近位尿細管性アシドーシス
WordNet
- write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
- a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
- (biology) the taxonomic group whose characteristics are used to define the next higher taxon
- a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
- all of the tokens of the same symbol; "the word `element contains five different types of character"
- printed characters; "small type is hard to read"
- identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
- constituting a tube; having hollow tubes (as for the passage of fluids) (同)cannular, tubelike, tube-shaped, vasiform
- abnormally high acidity (excess hydrogen-ion concentration) of the blood and other body tissues
- writing done with a typewriter (同)typewriting
PrepTutorEJDIC
- 〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
- 管状の,管から成る
- 酸性症,酸中毒(血液中のアルカリ濃度が異常に低い状態)
- 腎臓の
UpToDate Contents
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English Journal
- Kidney involvement in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy in a Finnish cohort.
- Kluger N1, Kataja J, Aho H, Rönn AM, Krohn K, Ranki A.Author information 1Department of Dermatology, Allergology and Venereology, Institute of Clinical Medicine, University of Helsinki, Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland.AbstractBACKGROUND: Autoimmune tubulo-interstitial nephritis (TIN) is a rare complication of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Previous data on TIN and other renal or urologic manifestations of APECED are sparse.
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.Nephrol Dial Transplant.2014 Apr 7. [Epub ahead of print]
- BACKGROUND: Autoimmune tubulo-interstitial nephritis (TIN) is a rare complication of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Previous data on TIN and other renal or urologic manifestations of APECED are sparse.METHODS: We performed a retrospective study on the urinar
- PMID 24711434
- Plasma exchange successfully treats central pontine myelinolysis after acute hypernatremia from intravenous sodium bicarbonate therapy.
- Chang KY, Lee IH, Kim GJ, Cho K, Park HS, Kim HW1.Author information 1Division of Nephrology, Department of Internal Medicine, St, Vincent's Hospital, The Catholic University of Korea, Seoul, Korea. khw@catholic.ac.kr.AbstractBACKGROUND: Osmotic demyelination syndrome (ODS) primarily occurs after rapid correction of severe hyponatremia. There are no proven effective therapies for ODS, but we describe the first case showing the successful treatment of central pontine myelinolysis (CPM) by plasma exchange, which occurred after rapid development of hypernatremia from intravenous sodium bicarbonate therapy.
- BMC nephrology.BMC Nephrol.2014 Apr 4;15(1):56. doi: 10.1186/1471-2369-15-56.
- BACKGROUND: Osmotic demyelination syndrome (ODS) primarily occurs after rapid correction of severe hyponatremia. There are no proven effective therapies for ODS, but we describe the first case showing the successful treatment of central pontine myelinolysis (CPM) by plasma exchange, which occurred a
- PMID 24708786
- Role of adaptor proteins and clathrin in the trafficking of human kidney anion exchanger 1 (kAE1) to the cell surface.
- Junking M1, Sawasdee N, Duangtum N, Cheunsuchon B, Limjindaporn T, Yenchitsomanus PT.Author information 1Division of Molecular Medicine, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.AbstractKidney anion exchanger 1 (kAE1) plays an important role in acid-base homeostasis by mediating chloride/bicarbornate (Cl- /HCO3 - ) exchange at basolateral membrane of α-intercalated cells in distal nephron. Impaired intracellular trafficking of kAE1 caused by mutations of SLC4A1 encoding kAE1 results in kidney disease - distal renal tubular acidosis (dRTA). However, it is not known how the intracellular sorting and trafficking of kAE1 from trans-Golgi network (TGN) to the basolateral membrane occur. Here, we studied the role of basolateral-related sorting proteins, including mu1 subunit of adaptor protein (AP) complexes, clathrin, and protein kinase D, on kAE1 trafficking in polarized and non-polarized kidney cells. By using RNA interference, co-immunoprecipitation, yellow fluorescent protein-based protein fragment complementation assay, and immunofluorescence staining, we demonstrated that AP-1 mu1A, AP-3 mu1, AP-4 mu1 and clathrin (but not AP-1 mu1B, PKD1 or PKD2) play crucial roles in intracellular sorting and trafficking of kAE1. We also demonstrated co-localization of kAE1 and basolateral-related sorting proteins in human kidney tissues by double immunofluorescence staining. These findings indicate that AP-1 mu1A, AP-3 mu1, AP-4 mu1, and clathrin are required for kAE1 sorting and trafficking from TGN to the basolateral membrane of acid-secreting α-intercalated cells.
