膵ソマトスタチン
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. ソマトスタチンの生理学とその類縁体physiology of somatostatin and its analogues [show details]
… direct result of the inhibitory effects of somatostatin on insulin secretion, pancreatic exocrine secretion, and gallbladder contraction, respectively. Somatostatin deficiency occurs with persistent Helicobacter …
- 2. 膵体頭部病変の外科的切除surgical resection of lesions of the head of the pancreas [show details]
… of postoperative pancreatic fistula using various techniques for handling the pancreatic stump or anastomosis, prophylactic somatostatin and its analogues, and prophylactic pancreatic duct stenting has …
- 3. 転移性の高分化型膵管系神経内分泌（カルチノイド）腫瘍：腫瘍増殖およびホルモン過剰分泌による症状を管理するための全身治療の選択肢metastatic well differentiated pancreatic neuroendocrine tumors systemic therapy options to control tumor growth and symptoms of hormone hypersecretion [show details]
… with somatostatin analogs. In series that include patients with only pancreatic NET or combined series of patients with functioning gastroenteropancreatic NET (gastrointestinal NET and pancreatic NET) …
- 4. 膵体および膵体尾部病変の外科的切除surgical resection of lesions of the body and tail of the pancreas [show details]
… long-acting somatostatin analogue that reduces pancreatic, gastric, and enteric secretions. In theory, somatostatin should be helpful for reducing postoperative pancreatic fistula, but studies evaluating …
- 5. 膵液瘻：臨床的特徴および診断pancreatic fistulas clinical manifestations and diagnosis [show details]
… prevention and management of pancreatic fistulas are discussed in detail, separately. A pancreatic fistula (PF) is defined as an abnormal connection between the pancreas and adjacent or distant organs …
English Journal
- Neuroendocrine Tumors (NETs) of the Minor Papilla/Ampulla: Analysis of 16 Cases Underlines Homology With Major Ampulla NETs and Differences From Extra-Ampullary Duodenal NETs.
- Vanoli A, Albarello L, Uncini S, Fassan M, Grillo F, Di Sabatino A, Martino M, Pasquali C, Milanetto AC, Falconi M, Partelli S, Doglioni C, Schiavo-Lena M, Brambilla T, Pietrabissa A, Sessa F, Capella C, Rindi G, La Rosa S, Solcia E, Paulli M.
- The American journal of surgical pathology. 2019 Jun;43(6)725-736.
- Neuroendocrine tumors (NETs) of the minor papilla/ampulla (MIPA) are rare and poorly studied. Only individual case reports and no comprehensive analysis are available from the literature. We collected 16 MIPA NETs and investigated their clinicopathologic and immunohistochemical features, including m
- PMID 30913089
- Metastatic Insulinoma Controlled by Targeted Radionuclide Therapy With 177Lu-DOTATATE in a Patient With Solitary Kidney and MEN-1 Syndrome.
- Novruzov F, Mehmetbeyli L, Aliyev JA, Abbasov B, Mehdi E.
- Clinical nuclear medicine. 2019 Jun;44(6)e415-e417.
- A 54-year-old man with multiple endocrine neoplasia type 1 had previous history of parathyroid surgery and left thyroid lobectomy 5 years earlier, and was referred for recurrent hypoglycemic episodes. Ga-DOTATATE PET/CT had showed multiple lesions in the right lung, liver, and pancreas. Biopsy from
- PMID 30789400
- No direct effect of SGLT2 activity on glucagon secretion.
- Kuhre RE, Ghiasi SM, Adriaenssens AE, Wewer Albrechtsen NJ, Andersen DB, Aivazidis A, Chen L, Mandrup-Poulsen T, Ørskov C, Gribble FM, Reimann F, Wierup N, Tyrberg B, Holst JJ.
- Diabetologia. 2019 Jun;62(6)1011-1023.
