WordNet
- grow out of, have roots in, originate in; "The increase in the national debt stems from the last war"
- stop the flow of a liquid; "staunch the blood flow"; "stem the tide" (同)stanch, staunch, halt
- remove the stem from; "for automatic natural language processing, the words must be stemmed"
- the tube of a tobacco pipe
- cause to point inward; "stem your skis"
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- of or relating to the spinal cord
- of or relating to bone marrow
PrepTutorEJDIC
- (草の)『茎』,(木の)『幹』 / 葉柄,花梗(かこう) / 『茎状のもの』;(杯・グラスの)『脚』,(パイプ・さじの)柄,(時計の)りゅうず / (単語の)語幹,語根 / 船首;船首材 / …‘の'茎(軸)を取り去る,へたをとる / (…から)生じる,(…に)由来する《+『from』+『名』(do『ing』)》
- 〈流れなど〉‘を'止める / 〈風・水流など〉‘に'逆らって進む,抵抗する / 〈攻撃・反対など〉‘を'くい止める,押さえる
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/07 12:07:19」(JST)
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- 1. 造血および幹細胞の機能の概要 overview of hematopoiesis and stem cell function
- 2. 幹細胞の概要 overview of stem cells
- 3. 造血幹細胞の分布 sources of hematopoietic stem cells
- 4. 急性骨髄性白血病の病因 pathogenesis of acute myeloid leukemia
- 5. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia
English Journal
- Innovative cell therapy in the treatment of serious adverse events related to both chemo-radiotherapy protocol and acute myeloid leukemia syndrome: the infusion of mesenchymal stem cells post-treatment reduces hematopoietic toxicity and promotes hematopoietic reconstitution.
- Fouillard L, Francois S, Bouchet S, Bensidhoum M, Elm'selmi A, Chapel A1.Author information 1Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Laboratoire de Radiopathologie et de Thérapie Expérimentale, BP 17, 92262 Fontenay- aux-Roses, France. alain.chapel@irsn.fr.AbstractBone marrow stroma is damaged by chemotherapy and irradiation protocol. Bone marrow microenvironment supports haematopoiesis and comprises Mesenchymal Stem Cells (MSCs). Coinfusion of MSCs with hematopoietic stem cells (HSC) improves engraftment and accelerates haematopoietic recovery. Stroma-derived factor-1 (SDF-1) is a chemotactic factor which plays a crucial role in stem cell transplantation by enhancing the ability of HSC to engraft. In this study expression of SDF-1 in bone marrow MSCs and the level of Colony Forming Unit Fibroblast (CFU-F) were evaluated in 8 patients with Acute Myeloid leukemia (AML). Evaluation was done at diagnosis and after induction/consolidation chemotherapy before the onset of haematopoietic stem cell transplantation (HSCT). CFU-F frequency increases from diagnosis to remission. Nevertheless level of stromal derived factor-1 (SDF-1) transcripts in bone marrow MSCs of patients with AML stays low. Considering the role of SDF-1 in the homing of HSC, the consequences of SDF-1 deficiency observed in this study might be deleterious on the engraftment after HSCT and haematopoietic recovery. The whole result of this clinical study is an argument for MSC infusion to restore a normal level of SDF1 in the bone marrow microenvironment that could reduce hematopoietic toxicity of chemotherapy and improve HSC engraftment after HSCT.
- Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2014 Oct;14(9):842-8.
- Bone marrow stroma is damaged by chemotherapy and irradiation protocol. Bone marrow microenvironment supports haematopoiesis and comprises Mesenchymal Stem Cells (MSCs). Coinfusion of MSCs with hematopoietic stem cells (HSC) improves engraftment and accelerates haematopoietic recovery. Stroma-derive
- PMID 24372262
- Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid.