- Traffic (Copenhagen, Denmark).Traffic.2014 Apr 3. doi: 10.1111/tra.12172. [Epub ahead of print]
- Kidney anion exchanger 1 (kAE1) plays an important role in acid-base homeostasis by mediating chloride/bicarbornate (Cl- /HCO3 - ) exchange at basolateral membrane of α-intercalated cells in distal nephron. Impaired intracellular trafficking of kAE1 caused by mutations of SLC4A1 encoding kAE1 resul
- PMID 24698155
Japanese Journal
- トピラマート(トピナ)服用中に腎尿管結石を生じたてんかん患者の2例
- 福本 亮,片山 欽三,林 哲也 [他]
- 泌尿器科紀要 57(3), 125-128, 2011-03
- … Topiramate has been shown to inhibit specific carbonic anhydrase activity in the kidney and may induce a distal type of renal tubular acidosis. …
- NAID 120003001367
Related Links
- Renal tubular acidosis, type 2 symptoms, causes, diagnosis, and treatment information for Renal tubular acidosis, type 2 (Proximal Renal Tubular Acidosis) with alternative diagnoses, full-text book chapters, misdiagnosis, research ...
- 1 Renal Tubular Acidosis National Kidney and Urologic Diseases Information Clearinghouse U.S. Department of Health and Human Services NATIONAL INSTITUTES OF HEALTH What is renal tubular acidosis (RTA)? Renal tubular ...
★リンクテーブル★
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- 英
- proximal renal tubular acidosis, proximal RTA, pRTA, proximal tubular acidosis
- 同
- 2型尿細管性アシドーシス、II型尿細管性アシドーシス、尿細管性アシドーシス2型、尿細管性アシドーシスII型
- 2型腎尿細管性アシドーシス、II型腎尿細管性アシドーシス、腎尿細管性アシドーシス2型、腎尿細管性アシドーシスII型
- type 2 renal tubular acidosis, type II renal tubular acidosis, renal tubular acidosis type 2, renal tubular acidosis type II
- type 2 RTA, type II RTA, RTA type 2, RTA type II
- 関
- 尿細管性アシドーシス、アシドーシス。遠位尿細管性アシドーシス
[show details]
概念
- 腎尿細管アシドーシスの中で、近位尿細管における重炭酸イオン再吸収障害に伴う酸排泄障害を原因とするものをいう。
- アニオンギャップが正常な高Cl性の代謝性アシドーシス
病因
- 参考1
-
- 多発性骨髄腫 → 成人におけるRTA type 2の原因で最多
- 薬物性
病態
- 参考1
- 重炭酸が何らかの原因により再吸収されない。 → 高Cl性代謝性アシドーシス
- リン酸、グルコース、尿酸、アミノ酸が再吸収されない。 → 低リン酸血症、腎性糖尿、低尿酸症、アミノ酸尿
- 水・電解質と酸塩基平衡 改訂第2版 p.151
- 近位尿細管で重炭酸イオン(その他各種電解質も)の再吸収が低下するために血清HCO3-が低下する
- 血清HCO3-が15mEq/l以下になると再吸収が可能となるので、proximal RTAにおいて血清HCO3-が15-17mEq/l以下になることはまれ。
- YN
- 近位尿細管におけるNa+/H+交輸送体の異常や、炭酸脱水酵素遺伝子異常、Na+/HCO3-共輸送体遺伝子異常
治療
- アシドーシス補正：重曹
- 低カリウム血症：カリウム補充
参考
- わかりにくい
- http://omim.org/entry/179830
- 2. [charged] Etiology and diagnosis of distal (type 1) and proximal (type 2) renal tubular acidosis - uptodate [1]
- 3. [charged] Pathophysiology of renal tubular acidosis and the effect on potassium balance - uptodate [2]
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- (windows)ファイル内容表示(linux -> cat])
- ex. type report_20111118.jp.htm | php a.php > report_20111118.jp.jp.jp.html
- 関
- form、mode、pattern、type specimen、typed
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- 関
- canalicular、kidney tubule、renal tubular、renal tubule、tracheary、tubule、uriniferous tubule
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- 関
- kidney tubule、renal tubule、tubular、tubule、uriniferous tubule
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- 関
- kidney、renally
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- 関
- form、mode、pattern、type