WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
antacid (trade name Prilosec) that suppresses acid secretion in the stomach (同)Prilosec

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1. 酸関連疾患治療のためのプロトンポンプ阻害剤の概要および比較 overview and comparison of the proton pump inhibitors for the treatment of acid related disorders
2. 尿素サイクル障害：管理 urea cycle disorders management
3. 消化性潰瘍の合併症の概要 overview of the complications of peptic ulcer disease
4. 小児における慢性下痢の原因の概要 overview of the causes of chronic diarrhea in children
5. 非ステロイド性抗炎症剤（NSAIDs）（アスピリンを含む）：胃十二指腸障害の一次予防 nsaids including aspirin primary prevention of gastroduodenal toxicity

Development and Validation of a Novel Stability-Indicating RP-HPLC Method for the Simultaneous Determination of Related Substances of Ketoprofen and Omeprazole in Combined Capsule Dosage Form.

Koppala S1, Ranga Reddy V2, Anireddy JS3.
Journal of chromatographic science.J Chromatogr Sci.2016 May;54(5):765-75. doi: 10.1093/chromsci/bmw008. Epub 2016 Feb 8.
A novel, simple, sensitive, selective and reproducible stability-indicating high performance liquid chromatographic method was developed for the quantitative determination of degradation products and process-related impurities of ketoprofen (KET) and omeprazole (OMZ) in combined oral solid dosage fo
PMID 26860397

Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging.

Huizer-Pajkos A1, Kane AE2, Howlett SE3, Mach J2, Mitchell SJ4, de Cabo R4, Le Couteur DG5, Hilmer SN6.
The journals of gerontology. Series A, Biological sciences and medical sciences.J Gerontol A Biol Sci Med Sci.2016 May;71(5):571-7. doi: 10.1093/gerona/glv046. Epub 2015 May 4.
We aimed to develop a mouse model of polypharmacy, primarily to establish whether short-term exposure to polypharmacy causes adverse geriatric outcomes. We also investigated whether old age increased susceptibility to any adverse geriatric outcomes of polypharmacy. Young (n= 10) and old (n= 21) male
PMID 25940962

Gastroprotective activity of chloroform extract of Muntingia calabura and Melastoma malabathricum leaves.

Zakaria ZA1,2,3, Zainol AS3, Sahmat A3, Salleh NI3, Hizami A3, Mahmood ND3, Nasir N3, Mamat SS3, Kamisan FH3, Mohtarrudin N4, Abdul Hamid SS5, Tohid SF1, Teh LK2, Salleh MZ2.
Pharmaceutical biology.Pharm Biol.2016 May;54(5):812-26. doi: 10.3109/13880209.2015.1085580. Epub 2015 Oct 9.
CONTEXT: Muntingia calabura L. (family Muntingiaceae) and Melastoma malabathricum L. (family Melastomaceae) are traditionally used to treat gastric ulcer.OBJECTIVE: The present study determines the mechanisms of gastroprotective activity of the chloroform extract of leaves obtained from both the pla
PMID 26452435

Effect of long-term proton pump inhibitor therapy and healing effect of irsogladine on nonsteroidal anti-inflammatory drug-induced small-intestinal lesions in healthy volunteers

Kojima Yuichi,Takeuchi Toshihisa,Ota Kazuhiro,Harada Satoshi,Edogawa Shoko,Narabayashi Ken,Nouda Sadaharu,Okada Toshihiko,Kakimoto Kazuki,Kuramoto Takanori,Inoue Takuya,Higuchi Kazuhide
Journal of Clinical Biochemistry and Nutrition 57(1), 60-65, 2015
… This study assessed time-course changes of the small intestinal lesions during long-term treatment with diclofenac sodium plus omeprazole and the effects of irsogladine on such lesions. … Thirty two healthy volunteers were treated with diclofenac sodium (75 mg/day) plus omeprazole (10 mg/day) for 6 weeks, with irsogladine (4 mg/day) added from weeks 6 to 10 (Group A) or with diclofenac sodium plus irsogladine for 6 weeks (Group B). …
NAID 130005085263

Effect of long-term proton pump inhibitor therapy and healing effect of irsogladine on nonsteroidal anti-inflammatory drug-induced small-intestinal lesions in healthy volunteers

Kojima Yuichi,Takeuchi Toshihisa,Ota Kazuhiro,Harada Satoshi,Edogawa Shoko,Narabayashi Ken,Nouda Sadaharu,Okada Toshihiko,Kakimoto Kazuki,Kuramoto Takanori,Inoue Takuya,Higuchi Kazuhide
Journal of Clinical Biochemistry and Nutrition advpub(0), 2015
… This study assessed time-course changes of the small intestinal lesions during long-term treatment with diclofenac sodium plus omeprazole and the effects of irsogladine on such lesions. … Thirty two healthy volunteers were treated with diclofenac sodium (75 mg/day) plus omeprazole (10 mg/day) for 6 weeks, with irsogladine (4 mg/day) added from weeks 6 to 10 (Group A) or with diclofenac sodium plus irsogladine for 6 weeks (Group B). …
NAID 130005078151

大塚恭寛
日本腹部救急医学会雑誌 = Journal of abdominal emergency medicine 32(5), 967-971, 2012-07-31
症例はアルコール性肝硬変（Child-Pugh分類Grade C）を有する62歳男性で，嘔吐に続く呼吸苦を主訴に嘔吐4時間後に当院を救急受診。食道造影にて下部食道右側壁に径1cmの破裂部を認め，右胸腔内穿破型の特発性食道破裂と診断。基礎疾患の重症度を考慮し，右胸腔穿刺ドレナージ・破裂部口側への経鼻的減圧チューブ挿入・中心静脈栄養管理・オメプラゾールと抗菌薬投与による保存的治療を選択した。第2病日に …
NAID 10031165278