キノロン系抗菌薬
WordNet
- a substance that exerts some force or effect
- a businessman who buys or sells for another in exchange for a commission (同)factor, broker
- any agent or representative of a federal agency or bureau (同)federal agent
- a representative who acts on behalf of other persons or organizations
- an active and efficient cause; capable of producing a certain effect; "their research uncovered new disease agents"
- how long something has existed; "it was replaced because of its age"
- a time of life (usually defined in years) at which some particular qualification or power arises; "she was now of school age"; "tall for his eld" (同)eld
- begin to seem older; get older; "The death of his wife caused him to age fast"
- make older; "The death of his child aged him tremendously"
- any drug that destroys bacteria or inhibits their growth (同)antibacterial_drug, bactericide
- destroying bacteria or inhibiting their growth
PrepTutorEJDIC
- 『代理人』;周旋人 / 働き(作用)を起こすもの;作用物,薬剤 / (政府機関,特にFBI,CIAなどの)部員,機関員
- 〈U〉(一般に)『年齢』,寿命;〈C〉(個々の)『年齢』,年 / 〈U〉成年(おとなとしての資格・権利を得る年齢;通例18または21歳) / 〈U〉『老齢』;《集合的に》老人たち / 〈U〉(人生の)『一時期』;〈C〉世代(generation) / 〈U〉〈C〉《しばしばA-》(歴史上の)『時代』 / 〈C〉《話》長い間 / 年をとる,ふける;〈物が〉古くなる / 〈年〉'を'とらせる;〈物〉'を'古びさせる
UpToDate Contents
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English Journal
- Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
- Salminen P1, Paajanen H2, Rautio T3, Nordström P4, Aarnio M5, Rantanen T6, Tuominen R7, Hurme S8, Virtanen J9, Mecklin JP10, Sand J4, Jartti A11, Rinta-Kiikka I12, Grönroos JM1.
- JAMA.JAMA.2015 Jun 16;313(23):2340-8. doi: 10.1001/jama.2015.6154.
- IMPORTANCE: An increasing amount of evidence supports the use of antibiotics instead of surgery for treating patients with uncomplicated acute appendicitis.OBJECTIVE: To compare antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis confirmed by computed tomography
- PMID 26080338
- Letter: bismuth, levofloxacin, amoxicillin, PPI quadruple therapy is not an effective first or second-line regimen in the presence of levofloxacin resistance--authors' reply.
- Gisbert JP1, Romano M, Molina-Infante J.
- Alimentary pharmacology & therapeutics.Aliment Pharmacol Ther.2015 Jun;41(11):1221-2. doi: 10.1111/apt.13182.
- PMID 25939470
- Letter: bismuth, levofloxacin, amoxicillin, PPI quadruple therapy is not an effective first or second line regimen in the presence of levofloxacin resistance.
- Graham DY1, Lu H.
- Alimentary pharmacology & therapeutics.Aliment Pharmacol Ther.2015 Jun;41(11):1220-1. doi: 10.1111/apt.13177.
- PMID 25939469
Japanese Journal
- Efficacy and safety of garenoxacin tablets on bacterial pneumonia: Postmarketing surveillance in Japan
- Efficacy and safety of garenoxacin tablets on clinically diagnosed atypical pneumonia: Postmarketing surveillance in Japan
- キノロン系抗菌薬オフロキサシンの幼若ラットにおける関節毒性発症機序に関する研究
Related Links
- 1. Mol Pharm. 2007 Jan-Feb;4(1):85-94. Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Maeda T, Takahashi K, Ohtsu N, Oguma T, Ohnishi T, Atsumi R, Tamai I. Tokyo University of Science, Noda ...
- October 4, 2007 Announcement of the Launch of Geninax (R) Tablet, an Oral New-Type Quinolone Antibacterial Agent, in Japan Astellas Pharma Inc. ("Astellas"; Headquarters: Tokyo; President and CEO: Masafumi Nogimori), Taisho ...
★リンクテーブル★
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- 英
- quinolone antibacterial agent, quinolone
- 同
- ピリドンカルボン酸系抗菌薬 pyridone carboxylic acid anti-microbials pyridone carboxylic acid antibacterial agent
- 関
- 抗菌薬、ニューキノロン
キノロン系抗菌薬
概念
- クロロキンを改良してつくられた抗菌薬をキノロン系抗菌薬と呼ぶ。
- 超らせん構造の維持に関わる酵素とDNAの複合体を安定化し、DNA鎖を切断したままにしておくことにより、生存・細胞分裂を障害する。
- キノロン系抗菌薬にフッ素を導入して改良した抗菌薬がニューキノロン系抗菌薬である。
- ニューキノロン系抗菌薬はグラム陰性菌とグラム陽性菌に対して強い抗菌力を有する。
作用機序
副作用
- 消化器症状:(5-10%)
- 発疹:(1-2%)
- 中枢神経症状:(5%)頭痛・浮動性眩暈
- 軟骨毒性:幼弱な動物で軟骨に異常をきたす → 18歳未満は注意。妊婦には使用しない。 (ABM.106)
- 日光過敏症
- 低血糖
適応
第一選択となる適応(IRE.158)
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- 代行者、代理人。代理業者
- 政府職員、官吏
- ある後位をする人、ある作用をするもの。動員、動力因、作用因。(文法)動作主。科学的変化を起こさせるもの、薬品、~剤。病原体
- 関
- agonist、agonistic、attorney、delegate、drug、etiologic agent、fomes、fomites、mediator、pathogen、pathogenic、pharmaceutical preparation、vector、vehicle
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- 関
- anti-bacterial agent、antibacterial agent、antibacterial drug、antibacterially、antibacterials、antibiotic、antibiotics、antimicrobial、antimicrobial agent、antimicrobials
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- 関
- aged、ageing、aging、year old