- Ma D1, Fang Q, Li Y, Wang J, Sun J, Zhang Y, Hu X, Wang P, Zhou S.Author information 1aDepartment of Pharmacy, Affiliated BaiYun Hospital of Guiyang Medical College Departments of bPharmacy cHematology dGuiZhou Province Hematopoietic Stem Cell Transplantation Center, Affiliated Hospital of Guiyang Medical College eKey Laboratory of Hematological Disease Diagnostic and Treat Centre of GuiZhou Province, Guiyang, China.AbstractUrsolic acid (UA), which has been used extensively as an antileukemic agent in traditional Chinese medicine, is safely edible if originating from food. We found that the apoptotic rate of acute myeloid leukemia (AML) subtype M2 (AML-M2) cell line Kasumi-1 treated by UA was higher than those of other leukemia cell lines, but was not as high as that treated by arabinofuranosyl cytidine (Ara-C), suggesting that UA is an important chemotherapeutic agent to treat AML-M2. Heme oxygenase-1 (HO-1) is a key enzyme exerting potent cytoprotection, cell proliferation, and drug resistance. HO-1 in Kasumi-1 cells was upregulated by being treated with low-dose rather than high-dose UA. Inhibition of HO-1 by zinc protoporphyrin (ZnPP) IX sensitized Kasumi-1 cells to UA, and the apoptotic rate was close to that induced by Ara-C (P<0.01). The sensitizing effect of ZnPP was associated with caspase activation, bcl-2 downregulation, and PARP activation. After silencing HO-1 by siRNA transfection with lentivirus, the cells' proliferation induced by UA was increased as it was by Ara-C. Furthermore, combining ZnPP with UA prolonged the survival of mice bearing the AML subtype M2 tumor with smaller volume of tumor and size of spleen. The results showed that the Kasumi-1 cell line was the most sensitive to UA, but the apoptotic effect was inferior to that treated by Ara-C because of HO-1 upregulation. AML-M2 can feasibly be treated by target-inhibiting HO-1 that enhances the antileukemia effects of UA in vitro and in vivo.
- Anti-cancer drugs.Anticancer Drugs.2014 Apr;25(4):406-14. doi: 10.1097/CAD.0000000000000068.
- Ursolic acid (UA), which has been used extensively as an antileukemic agent in traditional Chinese medicine, is safely edible if originating from food. We found that the apoptotic rate of acute myeloid leukemia (AML) subtype M2 (AML-M2) cell line Kasumi-1 treated by UA was higher than those of other
- PMID 24413389
- Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells.
- Jovanovic IP1, Pejnovic NN, Radosavljevic GD, Pantic JM, Milovanovic MZ, Arsenijevic NN, Lukic ML.Author information 1Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.AbstractThe role of IL-33/ST2 pathway in antitumor immunity is unclear. Using 4T1 breast cancer model we demonstrate time-dependent increase of endogenous IL-33 at both the mRNA and protein levels in primary tumors and metastatic lungs during cancer progression. Administration of IL-33 accelerated tumor growth and development of lung and liver metastases, which was associated with increased intratumoral accumulation of CD11b(+) Gr-1(+) TGF-β1(+) myeloid-derived suppressor cells (MDSCs) that expressed IL-13α1R, IL-13-producing Lin(-) Sca-1(+) ST2(+) innate lymphoid cells (ILCs) and CD4(+) Foxp3(+) ST2(+) IL-10(+) Tregs compared to untreated mice. Higher incidence of monocytic vs. granulocytic MDSCs and plasmocytoid vs. conventional dendritic cells (DCs) was present in mammary tumors of IL-33-treated mice. Intratumoral NKp46(+) NKG2D(+) and NKp46(+) FasL(+) cells were markedly reduced after IL-33 treatment, while phosphate-buffered saline-treated ST2-deficient mice had increased frequencies of these tumoricidal natural killer (NK) cells compared to untreated wild-type mice. IL-33 promoted intratumoral cell proliferation and neovascularization, which was attenuated in the absence of ST2. Tumor-bearing mice given IL-33 had increased percentages of splenic MDSCs, Lin(-) Sca-1(+) ILCs, IL-10-expressing CD11c(+) DCs and alternatively activated M2 macrophages and higher circulating levels of IL-10 and IL-13. A significantly reduced NK cell, but not CD8(+) T-cell cytotoxicity in IL-33-treated mice was observed and the mammary tumor progression was not affected when CD8(+) T cells were in vivo depleted. We show a previously unrecognized role for IL-33 in promoting breast cancer progression through increased intratumoral accumulation of immunosuppressive cells and by diminishing innate antitumor immunity. Therefore, IL-33 may be considered as an important mediator in the regulation of breast cancer progression.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Apr 1;134(7):1669-82. doi: 10.1002/ijc.28481. Epub 2013 Oct 10.
