erythropoiesis-stimulating factor

赤血球生成促進因子

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
8. a concept whose truth can be proved; "scientific hypotheses are not facts"
9. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
10. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
11. rousing or quickening activity or the senses; "a stimulating discussion"
12. the process of producing red blood cells by the stem cells in the bone marrow

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
3. 刺激する;激励する,元気づける

UpToDate Contents

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• 1. 癌患者での貧血における赤血球生成刺激剤の役割 role of erythropoiesis stimulating agents in the treatment of anemia in patients with cancer
• 2. 組換え造血成長因子の概要 introduction to recombinant hematopoietic growth factors
• 3. 慢性腎疾患における貧血のマネージメントのためのダルベポエチンアルファ darbepoetin alfa for the management of anemia in chronic kidney disease
• 4. 心不全を有する成人における貧血に対するアプローチ approach to anemia in adults with heart failure
• 5. 透析患者における赤血球造血刺激因子製剤に対する非鉄薬理学的補助 non iron pharmacologic adjuvants to erythropoiesis stimulating agent therapy in dialysis patients

English Journal

• Modulation of circulating endothelial progenitor cells by erythropoiesis-stimulating agents in patients with chronic kidney disease stage G5 and 5D
.

• Naito T, Sanaka T, Mikami H, Soga A, Yamatani K, Segawa K, Kawashima M, Yoshikura T, Niwayama J, Nishimura H, Ogawa T, Ando A, Teramoto A, Nitta K.
• Clinical nephrology.Clin Nephrol.2016 Nov;86 (2016)(11):242-252.
• AIMS: Circulating endothelial progenitor cells (EPCs) play a pivotal role in vasculogenesis and promote angiogenesis by secreting growth factors. Recent studies have suggested that erythropoietin (EPO) may accelerate not only angiogenesis but also vasculogenesis, beyond erythropoiesis. The aim of th
• PMID 27641052

• HIF stabilization by prolyl hydroxylase inhibitors for the treatment of anemia in chronic kidney disease.

• Wyatt CM1, Drüeke TB2.
• Kidney international.Kidney Int.2016 Nov;90(5):923-925. doi: 10.1016/j.kint.2016.08.016.
• The treatment of anemia with erythropoiesis-stimulating agents and iron supplementation has become the standard of care in patients with chronic kidney disease. Because of the risks associated with this approach, hypoxia inducible factor stabilizing prolyl hydroxylase inhibitors were developed as a
• PMID 27742192

• Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease.

• Pergola PE1, Spinowitz BS2, Hartman CS3, Maroni BJ3, Haase VH4.
• Kidney international.Kidney Int.2016 Nov;90(5):1115-1122. doi: 10.1016/j.kint.2016.07.019. Epub 2016 Sep 17.
• Current treatment of anemia in chronic kidney disease (CKD) with erythropoiesis-stimulating agents can lead to substantial hemoglobin oscillations above target range and high levels of circulating erythropoietin. Vadadustat (AKB-6548), a novel, titratable, oral hypoxia-inducible factor prolyl hydrox
• PMID 27650732

Japanese Journal

• Comparison between Long- and Short-Acting Erythropoiesis-Stimulating Agents in the Period Required for Haemoglobin Stabilisation in Treatment of Anaemia in Patients with Chronic Kidney Disease

• Biological and Pharmaceutical Bulletin 38(5), 740-745, 2015
• NAID 130005068083

• Comparison between Long- and Short-Acting Erythropoiesis-Stimulating Agents in the Period Required for Haemoglobin Stabilisation in Treatment of Anaemia in Patients with Chronic Kidney Disease

• Biological and Pharmaceutical Bulletin advpub(0), 2015
• NAID 130004872302

• 血液透析患者の血漿 8-hydroxy-2'-deoxyguanosine(8-OHdG) と各種パラメーターとの関連についての検討

• 日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 45(11), 1035-1043, 2012-11-28
• NAID 10031130524

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★リンクテーブル★

リンク元	「エリスロポエチン」「赤血球生成促進因子」
関連記事	「fact」「factor」「erythropoiesis」「stimulating」

「エリスロポエチン」

　　[★]

英

erythropoietin EPO EP Ep

同

赤血球生成促進因子 erythropoiesis-stimulating factor、エリスロポイエチン、ヒトエリスロポエチン human erythropoietin

商

epoetin alfa, Epogen, Procrit

性状

• 糖タンパク質
• 34kDa

産生組織

• 腎臓の傍糸球体細胞

the interstitium of the renal parenchyma, outside the tubular basement membrane , mostly in the inner cortex and outer medulla. (WINTEROBE'S CLINICAL HEMATOLOGY. 209)

標的組織

• 分化赤血球系前駆細胞(CFU-E)

作用

• 後期赤芽球系前駆細胞の赤芽球分化
• CFU-Eを前赤芽球に分化誘導する。

分泌の調整

• EPO分泌↑

• 血液中の酸素分圧低下

• 失血、気圧減少、肺疾患、心疾患

• エリスロポエチン産生腫瘍

• 小脳血管芽細胞種、肝癌、腎癌

• EPO分泌↓

• 大量輸血

低酸素状態に対するエリスロポエチンによる代償機構の発現には数日かかる。2,3-DPGによる代償機構は2日。(SP.489,654)

分子機構

• 低酸素刺激で発現誘導される転写因子HIF(ヘテロダイマー：HIF-1α、HIF-1β)がエリスロポエチンの発現に関与

基準範囲

• 7.4～29.8mIU/mL

判断

高値

• 貧血、骨髄異形成症候群、再生不良性貧血、鉄欠乏性貧血、偽性多血症、二次性赤血球増加症、再生不良性貧血、骨髄異形成症候群、鉄欠乏性貧血、慢性疾患に伴う貧血の一部、偽性多血症、二次性赤血球増加症(組織の低酸素状態、EPO産生増加状態)

低値

• 貧血、多発性骨髄腫、慢性腎不全、膠原病、真性多血症、腎性貧血、慢性炎症性疾患、慢性感染症、慢性腎不全に伴う腎性貧血、真性多血症、多発性骨髄腫、慢性炎症性疾患(慢性感染症、膠原病など)に伴う貧血の一部

臨床関連

• 腎性貧血

腎不全で分泌↓

「赤血球生成促進因子」

　　[★]

英

erythropoiesis-stimulating factor

関

エリスロポエチン

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「erythropoiesis」

　　[★]

• 赤血球生成、赤血球産生、赤血球新生、赤血球形成、赤血球造血

　

「stimulating」

　　[★]

• adj.

• 刺激的な

関

exciting、irritant