WordNet
- of or relating to the study of the literary works of ancient Greece and Rome; " a classical scholar"
- of or relating to the most highly developed stage of an earlier civilisation and its culture; "classic Cinese pottery" (同)classic
- of or pertaining to or characteristic of the ancient Greek and Roman cultures; "classical mythology"; "classical (同)classic, Greco-Roman, Graeco-Roman, Hellenic
- (language) having the form used by ancient standard authors; "classical Greek
- a creation of the highest excellence
- an artist who has created classic works
- a trodden path (同)footpath
PrepTutorEJDIC
- 古典の;古典時代の;古典様式の / (文学・芸術において)古典主義の(簡潔で調和を保ち洗練されているのが特徴) / (ジャズ・フォークなどに対して主として20世紀初頭までの)古典派の / (新奇な・実験的なものではなく)伝統的な,正統的な / (専門科目に対して)教養科目の
- (一つの分野の中で)『規範となる』,典型的な;第1級の / 伝統的な,由緒のある(traditional) / (型・様式などについて)単純で洗練された / 古典の;古典的な(classical) / 〈C〉(一つの分野の中で)『規範』(『模範』)『となる作品』,代表作 / 〈C〉代表的芸術家,古典的作家 / 《the classics》《しばしばC-》古典文学 / 〈C〉伝統的な(由緒ある)行事
- 道,小道(path)
UpToDate Contents
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- 1. 補体系の後天性疾患 acquired disorders of the complement system
- 2. 補体系の遺伝性疾患 inherited disorders of the complement system
- 3. 後天性C1インヒビター欠損症：臨床症状、疫学、病因、および診断 acquired c1 inhibitor deficiency clinical manifestations epidemiology pathogenesis and diagnosis
- 4. 髄膜炎菌感染の疫学 epidemiology of neisseria meningitidis infection
- 5. リウマチ性血管炎の疫学および病因 epidemiology and pathogenesis of rheumatoid vasculitis
English Journal
- Some natural flavonoids are competitive inhibitors of Caspase-1, -3 and -7 despite their cellular toxicity.
- White JB, Beckford J, Yadegarynia S, Ngo N, Lialiutska T, d'Alarcao M.SourceDepartment of Biological Sciences, San José State University, One Washington Square, San Jose, CA 95192-0100.
- Food chemistry.Food Chem.2012 Apr 15;131(4):1453-1459.
- A common feature of both apoptosis and inflammation is the activation of caspases. Caspases are aspartate-directed cysteine proteases that have numerous cellular targets. It has been discovered that several flavonoids are inhibitors of caspases. Flavonoids are members of a family of polyphenolic com
- PMID 22140296
- Ugonin K-stimulated osteogenesis involves estrogen receptor-dependent activation of non-classical Src signaling pathway and classical pathway.
- Lee CH, Huang YL, Liao JF, Chiou WF.SourceDepartment of Pharmacology, National Yang-Ming University, Taipei, Taiwan.
- European journal of pharmacology.Eur J Pharmacol.2012 Feb 15;676(1-3):26-33. Epub 2011 Dec 14.
- We have reported previously that ugonin K, a flavonoid isolated from Helminthostachys zeylanica (L.) Hook, potently induces cell differentiation and mineralization of MC3T3-E1 mouse osteoblast-like cells. Here we aimed to elucidate whether ugonin K evoked osteogenesis required interaction with estro
- PMID 22192930
- Chronic Exposure to Nicotine Is Associated with Reduced Reward-Related Activity in the Striatum but not the Midbrain.
- Rose EJ, Ross TJ, Salmeron BJ, Lee M, Shakleya DM, Huestis M, Stein EA.SourceNeuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland.
- Biological psychiatry.Biol Psychiatry.2012 Feb 1;71(3):206-13. Epub 2011 Oct 26.
- BACKGROUND: The reinforcing effects of nicotine are mediated by brain regions that also support temporal difference error (TDE) processing; yet, the impact of nicotine on TDE is undetermined.METHODS: Dependent smokers (n = 21) and matched control subjects (n = 21) were trained to associate a juice r
- PMID 22032832
Japanese Journal
- Surface plasmon resonance in monitoring of complement activation on biomaterials.
- Arima Yusuke,Toda Mitsuaki,Iwata Hiroo
- Advanced drug delivery reviews 63(12), 988-999, 2011-09-16
- When artificial materials come into contact with blood, various biological responses are induced. For successful development of biomaterials used in biomedical devices that will be exposed to blood, u …
- NAID 120003405538
- Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages.
- Yamamoto Hiroshi,Naito Yuko,Okano Maho,Kanazawa Takayuki,Takematsu Hiromu,Kozutsumi Yasunori
- Archives of biochemistry and biophysics 506(1), 83-91, 2011-02-01
- … Molecular analyses revealed that SPC enhances, whereas LSF suppresses, phorbol ester-induced classical (M1-polarized) differentiation to macrophages. … The expression of CD11b, a macrophage marker, was induced in accordance with the activation status of the Raf/MEK/ERK signaling pathway in which SPC and LSF had opposite effects. … Pharmacological inhibition of this pathway aborted the differentiation, indicating that this signaling pathway is required. …
- NAID 120002770476
- Notch 受容体の細胞外領域におけるO-GlcNAc修飾
- OKAJIMA Tetsuya,FURUKAWA Koichi,SAKAIDANI Yuta
- Trends in glycoscience and glycotechnology 22(126), 247-255, 2010-11-30
- 上皮増殖因子 (EGF) ドメインはユニークなO-結合型糖鎖による翻訳後修飾を受ける。EGFドメイン上のO-型糖鎖として知られるO-フコースやO-グルコースは、多くの血漿糖タンパク質やシグナリング分子に見出されており、とりわけNotchシグナリング経路における生物学的機能がこれまでに示されてきた。我々は最近、EGFドメインにおける新規の糖鎖修飾としてO-GlcNAcを発見した。そしてこの修飾が、シ …
- NAID 10027893118
Related Links
- Classical-pathway definition, the activation of complement by an antigen-antibody reaction. See more. Dictionary.com Word of the Day Translate Games Blog Thesaurus.com Apps Favorites Log Out Log In follow Dictionary.com ...
