WordNet

reason or establish by induction
cause to arise; "induce a crisis" (同)bring_on
produce electric current by electrostatic or magnetic processes (同)induct
cause to do; cause to act in a specified manner; "The ads induced me to buy a VCR"; "My children finally got me to buy a computer"; "My wife made me buy a new sofa" (同)stimulate, cause, have, get, make
cause to occur rapidly; "the infection precipitated a high fever and allergic reactions" (同)stimulate, rush, hasten
marked strangeness as a consequence of being abnormal (同)freakishness
behavior that breaches the rule or etiquette or custom or morality (同)irregularity
an abnormal physical condition resulting from defective genes or developmental deficiencies (同)abnormalcy
retardation sufficient to fall outside the normal range of intelligence (同)mental defectiveness
use recreational drugs (同)do drugs
administer a drug to; "They drugged the kidnapped tourist" (同)dose
a substance that is used as a medicine or narcotic
brought about or caused; not spontaneous; "a case of steroid-induced weakness"

PrepTutorEJDIC

〈人〉‘に'『勧めて』(…)『させる』 / …‘を'『引き起こす』,もたらす(cause) / 〈電気〉‘を'誘導する / …‘を'帰納する
〈U〉異常,変則 / 〈U〉異常なもの(事件)
『薬』,薬品,薬剤 / 『麻薬』,麻酔剤 / 〈人〉‘に'薬(特に麻酔剤)を与える / 〈飲食物〉‘に'(麻酔薬・毒薬などの)薬を混ぜる

UpToDate Contents

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1. 薬物誘導性ミオパシー drug induced myopathies
2. 薬物誘発性免疫性血小板減少症 drug induced immune thrombocytopenia
3. 心血管系剤によって誘発された肺疾患 pulmonary disease induced by cardiovascular drugs
4. 妊娠中および授乳中のリウマチ性疾患における抗炎症剤および免疫抑制剤の使用 use of antiinflammatory and immunosuppressive drugs in rheumatic diseases during pregnancy and lactation
5. 成人におけるてんかんの初期治療 initial treatment of epilepsy in adults

English Journal

Drug-reaction eosinophilia and systemic symptoms and drug-induced hypersensitivity syndrome.

Fernando SL.Author information Department of Clinical Immunology and Allergy, Royal North Shore Hospital, Sydney, Australia; PaLMS Immunorheumatology Laboratory, Sydney, Australia; Sydney Medical School-Northern, Sydney University, Sydney, Australia.AbstractDrug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a rare, severe cutaneous adverse reaction characterised by fever, rash, lymphadenopathy, eosinophilia and/or other leukocyte abnormalities, and internal organ involvement and often has a relapsing-remitting course despite withdrawal of the drug. The drugs that are most implicated include aromatic anticonvulsants, allopurinol, sulphonamides, antiretrovirals (abacavir and nevirapine), and minocycline. The pathogenesis of DRESS/DIHS is far from clear but probably involves a combination of impaired pharmacokinetics and the accumulation of drug metabolites, the sequential reactivation of the herpesvirus family and genetic susceptibility conferred by the association with certain human leukocyte antigen (HLA) class I alleles. The strong association between abacavir and HLA-B*5701 has enabled pharmacogenetics screening to be employed successfully to minimise the occurrence of hypersensitivity. A prolonged course of oral corticosteroids is required to treat DRESS/DIHS, given the relapsing-remitting nature of the condition with i.v. immunoglobulin and valgangciclovir reserved for refractory or life-threatening cases.
The Australasian journal of dermatology.Australas J Dermatol.2014 Feb;55(1):15-23. doi: 10.1111/ajd.12085. Epub 2013 Jul 19.
Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a rare, severe cutaneous adverse reaction characterised by fever, rash, lymphadenopathy, eosinophilia and/or other leukocyte abnormalities, and internal organ involvement an
PMID 23866082

Three-dimensional filamentous human diseased cardiac tissue model.

