WordNet

cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
become attached by or as if by the process of growth; "The tree trunks had grown together"
become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
cause to grow or develop; "He grows vegetables in his backyard"
increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
pertaining to or constituting a base or basis; "a basic fact"; "the basic ingredients"; "basic changes in public opinion occur because of changes in priorities"
(usually plural) a necessary commodity for which demand is constant (同)staple
reduced to the simplest and most significant form possible without loss of generality; "a basic story line"; "a canonical syllable pattern" (同)canonic, canonical
serving as a base or starting point; "a basic course in Russian"; "basic training for raw recruits"; "a set of basic tools"; "an introductory art course" (同)introductory
of or denoting or of the nature of or containing a base
(biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
(pathology) an abnormal proliferation of tissue (as in a tumor)
a progression from simpler to more complex forms; "the growth of culture"
something grown or growing; "a growth of hair"
vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"

PrepTutorEJDIC

『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
『基礎の』,基本的な(fundamental) / 塩基性(アルカリ性)の
〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/05 18:11:26」(JST)

wiki en

Basic fibroblast growth factor, also known as bFGF, FGF2 or FGF-β, is a member of the fibroblast growth factor family.^[1]

Function

In normal tissue, basic fibroblast growth factor is present in basement membranes and in the subendothelial extracellular matrix of blood vessels. It stays membrane-bound as long as there is no signal peptide.

It has been hypothesized that, during both wound healing of normal tissues and tumor development, the action of heparan sulfate-degrading enzymes activates bFGF, thus mediating the formation of new blood vessels, a process known as angiogenesis.

In addition, it is synthesized and secreted by human adipocytes and the concentration of bFGF correlates with the BMI in blood samples. In this study, bFGF was also shown to act on preosteoblasts – in the form of an increased proliferation – after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase.^[2]

bFGF has been shown in preliminary animal studies to protect the heart from injury associated with a heart attack, reducing tissue death and promoting improved function after reperfusion.^[3]

Recent evidence has shown that low levels of FGF2 play a key role in the incidence of excessive anxiety.^[4]

Additionally, bFGF is a critical component of human embryonic stem cell culture medium; the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins.^[5] It is necessary in mouse-feeder cell dependent culture systems, as well as in feeder and serum-free culture systems.^[6] FGF2, in conjunction with BMP4, promote differentiation of stem cells to mesodermal lineages. After differentiation, BMP4 and FGF2 treated cells generally produces higher amounts of osteogenic and chondrogenic differentiation than untreated stem cells.^[7]

Interactions

Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1,^[8] RPL6^[9] and ribosomal protein S19.^[10]

References

^ Kim HS (1998). "Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping". Cytogenetics and Cell Genetics 83 (1-2): 73. doi:10.1159/000015129. PMID 9925931.
^ Kühn MC, Willenberg HS, Schott M, Papewalis C, Stumpf U, Flohé S, Scherbaum WA, Schinner S (Feb 2012). "Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation". Molecular and Cellular Endocrinology 349 (2): 180–8. doi:10.1016/j.mce.2011.10.018. PMID 22040599.
^ House SL, Bolte C, Zhou M, Doetschman T, Klevitsky R, Newman G, Schultz Jel J (Dec 2003). "Cardiac-specific overexpression of fibroblast growth factor-2 protects against myocardial dysfunction and infarction in a murine model of low-flow ischemia". Circulation 108 (25): 3140–8. doi:10.1161/01.CIR.0000105723.91637.1C. PMID 14656920.
^ Perez JA, Clinton SM, Turner CA, Watson SJ, Akil H (2009). "A new role for FGF2 as an endogenous inhibitor of anxiety". J. Neurosci. 29 (19): 6379–87. doi:10.1523/JNEUROSCI.4829-08.2009. PMC 2748795. PMID 19439615.
^ Pereira RC, Economides AN, Canalis E (Dec 2000). "Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts". Endocrinology 141 (12): 4558–63. doi:10.1210/en.141.12.4558. PMID 11108268.
^ Liu Y, Song Z, Zhao Y, Qin H, Cai J, Zhang H, Yu T, Jiang S, Wang G, Ding M, Deng H (Jul 2006). "A novel chemical-defined medium with bFGF and N2B27 supplements supports undifferentiated growth in human embryonic stem cells". Biochemical and Biophysical Research Communications 346 (1): 131–9. doi:10.1016/j.bbrc.2006.05.086. PMID 16753134.
^ Lee TJ, Jang J, Kang S, Jin M, Shin H, Kim DW, Kim BS (Jan 2013). "Enhancement of osteogenic and chondrogenic differentiation of human embryonic stem cells by mesodermal lineage induction with BMP-4 and FGF2 treatment". Biochemical and Biophysical Research Communications 430 (2): 793–7. doi:10.1016/j.bbrc.2012.11.067. PMID 23206696.
^ Skjerpen CS, Nilsen T, Wesche J, Olsnes S (Aug 2002). "Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity". The EMBO Journal 21 (15): 4058–69. doi:10.1093/emboj/cdf402. PMC 126148. PMID 12145206.
^ Shen B, Arese M, Gualandris A, Rifkin DB (Nov 1998). "Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107". Biochemical and Biophysical Research Communications 252 (2): 524–8. doi:10.1006/bbrc.1998.9677. PMID 9826564.
^ Soulet F, Al Saati T, Roga S, Amalric F, Bouche G (Nov 2001). "Fibroblast growth factor-2 interacts with free ribosomal protein S19". Biochemical and Biophysical Research Communications 289 (2): 591–6. doi:10.1006/bbrc.2001.5960. PMID 11716516.

