WordNet

a three-dimensional shape with six square or rectangular sides (同)cube
(computer science) a sector or group of sectors that function as the smallest data unit permitted; "since blocks are often defined as a single sector, the terms `block and `sector are sometimes used interchangeably"
support, secure, or raise with a block; "block a plate for printing"; "block the wheels of a car"
a solid piece of something (usually having flat rectangular sides); "the pyramids were built with large stone blocks"
housing in a large building that is divided into separate units; "there is a block of classrooms in the west wing"
a rectangular area in a city surrounded by streets and usually containing several buildings; "he lives in the next block" (同)city block
an inability to remember or think of something you normally can do; often caused by emotional tension; "I knew his name perfectly well but I had a temporary block" (同)mental_block
a number or quantity of related things dealt with as a unit; "he reserved a large block of seats"; "he held a large block of the companys stock"
interrupt the normal function of by means of anesthesia; "block a nerve"; "block a muscle"
run on a block system; "block trains"
shape by using a block; "Block a hat"; "block a garment"
shape into a block or blocks; "block the graphs so one can see the results clearly"
stamp or emboss a title or design on a book with a block; "block the book cover"
direct the flow of; "channel information towards a broad audience" (同)canalize, canalise
a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels" (同)television channel, TV channel
a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"
(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms" (同)communication channel, line
a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company" (同)transmission channel
a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"
the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
a class of drugs that inhibit (block) some biological process (同)blocking_agent
a football player whose responsibility is to block players attempting to stop an offensive play
official routes of communication; "you have to go through channels"

PrepTutorEJDIC

(木・石などの,通例平らな面のある)『かたまり』 / 《米》(四団を街路に囲まれた)『区画』,街区 / 街区の1辺の距離(一般に40メートル前後) / 《英》ブロック(アパート・事務所・商店などに区切られている大きな建物) / 『妨害物』,障害物(obstacle);(障害によって生じた)停滞,渋滞 / 台木,台(まないた・肉切り台・まき割り台・せり売り台・帽子の木型など);《the~》炭頭台 / (特にアメリカンフットボールで)ブロック(相手の選手の突進を阻止する) / 滑車(pulley) / (座席券・株券などの)一組《+『of』+『名』》 / 〈通路など〉'を'『ふさぐ』,〈通行・進行など〉'を'妨げる / 〈帽子など〉の型取りをする / (特にアメリカンフットボールで)〈相手選手の突進〉'を'ブロックする;(ボクシングで)〈相手のパンチ〉'を'ブロックする
〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す
carbonの化学記号

UpToDate Contents

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1. カルシウム拮抗剤中毒 calcium channel blocker poisoning
2. カルシウム拮抗剤の主な副作用および安全性 major side effects and safety of calcium channel blockers
3. 腎集合管ナトリウムチャンネルの遺伝的障害：リドル症候群および偽性低アルドステロン
症1型 genetic disorders of the collecting tubule sodium channel liddles syndrome and pseudohypoaldosteronism type 1
4. 安定狭心症のマネージメントにおけるカルシウム拮抗剤 calcium channel blockers in the management of stable angina pectoris
5. 心筋活動電位および抗不整脈剤の作用 myocardial action potential and action of antiarrhythmic drugs

English Journal

Two distinct types of depolarizing afterpotentials are differentially expressed in stellate and pyramidal-like neurons of entorhinal-cortex layer II.

Alessi C1, Raspanti A1, Magistretti J1.
Hippocampus.Hippocampus.2016 Mar;26(3):380-404. doi: 10.1002/hipo.22529. Epub 2015 Oct 5.
Two types of principal neurons, stellate cells and pyramidal-like cells, are found in medial entorhinal-cortex (mEC) layer II, and are believed to represent two distinct channels of information processing and transmission in the entorhinal cortex-hippocampus network. In this study, we found that dep
PMID 26342161

Involvement of calcium/calmodulin-dependent protein kinase II in methamphetamine-induced neural damage.