Ma Z1, Koo S2, Finnegan MA1, Loskill P1, Huebsch N3, Marks NC1, Conklin BR3, Grigoropoulos CP2, Healy KE4.Author information 1Department of Bioengineering, University of California, Berkeley, CA 94720, USA.2Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA.3Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94143, USA; Department of Medicine, University of California, San Francisco, CA 94143, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.4Department of Bioengineering, University of California, Berkeley, CA 94720, USA; Department of Material Science and Engineering, University of California, Berkeley, CA 94720, USA. Electronic address: kehealy@berkeley.edu.AbstractA human in vitro cardiac tissue model would be a significant advancement for understanding, studying, and developing new strategies for treating cardiac arrhythmias and related cardiovascular diseases. We developed an in vitro model of three-dimensional (3D) human cardiac tissue by populating synthetic filamentous matrices with cardiomyocytes derived from healthy wild-type volunteer (WT) and patient-specific long QT syndrome type 3 (LQT3) induced pluripotent stem cells (iPS-CMs) to mimic the condensed and aligned human ventricular myocardium. Using such a highly controllable cardiac model, we studied the contractility malfunctions associated with the electrophysiological consequences of LQT3 and their response to a panel of drugs. By varying the stiffness of filamentous matrices, LQT3 iPS-CMs exhibited different level of contractility abnormality and susceptibility to drug-induced cardiotoxicity.
Biomaterials.Biomaterials.2014 Feb;35(5):1367-77. doi: 10.1016/j.biomaterials.2013.10.052. Epub 2013 Nov 21.
A human in vitro cardiac tissue model would be a significant advancement for understanding, studying, and developing new strategies for treating cardiac arrhythmias and related cardiovascular diseases. We developed an in vitro model of three-dimensional (3D) human cardiac tissue by populating synt
PMID 24268663

Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity.

Staikou C, Stamelos M, Stavroulakis E.Author information Department of Anaesthesia, Aretaieio Hospital, Medical School, University of Athens, 76 Vassilissis Sophias Ave., 11528 Athens, Greece.AbstractDrug-induced prolongation of cardiac repolarization may trigger malignant ventricular arrhythmias, such as torsade de pointes. The duration of QT interval, QT corrected for heart rate (QTc), JT interval, QT dispersion (QTd), QT variability index, and transmular dispersion of repolarization (TDR) are ECG markers of torsadogenicity. All volatiles, especially isoflurane and desflurane, have been found to prolong QTc and QTcd, while sevoflurane has probably no effects on TDR. Among i.v. anaesthetics, propofol seems superior due to its minimal effects on QTc and TDR; moreover, a decrease in QTc and QTcd has been demonstrated in many studies. Regarding opioids, fentanyl, alfentanil, and remifentanil produce no effects on QTc, while sufentanil, at high doses, may induce QT prolongation. Succinylcholine, but not the non-depolarizing neuromuscular blockers, produces QTc prolongation which can be attenuated by opioids and β-blockers. Reversal of neuromuscular block with anticholinesterase-anticholinergic combinations has been associated with significant QTc prolongation, while such an effect has not been demonstrated for sugammadex, even at high doses. Local anaesthetics have probably no intrinsic action on duration of repolarization; nevertheless, an extensive subarachnoid sympathetic block may increase the duration of QTc. On the contrary, thoracic epidural anaesthesia has been associated with a decrease in both QTc and TDR. Among adjuvants, midazolam seems to have no effect on QTc and TDR, while commonly used antiemetics, such as droperidol, domperidone, and most 5-HT3 antagonists, produce significant QT prolongation. The effects of anaesthetic drugs and techniques on electrocardiographic torsadogenic markers should be considered in the perioperative management of patients with preexisting repolarization abnormalities.
British journal of anaesthesia.Br J Anaesth.2014 Feb;112(2):217-30. doi: 10.1093/bja/aet412. Epub 2013 Dec 3.
Drug-induced prolongation of cardiac repolarization may trigger malignant ventricular arrhythmias, such as torsade de pointes. The duration of QT interval, QT corrected for heart rate (QTc), JT interval, QT dispersion (QTd), QT variability index, and transmular dispersion of repolarization (TDR) are
PMID 24305646