WordNet

processing a photosensitive material in order to make an image visible; "the development and printing of his pictures took only two hours" (同)developing
a process in which something passes by degrees to a different stage (especially a more advanced or mature stage); "the development of his ideas took many years"; "the evolution of Greek civilization"; "the slow development of her skill as a writer" (同)evolution
a state in which things are improving; the result of developing (as in the early part of a game of chess); "after he saw the latest development he changed his mind and became a supporter"; "in chess your should take care of your development before moving your queen"
act of improving by expanding or enlarging or refining; "he congratulated them on their development of a plan to meet the emergency"; "they funded research and development"
(music) the section of a composition or movement (especially in sonata form) where the major musical themes are developed and elaborated
a district that has been developed to serve some purpose; "such land is practical for small park developments"
a recent event that has some relevance for the present situation; "recent developments in Iraq"; "what a revolting development!"
cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
become attached by or as if by the process of growth; "The tree trunks had grown together"
become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
cause to grow or develop; "He grows vegetables in his backyard"
increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
(biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
(pathology) an abnormal proliferation of tissue (as in a tumor)
a progression from simpler to more complex forms; "the growth of culture"
something grown or growing; "a growth of hair"
vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out

PrepTutorEJDIC

〈U〉〈C〉『発達』,発展,発育,成長;『開発』;進化 / 〈U〉(写真の)現像 / 〈C〉発達(発展)の結果できたもの / 〈C〉開発した土地(地区);(特に)住宅団地(housing development) / 〈C〉(最近の)でき事,新事実
『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
《語・句・節を対等に結んで》…『と』…,…や…,および / 《数詞を結合して》…『足す』…,…に加えて / …『しかも』…,…して,同時に… / 《時間的に》『そして』,それから,すると(and then) / 《当然の帰結として》…『ので』,…だから(and so) / 《おもに話》《命令文などの後で》『そうすれば』,そうしたら / 《追加・強調して》それに,しかも / 《対照的な内容を導いて》ところが,しかし(but) / 《譲歩的に》それなのに,それでいながら / 《A and Bで一体の関係を表して》《単数扱い》 / 《同一語を反復して多数・継続などを表して》 / 《同一の複数名詞を結合して変化・種類などを表して》 / 《話》《「形容詞+and+形容詞」の形で前の形容詞が後に副詞的に働く》 / 《話》《「動詞come, goなど+and+動詞」の形でandとその後の動詞が不定詞の働きをして》 / 《「動詞+and+動詞」の形で後の動詞が現在分詞の意を表して》 / 《話》《文頭において前の質問・意見などに同意を示して》そうとも,そして(Yes!and) / 《話》《文頭に置いて驚き・疑念・非難などを表して》ほんとうに;…なのに
〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. トロンボポエチンの生物学および生理学 biology and physiology of thrombopoietin
2. 血小板産生因子の臨床応用 clinical applications of thrombopoietic growth factors
3. 組換え造血成長因子の概要 introduction to recombinant hematopoietic growth factors
4. 成人における慢性難治性免疫性（特発性）血小板減少性紫斑病 chronic refractory immune idiopathic thrombocytopenic purpura in adults
5. 骨髄異形成症候群の合併症のマネージメント management of the complications of the myelodysplastic syndromes

English Journal

Is there still a place for "old therapies" in the management of immune thrombocytopenia?

Audia S1, Godeau B2, Bonnotte B3.
La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne.Rev Med Interne.2016 Jan;37(1):43-9. doi: 10.1016/j.revmed.2015.08.007. Epub 2015 Oct 1.
New molecules such as rituximab or thrombopoietin receptor agonists (romiplostim and eltrombopag) have changed the management of immune thrombocytopenia. Therefore, old drugs which are less expensive and with a well-known benefit/risk ratio are being underused. We aim to define the place of dapsone,
PMID 26422785

Eltrombopag safety and efficacy for primary chronic immune thrombocytopenia in clinical practice.

González-López TJ1, Alvarez-Román MT2, Pascual C3, Sánchez-González B4, Fernández-Fuentes F5, Jarque I6, Pérez-Rus G3, Pérez-Crespo S7, Bernat S8, Hernández-Rivas JA9, Andrade MM10, Cortés M11, Gómez-Nuñez M12, Olivera P13, Martínez-Robles V14, Fernández-Rodríguez A15, Fuertes-Palacio MA16, Fernández-Miñano C17, de Cabo E18, Fisac R19, Aguilar C20, Bárez A21, Peñarrubia MJ22, García-Frade LJ23, González-Porras JR24.
European journal of haematology.Eur J Haematol.2015 Dec 28. doi: 10.1111/ejh.12725. [Epub ahead of print]
BACKGROUND: Eltrombopag is effective and safe in chronic immune thrombocytopenia (ITP). However, clinical trials may not accurately reflect what happens in clinical practice. We evaluated the efficacy and safety of eltrombopag in primary chronic ITP in a real-world setting.METHODS: 164 primary chron
PMID 26709028

Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program.

Park HJ1, Li J1, Hannah R1, Biddie S1, Leal-Cervantes AI1, Kirschner K1, Flores Santa Cruz D1, Sexl V2, Göttgens B3, Green AR4.
The EMBO journal.EMBO J.2015 Dec 23. pii: e201592383. [Epub ahead of print]
Metazoan development is regulated by transcriptional networks, which must respond to extracellular cues including cytokines. The JAK/STAT pathway is a highly conserved regulatory module, activated by many cytokines, in which tyrosine-phosphorylated STATs (pSTATs) function as transcription factors. H
PMID 26702099

Japanese Journal

Long-term Efficacy of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor in Therapy of Aplastic Anemia

YONEMURA Yuji,MIYAKE Hirosada,ASOU Norio,MITSUYA Hiroaki
International journal of hematology 82(4), 307-309, 2005-11-15
NAID 10016878829

Proliferation of Human Progenitor Cells in a Long-term Culture System is More Efficiently Sustained by the Addition of Flt-3 Ligand or Megakaryocyte Growth and Development Factor than by Kit Ligand

CARTRON G.,BINET C.,HERAULT O.,CAILLIOT C.,BERNARD M.C.,ESTIENNE M.H.,CLEMENT N.,COLOMBAT Ph.,DOMENECH J.
International journal of hematology 77(2), 133-141, 2003-02-01
NAID 50000755645

Involvement of the TGF-β1 Derived from Megakaryocyte in the PEG-rHuMGDF-Induced Myelofibrosis and Bone Formation

IDE Youichi,YAMANAKA Eri,NAMIKI Yasuko,IIJIMA Rieko,HARADA Katsuhiko,ISHI Hiromi,KAWAHARA Jun-ichi,DOI Kunio
Journal of toxicologic pathology 15(1), 31-38, 2002-03-25
… Bone marrow fibrosis and new bone formation were induced by Pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) injection in the rat. …
NAID 10020559768