ホスホトランスフェラーゼ、リン酸転移酵素、リン酸基転移酵素
- 関
- kinase
WordNet
- an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/09 21:57:29」(JST)
[Wiki en表示]
Phosphotransferases are a category of enzymes (EC number 2.7) that catalyze phosphorylation reactions. The general form of the reactions they catalyze is:
A-P + B B-P + A
Where P is a phosphate group and A and B are the donating and accepting molecules, respectively.
Contents
- 1 Classification of Phosphotransferases
- 2 Phosphotransferase system
- 3 See also
- 4 References
- 5 External links
Classification of PhosphotransferasesEdit
Phosphotransferases are generally classified according to the acceptor molecule.[1][2]
- EC 2.7.1 Phosphotransferases with an alcohol group as acceptor
- EC 2.7.2 Phosphotransferases with a carboxy group as acceptor
- EC 2.7.3 Phosphotransferases with a nitrogenous group as acceptor
- EC 2.7.4 Phosphotransferases with a phosphate group as acceptor
- EC 2.7.9 Phosphotransferases with paired acceptors. In these reactions, a single triphosphate-nucleotide transfers two phosphates to two different acceptor molecules, resulting in a monophosphate-nucleotide and two phosphorylated products.
Phosphotransferase systemEdit
The phosphotransferase system (PTS) is a complex group translocation system present in many bacteria. The PTS transports sugars (such as glucose, mannose, and mannitol) into the cell. The first step of this reaction is phosphorylation of the substrate via phosphotransferase during transport. In the case of glucose, the product of this phosphorylation is glucose-6-phosphate (Glc-6P). Due to the negative charge of the phosphate, this Glc-6P can no longer freely leave the cell. This is the first reaction of glycolysis, which degrades the sugar to pyruvate.
See alsoEdit
- Kinase
- Phosphorylase
- Diphosphotransferase
ReferencesEdit
- ^ [1] Phosphotransferases are any enzyme of sub‐subclasses EC 2.7.1 to 2.7.4, and EC 2.7.9
- ^ [2], Classification in this article follows the rules of Enzyme Nomenclature of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB).
External linksEdit
- Phosphotransferases at the US National Library of Medicine Medical Subject Headings (MeSH)
Proteins: enzymes
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Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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Transferases: phosphorus-containing groups (EC 2.7)
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2.7.1-2.7.4:
phosphotransferase/kinase
(PO4) |
2.7.1: OH acceptor |
- Hexo-
- Gluco-
- Fructo-
- Galacto-
- Phosphofructo-
- 1
- Liver
- Muscle
- Platelet
- 2
- Riboflavin
- Shikimate
- Thymidine
- NAD+
- Glycerol
- Pantothenate
- Mevalonate
- Pyruvate
- Deoxycytidine
- PFP
- Diacylglycerol
- Phosphoinositide 3
- Class I PI 3
- Class II PI 3
- Sphingosine
- Glucose-1,6-bisphosphate synthase
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2.7.2: COOH acceptor |
- Phosphoglycerate
- Aspartate kinase
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2.7.3: N acceptor |
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2.7.4: PO4 acceptor |
- Phosphomevalonate
- Adenylate
- Nucleoside-diphosphate
- Uridylate
- Guanylate
- Thiamine-diphosphate
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2.7.6: diphosphotransferase
(P2O7) |
- Ribose-phosphate diphosphokinase
- Thiamine diphosphokinase
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2.7.7: nucleotidyltransferase
(PO4-nucleoside) |
Polymerase |
DNA polymerase |
- DNA-directed DNA polymerase
- I
- II
- III
- IV
- V
- RNA-directed DNA polymerase
- Reverse transcriptase
- Telomerase
- DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase
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RNA nucleotidyltransferase |
- RNA polymerase/DNA-directed RNA polymerase
- RNA polymerase I
- RNA polymerase II
- RNA polymerase III
- RNA polymerase IV
- Primase
- RNA-dependent RNA polymerase
- PNPase
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Phosphorolytic
3' to 5' exoribonuclease |
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Nucleotidyltransferase |
- UTP—glucose-1-phosphate uridylyltransferase
- Galactose-1-phosphate uridylyltransferase
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Guanylyltransferase |
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Other |
- Recombinase (Integrase)
- Transposase
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2.7.8: miscellaneous |
Phosphatidyltransferases |
- CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
- CDP-diacylglycerol—serine O-phosphatidyltransferase
- CDP-diacylglycerol—inositol 3-phosphatidyltransferase
- CDP-diacylglycerol—choline O-phosphatidyltransferase
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Glycosyl-1-phosphotransferase |
- N-acetylglucosamine-1-phosphate transferase
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2.7.10-2.7.13: protein kinase
(PO4; protein acceptor) |
2.7.10: protein-tyrosine |
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2.7.11: protein-serine/threonine |
- see serine/threonine-specific protein kinases
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2.7.12: protein-dual-specificity |
- see serine/threonine-specific protein kinases
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2.7.13: protein-histidine |
- Protein-histidine pros-kinase
- Protein-histidine tele-kinase
- Histidine kinase
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UpToDate Contents
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English Journal
- Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors.
