- 関
- LTBP
WordNet
- to remain unmolested, undisturbed, or uninterrupted -- used only in infinitive form; "let her be"
- work in a specific place, with a specific subject, or in a specific function; "He is a herpetologist"; "She is our resident philosopher" (同)follow
- have life, be alive; "Our great leader is no more"; "My grandfather lived until the end of war" (同)live
- be identical to; be someone or something; "The president of the company is John Smith"; "This is my house"
- happen, occur, take place; "I lost my wallet; this was during the visit to my parents house"; "There were two hundred people at his funeral"; "There was a lot of noise in the kitchen"
- have the quality of being; (copula, used with an adjective or a predicate noun); "John is rich"; "This is not a good answer"
- occupy a certain position or area; be somewhere; "Where is my umbrella?" "The toolshed is in the back"; "What is behind this behavior?"
- spend or use time; "I may be an hour"
- of a later stage in the development of a language or literature; used especially of dead languages; "Late Greek"
- later than usual or than expected; "the train arrived late"; "we awoke late"; "the children came late to school"; "notice came so tardily that we almost missed the deadline"; "I belatedly wished her a happy birthday" (同)belatedly, tardily
- at or toward an end or late period or stage of development; "the late phase of feudalism"; "a later symptom of the disease"; "later medical science could have saved the child" (同)later
- of the immediate past or just previous to the present time; "a late development"; "their late quarrel"; "his recent trip to Africa"; "in recent months"; "a recent issue of the journal" (同)recent
- at an advanced age or stage; "she married late"; "undertook the project late in her career"
- being or occurring at an advanced period of time or after a usual or expected time; "late evening"; "late 18th century"; "a late movie"; "took a late flight"; "had a late breakfast"
- having died recently; "her late husband"
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- stake on the outcome of an issue; "I bet $100 on that new horse"; "She played all her money on the dark horse" (同)wager, play
- the act of gambling; "he did it on a bet" (同)wager
- maintain with or as if with a bet; "I bet she will be there!" (同)wager
- second in order of importance; "the candidate, considered a beta male, was perceived to be unable to lead his party to victory"
- the 2nd letter of the Greek alphabet
- preliminary or testing stage of a software or hardware product; "a beta version"; "beta software"
PrepTutorEJDIC
- 《連結語として補語を伴なって…『である』,…だ,…です / 《位置・場所を表す語句を伴って》(…に)『ある』,いる(occupy a place or situation) / 〈物事が〉『存在する』,ある(exist);〈生物が〉生存する,生きている(live) / 行われる,起こる,発生する(take place, occur) / 存続する,そのままでいる(remain as before) / 《『be to』 do》 / …する予定である,…することになっている / …すべきだ / 《受動態の不定詞を伴って》…できる / 《命令》…するのだ / 《条件節に》…する意図がある / 《『if…were to』 do》…するとしたなら / 《『be』 do『ing』》《進行形》 / 《進行中の動作》…している,しつつある / 《近い未来》…しようとしている,するつもり / 《動作の反復》(いつも)…している / 《『be』+『他動詞の過去分詞』》《受動態》…される,されている / 《『be』+『自動詞の過去分詞』》《完了形》…した[状態にある]
- (定刻・通常・予定の時間より)『遅れた』,遅い / (時刻が)『遅い』,遅く始まる,遅くまで続く;夜更けの / (時期が)『遅い』,終りごろの,後期の / 『最近の』,最新の(recent) / 《the~,one's~》『前の』,先の,前任の(former) / 《the~,one's~》『故』…,つい先ごろ死んだ / (定刻などより)『遅れて』,遅く / (時刻が)『遅く』,遅くまで,(特に)夜更けに;(時期が)遅く,終りごろに / 『最近』,近ごろ(recently)
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- 『かけ』・(…との)かけ《+『with』+『名』》 / かけた物(金) / かけの対象 / 〈金・物〉'を'『かける』 / (かけ事・ゲームなどで)〈人〉‘と'『かけをする』《+『名』〈人〉+『on』+『名』》 / (…に)『かける』《+『on』(『against』)+『名』(one's do『ing』)》
- ベータ(ギリシア語アルファベットの第2文字;B,β;英語のB,b に遭当)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/12 22:54:47」(JST)
[Wiki en表示]
The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins.[1][2]
LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors. They interact with a variety of extracellular matrix proteins and may play a role in the regulation of TGF beta bioavailability.
