メチルマロニルCoAラセマーゼ
WordNet
- the 3rd letter of the Roman alphabet (同)c
- (music) the keynote of the scale of C major
- a general-purpose programing language closely associated with the UNIX operating system
PrepTutorEJDIC
- carbonの化学記号
- cobaltの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/03 23:33:21」(JST)
[Wiki en表示]
methylmalonyl CoA epimerase |
Ribbon diagram of methylmalonyl-CoA epimerase from Propionibacterium shermanii. From PDB: 1JC5 .
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Identifiers |
EC number |
5.1.99.1 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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methylmalonyl CoA epimerase |
Identifiers |
Symbol |
MCEE |
Entrez |
84693 |
HUGO |
16732 |
OMIM |
608419 |
RefSeq |
NM_028626 |
UniProt |
Q96PE7 |
Other data |
EC number |
5.1.99.1 |
Locus |
Chr. 2 p13.3 |
Methylmalonyl CoA epimerase (EC 5.1.99.1, methylmalonyl-CoA racemase, methylmalonyl coenzyme A racemase, DL-methylmalonyl-CoA racemase, 2-methyl-3-oxopropanoyl-CoA 2-epimerase [incorrect]) is an enzyme that converts (S)-methylmalonyl-CoA to the (R) form.[1][2] This enzyme catalyses the following chemical reaction
- (R)-methylmalonyl-CoA (S)-methylmalonyl-CoA
Contents
- 1 Role in Fatty Acid Catabolism
- 2 Reaction Mechanism
- 3 References
- 4 External links
Role in Fatty Acid Catabolism
Methylmalonyl CoA epimerase plays an important role in the catabolism of fatty acids with odd-length carbon chains. In the catabolism of even-chain saturated fatty acids, the β-oxidation pathway breaks down fatty acyl-CoA molecules in repeated sequences of four reactions to yield one acetyl CoA per repeated sequence. This means that, for each round of β-oxidation, the fatty acyl-Co-A is shortened by two carbons. If the fatty acid began with an even number of carbons, this process could break down an entire saturated fatty acid into acetyl-CoA units. If the fatty acid began with an odd number of carbons, however, β-oxidation would break the fatty acyl-CoA down until the three carbon propionyl-CoA is formed. In order to convert this to the metabolically useful succinyl-CoA, three reactions are needed. The propionyl-CoA is first carboxylated to (S)-methylmalonyl-CoA by the enzyme Propionyl-CoA carboxylase. Methylmalonyl CoA epimerase then catalyzes the rearrangement of (S)-methylmalonyl-CoA to the (R) form in a reaction that uses a vitamin B12 cofactor and a resonance-stabilized carbanion intermediate. The (R)-methylmalonyl-CoA is then converted to succinyl-CoA in a reaction catalyzed by methylmalonyl-CoA mutase.
Reaction Mechanism
Acting as a general base, the enzyme abstracts a proton from the β-carbon of (R)-methylmalonyl-CoA. This results in the formation of a carbanion intermediate in which the α-carbon is stabilized by resonance. The enzyme then acts as a general acid to protonate the β-carbon, resulting in the formation of (S)-methylmalonyl-CoA.
References
- ^ Mazumder, R., Sasakawa, T., Kaziro, Y. and Ochoa, S. (1962). "Metabolism of propionic acid in animal tissues. IX. Methylmalonyl coenzyme A racemase". J. Biol. Chem. 237: 3065–3068. PMID 13934211.
- ^ Overath, P., Kellerman, G.M., Lynen, F., Fritz, H.P. and Keller, H.J. (1962). "Zum Mechanismus der Umlagerung von Methylmalonyl-CoA in Succinyl-CoA. II. Versuche zur Wirkungsweise von Methylmalonyl-CoA-Isomerase and Methylmalonyl-CoA-Racemase". Biochem. Z. 335: 500–518. PMID 14482843.
