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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/10 15:18:08」(JST)

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Main article: Mitogen-activated protein kinase

Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene.^[1]^[2]

Function

MAPK7 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor tyrosine kinases, and G protein-coupled receptors. In response to extracellular signals, this kinase translocates to the cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.^[3]

MAPK7 is also critical for cardiovascular development ^[4] and is essential for endothelial cell function.^[5] ^[6]

Interactions

MAPK7 has been shown to interact with SGK,^[7] MEF2C,^[8] YWHAB,^[9] MEF2D,^[8] C-Raf,^[10] PTPRR,^[11] Gap junction protein, alpha 1^[12] and MAP2K5.^[2]

References

^ Purandare SM, Lee JD, Patel PI (Mar 1999). "Assignment of big MAP kinase (PRKM7) to human chromosome 17 band p11.2 with somatic cell hybrids". Cytogenet Cell Genet 83 (3–4): 258–9. doi:10.1159/000015199. PMID 10072598.
^ ^a ^b Zhou G, Bao ZQ, Dixon JE (Jun 1995). "Components of a new human protein kinase signal transduction pathway". J Biol Chem 270 (21): 12665–9. doi:10.1074/jbc.270.21.12665. PMID 7759517.
^ "Entrez Gene: MAPK7 mitogen-activated protein kinase 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5598.
^ Hayashi M, Lee JD. (Oct 2004). "Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice". J Mol Med. 82 (12): 800–8. doi:10.1007/s00109-004-0602-8. PMID 15517128.
^ Roberts OL, Holmes K, Müller J, Cross DA, Cross MJ. (Dec 2009). "ERK5 and the regulation of endothelial cell function". Biochem Soc Trans. 37 (6): 1254–9. doi:10.1042/BST0371254. PMID 19909257.
^ Roberts OL, Holmes K, Müller J, Cross DA, Cross MJ. (Sept 2010). "ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells". J Cell Sci. 123 (18): 3189–3200. doi:10.1242/jcs.072801. PMID 20736307.
^ Hayashi, M; Tapping R I, Chao T H, Lo J F, King C C, Yang Y, Lee J D (Mar. 2001). "BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase". J. Biol. Chem. (United States) 276 (12): 8631–4. doi:10.1074/jbc.C000838200. ISSN 0021-9258. PMID 11254654.
^ ^a ^b Yang, C C; Ornatsky O I, McDermott J C, Cruz T F, Prody C A (Oct. 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Res. (ENGLAND) 26 (20): 4771–7. doi:10.1093/nar/26.20.4771. ISSN 0305-1048. PMC 147902. PMID 9753748. //www.ncbi.nlm.nih.gov/pmc/articles/PMC147902/.
^ Zheng, Qinlei; Yin Guoyong, Yan Chen, Cavet Megan, Berk Bradford C (Mar. 2004). "14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function". J. Biol. Chem. (United States) 279 (10): 8787–91. doi:10.1074/jbc.M310212200. ISSN 0021-9258. PMID 14679215.
^ English, J M; Pearson G, Hockenberry T, Shivakumar L, White M A, Cobb M H (Oct. 1999). "Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control". J. Biol. Chem. (UNITED STATES) 274 (44): 31588–92. doi:10.1074/jbc.274.44.31588. ISSN 0021-9258. PMID 10531364.
^ Buschbeck, Marcus; Eickhoff Jan, Sommer Marc N, Ullrich Axel (Aug. 2002). "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway". J. Biol. Chem. (United States) 277 (33): 29503–9. doi:10.1074/jbc.M202149200. ISSN 0021-9258. PMID 12042304.
^ Cameron, Scott J; Malik Sundeep, Akaike Masashi, Lerner-Marmarosh Nicole, Yan Chen, Lee Jiing-Dwan, Abe Jun-Ichi, Yang Jay (May. 2003). "Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation". J. Biol. Chem. (United States) 278 (20): 18682–8. doi:10.1074/jbc.M213283200. ISSN 0021-9258. PMID 12637502.

External links

MAP Kinase Resource .

English Journal

Modulation of ERK5 Is a Novel Mechanism by Which Cdc42 Regulates Migration of Breast Cancer Cells.

Zuo Y1, Wu Y, Wehrli B, Chakrabarti S, Chakraborty C.
Journal of cellular biochemistry.J Cell Biochem.2015 Jan;116(1):124-32. doi: 10.1002/jcb.24950.
Members of Rho family GTPases including Cdc42 are known to play pivotal roles in cell migration. Cell migration is also known to be regulated by many protein kinases. Kinetworks KPSS 11.0 phospho-site screening of Cdc42-silenced Hs578T breast cancer cells revealed most dramatic change in ERK5 MAP ki
PMID 25160664

Tumor suppressors miRNA-143 and miR-145 and predicted target proteins API5, ERK5, KRAS, and IRS-1 are differentially expressed in proximal and distal colon.

