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Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling.

Takahashi K1,2, Hosono M3, Sato I4, Hata K1, Wada T1, Yamaguchi K5, Nitta K2, Shima H2, Miyagi T1.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Oct 1;137(7):1560-73. doi: 10.1002/ijc.29527. Epub 2015 Apr 1.
The plasma membrane-associated sialidase NEU3 is a key enzyme for ganglioside degradation. We previously demonstrated remarkable up-regulation of NEU3 in various human cancers, with augmented malignant properties. Here, we provide evidence of a close link between NEU3 expression and Wnt/β-catenin s
PMID 25810027

Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6.

Chiu HW1, Lin SW2, Lin LC3, Hsu YH4, Lin YF1, Ho SY5, Wu YH6, Wang YJ7.
Cancer letters.Cancer Lett.2015 Sep 1;365(2):229-39. doi: 10.1016/j.canlet.2015.05.025. Epub 2015 Jun 4.
Ninety percent of human pancreatic cancer is characterized by activating K-RAS mutations. TRAF6 is an oncogene that plays a vital role in K-RAS-mediated oncogenesis. We investigated the synergistic effect of combining ionizing radiation (IR) and proteasome inhibitor (MG132). Furthermore, following c
PMID 26052093

Epstein-Barr virus infection induces miR-21 in terminally differentiated malignant B cells.

Anastasiadou E1, Garg N2, Bigi R1, Yadav S1, Campese AF2, Lapenta C3, Spada M3, Cuomo L4, Botta A5, Belardelli F3, Frati L1, Ferretti E2, Faggioni A1, Trivedi P1.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Sep;137(6):1491-7. doi: 10.1002/ijc.29489. Epub 2015 Mar 4.
The association of Epstein-Barr virus (EBV) with plasmacytoid malignancies is now well established but how the virus influences microRNA expression in such cells is not known. We have used multiple myeloma (MM) cell lines to address this issue and find that an oncomiR, miR-21 is induced after in vit
PMID 25704079