External links
- methylmalonyl-CoA epimerase at the US National Library of Medicine Medical Subject Headings (MeSH)
Isomerases: Epimerase and racemases (EC 5.1)
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5.1.1: Amino acids |
- Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing)
- Serine racemase
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5.1.2: Hydroxy acids |
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5.1.3: Carbohydrates |
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5.1.99: Other |
- Methylmalonyl CoA epimerase
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- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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Metabolism: Protein metabolism, synthesis and catabolism enzymes
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Essential amino acids are in Capitals
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K→acetyl-CoA |
LYSINE→ |
- Saccharopine dehydrogenase
- Glutaryl-CoA dehydrogenase
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LEUCINE→ |
- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- Isovaleryl coenzyme A dehydrogenase
- Methylcrotonyl-CoA carboxylase
- Methylglutaconyl-CoA hydratase
- 3-hydroxy-3-methylglutaryl-CoA lyase
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TRYPTOPHAN→ |
- Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase
- Arylformamidase
- Kynureninase
- 3-hydroxyanthranilate oxidase
- Aminocarboxymuconate-semialdehyde decarboxylase
- Aminomuconate-semialdehyde dehydrogenase
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PHENYLALANINE→tyrosine→ |
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G |
G→pyruvate
→citrate |
glycine→serine→ |
- Serine hydroxymethyltransferase
- Serine dehydratase
- glycine→creatine: Guanidinoacetate N-methyltransferase
- Creatine kinase
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alanine→ |
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cysteine→ |
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threonine→ |
- L-threonine dehydrogenase
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G→glutamate→
α-ketoglutarate |
HISTIDINE→ |
- Histidine ammonia-lyase
- Urocanate hydratase
- Formiminotransferase cyclodeaminase
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proline→ |
- Proline oxidase
- Pyrroline-5-carboxylate reductase
- 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1
- PYCR1
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arginine→ |
- Ornithine aminotransferase
- Ornithine decarboxylase
- Agmatinase
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→alpha-ketoglutarate→TCA |
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Other |
- cysteine+glutamate→glutathione: Gamma-glutamylcysteine synthetase
- Glutathione synthetase
- Gamma-glutamyl transpeptidase
- glutamate→glutamine: Glutamine synthetase
- Glutaminase
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G→propionyl-CoA→
succinyl-CoA |
VALINE→ |
- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- Enoyl-CoA hydratase
- 3-hydroxyisobutyryl-CoA hydrolase
- 3-hydroxyisobutyrate dehydrogenase
- Methylmalonate semialdehyde dehydrogenase
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ISOLEUCINE→ |
- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
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METHIONINE→ |
- generation of homocysteine: Methionine adenosyltransferase
- Adenosylhomocysteinase
- regeneration of methionine: Methionine synthase/Homocysteine methyltransferase
- Betaine-homocysteine methyltransferase
- conversion to cysteine: Cystathionine beta synthase
- Cystathionine gamma-lyase
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THREONINE→ |
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→succinyl-CoA→TCA |
- Propionyl-CoA carboxylase
- Methylmalonyl CoA epimerase
- Methylmalonyl-CoA mutase
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G→fumarate |
PHENYLALANINE→tyrosine→ |
- Phenylalanine hydroxylase
- Tyrosine aminotransferase
- 4-Hydroxyphenylpyruvate dioxygenase
- Homogentisate 1,2-dioxygenase
- Fumarylacetoacetate hydrolase
- tyrosine→melanin: Tyrosinase
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G→oxaloacetate |
asparagine→aspartate→ |
- Asparaginase/Asparagine synthetase
- Aspartate transaminase
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Index of inborn errors of metabolism
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Description |
- Metabolism
- Enzymes and pathways: citric acid cycle
- pentose phosphate
- glycoproteins
- glycosaminoglycans
- phospholipid
- cholesterol and steroid
- sphingolipids
- eicosanoids
- amino acid
- urea cycle
- nucleotide
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Disorders |
- Citric acid cycle and electron transport chain
- Glycoprotein
- Proteoglycan
- Fatty-acid
- Phospholipid
- Cholesterol and steroid
- Eicosanoid
- Amino acid
- Purine-pyrimidine
- Heme metabolism
- Symptoms and signs
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Treatment |
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UpToDate Contents
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Japanese Journal
- 動物組織におけるプロピオン酸の代謝(IX)Methylmalonyl-CoA racemase
Related Links
- Methylmalonyl CoA epimerase (EC 5.1.99.1, methylmalonyl-CoA racemase, methylmalonyl coenzyme A racemase, DL-methylmalonyl-CoA racemase, 2- methyl-3-oxopropanoyl-CoA 2-epimerase [incorrect]) is an enzyme that converts ...
- Synonyms: DL-methylmalonyl-coenzyme A racemase, methylmalonyl-CoA epimerase. Species: Rattus norvegicus ... Subunit composition of DL- methylmalonyl-CoA racemase = [methylmalonyl-CoA racemase subunit]2. Molecular Weight of ...
Related Pictures
★リンクテーブル★
[★]
- 英
- propionic acid
- 同
- プロパン酸、プロパン
- 関
- カルボン酸
- プロピオン酸(プロピオンさん、propionic acid)は示性式CH3CH2COOH、分子量74.08のカルボン酸。IUPAC命名法ではプロパン酸 (propanoic acid) となる。CAS登録番号は79-09-4。
物性
反芻動物におけるプロピオン酸
ヒト(非反芻動物を含む)におけるプロピオン酸
- 奇数脂肪酸のβ酸化、イソロイシンとコレステロール側鎖の酸化によって得られる。(HBC.169)
代謝
- HBC. 169
- →プロピオン酸血症
- →メチルマロン酸尿症
誘導体
臨床関連
[★]
- 英
- methylmalonyl-CoA racemase
[★]
[★]
ラセマーゼ、ラセミ化酵素
- 関
- epimerase、racemase and epimerase
[★]
[★]
補酵素A coenzyme A CoA
[★]
コバルト cobalt