Pekow J1, Meckel K2, Dougherty U2, Butun F2, Mustafi R2, Lim J2, Crofton C2, Chen X2, Joseph LJ2, Bissonnette M3.
American journal of physiology. Gastrointestinal and liver physiology.Am J Physiol Gastrointest Liver Physiol.2014 Dec 4:ajpgi.00208.2014. doi: 10.1152/ajpgi.00208.2014. [Epub ahead of print]
The colon differs regionally in local luminal environment, excretory function, and gene expression. Polycistronic miR-143 and miR-145 are down-regulated early in colon cancer. We asked if these miRNA might be differentially expressed in the proximal versus the distal colon, contributing to regional
PMID 25477374

A place and a grid in the sun.

Kandel E.
Cell.Cell.2014 Dec 4;159(6):1239-42. doi: 10.1016/j.cell.2014.11.033.
The 2014 Nobel Prize in Physiology or Medicine, awarded to John O'Keefe, May-Britt Moser, and Edvard I. Moser, recognizes the first deep-brain insights into a cognitive function. Their insights established a new view for how the brain represents spatial location. Copyright © 2014 Elsevier Inc. All
PMID 25480286

Japanese Journal

Disturbed-Flow-Mediated Vascular Reactive Oxygen Species Induce Endothelial Dysfunction

Heo Kyung-Sun,Fujiwara Keigi,Abe Jun-ichi
Circulation Journal 75(12), 2722-2730, 2011
… Here, we propose a new signaling pathway involving d-flow-induced EC inflammation via PKCζ-ERK5 interaction-mediated downregulation of KLF2/eNOS stability, which leads to PKCζ-mediated p53-SUMOylation and EC apoptosis. …
NAID 130001275744

Big Mitogen-Activated Protein Kinase 1 Protects Cultured Rat Aortic Smooth Muscle Cells From Oxidative Damage

Zhao Jing,Kyotani Yoji,Itoh Satoyasu,Nakayama Hitoshi,Isosaki Minoru,Yoshizumi Masanori
Journal of Pharmacological Sciences 116(2), 173-180, 2011
… Big mitogen-activated protein kinase-1 / extracellular signal–regulated kinase 5 (BMK1/ERK5) is a newly identified member of the mitogen-activated protein kinases family. … Like Src tyrosine kinase, BMK1/ERK5 is known to be sensitive to oxidative stress; …
NAID 130000835861

Related Pictures

the MAP2K5–ERK5 signaling pathway ERK5はSp1とKlf2，Klf4を介して ERK5 MAPK信号通路(Signaling Pathway Figure 1. The location of activated Trk of cell survival by the erk5 cascade erk5 Download] myometrium labeled with Anti-phospho-ERK5

★リンクテーブル★

リンク元	「MAPキナーゼ」「MAPKスーパーファミリー」「細胞外シグナル制御キナーゼ5」「extracellular signal-regulated kinase 5」
関連記事	「ERK」「ER」

「MAPキナーゼ」

Mitogen-activated protein kinase 7
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	4B99, 4IC7, 4IC8
Identifiers
Symbols	MAPK7; BMK1; ERK4; ERK5; PRKM7
External IDs	OMIM: 602521 MGI: 1346347 HomoloGene: 2060 ChEMBL: 5332 GeneCards: MAPK7 Gene
EC number	2.7.11.24
Gene Ontology
Molecular function	• MAP kinase activity; • protein binding; • ATP binding; • mitogen-activated protein kinase binding;
Cellular component	• nucleus; • nucleoplasm; • cytosol;
Biological process	• toll-like receptor signaling pathway; • MyD88-dependent toll-like receptor signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • apoptotic process; • cell cycle; • signal transduction; • Toll signaling pathway; • peptidyl-serine phosphorylation; • cell differentiation; • negative regulation of heterotypic cell-cell adhesion; • toll-like receptor 1 signaling pathway; • toll-like receptor 2 signaling pathway; • toll-like receptor 3 signaling pathway; • toll-like receptor 4 signaling pathway; • TRIF-dependent toll-like receptor signaling pathway; • positive regulation of transcription from RNA polymerase II promoter in response to stress; • negative regulation of apoptotic process; • innate immune response; • regulation of angiogenesis; • positive regulation of transcription from RNA polymerase II promoter; • protein autophosphorylation; • nerve growth factor receptor signaling pathway; • negative regulation of inflammatory response; • positive regulation of protein metabolic process; • stress-activated MAPK cascade; • negative regulation of NFAT protein import into nucleus; • negative regulation of cell death; • negative regulation of response to cytokine stimulus; • cellular response to hydrogen peroxide; • ERK5 cascade; • cellular response to growth factor stimulus; • cellular response to laminar fluid shear stress; • cellular response to transforming growth factor beta stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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