extracellular signal-regulated MAP kinase

• 細胞外シグナル制御MAPキナーゼ

関

extracellular signal-regulated kinase

WordNet

1. place signs, as along a road; "sign an intersection"; "This road has been signed"
2. (medicine) any objective evidence of the presence of a disorder or disease; "there were no signs of asphyxiation"
3. a perceptible indication of something not immediately apparent (as a visible clue that something has happened); "he showed signs of strain"; "they welcomed the signs of spring" (同)mark
4. a character indicating a relation between quantities; "dont forget the minus sign"
5. a fundamental linguistic unit linking a signifier to that which is signified; "The bond between the signifier and the signified is arbitrary"--de Saussure
6. a gesture that is part of a sign language
7. a public display of a message; "he posted signs in all the shop windows"
8. engage by written agreement; "They signed two new pitchers for the next season" (同)contract, sign on, sign_up
9. approve and express assent, responsibility, or obligation; "All parties ratified the peace treaty"; "Have you signed your contract yet?" (同)ratify
10. communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" (同)signal, signalize, signalise
11. mark with ones signature; write ones name (on); "She signed the letter and sent it off"; "Please sign here" (同)subscribe
12. be engaged by a written agreement; "He signed to play the casino on Dec. 18"; "The soprano signed to sing the new opera"
13. communicate in sign language; "I dont know how to sign, so I could not communicate with my deaf cousin"
14. make a map of; show or establish the features of details of; "map the surface of Venus"
15. to establish a mapping (of mathematical elements or sets) (同)represent
16. a diagrammatic representation of the earths surface (or part of it)
17. plan, delineate, or arrange in detail; "map ones future" (同)map out
18. depict as if on a map; "sorrow was mapped on the mothers face"
19. explore or survey for the purpose of making a map; "We havent even begun to map the many galaxies that we know exist"
20. locate within a specific region of a chromosome in relation to known DNA or gene sequences; "map the genes"
21. notably out of the ordinary; "the year saw one signal triumph for the Labour party"
22. an electric quantity (voltage or current or field strength) whose modulation represents coded information about the source from which it comes
23. any nonverbal action or gesture that encodes a message; "signals from the boat suddenly stopped" (同)signaling, sign
24. any incitement to action; "he awaited the signal to start"; "the victory was a signal for wild celebration"
25. bring into conformity with rules or principles or usage; impose regulations; "We cannot regulate the way people dress"; "This town likes to regulate" (同)regularize, regularise, order, govern
26. fix or adjust the time, amount, degree, or rate of; "regulate the temperature"; "modulate the pitch" (同)modulate

PrepTutorEJDIC

1. (ある事実・状態・感情などの)『表れ』,印,気配,徴侯(indication);(…の)こん跡,計跡《+『of』+『名』》・『身ぶり』,手まね,合図 / 『標識』,看板 / (数学・音楽などの)記号 / (…の)『象徴』,シンボル(symbol)《+『of』+『名』》・《文》(…の)『前兆』,きざし《+『of』+『名』》・宮(きゅう)(黄道12区分の一つ) ・〈手紙・書類・作品など〉‘に'『署名する』・(…に)〈名前など〉‘を'書く《+『名』+『on』(『to』)+『名』》 / …‘を'雇う契約に署名する・…‘を'合図する,知らせる;…に合図する・署名する・契約書に署名して雇われる
2. (1枚1枚の)『地図』;天体図 / …‘の'地図を作る;…‘を'地図にかく
3. (警告・指示・情報などを伝える)『信号』,合図 / (…の)きっかけ,動機,導火線《+『for』+『名』》 / 〈人・車など〉‘に'『合図する』,信号を送る / …‘を'『合図』(信号)『で知らせる』 / 『合図する』,信号する / 合図の,信号の / めざましい,顕著な
4. (規則などで)…‘を'『規制する』,『統制する』 / 〈機械など〉‘を'『調整する』 / 〈量や率など〉‘を'ある限度内におさえる

UpToDate Contents

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• 1. 進行性肝細胞癌に対する全身治療 systemic treatment for advanced hepatocellular carcinoma
• 2. エストロゲン作用の分子生物学および生理学 molecular biology and physiology of estrogen action
• 3. 黒色腫（メラノーマ）の分子生物学 the molecular biology of melanoma
• 4. 前立腺癌の分子生物学 molecular biology of prostate cancer
• 5. ヘリコバクターピロリ感染の病態生理およびそれへの免疫応答 pathophysiology of and immune response to helicobacter pylori infection

English Journal

• Oscillation of mitogen-activated protein kinases in response to endoplasmic reticulum stress.

• Zhang H, Zhao Y, Tian T, Paton AW, Paton JC, Kitamura M.SourceDepartment of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan; Department of Nephrology, First Affiliated Hospital of China Medical University, Shenyang 110001, China.
• Analytical biochemistry.Anal Biochem.2011 Oct 15;417(2):292-4. Epub 2011 Jun 26.
• Periodic patterns of biochemical systems determine the function, behavior, and fate of eukaryotic cells. The cascades of mitogen-activated protein (MAP) kinases play crucial roles in a diverse range of cell function, and recent reports indicate that oscillation of extracellular signal-regulated kina
• PMID 21756869

• The Inhibitory Effect of Simvastatin on Osteoclast Differentiation by Scavenging Reactive Oxygen Species.

