extracellular signal-regulated kinase 5

細胞外シグナル制御キナーゼ5

関

ERK5、mitogen-activated protein kinase 7

WordNet

1. place signs, as along a road; "sign an intersection"; "This road has been signed"
2. (medicine) any objective evidence of the presence of a disorder or disease; "there were no signs of asphyxiation"
3. a perceptible indication of something not immediately apparent (as a visible clue that something has happened); "he showed signs of strain"; "they welcomed the signs of spring" (同)mark
4. a character indicating a relation between quantities; "dont forget the minus sign"
5. a fundamental linguistic unit linking a signifier to that which is signified; "The bond between the signifier and the signified is arbitrary"--de Saussure
6. a gesture that is part of a sign language
7. a public display of a message; "he posted signs in all the shop windows"
8. engage by written agreement; "They signed two new pitchers for the next season" (同)contract, sign on, sign_up
9. approve and express assent, responsibility, or obligation; "All parties ratified the peace treaty"; "Have you signed your contract yet?" (同)ratify
10. communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" (同)signal, signalize, signalise
11. mark with ones signature; write ones name (on); "She signed the letter and sent it off"; "Please sign here" (同)subscribe
12. be engaged by a written agreement; "He signed to play the casino on Dec. 18"; "The soprano signed to sing the new opera"
13. communicate in sign language; "I dont know how to sign, so I could not communicate with my deaf cousin"
14. notably out of the ordinary; "the year saw one signal triumph for the Labour party"
15. an electric quantity (voltage or current or field strength) whose modulation represents coded information about the source from which it comes
16. any nonverbal action or gesture that encodes a message; "signals from the boat suddenly stopped" (同)signaling, sign
17. any incitement to action; "he awaited the signal to start"; "the victory was a signal for wild celebration"
18. bring into conformity with rules or principles or usage; impose regulations; "We cannot regulate the way people dress"; "This town likes to regulate" (同)regularize, regularise, order, govern
19. fix or adjust the time, amount, degree, or rate of; "regulate the temperature"; "modulate the pitch" (同)modulate
20. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
21. located or occurring outside a cell or cells; "extracellular fluid"

PrepTutorEJDIC

1. (ある事実・状態・感情などの)『表れ』,印,気配,徴侯(indication);(…の)こん跡,計跡《+『of』+『名』》・『身ぶり』,手まね,合図 / 『標識』,看板 / (数学・音楽などの)記号 / (…の)『象徴』,シンボル(symbol)《+『of』+『名』》・《文》(…の)『前兆』,きざし《+『of』+『名』》・宮(きゅう)(黄道12区分の一つ) ・〈手紙・書類・作品など〉‘に'『署名する』・(…に)〈名前など〉‘を'書く《+『名』+『on』(『to』)+『名』》 / …‘を'雇う契約に署名する・…‘を'合図する,知らせる;…に合図する・署名する・契約書に署名して雇われる
2. (警告・指示・情報などを伝える)『信号』,合図 / (…の)きっかけ,動機,導火線《+『for』+『名』》 / 〈人・車など〉‘に'『合図する』,信号を送る / …‘を'『合図』(信号)『で知らせる』 / 『合図する』,信号する / 合図の,信号の / めざましい,顕著な
3. (規則などで)…‘を'『規制する』,『統制する』 / 〈機械など〉‘を'『調整する』 / 〈量や率など〉‘を'ある限度内におさえる

UpToDate Contents

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• 1. 黒色腫（メラノーマ）の分子生物学 the molecular biology of melanoma
• 2. 進行性肝細胞癌に対する全身治療 systemic treatment for advanced hepatocellular carcinoma
• 3. 結節性硬化症：遺伝学、臨床的特徴、および診断 tuberous sclerosis complex genetics clinical features and diagnosis
• 4. 薬物誘発性ループス drug induced lupus
• 5. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化 head and neck squamous cell carcinogenesis molecular and genetic alterations

English Journal

• Novel Mechanisms of Endothelial Mechanotransduction.

• Abe JI, Berk BC.
• Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2014 Oct 9. pii: ATVBAHA.114.303428. [Epub ahead of print]
• Atherosclerosis is a focal disease that develops preferentially where nonlaminar, disturbed blood flow occurs, such as branches, bifurcations, and curvatures of large arteries. Endothelial cells sense and respond differently to disturbed flow compared with steady laminar flow. Disturbed flow that oc
• PMID 25301843

• The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma.