External links

Basic Fibroblast Growth Factor at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 難治性狭心症マネージメントのための血管新生療法 therapeutic angiogenesis for management of refractory angina
2. 原発性骨髄線維症における病態 pathogenetic mechanisms in primary myelofibrosis
3. 全身性硬化症（強皮症）の病因 pathogenesis of systemic sclerosis scleroderma
4. 糖尿病性網膜症：病因 diabetic retinopathy pathogenesis
5. 悪性神経膠腫の病因と分子生物学 pathology and molecular pathogenesis of diffuse gliomas

English Journal

Effects of mature adipocyte-derived dedifferentiated fat (DFAT) cells on generation and vascularisation of dermis-like tissue after artificial dermis grafting.

Soejima K1, Kashimura T, Asami T, Kazama T, Matsumoto T, Nakazawa H.
Journal of plastic surgery and hand surgery.J Plast Surg Hand Surg.2015 Feb;49(1):25-31. doi: 10.3109/2000656X.2014.920712. Epub 2014 Jun 9.
Abstract Although artificial dermis (AD) is effective for skin reconstruction, it requires two separate procedures, because the AD must be vascularised before skin grafts. To shorten the period of the dermis-like tissue generation before the secondary skin grafting must be beneficial. Dedifferentiat
PMID 24909822

The hamster cheek pouch model for field cancerization studies.

Monti-Hughes A, Aromando RF, Pérez MA, Schwint AE, Itoiz ME.
Periodontology 2000.Periodontol 2000.2015 Feb;67(1):292-311. doi: 10.1111/prd.12066.
External carcinogens, such as tobacco and alcohol, induce molecular changes in large areas of oral mucosa, which increase the risk of malignant transformation. This condition, known as 'field cancerization', can be detected in biopsy specimens using histochemical techniques, even before histological
PMID 25494606

Japanese Journal

bFGF徐放性人工真皮の基礎的評価と臨床応用について (特集人工真皮の現況と展望)

形成外科 58(12), 1303-1313, 2015-12
NAID 40020670687

The effect of basic fibroblast growth factor on regeneration in a surgical wound model of rat submandibular glands

International Journal of Oral Science, 2015-11
NAID 120005676942

Limited hair cell induction from human induced pluripotent stem cells using a simple stepwise method.

Neuroscience letters 599, 49-54, 2015-07-10
NAID 120005663317

Related Pictures

★リンクテーブル★

リンク元	「bFGF」「fibroblast growth factor-2」「塩基性線維芽細胞成長因子」
関連記事	「basic」「grow」「fact」「factor」「fibroblast」

「bFGF」

Fibroblast growth factor 2 (basic)
	PDB rendering based on 1bas.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1BAS, 1BFB, 1BFC, 1BFF, 1BFG, 1BLA, 1BLD, 1CVS, 1EV2, 1FGA, 1FQ9, 1II4, 1IIL, 2BFH, 2FGF, 2M49, 4FGF, 4OEE, 4OEF, 4OEG
Identifiers
Symbols	FGF2 ; BFGF; FGF-2; FGFB; HBGF-2
External IDs	OMIM: 134920 MGI: 95516 HomoloGene: 1521 ChEMBL: 3107 GeneCards: FGF2 Gene
Gene ontology
Molecular function	• fibroblast growth factor receptor binding; • cytokine activity; • protein binding; • growth factor activity; • heparin binding; • ligand-dependent nuclear receptor transcription coactivator activity; • chemoattractant activity;
Cellular component	• extracellular region; • extracellular space; • nucleus;
Biological process	• activation of MAPK activity; • branching involved in ureteric bud morphogenesis; • positive regulation of endothelial cell proliferation; • cell migration involved in sprouting angiogenesis; • phosphatidylinositol biosynthetic process; • chemotaxis; • signal transduction; • epidermal growth factor receptor signaling pathway; • Ras protein signal transduction; • nervous system development; • positive regulation of cell proliferation; • insulin receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • organ morphogenesis; • negative regulation of fibroblast migration; • positive regulation of phospholipase C activity; • growth factor dependent regulation of skeletal muscle satellite cell proliferation; • extracellular matrix organization; • hyaluronan catabolic process; • inositol phosphate biosynthetic process; • somatic stem cell maintenance; • Fc-epsilon receptor signaling pathway; • wound healing; • positive regulation of cell fate specification; • positive regulation of MAP kinase activity; • positive regulation of blood vessel endothelial cell migration; • negative regulation of blood vessel endothelial cell migration; • positive regulation of phosphatidylinositol 3-kinase activity; • innate immune response; • regulation of angiogenesis; • positive regulation of angiogenesis; • positive regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • neurotrophin TRK receptor signaling pathway; • phosphatidylinositol-mediated signaling; • embryonic morphogenesis; • positive chemotaxis; • release of sequestered calcium ion into cytosol; • positive regulation of cell division; • positive regulation of cardiac muscle cell proliferation; • negative regulation of cell death; • chondroblast differentiation; • negative regulation of wound healing; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of sprouting angiogenesis; • regulation of endothelial cell chemotaxis to fibroblast growth factor; • positive regulation of endothelial cell chemotaxis to fibroblast growth factor;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;