TGF
WordNet
- cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
- come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
- become attached by or as if by the process of growth; "The tree trunks had grown together"
- become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
- cause to grow or develop; "He grows vegetables in his backyard"
- increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
- (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
- (pathology) an abnormal proliferation of tissue (as in a tumor)
- a progression from simpler to more complex forms; "the growth of culture"
- something grown or growing; "a growth of hair"
- vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
PrepTutorEJDIC
- 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
- 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/10/28 04:01:40」(JST)
[Wiki en表示]
Transforming growth factor (sometimes referred to as Tumor growth factor, or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ.
The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms. Furthermore, they do not always induce cellular transformation, and are not the only growth factors that induce cellular transformation.
Contents
- 1 Types
- 2 Function
- 3 See also
- 4 References
- 5 External links
Types
- TGFα is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development.
- TGFβ exists in three known subtypes in humans, TGFβ1, TGFβ2, and TGFβ3. These are upregulated in Marfan's syndrome[1][2] and some human cancers, and play crucial roles in tissue regeneration, cell differentiation, embryonic development, and regulation of the immune system. Isoforms of transforming growth factor-beta (TGF-β1) are also thought to be involved in the pathogenesis of pre-eclampsia. TGFβ receptors are single pass serine/threonine kinase receptors.
Function
These proteins were originally characterized by their capacity to induce oncogenic transformation in a specific cell culture system, rat kidney fibroblasts. Application of the transforming growth factors to normal rat kidney fibroblasts induces the cultured cells to proliferate and overgrow, no longer subject to the normal inhibition caused by contact between cells.
See also
- Bone morphogenetic protein
- TGF beta signaling pathway
References
- ^ Circulating transforming growth factor-{beta} in Marfan syndrome. Matt P, Schoenhoff F, Habashi J, Holm T, Van Erp C, Loch D, Carlson OD, Griswold BF, Fu Q, De Backer J, Loeys B, Huso DL, McDonnell NB, Van Eyk JE, Dietz HC; GenTAC Consortium. Circulation. 2009 Aug 11;120(6):526-32. Epub 2009 Jul 27. PMID 19635970
- ^ Inhibiting TGF to help Marfan
External links
- Tumor growth factor (TGF) citations
- "Hoffmann, R., Valencia, A. A gene network for navigating the literature. Nature Genetics 36, 664 (2004)
- Transforming Growth Factors at the US National Library of Medicine Medical Subject Headings (MeSH)
Growth factors
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Fibroblast |
FGF receptor ligands: |
- FGF1/FGF2/FGF5
- FGF3/FGF4/FGF6
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KGF |
- FGF7/FGF10/FGF22
- FGF8/FGF17/FGF18
- FGF9/FGF16/FGF20
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FGF homologous factors: |
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hormone-like: |
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EGF-like domain |
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TGFβ pathway |
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Insulin-like |
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Platelet-derived |
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Vascular endothelial |
- VEGF-A
- VEGF-B
- VEGF-C
- VEGF-D
- PGF
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Other |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
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English Journal
- Thrombospondin-1 Affects Bovine Luteal Function via Transforming Growth Factor-Beta1-Dependent and Independent Actions.
- Farberov S1, Meidan R2.
- Biology of reproduction.Biol Reprod.2016 Dec;94(1):25. doi: 10.1095/biolreprod.115.135822. Epub 2015 Dec 9.
- Thrombospondin-1 (THBS1) and transforming growth factor-beta1 (TGFB1) are specifically up-regulated by prostaglandin F2alpha in mature corpus luteum (CL). This study examined the relationship between the expression of THBS1 and TGFB1 and the underlying mechanisms of their actions in luteal endotheli
- PMID 26658711
- Long-Term Effects of Diesel Exhaust Particles on Airway Inflammation and Remodeling in a Mouse Model.
- Kim BG1, Lee PH1, Lee SH1, Kim YE1, Shin MY2, Kang Y1, Bae SH1, Kim MJ1, Rhim T3, Park CS1, Jang AS4.
- Allergy, asthma & immunology research.Allergy Asthma Immunol Res.2016 May;8(3):246-56. doi: 10.4168/aair.2016.8.3.246.
- PURPOSE: Diesel exhaust particles (DEPs) can induce and trigger airway hyperresponsiveness (AHR) and inflammation. The aim of this study was to investigate the effect of long-term DEP exposure on AHR, inflammation, lung fibrosis, and goblet cell hyperplasia in a mouse model.METHODS: BALB/c mice were
- PMID 26922935
- Reduced Dentin Matrix Protein Expression in Camurati-Engelmann Disease Transgenic Mouse Model.
- Gullard A1,2, Croney CM2, Wu X3, Mamaeva O2, Sohn P2, Cao X4, MacDougall M2.
- Journal of cellular physiology.J Cell Physiol.2016 May;231(5):1106-13. doi: 10.1002/jcp.25207. Epub 2015 Dec 29.
- Overexpression of transforming growth factor-β1 (TGF-β1) has been shown to lead to mineralization defects in both the enamel and dentin layers of teeth. A TGFB1 point mutation (H222D), derived from published cases of Camurati-Engelmann disease (CED), has been shown to constitutively activate TGF-�
- PMID 26427011
Japanese Journal
- TGF-β1 Induces Fibroblast Proliferation Partly Through Actibation of RaF/MEK/ERK Signaling Pathway by Inhibition of RAF-KINASE Inhibitor Protein Expression
- 臨床免疫・アレルギー科 = Clinical immunology & allergology 65(3), 255-261, 2016-03
- NAID 40020765780
- 臨床免疫・アレルギー科 = Clinical immunology & allergology 65(2), 157-163, 2016-02
- NAID 40020742039
Related Pictures
★リンクテーブル★
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- 英
- transforming growth factor
- 同
- トランスフォーミング成長因子、トランスフォーミング増殖因子、形質転換増殖因子、形質転換成長因子
- 関
- TGF-β, transforming growth factor β
TGF
- TGF-β1、TGF-β2、TGF-β3、TGF-β4、TGF-β5
[★]
- 英
- transforming growth factor
- 関
- TGF-β
[★]
[★]
[★]
[★]
トランスフォーミング増殖因子β
- 同
- TGF-β
[★]
- (過去: grew-過去分詞: grown)
- 関
- extend、growth、outgrow、outgrowth、stretch
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter
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- 関
- transform、transformation、transgenic
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