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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/21 09:02:07」(JST)
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English Journal
- High prevalence of human parvovirus 4 infection in HBV and HCV infected individuals in shanghai.
- Yu X, Zhang J, Hong L, Wang J, Yuan Z, Zhang X, Ghildyal R.SourceMicrobiology Laboratory, Hongkou District Center for Disease Control and Prevention, Shanghai, People's Republic of China.
- PloS one.PLoS One.2012;7(1):e29474. Epub 2012 Jan 3.
- Human parvovirus 4 (PARV4) has been detected in blood and diverse tissues samples from HIV/AIDS patients who are injecting drug users. Although B19 virus, the best characterized human parvovirus, has been shown to co-infect patients with hepatitis B or hepatitis C virus (HBV, HCV) infection, the ass
- PMID 22235298
- Brief report: no association between parental age and extreme social-communicative autistic traits in the general population.
- Robinson EB, Munir K, McCormick MC, Koenen KC, Santangelo SL.SourceDepartment of Epidemiology, Harvard School of Public Health, Simches Research Building, Boston, MA 02114, USA. erobinso@hsph.harvard.edu
- Journal of autism and developmental disorders.J Autism Dev Disord.2011 Dec;41(12):1733-7.
- This is the first investigation of the relationship between parental age and extreme social-communicative autistic traits in the general population. The parents of 5,246 children in the Avon Longitudinal Study of Parents and Children (ALSPAC) completed the Social and Communication Disorders Checklis
- PMID 21350918
- Dynamic imaging of the effector immune response to listeria infection in vivo.
- Waite JC, Leiner I, Lauer P, Rae CS, Barbet G, Zheng H, Portnoy DA, Pamer EG, Dustin ML.SourceProgram in Molecular Pathogenesis, Helen L. and Martin S. Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York City, New York, United States of America.
- PLoS pathogens.PLoS Pathog.2011 Mar;7(3):e1001326. Epub 2011 Mar 24.
- Host defense against the intracellular pathogen Listeria monocytogenes (Lm) requires innate and adaptive immunity. Here, we directly imaged immune cell dynamics at Lm foci established by dendritic cells in the subcapsular red pulp (scDC) using intravital microscopy. Blood borne Lm rapidly associated
- PMID 21455492
- Autistic traits and autism spectrum disorders: the clinical validity of two measures presuming a continuum of social communication skills.
- Bölte S, Westerwald E, Holtmann M, Freitag C, Poustka F.SourceDepartment of Woman and Child Health, Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Q2:07, 17176, Stockholm, Sweden. sven.bolte@ki.se
- Journal of autism and developmental disorders.J Autism Dev Disord.2011 Jan;41(1):66-72.
- Research indicates that autism is the extreme end of a continuously distributed trait. The Social Responsiveness Scale (SRS) and the Social and Communication Disorders Checklist (SCDC) aim to assess autistic traits. The objective of this study was to compare their clinical validity. The SRS showed s
- PMID 20422277
Japanese Journal
- Vascular Cell-Like Potential of Undifferentiated Ligament Fibroblasts to Construct Vascular Cell-Specific Marker-Positive Blood Vessel Structures in a PI3K Activation-Dependent Manner
- Okubo Naoto,Ishisaki Akira,Iizuka Tadashi,Tamura Masato,Kitagawa Yoshimasa
- Journal of Vascular Research 47(5), 369-383, 2010-08
- … Results: Each SCDC expressed endothelial cell (EC) and smooth muscle cell-specific markers, in addition to MSC- and ligament cell-specific markers. … SCDC2 cells, which abundantly expressed the EC markers Flk-1 and Tie-2, vigorously constructed a blood vessel structure in a phosphoinositide 3-kinase activation-dependent manner. …
- NAID 120002400574
- 胆汁酸の代謝(第14報)サルコシン抱合胆汁酸
- 鳩野 俊三,広中 洋子,倉本 戴寿,穂下 剛彦
- 藥學雜誌 104(5), 466-471, 1984-05-25
- … In order to develop new cholelitholytic agents, sarcosine conjugated chenodeoxycholic acid (SCDC) and ursodeoxycholic acid (SUDC) were synthesized. … The effect of oral administration of SCDC and SUDC on the formation of gallstones was studied in a mouse model of cholesterol cholelithiasis. … Cholesterol gallstones formed in 100% of the animals fed a lithogenic diet, 75% of those fed 0.03% of SCDC and SUDC, and 35% and 15% of those fed 0.15% of SCDC and SUDC, respectively. …
- NAID 110003661110
Related Links
- SCDC's vision is for an active, inclusive and just Scotland where our communities are strong, equitable and sustainable. ... Resilience and public health event The Scottish Community Development Centre was pleased to support a ...