- The role of IL-33/ST2 pathway in antitumor immunity is unclear. Using 4T1 breast cancer model we demonstrate time-dependent increase of endogenous IL-33 at both the mRNA and protein levels in primary tumors and metastatic lungs during cancer progression. Administration of IL-33 accelerated tumor gro
- PMID 24105680
Japanese Journal
- Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with t(6;9)(p23;q34) dramatically improves the patient prognosis: A matched-pair analysis
- Ishiyama Ken,Takami Akiyoshi,Kanda Yoshinobu,Nakao Shinji,Hidaka Michihiro,Maeda Tetsuo,Naoe Tomoki,Taniguchi Shuichi,Kawa Keisei,Nagamura Tokiko,Atsuta Yoshiko,Sakamaki Hisashi
- Leukemia 26(3), 461-464, 2012-03
- … Acute myeloid leukemia (AML) with t(6;9)(p23;q34) is well known to have a poor prognosis treated with chemotherapy and autotransplantation. … The presence of this karyotype is an indicator for allogeneic hematopoietic stem cell transplantation (HSCT); …
- NAID 120003989050
- Prognostic factors for acute myeloid leukemia patients with t(6;9)(p23;q34) who underwent an allogeneic hematopoietic stem cell transplant
- Ishiyama Ken,Takami Akiyoshi,Kanda Yoshinobu,Nakao Shinji,Hidaka Michihiro,Maeda Tetsuo,Naoe Tomoki,Taniguchi Shuichi,Kawa Keisei,Nagamura Tokiko,Tabuchi Ken,Atsuta Yoshiko,Sakamaki Hisashi
- Leukemia xx(xx), xxxx-xxxx, 2012
- … We have recently reported that the outcome of acute myeloid leukemia (AML) patientswith t(6;9)(p23;q34) who underwent allogeneic hematopoietic stem cell transplantation(allo-HSCT) was comparable to that of patients with a normal karyotype. …
- NAID 120003989052
Related Links
- β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells Cancer Cell, Volume 18, Issue 6, 14 December 2010, Pages 606-618 Jenny Yeung, Maria Teresa Esposito, Arnaud Gandillet, Bernd B. Zeisig ...
- myeloid cell ( mlid sel ) ( histology ) Any of the white blood cell (leukocyte) types that do not fall into the lymphocy ... What is myeloid progenitor cell? Myeloid stem cells are not precursors to? What cells do myeloid tissues form?
Related Pictures
★リンクテーブル★
| リンク元 | 「造血幹細胞」「骨髄系幹細胞」「骨髄幹細胞」 |
| 関連記事 | 「stem」「myeloid」「STEM」「myelo」「cell」 |
「造血幹細胞」
細胞表面マーカー
分化
| 血液中 | 組織 | |||
| 造血幹細胞 hematopoietic stem cell |
リンパ球幹細胞 lymphoid stem cell |
T細胞 T cell | ||
| B細胞 B cell | ||||
| NK細胞 natuarl killer cell | ||||
| 骨髄球幹細胞 myeloid stem cell |
granulocyte/macrophage progenitor | 好中球 neutrophil | ||
| 好酸球 eosinophil | ||||
| 好塩基球 basophil | ||||
| unknown precursor of mast cell | 肥満細胞 mast cell | |||
| 単球 | マクロファージ macrophage | |||
| 赤芽球 erythroblast |
赤血球 erythrocyte | |||
| 巨核球 megakaryocyte |
血小板 platelet | |||
「骨髄系幹細胞」
「骨髄幹細胞」
「stem」
- n.
- (草木の)茎、幹、軸。(菌類の)柄。葉柄、花梗、
- vt
- vi.
- 生じる、起こる、由来する(from,in,out of)
- In volvement in such disparate conditions stems from the widespread influences of GSK3 on many cellular functions.
- 関
- accrue、arise、basilar、basilaris、borne、come from、derive、descend、give rise to、happen、occur、plant stem、produce、proximal、proximal region、raise、scanning transmission electron microscopy
「myeloid」
- adj.
- 骨髄の、骨髄性の、骨髄球性の、ミエロイド
「STEM」
「myelo」
- comb form
- ex.