal of gastroenterology 47(10), 1073-1083, 2012-10-01
- NAID 10031122095
- Methylglyoxal Accumulation in Arterial Walls Causes Vascular Contractile Dysfunction in Spontaneously Hypertensive Rats
- Mukohda Masashi,Okada Muneyoshi,Hara Yukio [他],YAMAWAKI Hideyuki
- Journal of pharmacological sciences 120(1), 26-35, 2012-09-20
- … Five-week-old SHR were treated with an MGO scavenger, aminoguanidine (AG), for 5 weeks. … In mesenteric artery from SHR treated with AG, increased accumulation of MGO-derived advanced glycation end-products was reversed. … Protein expression of NOX1 and Ang II type 2 receptor (AT2R) increased in SHR mesenteric artery, which was normalized by AG. …
- NAID 10031071852
Related Links
- The multiligand receptor for advanced glycation end products (RAGE) of the immunoglobulin superfamily is expressed onmultiple cell types implicated in the immune–inflammatory response and in atherosclerosis. Multiple studies ...
- （ 2 ） フランス人のメイラード（Maillard）によって、食品の加熱調理・ 貯蔵に伴う褐変反応が発見されてからおよそ100年が経つが、 生体におけるAGEs （advanced glycation end product）研究の 歴史は意外と浅い。現在、血糖 ...
Related Pictures
★リンクテーブル★
| リンク元 | 「終末糖化産物受容体」「終末糖化産物レセプター」「RAGE」 |
| 関連記事 | 「end」「advance」「product」「advanced」「glycation」 |
「終末糖化産物受容体」
「終末糖化産物レセプター」
「RAGE」
「end」
- n.
- v.
- 終了する、終わる
- 関
- aim、brink、cease、complete、conclude、corner、distal、eventuate、extremity、goal、object、objective、side、terminal、terminally、terminate、termination
「advance」
- n.
- v.
- 進行する、進歩する、前進する、進む
「product」
- n.
「advanced」
- adj.
- 高度な、先端的な、進行型の、後生的な