- 関
- 血管新生
- transthyretinの分解産物
English Journal
- A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1.
- Cork SM, Kaur B, Devi NS, Cooper L, Saltz JH, Sandberg EM, Kaluz S, Van Meir EG.SourceDepartment of Neurosurgery, Laboratory of Molecular Neuro-Oncology, Emory University School of Medicine, Atlanta, GA, USA.
- Oncogene.Oncogene.2012 Dec 13;31(50):5144-52. doi: 10.1038/onc.2012.1. Epub 2012 Feb 13.
- Brain-specific angiogenesis inhibitor 1 (BAI1), an orphan G protein-coupled receptor-type seven transmembrane protein, was recently found mutated or silenced in multiple human cancers and can interfere with tumor growth when overexpressed. Yet, little is known about its regulation and the molecular
- PMID 22330140
- Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin.
- Klenotic PA, Huang P, Palomo J, Kaur B, Van Meir EG, Vogelbaum MA, Febbraio M, Gladson CL, Silverstein RL.SourceDepartment of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
- The American journal of pathology.Am J Pathol.2010 Apr;176(4):2039-50. doi: 10.2353/ajpath.2010.090782. Epub 2010 Feb 18.
- Brain angiogenesis inhibitor 1 (BAI1) is a transmembrane protein expressed on glial cells within the brain. Its expression is dramatically down-regulated in many glioblastomas, consistent with its functional ability to inhibit angiogenesis and tumor growth in vivo. We have shown that the soluble ant
- PMID 20167858
- Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1.
- Hardcastle J, Kurozumi K, Dmitrieva N, Sayers MP, Ahmad S, Waterman P, Weissleder R, Chiocca EA, Kaur B.SourceDardinger Laboratory for Neuro-oncology and Neurosciences, Department of Neurological Surgery, James Comprehensive Cancer Center and The Ohio State University Medical Center, Columbus, Ohio 43210, USA.
- Molecular therapy : the journal of the American Society of Gene Therapy.Mol Ther.2010 Feb;18(2):285-94. doi: 10.1038/mt.2009.232. Epub 2009 Oct 20.
- Oncolytic viral (OV) therapy is a promising therapeutic modality for brain tumors. Vasculostatin (Vstat120) is the cleaved and secreted extracellular fragment of brain-specific angiogenesis inhibitor 1 (BAI1), a brain-specific receptor. To date, the therapeutic efficacy of Vstat120 delivery into est
- PMID 19844198
Japanese Journal
- Vasculostatin, a proteolytic fragment of brain Angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor
- KAUR B
- Oncogene 24, 3632-3642, 2005
- NAID 30013810408
Related Links
- Click BACKLINKS to see which COPE entries contain the term Vasculostatin . COPE Homepage Top of Page SUPPORT COPE | Santa Claus | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials # A | | ...
- 1. Oncogene. 2005 May 19;24(22):3632-42. Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor. Kaur B, Brat DJ, Devi NS, Van Meir EG. Laboratory of Molecular Neuro ...
Related Pictures
★リンクテーブル★
| リンク元 | 「血管内皮増殖因子」「bFGF」「トランスサイレチン」「血管新生」 |
「血管内皮増殖因子」
- 英
- vascular endothelial growth factor, VEGF
- 同
- 血管内皮細胞増殖因子、vascular endothelial cell growth factor
- 関
- 血管新生
- 癌における血管新生に関与している (同：VEGF。対：angiostatin, endostatin, vasculostatin)
- 標的は血管内皮細胞のみ
- 腫瘍や心臓や網膜の虚血部位で過剰に産生される。
- 低酸素状態にさらされた組織で過剰に産生される。
「bFGF」
- 癌における血管新生に関与している (同：VEGF。対：angiostatin, endostatin, vasculostatin)
- 細胞間マトリックスに蓄えらているbFGFはプロテアーゼによって放出される (BPT.201)
- mitogenである：mesenchymall, neural, and epithelial organ
「トランスサイレチン」
- 蛋白分画でAlb分画に分けられる
- トランスサイレチンの分解産物はangiostatic factorのvasculostatinと呼ばれる
臨床関連
「血管新生」
- 英
- angiogenesis
- 同
- 二次血管発生
- 関
- 脈管形成 vasculogenesis
- 既存の血管から芽が出て新たな血管が形成される
==血管新生促進