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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/08 16:46:37」(JST)
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- 1. 補体系の概要および臨床的評価 overview and clinical assessment of the complement system
- 2. 補体系の遺伝性疾患 inherited disorders of the complement system
- 3. マンノース結合レクチン mannose binding lectin
- 4. マンノース結合レクチン欠損症 mannose binding lectin deficiency
- 5. 補体経路 complement pathways
English Journal
- Association of MASP2 polymorphisms and protein levels with rheumatic fever and rheumatic heart disease.
- Catarino SJ1, Boldt AB2, Beltrame MH1, Nisihara RM1, Schafranski MD3, de Messias-Reason IJ4.
- Human immunology.Hum Immunol.2014 Dec;75(12):1197-202. doi: 10.1016/j.humimm.2014.10.003. Epub 2014 Oct 12.
- MASP-2 is a key protein of the lectin pathway of complement system. Several MASP2 polymorphisms were associated with MASP-2 serum levels or functional activity. Here we investigated a possible association between MASP2 polymorphisms and MASP-2 serum levels with the susceptibility to rheumatic fever
- PMID 25318078
- Impact of passive smoking, cooking with solid fuel exposure, and MBL/MASP-2 gene polymorphism upon susceptibility to tuberculosis.
- Chen M1, Deng J2, Su C3, Li J4, Wang M2, Abuaku BK2, Hu S2, Tan H5, Wen SW6.
- International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.Int J Infect Dis.2014 Dec;29C:1-6. doi: 10.1016/j.ijid.2014.08.010. Epub 2014 Oct 13.
- BACKGROUND: To explore the impact of passive smoking, cooking with solid fuel, mannose-binding lectin (MBL) gene, MBL-associated serine proteases 2 (MASP-2) gene, and gene-environment interactions on the susceptibility to tuberculosis (TB) in non-smokers.METHODS: A total of 205 TB patients and 216 h
- PMID 25312983
Japanese Journal
- Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
- MOLLER-KRISTENSEN Mette,THIEL Steffen,SJOHOLM Anders,MATSUSHITA Misao,JENSENIUS Jens C.
- International immunology 19(2), 141-149, 2007-02-01
- NAID 10020111627
- Spider Silk Proteins : Mechanical Property and Gene Sequence
- Rising Anna,Nimmervoll Helena,Grip Stefan,Fernandez-Arias Armando,Storckenfeldt Erica,Knight David P,Vollrath Fritz,Engstrom Wilhelm
- Zoological science 22(3), 273-281, 2005-03-25
- Spiders spin up to seven different types of silk and each type possesses different mechanical properties. The reports on base sequences of spider silk protein genes have gained importance as the mecha …
- NAID 110006281798
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★リンクテーブル★
| リンク元 | 「補体」 |
| 拡張検索 | 「MASP-2 deficiency」 |
| 関連記事 | 「MAS」「MA」「MASP」 |
「補体」
- 英
- complement
- 同
- アレキシン alexin
- 関
- 補体活性化経路、補体価
- 図：IMM.63
| pathway | start | first step |
| classical pathway | antigen-antibody complex | C1q, C1r, C1s, C4, C2 |
| lectin pathway | mannose-binding lectin or ficolin binds carbohydrate on pathogen surface | MBL/ficolin, MASP-2, C4, C2 |
| alternative pathway | pathogen surface | C3, B, D |
補体の相互作用 IMM.62
- C1qがカスケードの最初となる。3つの方法で補体カスケードがはじまる。
- (1)多価陰イオン表面(例えば、グラム陰性細菌のリポテイコ酸)
- (2)バクテリアの多糖のホスホコリンに結合(例えば肺炎球菌のC蛋白質)
- (3)抗原抗体複合体に結合して自然免疫と獲得免疫のエフェクター機構を結びつける。
- 炭化水素鎖を認識するレクチンがカスケードの最初となる。
- 1. lectin MBL：mannose-containing carbohydrates
- 2. ficolin ：N-acetylglucosamine
- C3からはじまる。血漿中のC3が病原体の表面で自発的に活性化されることで補体反応がはじまる。
３つの経路は共通してC3 convertaseを生成。C3 convertaseはC3→C3a+C3b C3a: C3a is a peptide mediator of local inflammation C3b: C3b binds covalently to the bacterial cell membrane and opsonizes the bacteria
C5 convertaseはC3bにC3 convertaseが結合してできる C5 converaseはC5→C5a+C5b C5a: powerful peptide mediator of inflammation C5b: C5b,C6,C7,C8,C9: membrane-attack complex
C3aとC5a。C4a
- 炎症部位に血管外に抗体、補体、食細胞を集め、組織液を増やすことで抗原提示細胞がリンパ節に移動するのを促進する(IMM.75)
- C5a,C3a,C4a: smooth muscle contraction.(IMM.75)
- C5a,C3a: act on the endo thelial cells lining blood vessels to induce adhesion molecules.(IMM.75)
- C5a>C3a>C4a: increase in blood flow, increase vascular permeability, increase binding of phagocytes to exdothielial cells.(IMM.76)
- C5a: activates mast cells to release mediators, such as histamine and TNF-α. that contribute the inflammatory response(IMM.76).
- C5a: acts directly on neutrophils and monocytes and attracting neutrophils and monocytes(IMM.75)
- C3a: contributes to the pypotension and edema seen in endotoxic shock
- C5a: activated by endotoxin, funcions in neutrophil chemotaxis
C5a
臨床関連
- 増加：
- 減少：低補体血症
「MASP-2 deficiency」
- 同
- mannan-binding lectin -associated serine protease 2
「MAS」
- 胎便吸引症候群 meconium aspiration syndrome
- マクロファージ活性化症候群 macrophage activation syndrome
- 吸収不良症候群 malabsorption syndrome
「MA」
「MASP」
- 同
- mannan-binding lectin-associated serine proteases, MASPs