Chen X1, Xing J1, Jiang L1, Qian W2, Wang Y2, Sun H1, Wang Y2, Xiao H2, Wang J2, Zhang J1.
Journal of applied toxicology : JAT.J Appl Toxicol.2016 Feb 29. doi: 10.1002/jat.3301. [Epub ahead of print]
Methamphetamine (METH), an illicit drug, is widely abused in many parts of the world. Mounting evidence shows that METH exposure contributes to neurotoxicity, particularly for the monoaminergic neurons. However, to date, only a few studies have tried to unravel the mechanisms involved in METH-induce
PMID 26923100

Inhibition of voltage-gated potassium channels mediates uncarboxylated osteocalcin-regulated insulin secretion in rat pancreatic β cells.

Gao J1, Zhong X2, Ding Y3, Bai T4, Wang H5, Wu H6, Liu Y7, Yang J8, Zhang Y9.
European journal of pharmacology.Eur J Pharmacol.2016 Feb 26. pii: S0014-2999(16)30104-2. doi: 10.1016/j.ejphar.2016.02.060. [Epub ahead of print]
Insulin secretion from pancreatic β cells is important to maintain glucose homeostasis and is regulated by electrical activities. Uncarboxylated osteocalcin, a bone-derived protein, has been reported to regulate glucose metabolism by increasing insulin secretion, stimulating β cell proliferation a
PMID 26927753

Japanese Journal

Effect of Azelastine on Cardiac Repolarization of Guinea-Pig Cardiomyocytes, hERG K+ Channel, and Human L-type and T-type Ca2+ Channel

Park Mi-Hyeong,Ho Lee Seung,Hyun Chu Dae,Hee Won Kwang,Hee Choi Bok,Choe Han,Jo Su-Hyun
Journal of Pharmacological Sciences, 2013
… We investigated the acute effects of azelastine on human ether-a-go-go-related gene (hERG) channels, action potential duration (APD), and L-type (ICa,L) and T-type Ca2+ current (ICa,T) to determine the electrophysiological basis for its proarrhythmic potential. … These results suggest that azelastine is a potent blocker of hERG channels rather than ICa,L or ICa,T, providing molecular mechanisms for the arrhythmogenic side effects during the clinical administration of azelastine. …
NAID 130003362736

Effect of bis-1,4-Dihydropyridine in the Kidney of Diabetic Rats

Gómez-Pliego Raquel,Gómez-Zamudio Jaime,Velasco-Bejarano Benjamín,Ibarra-Barajas Maximiliano,Villalobos-Molina Rafael
Journal of Pharmacological Sciences 122(3), 184-192, 2013
… The in vivo effectiveness of 4-dihydropyridine (bis-1,4-DHP), a new calcium-channel blocker, as a nephroprotector in isolated perfused kidney was evaluated by determining its effects on parameters associated with renal injury in diabetic rats. … Bis-1,4-DHP, by inhibiting Ca2+ entrance, induced vasodilation in renal vascular bed and thus may have a nephroprotective effect against diabetes-induced renal dysfunction, but does not have significant impact on hyperglycemia. …
NAID 130003362718

Dopamine Release Suppression Dependent on an Increase of Intracellular Ca²⁺ Contributed to Rotenone-induced Neurotoxicity in PC12 Cells

Sai Yan,Chen Junfeng,Ye Feng [他],ZHAO Yuanpeng,ZOU Zhongmin,CAO Jia,DONG Zhaojun
Journal of Toxicologic Pathology 26(2), 149-157, 2013
… In neurons, exocytosis is one of the processes associated with dopamine release and is dependent on Ca2+ dynamic changes of the cell. … In the present study, we have investigated the exocytosis of dopamine and the involvement of Ca2+ in dopamine release in PC12 cells administrated with rotenone. …
NAID 130003362362