WordNet

very bad in degree or extent; "a severe worldwide depression"; "the house suffered severe damage"
unsparing and uncompromising in discipline or judgment; "a parent severe to the pitch of hostility"- H.G.Wells; "a hefty six-footer with a rather severe mien"; "a strict disciplinarian"; "a Spartan upbringing" (同)spartan
intensely or extremely bad or unpleasant in degree or quality; "severe pain"; "a severe case of flu"; "a terrible cough"; "under wicked fire from the enemys guns"; "a wicked cough" (同)terrible, wicked
join for a common purpose or in a common action; "These forces combined with others"
harvester that heads and threshes and cleans grain while moving across the field
add together from different sources; "combine resources"
set or keep apart; "sever a relationship" (同)break_up
incapable of developing an immune response following exposure to an antigen; "immunodeficient rodents"
detached by cutting; "cut flowers"; "a severed head"; "an old tale of Anne Bolyn walking the castle walls with her poor cut-off head under her arm" (同)cut_off

PrepTutorEJDIC

(人・法律などが)『厳しい』,厳格な / (態度・表情が)厳粛な,いかめしい / (病気などが)『重い』,危険な / (様式・趣味などが)簡素な,じみな,飾りのない / (人の体に)厳しくこたえる,激しい / (試験などが)難しい,厳しい
…'を'『結合する』,合同する / …'を'兼ね備える;(…と)…'を'兼ね合わさせる《+『名』+『with』+『名』》 / …'を'化合させる;(…と)…'を'化合させる《+『名』+『with』+『名』》 / 『結合する』,連合する,合同する / (…と)化合する《+『with』+『名』》 / 連合,合同;(特に)企業合同,政治連合 / (また『combine harvester』)(刈り取りと脱穀が同時にできる)複式収穫機,コンバイン
(全体から)…‘を'切断する《+『名』+『from』+『名』》 / (いくつかの部分に)…‘を'分ける《+『名』+『in』(『into』)+『名』》 / 〈関係など〉‘を'断つ / 切れる,分かれる,分裂する

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1. 重度複合型免疫不全（SCID）：概要 severe combined immunodeficiency scid an overview
2. 重度複合型免疫不全（SCID）：特定の欠損 severe combined immunodeficiency scid specific defects
3. X連鎖重度複合型免疫不全（SCID） x linked severe combined immunodeficiency scid
4. T細胞陰性、B細胞陰性、NK細胞陽性の重度複合型免疫不全 t cell negative b cell negative nk cell positive severe combined immunodeficiency
5. JAK3欠損を伴う重度複合型免疫不全（SCID） severe combined immunodeficiency scid with jak3 deficiency

Diverging biological roles among human monocyte subsets in the context of tuberculosis infection.

Balboa L1, Barrios-Payan J2, González-Domínguez E3, Lastrucci C4, Lugo-Villarino G4, Mata-Espinoza D2, Schierloh P1, Kviatcovsky D1, Neyrolles O4, Maridonneau-Parini I4, Sánchez-Torres C3, Sasiain Mdel C1, Hernández-Pando R2.
Clinical science (London, England : 1979).Clin Sci (Lond).2015 Aug 1;129(4):319-30. doi: 10.1042/CS20150021.
Circulating monocytes (Mo) play an essential role in the host immune response to chronic infections. We previously demonstrated that CD16pos Mo were expanded in TB (tuberculosis) patients, correlated with disease severity and were refractory to dendritic cell differentiation. In the present study, w
PMID 25858460

Oncogenic Activity of miR-650 in Prostate Cancer Is Mediated by Suppression of CSR1 Expression.

Zuo ZH1, Yu YP1, Ding Y2, Liu S2, Martin A1, Tseng G2, Luo JH3.
The American journal of pathology.Am J Pathol.2015 Jul;185(7):1991-1999. doi: 10.1016/j.ajpath.2015.03.015. Epub 2015 May 5.
Cellular stress response 1 (CSR1) is a tumor suppressor gene whose expression was frequently down-regulated in prostate cancer. The mechanism of its down-regulation, however, is not clear. Here, we show that the 3' untranslated region of CSR1 contains a target site of miR-650. High level of miR-650
PMID 25956032

Targeting CD133high Colorectal Cancer Cells In Vitro and In Vivo With an Asymmetric Bispecific Antibody.

Zhao L1, Yang Y, Zhou P, Ma H, Zhao X, He X, Wang T, Zhang J, Liu Y, Zhang T.
Journal of immunotherapy (Hagerstown, Md. : 1997).J Immunother.2015 Jul-Aug;38(6):217-28. doi: 10.1097/CJI.0000000000000086.
A critical obstacle in advanced colorectal cancer (CRC) treatment is the insufficient improvement on survival of conventional chemotherapy. Cancer stem cells are reported to be one of the crucial explanations. CD133 has been identified as a surface marker of CRC stem cells. Bispecific antibodies (Bi
PMID 26049545

Establishment of a Novel Xenograft Model for Human Uterine Leiomyoma in Immunodeficient Mice

Gender difference in bone metastasis of human small cell lung cancer, SBC-5 cells in natural killer-cell depleted severe combined immunodeficient mice

Sakaguchi Satoshi,Goto Hisatsugu,Hanibuchi Masaki,Otsuka Shinsaku,Ogino Hirokazu,Kakiuchi Soji,Uehara Hisanori,Yano Seiji,Nishioka Yasuhiko,Sone Saburo
CLINICAL & EXPERIMENTAL METASTASIS 27(5), 351-359, 2010
NAID 120004738208