- SCDC's vision is for an active, inclusive and just Scotland where our communities are strong, equitable and sustainable. ... Community Engagement and Community Safety The Community Safety Unit of the Scottish Government ...
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★リンクテーブル★
| リンク元 | 「亜急性連合性脊髄変性症」「ビタミンB12」 |
| 関連記事 | 「SCD」「SC」 |
「亜急性連合性脊髄変性症」
- 英
- subacute combined degeneration of spinal cord, subacute combined degeneration of the spinal cord, SCDC
- 同
- 後索側索硬化症 posterolateral sclerosis、subacute combined degeneration of the dorsal (posterior) and lateral spinal columns (uptodate)
- 関
- ビタミンB12、subacute combined degeneration？
- 図：BET.334
病因
- ビタミンB12の欠乏
- メカニズムは不明であるがミエリンの形成に異常が生じる (参考1)
病理
- 脊髄後索と側索の脱髄・変性
- 大脳白質・末梢神経にも髄鞘の脱髄と軸索の変性が起こる。軸索の変性は軽度。
病態
- 錐体路徴候、深部感覚障害・運動失調(BET.156)
病因
- ビタミンB12の欠乏(詳しくは→ビタミンB12欠乏症)
- 悪性貧血に続発する病態
- 悪性貧血以外の原因による
- 葉酸の欠乏(完全に同一の症状ではない)
検査
- 画像は参考3より引用
診断
- 症候と検査(血中ビタミンB12、シリングテスト)により診断
治療
- ビタミンB12の筋注
参考
- 亜急性連合性脊髄変性症 - nurs
- . [charged] Etiology and clinical manifestations of vitamin B12 and folic acid deficiency - uptodate [1]
- 3. Anitha Sen et al;Ann Indian Acad Neurol 2013 Apr;16(2):255-8. Spinal MR Imaging in Vitamin B12 Deficiency: Case Series; Differential Diagnosis of Symmetrical Posterior Spinal Cord Lesions
「ビタミンB12」
- 構造：FB.387
吸収
- 食物(コバラミン＋蛋白質)→胃(コバラミン)＋壁細胞が分泌する糖タンパク;内因子→コバラミン-内因子複合体→回腸 (SP.742)
- 回腸上皮細胞の刷子縁膜にコバラミン-内因子複合体に特異的なレセプターが存在 (SP.742)
- 細胞内ではβグロブリン(トランスコバラミン II)と結合して血中に入り組織に運ばれる (SPC.280, SPC.742)
部位： ビタミンB12は回腸。 葉酸は空腸。 鉄も空腸、ついでに十二指腸でも。
機能
- コバラミン依存の酵素は全部で十数種ある。コバラミン依存の酵素は分子内転移、メチル転移を触媒 (FB.387)
- 正常ミエリンの維持 (SPC.280)
- 葉酸の代謝(葉酸は核酸代謝に関わっている) (SPC.280)
- 奇数脂肪酸の酸化 (FB.386)
- メチルマロニルCoAムターゼの補酵素(奇数脂肪酸の酸化)
補酵素
- methylmalonyl-CoA mutase：
- methionine synthase：homocysteine + methyl THF－→methionine + THF
必要量
- 一日の消費量(排泄)：1-3ug (体の貯蔵量の-0.1%) (HIM.643)
- 体に貯蔵されてる量：2-3mg → 摂取しなくとも3-4年は欠乏しない
基準値
- 260-1,050pg/ml(192-775pmol/ml)
判定
低値
- 悪性貧血(内因子抗体、壁細胞抗体？)
- 胃切除後
- 萎縮性胃炎
- 吸収不良をきたす病態：クローン病、セリアック病、吸収不良症候群
高値
- 血液疾患：顆粒球増加を示す疾患 ← 顆粒球由来のビタミンB12輸送蛋白(トランスコバラミン?)が増加するため(QB.G-257)、崩壊した白血球から放出するため(YN.G-53)
臨床関連
- 白血球の破壊により末梢へのビタミンB12の漏出
「SCD」
- 心臓性突然死 sudden cardiac death
- 鎌状赤血球症 sickle cell disease
- ステアリン酸CoA脱飽和酵素 stearoyl-CoA desaturase
- 脊髄小脳変性症 spinocerebellar degeneration
- 脊椎肋骨異骨症 spondylocostal dysostosis