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1. 成長ホルモンの生理学physiology of growth hormone [show details]
… hormone (GH) is produced by the pituitary somatotroph cells. GH production begins early in fetal life and continues throughout life, although at a progressively lower rate. The basic aspects of GH physiology …
2. 成人における成長ホルモン欠乏症growth hormone deficiency in adults [show details]
… Growth hormone (GH) deficiency in adults is important for two reasons: the evidence that GH deficiency can have adverse effects and the availability of GH preparations for treatment . The clinical manifestations …
3. 過渡期における成長ホルモン治療growth hormone treatment during the transition period [show details]
… discussed in detail with the family before GH treatment is begun: The child may require ongoing GH treatment during the transition period. The child should be retested for GH deficiency during late adolescence …
4. 先端巨大症の診断diagnosis of acromegaly [show details]
…measure serum GH before and two hours after glucose administration; the criterion for the diagnosis of acromegaly is a GH concentration greater than 1 ng/mL. In normal subjects, serum GH concentrations …
5. 小児における成長ホルモン欠乏症の診断diagnosis of growth hormone deficiency in children [show details]
… undetectable GH release during standard provocative tests and after exogenous GHRH administration, but they respond to GH treatment. Deletions and mutations of GH1 — GH1 is the gene encoding GH, located …

English Journal

[Advances in gastrointestinal peptides: somatostatin].

, U U, R R, R R, .
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru. 1993 ;13(3)178-85.
Twenty years after being identified as "somatotropin release inhibiting factor" (SRIF) and "growth-hormone release inhibiting hormone" (GH-RIH), under a new name, somatostatin (SMS) has reached an outstanding position in gastroenteropancreatic endocrinology. It is a powerful and universal inhibitor
PMID 7910493

Early changes in plasma pancreatic polypeptide, somatostatin, gastrin and motilin levels induced by H. contortus infection in lamb.

Honde C, Chayvialle JA, Cuber JC, Bueno L.
Annales de recherches veterinaires. Annals of veterinary research. 1985 ;16(3)195-200.
Plasma levels of pancreatic polypeptide (PP), somatostatin (GH-RIH), gastrin and motilin were measured during 6-7 h after oral infection with 25 000 infective (3rd stage) larvae of H. contortus in lambs or after intravenous injection of larvae or worm antigenic (Ag) extracts. A 3-fold increase in pl
PMID 2865925

TRH, GH-RIH, and LH-RH in metamorphosing Xenopus laevis.

King JA, Millar RP.
General and comparative endocrinology. 1981 May;44(1)20-7.
PMID 6113189

Japanese Journal

Effect of Somatostatin on Blood Levels of Motilin and the Interdigestive Myoelectric Complex in Dogs

POITRAS P.,STEINBACH J.H.,DEVENTER G.VAN,CODE C.F.,WALSH J.H.
Ｅｎｄｏｃｒｉｎｏｌｏｇｉａ　Ｊａｐｏｎｉｃａ 27(Supplement), 163-166, 1980
… Somatostatin (GH-RIH) has been shown to inhibit motilin release in man (Mitznegg <I>et al</I>., 1977). … The following study was designed to look at the effect of GH-RIH on blood levels of motilin and on the IDMC in dog. …
NAID 130000954284

Distribution of LH-RH nerve endings in the median eminence of proestrus female rats: fluorescence and peroxidase anti-peroxidase(PAP) immunohistochemistry.

Ibata Y. [他],WATANABE K.,KIMURA H.,SANO Y.,SIN S.,HASHIMURA E.,IMAGAWA K.
Ｅｎｄｏｃｒｉｎｏｌｏｇｉａ　Ｊａｐｏｎｉｃａ 25(2), 141-148, 1978
… The distributional patterns of LH-RH, GH-RIH and monoamine in the median eminence as well as their relationships were briefly discussed. …
NAID 130000954728

Growth-hormone release-inhibiting hormone (GH-RIH) in gastrointestinal and pancreatic D cells

POLAK J. M.
Lancet 1, 1220-1222, 1975
NAID 30005853279

「ソマトスタチン」

　　[★]

英: somatostatin (Z)
同: 膵ソマトスタチン pancreatic somatostatin、成長ホルモン分泌抑制因子 growth hormone release inhibiting hormone(GH-RIH)、somatotropin release inhibiting factor(SRIF)
関: 消化管ホルモン

成長ホルモンに拮抗する作用を有する
成長に必要な栄養の消化吸収を抑制

分類

消化管ホルモン？・中枢神経系のホルモン(様々なところで発現しており、多くの生理活性により神経の調節を行っている(参考1))？

性状

ペプチド

環状構造を取っており、ジスルフィド結合によりこの構造が保たれている。
二つの型があり、共通のpreprohormonが転写後プロセッシングを受けてsomatostatin-14(14 a.a.)とsomatostatin-28(28 a.a.)ができる。somatostatin-14はsomatostatin-28のC末の配列と同一である。