平均赤血球血色素濃度
WordNet
- have a specified degree of importance; "My ex-husband means nothing to me"; "Happiness means everything"
- an average of n numbers computed by adding some function of the numbers and dividing by some function of n (同)mean_value
- mean or intend to express or convey; "You never understand what I mean!"; "what do his words intend?" (同)intend
- denote or connote; "`maison means `house in French"; "An example sentence would show what this word means" (同)intend, signify, stand_for
- (used of persons or behavior) characterized by or indicative of lack of generosity; "a mean person"; "he left a miserly tip" (同)mingy, miserly, tight
- destine or designate for a certain purpose; "These flowers were meant for you"
- excellent; "famous for a mean backhand"
- the spatial property of being crowded together (同)density, denseness, tightness, compactness
- bringing together military forces
- strengthening the concentration (as of a solute in a mixture) by removing diluting material
- the strength of a solution; number of molecules of a substance in a given volume
- complete attention; intense mental effort (同)engrossment, absorption, immersion
- increase in density
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- rich in significance or implication; "a meaning look" (同)pregnant, significant
- the message that is intended or expressed or signified; "what is the meaning of this sentence"; "the significance of a red traffic light"; "the signification of Chinese characters"; "the import of his announcement was ambiguous" (同)significance, signification, import
- the idea that is intended; "What is the meaning of this proverb?" (同)substance
- considerable capital (wealth or income); "he is a man of means" (同)substance
- how a result is obtained or an end is achieved; "a means of control"; "an example is the best agency of instruction"; "the true way to success" (同)agency, way
- an instrumentality for accomplishing some end
PrepTutorEJDIC
- 〈人が〉…‘を'『意図する』,‘の'つもりである;…‘を'言おうとある;示そうとする / 〈単語・句・文章などが〉…‘を'『意味を持つ』,‘を'『意味する』 / (人に対して)…‘を'当てる,向ける《+『名』+『for』+『名』》 / 《受動態で》〈人・物〉‘を'(…)向きにする / 〈物事が〉…‘を'示す,表す / (結果として)〈物事が〉…‘を'もたらす,生じさせる / 《『mean』+『for』+『名』+『to』 do》《米話》(…が…するような)つもりでいる
- 《名詞の前にのみ用いて》(品質・価値・才能などが)『劣った』,つまらない / (人・行為などが)『卑劣な』,さもしい / 《古》(身分・地位などが)卑しい / 《まれ》(身なり・建物などが)みずぼらしい,見るもあわれな / 《米話》(動物が)御しにくい;(一般に)扱いにくい
- 中庸,中道 / (数学で) / 平均[値];(特に)算術平均,相加平均 / (比例式の)中項,内項 / (両極端の)中間の,中央に位置する / (大きさ・品質・程度などが)平均的な,平均の
- 〈U〉(…への)(光線・注意などの)集中;(仕事などへの)専念,専心《+『on』+『名』》 / 〈C〉(人口などの)集中 / 〈U〉濃縮;〈液体の〉濃度
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- (・・・の)『目的』,意義《+『of』+『名』》 / (吾・文の)『意味』(sense)《+『of』+『名』》 / 意味ありげな様子,意味深長 / 《名詞の前にのみ用いて》意味ありげな,意味常長な / 《複合吾を作って》・・・するつもりの,の意図をもった
- 〈C〉《単数・複数扱い》『方法』,『手段』 / 《複数扱い》『資力』,『財産』,富
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/22 08:18:37」(JST)
[Wiki en表示]
The mean corpuscular hemoglobin concentration, a measure of the concentration of hemoglobin in a given volume of packed red blood cells. It is reported as part of a standard complete blood count.
It is calculated by dividing the hemoglobin by the hematocrit. Reference ranges for blood tests are 32 to 36 g/dl,[1] or between 19.9 [2] to 22.3[2] mmol/L. It is thus a mass or molar concentration. Still, many instances[3][4] measure MCHC in percentage (%), as if it were a mass fraction (mHb / mRBC). Numerically, however, the MCHC in g/dl and the mass fraction of hemoglobin in red blood cells in % are identical, assuming a RBC density of 1g/mL and negligible hemoglobin in plasma.
Contents
- 1 Interpretation
- 2 Complications with cold agglutinin
- 3 Worked example
- 4 See also
- 5 References
- 6 External links
Interpretation
MCHC is diminished ("hypochromic") in microcytic anemias, and normal ("normochromic") in macrocytic anemias (due to larger cell size, though the hemoglobin amount or MCH is high, the concentration remains normal). MCHC is elevated ("hyperchromic") in hereditary spherocytosis, sickle cell disease and homozygous hemoglobin C disease.[5]
This count is used to give a rough guide to what shade of red erythrocytes will be (i.e., the paler the color the lower the MCHC will be than the standard).
