secretory component

分泌成分

WordNet

1. an artifact that is one of the individual parts of which a composite entity is made up; especially a part that can be separated from or attached to a system; "spare components for cars"; "a component or constituent element of a system" (同)constituent, element
2. an abstract part of something; "jealousy was a component of his character"; "two constituents of a musical composition are melody and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an effective ingredient of a s (同)constituent, element, factor, ingredient
3. of or relating to or producing a secretion; " a secretory cell"

PrepTutorEJDIC

1. 構成している,成分の / 構成要素,成分

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/05 23:42:25」(JST)

wiki en

[Wiki en表示]

The dimeric IgA molecule.
1: H-chain.
2: L-chain.
3: J-chain.

4: secretory component.

The secretory component is a component of immunoglobulin A (IgA) which consists of a portion of the polymeric immunoglobulin receptor. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen.

Secretory components wrap around two IgA units joined by a J chain protein fragment, resulting in a >--< configuration, with each of the two antigen binding regions of the two constituent y-shaped antibodies exposed. One identified function of secretory components is to protect IgA antibodies from degradation by the gastric acids and enzymes of the digestive system. This property is especially important in the transfer of immune system components during breastfeeding.

External links

• Secretory component at the US National Library of Medicine Medical Subject Headings (MeSH)

References

UpToDate Contents

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• 1. IgGの構造および生物学的機能 structure and biologic functions of iga
• 2. 小児における急性下痢症の病因 pathogenesis of acute diarrhea in children
• 3. 広範囲または合併性の腹壁欠損に対するcomponent separation法による修復 component separation repair of large or complex abdominal wall defects
• 4. 小児における慢性下痢の原因の概要 overview of the causes of chronic diarrhea in children
• 5. 先進国の成人における慢性下痢に対するアプローチ approach to the adult with chronic diarrhea in developed countries

English Journal

• The adipo-fibrokine activin A is associated with metabolic abnormalities and left ventricular diastolic dysfunction in obese patients.

• Zeller J, Krüger C, Lamounier-Zepter V, Sag S, Strack C, Mohr M, Loew T, Schmitz G, Maier L, Fischer M, Baessler A.
• ESC heart failure. 2019 Apr;6(2)362-370.
• Left ventricular diastolic dysfunction (LVDD) is common in obese subjects, and a relationship between epicardial adipose tissue (EAT), increased adipocytokines, and cardiovascular diseases has been reported. This study sought to examine as to whether the adipo-fibrokine activin A is a link between i
• PMID 30729712

• Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer.

• Ham IH, Oh HJ, Jin H, Bae CA, Jeon SM, Choi KS, Son SY, Han SU, Brekken RA, Lee D, Hur H.
• Molecular cancer. 2019 Mar;18(1)68.
• Although the tumor stroma in solid tumors like gastric cancer (GC) plays a crucial role in chemo-resistance, specific targets to inhibit the interaction between the stromal and cancer cells have not yet been utilized in clinical practice. The present study aims to determine whether cancer-associated
• PMID 30927911

• Kinase suppressor of Ras 1 and Exo70 promote fatty acid-stimulated neurotensin secretion through ERK1/2 signaling.

• Rock S, Li X, Song J, Townsend CM, Weiss HL, Rychahou P, Gao T, Li J, Evers BM.
• PloS one. 2019 ;14(3)e0211134.
• Neurotensin is a peptide hormone released from enteroendocrine cells in the small intestine in response to fat ingestion. Although the mechanisms regulating neurotensin secretion are still incompletely understood, our recent findings implicate a role for extracellular signal-regulated kinase 1 and 2
• PMID 30917119

Japanese Journal

• Intranasal Inactivated Influenza Vaccines: a Reasonable Approach to Improve the Efficacy of Influenza Vaccine?

• Japanese Journal of Infectious Diseases 69(3), 165-179, 2016
• NAID 130005152012

• Investigation of Antiulcer and Antioxidant Activity of <i>Juniperus phoenicea</i> L. (1753) Essential Oil in an Experimental Rat Model

• Biological and Pharmaceutical Bulletin 38(11), 1738-1746, 2015
• NAID 130005106387

• 扁平上皮癌への分化を伴う充実腺管癌と分泌癌が併存した乳癌の 1 例

• 日本臨床細胞学会雑誌 54(4), 264-269, 2015
• NAID 130005098188

Related Pictures

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★リンクテーブル★

リンク元	「分泌成分」「S component」「SC」
関連記事	「component」「secretory」

「分泌成分」

　　[★]

英

secretory component SC

同

S成分 S component、分泌片 secretory piece、輸送片 transport piece、多量体免疫グロブリン受容体 polymeric immunoglobulin receptor

関

分泌因子、分泌片

[show details]

分泌成分 : 約 8,080 件
S成分 : 約 8,690 件
分泌因子 : 約 3,320 件
分泌片 : 65 件
輸送片 : 15 件
多量体免疫グロブリン受容体 : 19 件

「S component」

　　[★]

英

secretory component, S component, SC

同

分泌片

poly Ig receptor, poly Ig receptor

関

分泌型IgA、IgA

「SC」

　　[★]

• 分泌成分 secretory component
• 皮下の subcutaneous
• systemic candidiasis

「component」

　　[★]

• n.

• 成分、構成成分、構成要素、コンポーネント

関

building block、composition、constituent、element、ingredient、moiety

　 　 　

「secretory」

　　[★]

• adj.

• 分泌性の、分泌型の