- Sodium-glucose cotransporter (SGLT) 2 inhibitors constitute a new class of glucose-lowering drugs, but they increase glucagon secretion, which may counteract their glucose-lowering effect. Previous studies using static incubation of isolated human islets or the glucagon-secreting cell line α-TC1 su
- PMID 30903205
Japanese Journal
- 膵神経内分泌腫瘍に対する薬物療法 (特集 神経内分泌腫瘍の薬物療法)
- Surgical management of sporadic pancreatic neuroendocrine tumor
- Tezuka Koji,Kimura Wataru,Hirai Ichiro,Sugawara Shuichiro,Watanabe Toshihiro,Ashitomi Yuya,Nozu Shintaro,Takahashi Ryosuke
- 山形大学紀要. 医学 : 山形医学 = Bulletin of the Yamagata University. Medical science : Yamagata medical journal 36(2), 139-162, 2018-08-15
- … Recently, new treatment guidelines and classifications were proposed for the management of pancreatic neuroendocrine tumors（P-NETs）, and are now being used in clinical practice. … However, there are still no clear indications for organ-preserving pancreatic resection or lymph node dissection. …
- NAID 120006501534
- 膵α,βおよびδ細胞の傍分泌メカニズム解明のための膵島細胞の電気生理に関する研究 (非線形問題)
- 伊藤 亜以子,土居 伸二
- 電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 117(505), 51-56, 2018-03-13
- NAID 40021521755
Related Links
- Somatostatin: Somatostatin, polypeptide that inhibits the activity of certain pancreatic and gastrointestinal hormones. Somatostatin exists in two forms: one composed of 14 amino acids and a second composed of 28 amino acids.
- The δ-cells of the pancreatic islets secrete somatostatin, a powerful paracrine inhibitor of both insulin and glucagon secretion from islet α-cells and β-cells. δ-Cells are electrically excitable, and glucose stimulates action ...
- Request PDF on ResearchGate | Pancreatic β-cell somatostatin receptors | The characteristics of somatostatin (SRIF) receptors in rat pancreatic beta-cells were investigated using rat islets and the beta-cell line HIT-T15 (HIT). The ...
★リンクテーブル★
[★]
- 英
- somatostatin (Z)
- 同
- 膵ソマトスタチン pancreatic somatostatin、成長ホルモン分泌抑制因子 growth hormone release inhibiting hormone(GH-RIH)、somatotropin release inhibiting factor(SRIF)
- 関
- 消化管ホルモン
- 成長ホルモンに拮抗する作用を有する
- 成長に必要な栄養の消化吸収を抑制
分類
- 消化管ホルモン？・中枢神経系のホルモン(様々なところで発現しており、多くの生理活性により神経の調節を行っている(参考1))？
性状
- 環状構造を取っており、ジスルフィド結合によりこの構造が保たれている。
- 二つの型があり、共通のpreprohormonが転写後プロセッシングを受けてsomatostatin-14(14 a.a.)とsomatostatin-28(28 a.a.)ができる。somatostatin-14はsomatostatin-28のC末の配列と同一である。
産生組織
参考1
- 神経系：大脳皮質、視床下部、脳幹、脊髄の皮質に豊富。心臓、甲状腺、皮膚、眼、胸腺の神経に局在している。
- 消化器系：消化管と膵臓に豊富。そこで傍分泌あるいは内分泌のような形でD細胞により、そして腸神経によって産生されている。
標的組織
受容体
- G蛋白共役型受容体(5つのサブタイプがある。どのサブタイプもGiαサブユニットを介する)
作用
First Aid step 1 p.269
- 総じて、消化活動を止めさせる方向に作用
- (下垂体で？)
参考1より
- ソマトスタチンにより抑制されるホルモン (↓ホルモンとは思えない物もまじっていいる気が)
分泌の調整
分泌亢進
分泌抑制
臨床関連
参考
- 1.[charged]Physiology of somatostatin and its analogues - uptodate [1]
[★]
- 関
- pancreas、pancreata