トランスフォーミング増殖因子β
- 同
- TGF-β
- 同
- TGF-P
WordNet
- cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
- come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
- become attached by or as if by the process of growth; "The tree trunks had grown together"
- become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
- cause to grow or develop; "He grows vegetables in his backyard"
- increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
- (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
- (pathology) an abnormal proliferation of tissue (as in a tumor)
- a progression from simpler to more complex forms; "the growth of culture"
- something grown or growing; "a growth of hair"
- vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
PrepTutorEJDIC
- 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
- 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
UpToDate Contents
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- 1. 原発性骨髄線維症における病態pathogenetic mechanisms in primary myelofibrosis [show details]
…of PMF. Bone marrow fibrosis – BMF may be related to abnormal expression of transforming growth factor-beta (TGF-beta), thrombopoietin (TPO), and/or the TPO receptor, MPL. The editors of UpToDate …
- 2. 骨格の正常な発達および骨形成ならびに骨吸収の調節normal skeletal development and regulation of bone formation and resorption [show details]
…growth factor (TGF)-beta and the BMP family of proteins consist of at least 10 proteins that are produced by many different cells and that have multiple actions on growth and development . TGF-beta can inhibit …
- 3. 全身性硬化症（強皮症）の病因pathogenesis of systemic sclerosis scleroderma [show details]
…may be the dependence of these cell types on transforming growth factor-beta (TGF-beta) and its regulated pathways and mediators . Thus, deletion of TGF-beta responses by genetic modification in animal …
- 4. 細胞性免疫応答the adaptive cellular immune response t cells and cytokines [show details]
…to a purine-rich DNA sequence called the PU-box) in the presence of transforming growth factor (TGF) beta, IL-2, and IL-4. These cells have a role in antitumor immunity, allergy, and autoimmune disease …
- 5. 肥満細胞由来のメディエーターmast cell derived mediators [show details]
…lymph node hypertrophy in response to bacterial inflammation . Transcripts for transforming growth factor-beta (TGF-beta), a potent fibroblast activator and proliferation factor, are localized in human…
Japanese Journal
- 臨床免疫・アレルギー科 = Clinical immunology & allergology 65(2), 157-163, 2016-02
- NAID 40020742039
- TGF-β3発現CD4⁺CD25⁻LAG3⁺制御性T細胞による全身性自己免疫応答制御 (特集 全身性免疫疾患の機序の解明)
- 臨床免疫・アレルギー科 = Clinical immunology & allergology 65(2), 126-131, 2016-02
- NAID 40020741944
- Isoform-specific regulation of transforming growth factor-β mRNA expression in macrophages in response to adrenoceptor stimulation
Related Links
- トランスフォーミング増殖因子-β1（Transforming Growth Factor-β1：TGF-β1） トランスフォーミング増殖因子-β（TGF-β）は、当初、線維芽細胞の形質転換を促進する因子として見出され命名されたが、現在では多くの細胞に対してむしろ強力な ...
- Transforming Growth Factor-β Governing the Transition From Inflammation to Fibrosis in Heart Failure With Preserved Left Ventricular Function Navin K. Kapur, MD From the Molecular Cardiology Research Institute, Division of ...
★リンクテーブル★
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- 英
- transforming growth factor β, transforming growth factor-β、TGFβ, TGF-β
- 同
- トランスフォーミング成長因子
- 関
- TGF
- stimulatory: cells of mesenchymal origin
- inhibitory: cells of epithelial or neuroectodermal origin
- important mediator of the formation of extracellular matrix
- 細胞内のシグナル系にSmadが関与。セリン・スレオニンキナーゼ連結受容体型の受容体
- EGF, IFN-γ, TNF-αの細胞内情報伝達経路とクロストークする
産生細胞
機能
- 細胞の成長阻害、抗炎症作用、IgAへのクラススイッチ
受容体
- TGFβR
- type I受容体とtype II受容体が一つのサブユニットを作り、このサブユニットがホモ二量体を形成してTGFβの受容体を形成している
- TGFβ毛結合した受容体は活性化してSmad2/Smad3をリン酸化する
- リン酸化されたSmad2/Smad3はSmad4と結合して核移行しDNAに結合して転写を促進する
[★]
- 英
- transforming growth factor
- 同
- トランスフォーミング成長因子、トランスフォーミング増殖因子、形質転換増殖因子、形質転換成長因子
- 関
- TGF-β, transforming growth factor β
TGF
- TGF-β1、TGF-β2、TGF-β3、TGF-β4、TGF-β5
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トランスフォーミング増殖因子β
- 同
- transforming growth factor β
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トランスフォーミング増殖因子β
- 同
- TGF-β
[★]
- (過去: grew-過去分詞: grown)
- 関
- extend、growth、outgrow、outgrowth、stretch
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- 関
- actual、actually、in fact、in practice、indeed、practically
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- 関
- element、elementary、factorial、parameter
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- 関
- transform、transformation、transgenic
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