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1. 成長ホルモンの生理学physiology of growth hormone [show details]
…hormone deficiencies . Growth hormone (GH) secretion is directly controlled by hypothalamic and peripheral factors acting on the somatotrophs . Hypothalamic growth hormone-releasing hormone (GHRH) and somatostatin …
2. 慢性腎疾患における成長ホルモン代謝growth hormone metabolism in chronic kidney disease [show details]
… example, normal individuals suppress growth hormone release in response to induced hyperglycemia; in contrast, glucose induces a paradoxical rise in growth hormone levels in advanced renal failure . In …
3. 小児における成長ホルモン欠乏症の治療treatment of growth hormone deficiency in children [show details]
… Recombinant human growth hormone (GH) is the primary treatment for short stature associated with GH deficiency.… Sustained-release preparations of GH for subcutaneous administration are in development,…
4. 小児における成長ホルモン欠乏症の診断diagnosis of growth hormone deficiency in children [show details]
… responsible for pituitary-specific transcription of genes for GH, prolactin, thyrotropin, and the growth hormone releasing hormone (GHRH) receptor . Mutations of the POU1F1 gene are transmitted as autosomal recessive …
5. 成人における成長ホルモン欠乏症growth hormone deficiency in adults [show details]
… Growth hormone (GH) deficiency in adults is important for two reasons: the evidence that GH deficiency can have adverse effects and the availability of GH preparations for treatment .… hypoglycemia or the combination of arginine and GH-releasing hormone (GHRH).…

English Journal

Neuroendocrine Tumors (NETs) of the Minor Papilla/Ampulla: Analysis of 16 Cases Underlines Homology With Major Ampulla NETs and Differences From Extra-Ampullary Duodenal NETs.

Vanoli A, Albarello L, Uncini S, Fassan M, Grillo F, Di Sabatino A, Martino M, Pasquali C, Milanetto AC, Falconi M, Partelli S, Doglioni C, Schiavo-Lena M, Brambilla T, Pietrabissa A, Sessa F, Capella C, Rindi G, La Rosa S, Solcia E, Paulli M.
The American journal of surgical pathology. 2019 Jun;43(6)725-736.
Neuroendocrine tumors (NETs) of the minor papilla/ampulla (MIPA) are rare and poorly studied. Only individual case reports and no comprehensive analysis are available from the literature. We collected 16 MIPA NETs and investigated their clinicopathologic and immunohistochemical features, including m
PMID 30913089

Correction: .

Annals of the rheumatic diseases. 2019 Jun;78(6)e60.
PMID 31088801

Somatostatin as Inflow Modulator in Liver-transplant Recipients With Severe Portal Hypertension: A Randomized Trial.

Troisi RI, Vanlander A, Giglio MC, Van Limmen J, Scudeller L, Heyse B, De Baerdemaeker L, Croo A, Voet D, Praet M, Hoorens A, Antoniali G, Codarin E, Tell G, Reynaert H, Colle I, Sainz-Barriga M.
Annals of surgery. 2019 Jun;269(6)1025-1033.
To investigate the safety and efficacy of somatostatin as liver inflow modulator in patients with end-stage liver disease (ESLD) and clinically significant portal hypertension (CSPH) undergoing liver transplantation (LT) (ClinicalTrials.gov number,01290172). In LT, portal hyperperfusion can severely
PMID 31082898

Japanese Journal

Endogenous Nitric Oxide Inhibits Growth Hormone Secretion through Cyclic Guanosine Monophosphate-Dependent Mechanisms in GH3 Cells.

TSUMORI MICHIHIRO,MURAKAMI YOSHIO,KOSHIMURA KUNIO,KATO YUZURU
Endocrine Journal 46(6), 779-785, 1999
… The mechanisms of action of nitric oxide (NO) to inhibit hormone secretion and the possible role of (6R)-5, 6, 7, 8-tetrahydro-L-biopterin (THB) in the action of endogenous NO were studied in GH<sub>3</sub> … Inhibiting NOS with NG-nitro-L-arginine or trapping NO with oxyhemoglobin enhanced both the basal and TRH-stimulated rat GH release. …
NAID 130003549990

Gamma-aminobutyric acid (GABA) 及びその代謝産物の下垂体前葉ホルモン分泌調節における役割に関する研究第一報 GABA及びGamma-hydroxybutyric acid (GHB) のラット視床下部ホルモン及び下垂体前葉ホルモン分泌に及ぼす影響

柚木昌
岡山医学会雑誌 94(9-10), 891-897, 1982-10-30
… Effects of gamma-aminobutyric acid (GABA), aminooxy acetic acid (AOAA), a GABA transaminase inhibitor, and gamma-hydroxybutyric acid (GHB) on the release of serum growth hormone (GH), prolactin (PRL), luteinizing hormone (LH) and hypothalamic somatotropin release inhibiting hormone (SRIF) content were investigated in urethane or pentobarbital anesthetized Sprague-Dawley male rats. …
NAID 120005816542

ヒト胎児成長ホルモン分泌と性差の検討

深谷孝夫 [他],古橋信晃,河野秀昭,立花義史,新川尹,高橋徹,鈴木雅洲
日本産科婦人科学会雑誌 34(4), p491-496, 1982-04
… 早期産児・正期産児88例と妊娠33週から妊娠40週の間に出生した無脳児の臍帯静脈血,および一部正期産児の母体血中のGHとimmunoreactive somatotropin release inhibiting factor(SRIF:somatostatin)をradioimmunoassay(RIA)にて測定し以下の成績を得た.1)臍勝帯静脈血中GH値は,妊娠21週から妊娠30週で69.2±20.2ng/ml(N=6,mean±S.D.),妊娠31週から妊娠36週で31.5±24.3ng/ml(N=11),妊娠37週から妊娠41週で17.6±8.9ng/ml(N=71)であり妊娠週数が進むととも …
NAID 110002119285

「ソマトスタチン」

　　[★]

英: somatostatin (Z)
同: 膵ソマトスタチン pancreatic somatostatin、成長ホルモン分泌抑制因子 growth hormone release inhibiting hormone(GH-RIH)、somatotropin release inhibiting factor(SRIF)
関: 消化管ホルモン

成長ホルモンに拮抗する作用を有する
成長に必要な栄養の消化吸収を抑制

分類

消化管ホルモン？・中枢神経系のホルモン(様々なところで発現しており、多くの生理活性により神経の調節を行っている(参考1))？

性状

ペプチド

環状構造を取っており、ジスルフィド結合によりこの構造が保たれている。
二つの型があり、共通のpreprohormonが転写後プロセッシングを受けてsomatostatin-14(14 a.a.)とsomatostatin-28(28 a.a.)ができる。somatostatin-14はsomatostatin-28のC末の配列と同一である。