• Rovida E1, Di Maira G2, Tusa I1, Cannito S3, Paternostro C3, Navari N2, Vivoli E2, Deng X4, Gray NS5, Esparís-Ogando A6, David E7, Pandiella A6, Dello Sbarba P1, Parola M3, Marra F2.
• Gut.Gut.2014 Sep 2. pii: gutjnl-2014-306761. doi: 10.1136/gutjnl-2014-306761. [Epub ahead of print]
• OBJECTIVE: The extracellular signal-regulated kinase 5 (ERK5 or BMK1) is involved in tumour development. The ERK5 gene may be amplified in hepatocellular carcinoma (HCC), but its biological role has not been clarified. In this study, we explored the role of ERK5 expression and activity in HCC in vit
• PMID 25183205

• Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.

• Takeda AN1, Oberoi-Khanuja TK1, Glatz G2, Schulenburg K1, Scholz RP1, Carpy A3, Macek B3, Remenyi A2, Rajalingam K4.
• The EMBO journal.EMBO J.2014 Aug 18;33(16):1784-801. doi: 10.15252/embj.201487808. Epub 2014 Jun 28.
• Mitogen-activated protein kinases (MAPKs) are highly conserved protein kinase modules, and they control fundamental cellular processes. While the activation of MAPKs has been well studied, little is known on the mechanisms driving their inactivation. Here we uncover a role for ubiquitination in the
• PMID 24975362

Japanese Journal

• Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin.

• Hiratsuka Toru,Fujita Yoshihisa,Honda Naoki,Aoki Kazuhiro,Kamioka Yuji,Matsuda Michiyuki
• eLife 4, 2015-02-09
• … 2015-02-09.Extracellular signal-regulated kinase (ERK) is a key effector of many growth signalling pathways. …
• NAID 120005540395

• DA-9801 Promotes Neurite Outgrowth via ERK1/2-CREB Pathway in PC12 Cells

• Won Jong Hoon,Ahn Kyong Hoon,Back Moon Jung [他]
• Biological & pharmaceutical bulletin 38(2), 169-178, 2015-02
• NAID 40020343857

• Regorafenib suppresses sinusoidal obstruction syndrome in rats.

• Okuno Masayuki,Hatano Etsuro,Nakamura Kojiro,Miyagawa-Hayashino Aya,Kasai Yosuke,Nishio Takahiro,Seo Satoru,Taura Kojiro,Uemoto Shinji
• The Journal of surgical research 193(2), 693-703, 2015-02
• … This study aimed to examine the impact of regorafenib, the first small-molecule kinase inhibitor to show efficacy against metastatic colorectal cancer, on a rat model of SOS. … Regorafenib reduced the phosphorylation of extracellular signal-regulated kinase, which induced matrix metalloproteinase-9 (MMP-9) activation and decreased the activity of MMP-9, one of the crucial mediators of SOS development. …
• NAID 120005530955

Related Links

• Extracellular signal-regulated kinase 5: a potential therapeutic ...

1. Clin Cancer Res. 2013 Apr 15;19(8):2071-83. doi: 10.1158/1078-0432.CCR-12-3202. Epub 2013 Feb 27. Extracellular signal-regulated kinase 5: a potential therapeutic target for malignant mesotheliomas. Shukla A(1 ...

• Extracellular signal–regulated kinase 5 promotes acute ...

... extracellular signal–regulated kinase 5 (ERK5), promoted inflammatory responses to microbial stimuli in human endothelial and immune cells. Furthermore, inhibitors of ERK5 and its upstream activating kinase MEK5 reduced ...

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★リンクテーブル★

リンク元	「細胞外シグナル制御キナーゼ5」「mitogen-activated protein kinase 7」「ERK5」
関連記事	「regulate」「sign」「signaling」「kinase」「extracellular」

「細胞外シグナル制御キナーゼ5」

　　[★]

英

extracellular signal-regulated kinase 5、ERK5

関

マイトジェン活性化プロテインキナーゼ7

「mitogen-activated protein kinase 7」

　　[★]

マイトジェン活性化プロテインキナーゼ7

関

extracellular signal-regulated kinase 5

「ERK5」

　　[★]

• 細胞外シグナル制御キナーゼ5

関

extracellular signal-regulated kinase 5

「regulate」

　　[★]

• 制御する、調節する、(法的に)規制する

関

accommodation、accommodative、adjust、adjustment、baffle、control、modulate、modulation、regulation、regulatory

　 　 　

「sign」

　　[★]

• n.

• 徴候、兆候、サイン、(数学)符号

関

indication、manifestation、signature、stigma、stigmata、symptom、symptomatic

　 　 　 　 　 　 　 　 　 　 　 　 　 　

「signaling」

　　[★]

• n.

• シグナル伝達、情報伝達、シグナリング、信号伝達

関

signal transduction、signalling

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「extracellular」

　　[★]

• adj.

• 細胞外の

関

exocytic、extracellularly