Genes
| latent transforming growth factor beta binding protein 1 |
| Identifiers |
| Symbol |
LTBP1 |
| Alt. symbols |
TGF-beta1-BP-1 |
| Entrez |
4052 |
| HUGO |
6714 |
| OMIM |
150390 |
| RefSeq |
NM_206943 |
| UniProt |
Q14766 |
| Other data |
| Locus |
Chr. 2 p22-p21 |
|
| latent transforming growth factor beta binding protein 2 |
| Identifiers |
| Symbol |
LTBP2 |
| Alt. symbols |
LTBP3, C14orf141 |
| Entrez |
4053 |
| HUGO |
6715 |
| OMIM |
602091 |
| RefSeq |
NM_000428 |
| UniProt |
Q14767 |
| Other data |
| Locus |
Chr. 14 q24.3 |
|
| latent transforming growth factor beta binding protein 3 |
| Identifiers |
| Symbol |
LTBP3 |
| Alt. symbols |
LTBP2 |
| Entrez |
4054 |
| HUGO |
6716 |
| OMIM |
602090 |
| RefSeq |
NM_021070 |
| UniProt |
Q9NS15 |
| Other data |
| Locus |
Chr. 11 q12 |
|
| latent transforming growth factor beta binding protein 4 |
| Identifiers |
| Symbol |
LTBP4 |
| Alt. symbols |
LTBP-4, LTBP-4L |
| Entrez |
8425 |
| HUGO |
6717 |
| OMIM |
604710 |
| RefSeq |
NM_003573 |
| UniProt |
Q8N2S1 |
| Other data |
| Locus |
Chr. 19 q13.1-13.2 |
|
References
- ^ Rifkin DB (March 2005). "Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability". J. Biol. Chem. 280 (9): 7409–12. doi:10.1074/jbc.R400029200. PMID 15611103.
- ^ Todorovic V, Jurukovski V, Chen Y, Fontana L, Dabovic B, Rifkin DB (January 2005). "Latent TGF-beta binding proteins". Int. J. Biochem. Cell Biol. 37 (1): 38–41. doi:10.1016/j.biocel.2004.03.011. PMID 15381147.
External links
- Latent TGF-beta Binding Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Proteins: carrier proteins
|
|
| Fatty acid |
- FABP1
- FABP2
- FABP3
- FABP4
- FABP5
- FABP6
- FABP7
|
|
| Hormone |
- peptide hormone: Follistatin
- Growth hormone binding protein
- Insulin-like growth factor binding protein
- IGFBP1
- IGFBP2
- IGFBP3
- IGFBP4
- IGFBP5
- IGFBP6
- IGFBP7
- Neurophysins
- steroid hormone: Sex hormone binding globulin/Androgen binding protein
- Transcortin
- Thyroxine-binding globulin
- Transthyretin
|
|
| Metal/element |
- calcium
- Calcium-binding protein
- Calmodulin-binding proteins
- copper
- iron
- Iron-binding proteins
- Transferrin receptor
|
|
| Vitamin |
- Retinol binding protein
- Transcobalamin
|
|
| Pigment |
- Plant Light-Harvesting Complex
- Orange Carotenoid Protein
- Phycobiliprotein
- Photosynthetic Reaction Centers
- Phytochrome
- Rhodopsin
|
|
| Other |
- Acyl carrier protein
- Adaptor protein
- Cholesterylester transfer protein
- F-box protein
- GTP-binding protein
- Latent TGF-beta binding protein
- Major urinary proteins
- Membrane transport protein
- Odorant binding protein
|
|
|
Cell signaling: TGFβ signaling pathway
|
|
| TGF beta superfamily of ligands |
|
TGF beta family
|
|
|
|
Bone morphogenetic proteins
|
- BMP2
- BMP3
- BMP4
- BMP5
- BMP6
- BMP7
- BMP8a
- BMP8b
- BMP10
- BMP15
|
|
|
Growth differentiation factors
|
- GDF1
- GDF2
- GDF3
- GDF5
- GDF6
- GDF7
- Myostatin/GDF8
- GDF9
- GDF10
- GDF11
- GDF15
|
|
|
Other
|
- Activin and inhibin
- Anti-müllerian hormone
- Nodal
|
|
|
TGF beta receptors
(Activin, BMP) |
|
TGFBR1:
|
- Activin type 1 receptors
- ACVRL1
- BMPR1
|
|
|
TGFBR2:
|
- Activin type 2 receptors
- AMHR2
- BMPR2
|
|
|
TGFBR3:
|
|
|
|
| Transducers/SMAD |
- R-SMAD (SMAD1
- SMAD2
- SMAD3
- SMAD5
- SMAD9)
- I-SMAD (SMAD6
- SMAD7)
- SMAD4
|
|
| Ligand inhibitors |
- Cerberus
- Chordin
- Decorin
- Follistatin
- Gremlin
- Lefty
- LTBP1
- Noggin
- PARN
- THBS1
|
|
| Coreceptors |
|
|
| Other |
|
|
UpToDate Contents
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English Journal
- Regeneration of elastic fibers by three-dimensional culture on a collagen scaffold and the addition of latent TGF-β binding protein 4 to improve elastic matrix deposition.