- Mitachi K1, Siricilla S1, Yang D2, Kong Y2, Skorupinska-Tudek K3, Swiezewska E3, Franzblau SG4, Kurosu M5.
- Analytical biochemistry.Anal Biochem.2016 Nov 1;512:78-90. doi: 10.1016/j.ab.2016.08.008. Epub 2016 Aug 13.
- Polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) is an essential enzyme for the growth of Mycobacterium tuberculosis (Mtb) and some other bacteria. Mtb WecA catalyzes the transformation from UDP-GlcNAc to decaprenyl-P-P-GlcNAc, the first membrane-anchored glycophospholipid that is responsi
- PMID 27530653
- A counterselection method for Lactococcus lactis genome editing based on class IIa bacteriocin sensitivity.
- Wan X1, Usvalampi AM1,2, Saris PE1, Takala TM3.
- Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2016 Nov;100(22):9661-9669. Epub 2016 Sep 22.
- In this paper, we present a new counterselection method for deleting fragments from Lactococcus lactis chromosome. The method uses a non-replicating plasmid vector, which integrates into the chromosome and makes the cell sensitive to bacteriocins. The integration vector carries pUC ori functional in
- PMID 27654656
- dbPHCC: a database of prognostic biomarkers for hepatocellular carcinoma that provides online prognostic modeling.
- Ouyang J1, Sun Y2, Li W3, Zhang W4, Wang D1, Liu X1, Lin Y1, Lian B5, Xie L6.
- Biochimica et biophysica acta.Biochim Biophys Acta.2016 Nov;1860(11 Pt B):2688-95. doi: 10.1016/j.bbagen.2016.02.017. Epub 2016 Mar 2.
- BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a poor prognosis. For decades, more and more biomarkers were found to effect on HCC prognosis, but these studies were scattered and there were no unified identifiers. Therefore, we built the database of progn
- PMID 26940364
Japanese Journal
- 大腸菌走化性制御に関与する糖輸送系因子Enzyme Iの細胞内局在
- High efficiency Agrobacterium-mediated transformation of Dendrobium orchid using protocorms as a target material
- Additional Glucose-PTS Induction in Streptococcus mutans Mutant Deficient in Mannose- and Cellobiose-PTS
Related Links
- Phosphotransferaseとは?goo Wikipedia (ウィキペディア) 。出典:Wikipedia(ウィキペディア)フリー百科事典。 Phosphotransferaseとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ 本文へ ...
- Phosphotransferase definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now! ... phosphotransferase phos·pho·trans·fer·ase (fŏs'fō-trāns'fə-rās', -rāz') n. Any of a class of ...
Related Pictures
![It was originally discovered in the 1930s](https://1mg.info/0/e/f/2088.jpg)
![phosphotransferase system .](https://1mg.info/0/d/o/2375.jpg)
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- 英
- phosphotransferase
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- キナーゼ、リン酸基転移酵素、リン酸転移酵素
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- カイネース、リン酸化酵素 phosphoenzyme phosphotransferase
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キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase
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- 英
- phosphotransferase
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- phosphotransferase
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- ホスホトランスフェラーゼ、リン酸転移酵素
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ジアシルグリセロールコリンホスホトランスフェラーゼ
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- cholinephosphotransferase
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コリンホスホトランスフェラーゼ
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- diacylglycerol cholinephosphotransferase
[★]
ジホスホトランスフェラーゼ