赤芽球
WordNet
- a nucleated cell in bone marrow from which red blood cells develop
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/07/19 07:25:43」(JST)
[Wiki en表示]
An erythroblast is a type of red blood cell which still retains a cell nucleus. It is the immediate precursor of a normal erythrocyte.
Contents
- 1 Nomenclature
- 2 Development
- 3 Additional images
- 4 See also
- 5 External links
Nomenclature
The term normoblast is sometimes used as a synonym for erythroblast, but at other times it is considered a subcategory. In the latter context, there are two types of erythroblasts:
- "normoblasts" - develop as expected
- "megaloblasts" - unusually large erythroblasts that can be associated with vitamin B12 deficiency, such as pernicious anemia, or folic acid deficiency (collectively called megaloblastic anemia)
Development
There are four stages in the development of a normoblast.
A comprehensive diagram of human hematopoiesis
Illustration |
Description |
Image |
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Pronormoblast |
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Basophilic normoblast |
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Polychromatic normoblast (also polychromatophilic) |
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Orthochromatic normoblast (also orthochromatophilic) |
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Additional images
See also
- Erythropoiesis
- Hemopoiesis
- Pluripotential hemopoietic stem cell
External links
- Normoblasts at the US National Library of Medicine Medical Subject Headings (MeSH)
- Histology image: 01804loa - Histology Learning System at Boston University - "Bone Marrow and Hemopoiesis bone marrow smear, erythroblast series with proerythroblast "
- Histology at uiowa.edu
Myeloid lineage - Blood (WBC and RBC)
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Cellular/
HSCs |
Myeloid/
CFU-GEMM |
CFU-GM |
CFU-G:
Granulocytes |
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CFU-M:
Monocytes/
MPS |
Macrophages |
- Histiocytes
- Kupffer cells
- Alveolar macrophage
- Microglia
- Osteoclasts
- Epithelioid cells
- giant cells
- Langhans giant cells, Foreign-body giant cell
- Touton giant cells
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CFU-DL |
- Dendritic cells
- Langerhans cell
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Common |
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CFU-Baso |
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CFU-Eos |
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MEP |
CFU-Meg |
- Megakaryoblast (* primitive Kacheshmarova's cell)
- Megakaryocyte (Kacheshmarova's cell)
- Platelets
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CFU-E |
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CFU-Mast |
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Noncellular |
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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Myeloid physiology
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Hematopoiesis |
Myelopoiesis
(CFU-GEMM) |
CFU-GM |
- Granulopoiesis
- Myeloblast
- Promyelocyte
- Myelocyte
- Metamyelocyte
- Band cell
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MEP |
- Thrombopoiesis
- Megakaryoblast
- Promegakaryocyte
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- Erythropoiesis
- Proerythroblast
- Normoblast
- Reticulocyte
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General |
- Extramedullary hematopoiesis
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Hemostasis |
- Coagulation
- Clot retraction
- Platelet adhesiveness
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Other |
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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UpToDate Contents
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- 1. 赤血球産生調節 regulation of erythropoiesis
- 2. 骨髄異形成症候群の臨床症状および診断 clinical manifestations and diagnosis of the myelodysplastic syndromes
- 3. 急性骨髄性白血病の分類 classification of acute myeloid leukemia
- 4. 鉄芽球性貧血の病態生理 pathophysiology of the sideroblastic anemias
- 5. 先天性および後天性鉄芽球性貧血の原因 causes of congenital and acquired sideroblastic anemias
English Journal
- In vitro mucus transportability, cytogenotoxicity, and hematological changes as non-destructive physiological biomarkers in fish chronically exposed to metals.
- Seriani R1, Abessa DM2, Moreira LB2, Cabrera JP3, Sanches JQ4, Silva CL4, Amorim FA4, Rivero DH5, Silva FL6, Fitorra LS7, Carvalho-Oliveira R5, Macchione M5, Ranzani-Paiva MJ8.
- Ecotoxicology and environmental safety.Ecotoxicol Environ Saf.2015 Feb;112:162-8. doi: 10.1016/j.ecoenv.2014.11.003. Epub 2014 Nov 19.
- The biomonitoring of fish using biomarkers represents a useful tool for the assessment of aquatic pollution. This study evaluated the sublethal toxic effects of aquatic pollution on fish collected from a site contaminated by metals. Water and fish (Oreochromis niloticus) samples were collected from
- PMID 25463867
- The cytoskeletal binding domain of band 3 is required for multiprotein complex formation and retention during erythropoiesis.
- Satchwell TJ1, Hawley BR2, Bell AJ3, Ribeiro ML4, Toye AM1.
- Haematologica.Haematologica.2015 Jan;100(1):133-42. doi: 10.3324/haematol.2014.114538. Epub 2014 Oct 24.
- Band 3 is the most abundant protein in the erythrocyte membrane and forms the core of a major multiprotein complex. The absence of band 3 in human erythrocytes has only been reported once, in the homozygous band 3 Coimbra patient. We used in vitro culture of erythroblasts derived from this patient,
- PMID 25344524
- The utility of ERG, CD31 and CD34 in the cytological diagnosis of angiosarcoma: an analysis of 25 cases.
- Sullivan HC1, Edgar MA1, Cohen C1, Kovach CK1, HooKim K2, Reid MD1.
- Journal of clinical pathology.J Clin Pathol.2015 Jan;68(1):44-50. doi: 10.1136/jclinpath-2014-202629. Epub 2014 Oct 28.
- AIMS: Erythroblast transformation specific related gene (ERG), a proto-oncogene member of the erythroblast transformation specific transcription factor family, is a sensitive marker of endothelial differentiation and is expressed in vascular tumours, including angiosarcomas (AS). Immunohistochemistr
- PMID 25352641
Japanese Journal
- ミトコンドリアの鉄代謝機構と鉄芽球性貧血 (特集 鉄代謝制御機構と鉄過剰症)
- 母体血中からの胎児有核赤血球の効率的回収に向けた新たな試み
- 赤芽球脱核の分子機構と血液疾患 (特集 赤血球造血と疾患をめぐる最近の進歩)
Related Links
- erythroblast [ĕ-rith´ro-blast] a term originally used for any type of nucleated erythrocyte, but now usually limited to one of the nucleated precursors of an erythrocyte, i.e. one of the developmental stages in the erythrocytic series, in ...
- Erythroblast definition, a nucleated cell in the bone marrow from which red blood cells develop. See more. Thesaurus Translate Puzzles & Games Word of the Day Blog Slideshows Apps by Dictionary My Account Log Out Log In ...
Related Pictures
★リンクテーブル★
[★]
- 英
- hematopoietic stem cell, HSC
- 関
- 幹細胞
細胞表面マーカー
分化
[★]
- 英
- erythroblast
- 同
- 赤芽細胞、有核赤血球 nucleated red cell nucleated erythrocyte
- 関
- 赤血球、鉄芽球
- 前赤芽球→好塩基性赤芽球→多染性赤芽球→正染性赤芽球→網状赤血球→赤血球
臨床関連
[★]
有核赤血球
- 関
- erythroblast、normoblast、nucleated red cell、proerythroblast、pronormoblast
[★]
- 英
- normoblast
- 関
- erythroblast、nucleated erythrocyte、proerythroblast、pronormoblast
[★]
前正赤芽球
- 関
- erythroblast、normoblast、nucleated erythrocyte、proerythroblast
[★]
遺伝性酸溶血試験陽性多核赤芽球症
- 関
- congenital dyserythropoietic anemia、dyserythropoietic anemia、HEMPAS
[★]
- 関
- erythroblastosis