- Aya R1, Ishiko T2, Noda K3, Yamawaki S1, Sakamoto Y4, Tomihata K5, Katayama Y1, Yoshikawa K1, Kubota H6, Nakamura T7, Naitoh M8, Suzuki S1.
- Biomaterials.Biomaterials.2015 Dec;72:29-37. doi: 10.1016/j.biomaterials.2015.08.036. Epub 2015 Aug 20.
- The objective of this study was to investigate the effects of latent TGF-β binding protein 4 (LTBP-4) on elastic fiber regeneration in three-dimensional cultures of human dermal fibroblasts (HDFs). Appropriate collagen scaffold for elastic fiber regeneration was also examined. Collagen sponges cros
- PMID 26342558
- Extracellular matrix-induced Hic-5 expression in glomerular mesangial cells leads to a prosclerotic phenotype independent of TGF-β.
- Hornigold N1, Mooney A2.
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2015 Sep 24. pii: fj.14-269894. [Epub ahead of print]
- Chronic fibroproliferative diseases account for approximately 45% of all deaths in the developed world. In the kidney, glomerulosclerosis is the underlying pathology in approximately half of patients with renal failure receiving dialysis. Mesangial cell expression of the LIM protein hydrogen peroxid
- PMID 26405299
- Latent TGF-β-binding proteins.
- Robertson IB1, Horiguchi M1, Zilberberg L1, Dabovic B1, Hadjiolova K1, Rifkin DB2.
- Matrix biology : journal of the International Society for Matrix Biology.Matrix Biol.2015 Sep;47:44-53. doi: 10.1016/j.matbio.2015.05.005. Epub 2015 May 8.
- The LTBPs (or latent transforming growth factor β binding proteins) are important components of the extracellular matrix (ECM) that interact with fibrillin microfibrils and have a number of different roles in microfibril biology. There are four LTBPs isoforms in the human genome (LTBP-1, -2, -3, an
- PMID 25960419
Japanese Journal
- Proteolytic Release of Latent Transforming Growth Factor-.BETA. (TGF-.BETA.) Binding Protein-1 (LTBP-1) Fragment in Wound Healing
- Integrin alphav-beta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1
- Anti-latent TGF-beta binding protein-1 antibody or synthetic oligopeptides inhibit extracellular matrix expression induced by stretch in cultured rat mesangial cells
Related Links
- latent transforming growth-factor (TGF)-beta binding protein - definition of latent transforming growth-factor (TGF)-beta binding protein by Medical dictionary ... latent transforming growth-factor (TGF)-β binding protein a member of the ...
- Abstract Latent TGF-β binding proteins are multidomain proteins with a common, highly repetitive structural organization and partially overlapping expression patterns. Latent TGF-β binding protein-1, -3 and -4 bind latent TGF-β. TGF ...
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★リンクテーブル★
[★]
- 関
- latent TGF-beta binding protein
[★]
- 英
- latent TGF-beta binding protein、LTBP
[★]
- 関
- affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union
[★]
- 英
- transforming growth factor
- 同
- トランスフォーミング成長因子、トランスフォーミング増殖因子、形質転換増殖因子、形質転換成長因子
- 関
- TGF-β, transforming growth factor β
TGF
- TGF-β1、TGF-β2、TGF-β3、TGF-β4、TGF-β5
[★]
- (比較級later-最上級latest)遅い、遅発の、遅発型の、晩発の、後の、後期の
- 関
- after、afterward、afterwards、anaphase、behind、delayed、following、late-stage、post、posterior、slow、subsequent
[★]
- 関
- cryptic、inapparent、initiated、latency、masking、occult、subclinical
[★]
- 関
- BP、carrier protein、transport protein