Complications with cold agglutinin
Because of the way automated analysers count blood cells, a very high MCHC (greater than about 370 g/L) may indicate the blood is from someone with a cold agglutinin. This means that when their blood gets colder than 37°C it starts to clump together. As a result, the analyzer may incorrectly report a low number of very dense red blood cells for blood samples in which agglutination has occurred.
This problem is usually picked up by the laboratory before the result is reported. The blood is warmed until the cells separate from each other, and quickly put through the machine while still warm.This is the most sensitive test for iron deficiency anemia.
There are four steps to perform when an increase MCHC(>370 g/L or 37.0 g/dL) is received from the analyzer:
- Remix the EDTA tube—if the MCHC corrects, report corrected results
- Incubation at 37°C—if the MCHC corrects, report corrected results and comment on possible cold agglutinin
- Saline replacement: Replace plasma with same amount of saline to exclude interference e.g. Lipemia and Auto-immune antibodies—if the MCHC corrects, report corrected results and comment on Lipemia
- Check the slide for spherocytosis (e.g. in hereditary spherocytosis, among other causes)
Worked example
Measure |
Units |
Conventional units |
Conversion |
Hct |
40% |
|
|
Hb |
100 grams/liter |
10 grams/deciliter |
(deci- is 10-1) |
RBC |
5E+12 cells/liter |
5E+6 cells/μL |
(micro is 10-6) |
MCV = Hct / RBC |
8E-14 liters/cell |
80 femtoliters/cell |
(femto- is 10-15) |
MCH = Hb / RBC |
2E-11 grams/cell |
20 picograms/cell |
(pico- is 10-12) |
MCHC = MCH / MCV |
250 grams/liter |
25 grams/deciliter |
(deci is 10-1) |
See also
- Red blood cell indices
- Mean corpuscular volume
- Mean corpuscular hemoglobin
References
- ^ http://www.nlm.nih.gov/medlineplus/ency/article/003648.htm
- ^ a b Converted with conversion factor from (Wallach, Jacques Burton (2007). Interpretation of Diagnostic Tests. Lippincott Williams & Wilkins. ). 1 g/dL = 0.6206 mmol/L
- ^ Blood Test Results - Normal Ranges Bloodbook.Com. Retrieved on Jan 7, 2009
- ^ MedicineNet > Definition of MCHC Last Editorial Review: 7/21/1999
- ^ Rifkind, David; Cohen, Alan S. (2002). The Pediatric Abacus. Informa Healthcare. p. 54. ISBN 1-84214-147-3.
External links
- FP Notebook
- Cornell
- Medline
Medical test: Myeloid blood tests (CPT 85002–85999)
|
|
MEP |
Clotting
(megakaryocytes) |
- CBC
- Mean platelet volume
- vWF:
- Ristocetin-induced platelet aggregation
|
|
clotting factors: |
- Prothrombin time
- Partial thromboplastin time
- Thrombin time
- Activated clotting time
|
|
other/general: |
- coagulation
- Bleeding time
- animal enzyme
- Reptilase time
- Ecarin clotting time
- Dilute Russell's viper venom time
- Thromboelastography
|
|
fibrinolysis: |
- Euglobulin lysis time
- D-dimer
|
|
|
Red blood cell indices
(erythrocytes) |
CBC |
- RBC count
- Hematocrit
- Hemoglobin
|
|
ratios: |
- Mean corpuscular hemoglobin
- Mean corpuscular hemoglobin concentration
- Mean corpuscular volume
- Red blood cell distribution width
|
|
Fetal hemoglobin: |
- Apt–Downey test
- Kleihauer–Betke test
|
|
Other |
- Reticulocyte index
- Haptoglobin
- Mentzer index
|
|
|
|
CFU-GM |
- Nitro blue tetrazolium chloride test
- CBC
- Absolute neutrophil count
|
|
Other |
- Blood film
- Blood viscosity
- Erythrocyte sedimentation rate
|
|
|
cell/phys (coag, heme, immu, gran), csfs
|
rbmg/mogr/tumr/hist, sysi/epon, btst
|
drug (B1/2/3+5+6), btst, trns
|
|
|
|
UpToDate Contents
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English Journal
- Optimizing preoperative haemoglobin in major orthopaedic surgery using intravenous iron with or without erythropoietin. An epidemiologic study.