• Moon HJ, Kim SE, Yun YP, Hwang YS, Park JH, Kwon IK.AbstractOsteoclasts, together with osteoblasts, control the amount of bone tissue and regulate bone remodeling. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. Reactive oxygen species (ROS) acts as a signal mediator in osteoclast differentiation. Simvastatin, which inhibits 3-hydroxy-3-methylglutaryl coenzyme A, is a hypolipidemic drug which is known to affect bone metabolism and suppresses osteoclastogenesis induced by receptor activator of nuclear factor- kB ligand (RANKL). In this study, we analyzed whether simvastatin can inhibit RANKL-induced osteoclastogenesis through suppression of the subsequently formed ROS and investigated whether simvastatin can inhibit H2O2-induced signaling pathways in osteoclast differentiation. We found that simvastatin decreased expression of tartrate-resistant acid phosphatase (TRAP), a genetic marker of osteoclast differentiation, and inhibited intracellular ROS generation in RAW 264.7 cell lines. ROS generation activated IkBα, protein kinases B (AKT), mitogen-activated protein kinases (MAPKs) signaling pathways such as c-JUN N-terminal kinases (JNK), p38 MAP kinases (P38) as well as extracellular signal-regulated kinase (ERK). Simvastatin was found to suppress these H2O2-induced signaling pathways in osteoclastogenesis. Together, these results indicate that simvastatin acts as an osteoclastogenesis inhibitor through suppression of ROS-mediated signaling pathways. This indicates that simvastatin has potential usefulness for osteoporosis and pathological bone resorption.
• Experimental & molecular medicine.Exp Mol Med.2011 Aug 10. [Epub ahead of print]
• Osteoclasts, together with osteoblasts, control the amount of bone tissue and regulate bone remodeling. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. Reactive oxygen species (ROS) acts as a signal mediator in osteoclast differentiation.
• PMID 21832867

Japanese Journal

• High-dose tobramycin inhibits lipopolysaccharide-induced MUC5AC production in human lung epithelial cells.

• Nakamura Shigeki,Yanagihara Katsunori,Araki Nobuko,Yamada Koichi,Morinaga Yoshitomo,Izumikawa Koichi,Seki Masafumi,Kakeya Hiroshi,Yamamoto Yoshihiro,Kamihira Shimeru,Kohno Shigeru
• European journal of pharmacology 659(1), 67-71, 2011-05-20
• … Tobramycin suppressed the phosphorylation of extracellular signal-regulated protein kinase, p38 MAP kinase. … These results suggest that high-dose tobramycin, such as inhalation therapy, can inhibit MUC5AC gene expression and MUC5AC protein production in NCI-H292 cells, in part through the mitogen-activated protein kinase pathway. …
• NAID 120003220709

• Alpinumisoflavone Induces Apoptosis and Suppresses Extracellular Signal-Regulated Kinases/Mitogen Activated Protein Kinase and Nuclear Factor-κB Pathways in Lung Tumor Cells

• Namkoong Sim,Kim Tack-Joong,Jang Ik-Soon,Kang Keon-Wook,Oh Won-Keun,Park Junsoo
• Biological & Pharmaceutical Bulletin 34(2), 203-208, 2011
• … The extracellular signal-regulated kinases/mitogen activated protein kinase (ERK/MAPK) and nuclear factor-κB (NF-κB) pathways are critical for cell survival and proliferation. … Western blot analysis with antibodies to MAP/ERK kinase (MEK) and ERK showed that AIF dephosphorylates both MEK and ERK. …
• NAID 130000402190

Related Links

• Extracellular signal-regulated kinases - Wikipedia, the free ...

In molecular biology, extracellular-signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, ...

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★リンクテーブル★

リンク元	「extracellular signal-regulated kinase」「細胞外シグナル制御MAPキナーゼ」
関連記事	「map」「MAP」「regulate」「sign」「signaling」

「extracellular signal-regulated kinase」

　　[★]

細胞外シグナル制御キナーゼ

関

ERK、extracellular signal-regulated MAP kinase

「細胞外シグナル制御MAPキナーゼ」

　　[★]

英

extracellular signal-regulated MAP kinase

関

細胞外シグナル制御キナーゼ

「map」

　　[★]

• n.

• 地図、マップ

• v.

• 地図で表す、(遺伝子などを)位置づける、(遺伝子などが)位置する

関

lie、locate、location、loci、locus、mapping、position、rank、sit、situated、situation、stand、topo

　 　 　 　 　 　 　 　

「MAP」

　　[★]

• 僧帽弁輪形成術 mitral annuloplasty
• Miller assessment for Pre-schoolers
• 平均動脈圧 mean arterial pressure
• 平均気道内圧 mean airway pressure
• mannitol adenine phosphate
• リン酸アンモニウムマグネシウム magnesium ammonium phosphate

「regulate」

　　[★]

• 制御する、調節する、(法的に)規制する

関

accommodation、accommodative、adjust、adjustment、baffle、control、modulate、modulation、regulation、regulatory

　 　 　

「sign」

　　[★]

• n.

• 徴候、兆候、サイン、(数学)符号

関

indication、manifestation、signature、stigma、stigmata、symptom、symptomatic

　 　 　 　 　 　 　 　 　 　 　 　 　 　

「signaling」

　　[★]

• n.

• シグナル伝達、情報伝達、シグナリング、信号伝達

関

signal transduction、signalling