- The Classical Pathway of Complement Activation Carlos Jimenez Subscribe Subscribed Unsubscribe 343 343 Loading... Loading... Working...
Related Pictures
★リンクテーブル★
| リンク元 | 「補体」「古典的経路」 |
| 拡張検索 | 「classical pathway complement C3-C5 convertase」「classical pathway complement C3 convertase」「classical pathway complement C5 convertase」 |
| 関連記事 | 「classic」「classical」「pathway」 |
「補体」
- 英
- complement
- 同
- アレキシン alexin
- 関
- 補体活性化経路、補体価
- 図：IMM.63
| pathway | start | first step |
| classical pathway | antigen-antibody complex | C1q, C1r, C1s, C4, C2 |
| lectin pathway | mannose-binding lectin or ficolin binds carbohydrate on pathogen surface | MBL/ficolin, MASP-2, C4, C2 |
| alternative pathway | pathogen surface | C3, B, D |
補体の相互作用 IMM.62
- C1qがカスケードの最初となる。3つの方法で補体カスケードがはじまる。
- (1)多価陰イオン表面(例えば、グラム陰性細菌のリポテイコ酸)
- (2)バクテリアの多糖のホスホコリンに結合(例えば肺炎球菌のC蛋白質)
- (3)抗原抗体複合体に結合して自然免疫と獲得免疫のエフェクター機構を結びつける。
- 炭化水素鎖を認識するレクチンがカスケードの最初となる。
- 1. lectin MBL：mannose-containing carbohydrates
- 2. ficolin ：N-acetylglucosamine
- C3からはじまる。血漿中のC3が病原体の表面で自発的に活性化されることで補体反応がはじまる。
３つの経路は共通してC3 convertaseを生成。C3 convertaseはC3→C3a+C3b C3a: C3a is a peptide mediator of local inflammation C3b: C3b binds covalently to the bacterial cell membrane and opsonizes the bacteria
C5 convertaseはC3bにC3 convertaseが結合してできる C5 converaseはC5→C5a+C5b C5a: powerful peptide mediator of inflammation C5b: C5b,C6,C7,C8,C9: membrane-attack complex
C3aとC5a。C4a
- 炎症部位に血管外に抗体、補体、食細胞を集め、組織液を増やすことで抗原提示細胞がリンパ節に移動するのを促進する(IMM.75)
- C5a,C3a,C4a: smooth muscle contraction.(IMM.75)
- C5a,C3a: act on the endo thelial cells lining blood vessels to induce adhesion molecules.(IMM.75)
- C5a>C3a>C4a: increase in blood flow, increase vascular permeability, increase binding of phagocytes to exdothielial cells.(IMM.76)
- C5a: activates mast cells to release mediators, such as histamine and TNF-α. that contribute the inflammatory response(IMM.76).
- C5a: acts directly on neutrophils and monocytes and attracting neutrophils and monocytes(IMM.75)
- C3a: contributes to the pypotension and edema seen in endotoxic shock
- C5a: activated by endotoxin, funcions in neutrophil chemotaxis
C5a
臨床関連
- 増加：
- 減少：低補体血症
「古典的経路」
- 英
- classical pathway
- 同
- 古典経路、補体古典経路、古典補体経路、classical complement pathway CCP、補体第一経路 first complement pathway、第一経路 first pathway
- 関
- 補体
関与する分子
- C1(C1q, C1r, C1s), C4, C2
- C1INH(C1 inhibitor)
IMM.64
- C1qから古典的径路がはじまる。
- (1)多価陰イオン表面(例えば、グラム陰性細菌のリポテイコ酸)
- (2)バクテリアの多糖のホスホコリンに結合(例えば肺炎球菌のC蛋白質)
- (3)抗原抗体複合体に結合して自然免疫と獲得免疫のエフェクター機構を結びつける。
- 自然抗体(クラスはIgMであり、補体と高い効率で結合する)と結合して
C1の活性化 (IMM.65)
- 1. C1qの結合
- 1-a. C1q headが病原体の表面に結合
- 1-b. C1q headがFc領域と呼ばれる抗体の定常領域に結合して(C1r:C1s)2複合体の立体構造が変化
- 2. C1rの自己触媒活性が活性化してC1sを切断する
- 3. C1sのセリンプロテアーゼ活性が生じる。
C3 convertase(C4bC2a)の産生(IMM.65)
- 1. C1sがC4を切断してC4bを生じる。
- 2. C4bは共有結合的に病原体の表面に結合する。
- 3. C4bは病原体表面でC2と結合する。これでC1sがC2を切断させやすくする。
- 4. C1sがC2を切断してC3 convertase活性を持つC4bC2aが産生される。
「classical pathway complement C3-C5 convertase」
「classical pathway complement C3 convertase」
「classical pathway complement C5 convertase」
「classic」
- 古典的な、伝統的な、クラシックな
「classical」
- 古典的な
「pathway」
- 関
- route