- Basora M1, Colomina MJ2, Tio M3, Mora L2, Sánchez-Etayo G3, Salazar F3, Ciércoles E2, Paños M2, Guerrero E2, Berge R3.
- Revista espanola de anestesiologia y reanimacion.Rev Esp Anestesiol Reanim.2015 Jun-Jul;62(6):313-321. doi: 10.1016/j.redar.2014.07.011. Epub 2015 Feb 17.
- AIM: To evaluate the effectiveness of intravenous iron treatment, with or without associated erythropoietin (rHuEPO), measured as haemoglobin (Hb) increase. The relationships between the Hb increase and parameters used to evaluate anaemia were analysed.MATERIAL AND METHOD: Retrospective observationa
- PMID 25698609
- Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures.
- Chung SH1, Feldman MD2, Martinez D3, Kim H4, Putt ME5, Busch DR6,7, Tchou J8, Czerniecki BJ9, Schnall MD10, Rosen MA11, DeMichele A12, Yodh AG13, Choe R14.
- Breast cancer research : BCR.Breast Cancer Res.2015 May 27;17(1):72. [Epub ahead of print]
- INTRODUCTION: Non-invasive diffuse optical tomography (DOT) and diffuse correlation spectroscopy (DCS) can detect and characterize breast cancer and predict tumor responses to neoadjuvant chemotherapy, even in patients with radiographically dense breasts. However, the relationship between measured o
- PMID 26013572
- Physiological condition of bank voles (Myodes glareolus) during the increase and decline phases of the population cycle.
- Nieminen P1, Huitu O2, Henttonen H3, Finnilä MA4, Voutilainen L5, Itämies J6, Kärjä V7, Saarela S8, Halonen T9, Aho J10, Mustonen AM11.
- Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2015 May 22. pii: S1095-6433(15)00119-1. doi: 10.1016/j.cbpa.2015.05.007. [Epub ahead of print]
- The dynamics of animal populations are greatly influenced by interactions with their natural enemies and food resources. However, quantifying the relative effects of these factors on demographic rates remains a perpetual challenge for animal population ecology. Food scarcity is assumed to limit the
- PMID 26006298
Japanese Journal
- 28-Day dietary toxicity study of L-phenylalanine in rats
- Shibui Yusuke,Miwa Tadashi,Kodama Terutaka,Gonsho Akinori
- Fundamental Toxicological Sciences 1(2), 29-38, 2014
- … Effects of L-phenylalanine administration were noted in mean body weights and mean body weight gains in females fed 0.5% and in males and females fed 5.0% (w/w) L-phenylalanine diets. … Effects were also noted in mean food consumption in males and females fed the 5.0% (w/w) L-phenylalanine diet. …
- NAID 130005083333
- Use of Proton Pump Inhibitors Is Associated With Anemia in Cardiovascular Outpatients
- Shikata Toshiyuki,Sasaki Naoko,Ueda Masahiro,Kimura Takeshi,Itohara Kanako,Sugahara Masataka,Fukui Miho,Manabe Eri,Masuyama Tohru,Tsujino Takeshi
- Circulation Journal 79(1), 193-200, 2014
- … The effect of PPI on hemoglobin (Hb) concentration, however, has not been clarified in cardiovascular outpatients.Methods and Results:We retrospectively investigated the clinical characteristics of 278 continuous outpatients who received blood test including complete blood count and serum creatinine concentration (mean age, 69.9±10.8 years; …
- NAID 130004927034
- Use of Proton Pump Inhibitors Is Associated With Anemia in Cardiovascular Outpatients
- Shikata Toshiyuki,Sasaki Naoko,Ueda Masahiro,Kimura Takeshi,Itohara Kanako,Sugahara Masataka,Fukui Miho,Manabe Eri,Masuyama Tohru,Tsujino Takeshi
- Circulation Journal, 2014
- … The effect of PPI on hemoglobin (Hb) concentration, however, has not been clarified in cardiovascular outpatients.Methods and Results:We retrospectively investigated the clinical characteristics of 278 continuous outpatients who received blood test including complete blood count and serum creatinine concentration (mean age, 69.9±10.8 years; …
- NAID 130004704018
Related Links
- + Add to Word List Create new word list More... Word List Title: 3 to 50 characters max. Word List Description: 3 to 250 characters max. Shared Private Definitions mean cell hemoglobin concentration - Medical Definition noun Abbr. MCHC
- Featured Image Picture of Psoriasis A reddish, scaly rash often located over the surfaces of the elbows, knees, scalp, and around or in the ears, navel ... Mean cell hemoglobin concentration: The average concentration of hemoglobin in a given volume of blood.
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