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1. 呼気中一酸化窒素の分析および適用exhaled nitric oxide analysis and applications [show details]
… radical NO is the previously uncharacterized endothelial-derived relaxing factor. It is now clear that NO plays an important role in most human organ systems. Within the respiratory system, NO regulates …
2. 心不全における一酸化窒素、その他のホルモン、サイトカイン、およびケモカインnitric oxide other hormones cytokines and chemokines in heart failure [show details]
… reduction in NO synthesis via eNOS as well as a decrease in endothelial release of and response to NO . In contrast, venous endothelial function and tone and basal and stimulated NO release from… The following observations illustrate the range of findings: Transgenic mice…
3. アンドロゲン過剰症の妊婦への対処法approach to the patient with gestational hyperandrogenism [show details]
… for women with gestational hyperandrogenism are limited. There are no medical therapies; most women are treated conservatively (observation), while some undergo surgery, ideally during the second trimester …
4. 一酸化窒素と腎臓nitric oxide and the kidney [show details]
… Nitric oxide (NO) has a major role as a messenger molecule in most human organ systems . In the blood vessel wall, basal and calcium-agonist stimulated release of NO largely accounts for the bioactivity …
5. 男性性機能障害の概要overview of male sexual dysfunction [show details]
… family history of myocardial infarction. Based upon these observations, men with ED without an obvious cause (eg, pelvic trauma) and who have no symptoms of coronary or other vascular disease should be …

English Journal

Toxicity of microwave-assisted biosynthesized zinc nanoparticles in mice: a preliminary study.

Salimi A, Rahimi HR, Forootanfar H, Jafari E, Ameri A, Shakibaie M.
Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)1846-1858.
This study was designed to describe the oral acute and subacute toxicities and underlying toxicological mechanisms of biogenic Zn NPs in mice. The Zn NPs were prepared by a green microwave-assisted synthesis method in the presence of Lavandula vera leaf extract. Determination of median lethal dose (
PMID 31066299

Use of toxicant sensitivity distributions (TSD) for development of exposure guidelines for risk to human health from benzene.

Edokpolo B, Yu QJ, Connell D.
Environmental pollution (Barking, Essex : 1987). 2019 Jul;250()386-396.
This technique for setting guideline values differs from that currently used by regulatory agencies throughout the world. Data for benzene were evaluated from epidemiological studies on human populations (29 studies). Exposure durations were evaluated in terms of Long Term Exposure (LTE) and Lifetim
PMID 31022644

Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats.

Li Y, Kandhare AD, Mukherjee AA, Bodhankar SL.
Regulatory toxicology and pharmacology : RTP. 2019 Jul;105()77-85.
Citrus sinensis contains glycoside hesperetin-7-rhamnoglucoside (hesperidin) which harbor an array of therapeutic potentials including antioxidant, anticancer, and anti-inflammatory. However, a systematic examination of safety is needed before its utilization. Hence, the present investigation is aim
PMID 30991075

Japanese Journal

Effects of antiepileptic monotherapy on hematological and biochemical parameters

Yoshimura Yuri,Hara Keiko,Akaza Miho,Ohta Kaseya,Sumi Yuki,Inaji Motoki,Yanagisawa Eriko,Maehara Taketoshi
Epilepsy & Seizure 11(1), 1-13, 2019
… Purpose: Severe cytopenia and liver dysfunction are characterized as antiepileptic drug (AED) adverse effects dependent upon an idiosyncrasy. … This study aims to investigate the effect of antiepileptic monotherapy on hematological and biochemical parameters.Methods: We retrospectively recruited 480 patients untreated with AED at baseline. … Decreased WBC count tended to correlate with elevated serum CBZ level. …
NAID 130007631571

Food Safety

Food Safety Commission of Japan
Food Safety 7(1), 15-19, 2019
… The Food Safety Commission of Japan (FSCJ) conducted a risk assessment of flubendiamide (CAS No. 272451-65-7), an iodophthalimide insecticide for the setting of an acceptable daily intake (ADI) in 2006. …
NAID 130007627449

Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ

TOYODA Takeshi,CHO Young-Man,MATSUSHITA Kohei,TACHIBANA Shigehiro,SENUMA Mika,AKAGI Jun-ichi,OGAWA Kumiko
Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ, 2019
… Hexyl acetate (CAS No. 142-92-7) is a naturally occurring ester compound that has a fruity odor. … No significant toxicological changes in general condition, body weights, food intake, ophthalmology, hematology, organ weights, and histopathological findings were observed in any groups. …
NAID 130007626967