- having a sharp cutting edge or point; "a keen blade"
- a funeral lament sung with loud wailing
- in a keen and discriminating manner; "he was keenly aware of his own shortcomings"
- an arch whose height is less than half its width (同)skene arch, scheme arch, diminished arch
- a durable fabric formerly loomed by hand in China from natural cotton having a yellowish color
- (刃物などが)『鋭い』 / (寒さなどが)『厳しい』;(痛みなどが)『激しい』;(音などが)耳をつんざく;(言葉などが)人の心を刺す / (感覚・判断力などが)『鋭敏な』,鋭い / (感情・欲求などが)激しい,強烈な;(競争など)し烈な / 熱心な
- (死者のために)大声で泣きながら歌う哀歌;泣き叫ぶこと / (死者を悼んで)哀歌を歌う / 〈悲しみなど〉‘を'哀歌を歌うようにして表す;〈人〉‘を'哀歌を歌って悼む
- 鋭く,激しく / 鋭敏に / 熱心に
- 〈U〉南京(なんきん)もめん / 《複数形で》もめんのズボン
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- Silk sericin/polyacrylamide in situ forming hydrogels for dermal reconstruction.
- Kundu B, Kundu SC.SourceDepartment of Biotechnology, Indian Institute of Technology, Kharagpur 721302, India.
- Biomaterials.Biomaterials.2012 Oct;33(30):7456-67. Epub 2012 Jul 21.
- In situ forming tissue sealants are advantageous due to ease in application, complete coverage of defect site and assured comfort levels to patients. The interconnected three-dimensional hydrophilic networks perfectly manage typical dermal wounds by suitably scaffolding skin fibroblast, diffusing th
- PMID 22819495
- Deal or no deal: can incentives encourage widespread adoption of intelligent speed adaptation devices?
- Chorlton K, Hess S, Jamson S, Wardman M.SourceInstitute for Transport Studies, University of Leeds, 34-36 University Road, Leeds LS2 9JT, United Kingdom. email@example.com
- Accident; analysis and prevention.Accid Anal Prev.2012 Sep;48:73-82. Epub 2011 Apr 9.
- Given the burden of injury, economic, environmental and social consequences associated with speeding, reducing road traffic speed remains a major priority. Intelligent speed adaptation (ISA) is a promising but controversial new in-vehicle system that provides drivers with support on the speed-contro
- PMID 22664670
- The role of cholesterol on the activity and stability of neurotensin receptor 1.
- Oates J, Faust B, Attrill H, Harding P, Orwick M, Watts A.AbstractUnderstanding the role of specific bilayer components in controlling the function of G-protein coupled receptors (GPCRs) will be a key factor in the development of novel pharmaceuticals. Cholesterol-dependence in particular has become an area of keen interest with respect to GPCR function; not least since the 2.6Å crystal structure of the β2 adrenergic receptor revealed a putative cholesterol binding motif conserved throughout class-A GPCRs. Furthermore, experimental evidence for cholesterol-dependent GPCR function has been demonstrated in a limited number of cases. This modulation of receptor function has been attributed to both direct interactions between cholesterol and receptor, and indirect effects caused by the influence of cholesterol on bilayer order and lateral pressure. Despite the widespread occurrence of cholesterol binding motifs, available experimental data on the functional involvement of cholesterol on GPCRs are currently limited to a small number of receptors. Here we investigate the role of cholesterol in the function of the neurotensin receptor 1 (NTS1) a class-A GPCR. Specifically we show how cholesterol, and the analogue cholesteryl hemisuccinate, influence activity, stability, and oligomerisation of both purified and reconstituted NTS1. The results caution against using such motifs as indicators of cholesterol-dependent GPCR activity.
- Biochimica et biophysica acta.Biochim Biophys Acta.2012 Sep;1818(9):2228-33. Epub 2012 Apr 20.
- Understanding the role of specific bilayer components in controlling the function of G-protein coupled receptors (GPCRs) will be a key factor in the development of novel pharmaceuticals. Cholesterol-dependence in particular has become an area of keen interest with respect to GPCR function; not least
- PMID 22551944
- 書評 ケインズの逆襲 ハイエクの慧眼 : 巨人たちは経済政策の混迷を解く鍵をすでに知っていた 松尾匡著
- BEPS, Spillovers, etc. : Current issues in international corporate taxation (IMF財政局次長講演会 国際課税における最近の課題)