トリヨードサイロニン
English Journal
- Thyroid dysfunction in Chinese hepatitis C patients: Prevalence and correlation with TPOAb and CXCL10.
- Zhang RW1, Shao CP1, Huo N1, Li MR1, Xi HL1, Yu M1, Xu XY1.
- World journal of gastroenterology : WJG.World J Gastroenterol.2015 Sep 7;21(33):9765-73. doi: 10.3748/wjg.v21.i33.9765.
- AIM: To investigate the relationship among pretreatment serum CXC chemokine ligand 10 (CXCL10), thyroid peroxidase antibody (TPOAb) levels and thyroid dysfunction (TD) in Chinese hepatitis C patients.METHODS: One hundred and thirty-nine treatment-naive genotype 1 chronic hepatitis C patients with no
- PMID 26361424
- Second and third trimester amniotic fluid mesenchymal stem cells can repopulate a de-cellularized lung scaffold and express lung markers.
- Vadasz S1, Jensen T1, Moncada C1, Girard E2, Zhang F3, Blanchette A1, Finck C4.
- Journal of pediatric surgery.J Pediatr Surg.2014 Nov;49(11):1554-63. doi: 10.1016/j.jpedsurg.2014.04.006. Epub 2014 May 13.
- BACKGROUND/PURPOSE: This study examined the potential of amniotic fluid mesenchymal stem cells (AF-MSCs) to generate lung precursor cells in vitro and on a xenologous three-dimensional de-cellularized lung scaffold.METHODS: AF-MSCs were isolated from human amniotic fluid obtained from 17-37 weeks ge
- PMID 25475793
- Changes in thyroid hormone receptors after permanent cerebral ischemia in male rats.
- Lourbopoulos A1, Mourouzis I, Karapanayiotides T, Nousiopoulou E, Chatzigeorgiou S, Mavridis T, Kokkinakis I, Touloumi O, Irinopoulou T, Chouliaras K, Pantos C, Karacostas D, Grigoriadis N.
- Journal of molecular neuroscience : MN.J Mol Neurosci.2014 Sep;54(1):78-91. doi: 10.1007/s12031-014-0253-3. Epub 2014 Feb 28.
- Thyroid hormones (TH) and receptors (TRs) may play an important role in the pathophysiology of acute cerebral ischemia. In the present study, we sought to determine whether serum triodothyronine (T3)/thyroxine (T4) and brain TRs (TRα1, TRβ1) might change after experimental stroke. Male adult Wista
- PMID 24577884
Japanese Journal
- Identification of Thyroid Hormone-Responsive Genes in a Chicken Hepatoma Cell Line, LMH(Endocrinology)
- Yamauchi Kiyoshi,Sakamoto Akiko,Nishiyama Norihito [他],Shimada Naoyuki
- Zoological science 22(10), 1131-1135, 2005-10-25
- … Our study aimed to indentifyTH-responsive genes in as estogen-responsive chicken hepatoma cell line, LMH, RNA was prepared from cells treated with or without 10^8 M 3,3,5-triodothyronine (T_3) for 24 h and was analyzed by differential displays. …
- NAID 110006281709
- Reciprocal relation between serum thyrotropin levels and intrapituitary 3,5,3'L-triiodothyronine generating activity from thyroxine in perinatal rats.
- Naito Koichi [他],INADA MITSUO,MASHIO YASUO,TANAKA KIYOSHI,ISHII HITOSHI,NISHIKAWA MITSUSHIGE,IMURA HIROO
- Endocrinologia Japonica 28(4), 461-468, 1981
- … The conversion ratio of T<SUB>4 </SUB>to 3, 5, 3'L-triodothyronine (T<SUB>3</SUB>) was calculated from the radioactivity of T<SUB>3</SUB>spot to total radioactivity on the paper strip. …
- NAID 130000954348
- 妊婦糖尿と妊婦における糖質代謝に関する臨床的研究:第2編妊婦糖尿および妊娠時糖質代謝に対する内分泌学的考察
- 三田 稔
- 関西医科大学雑誌 21(3), 99-112, 1969
- … They were classified into normal pregnant women, pregnant women with renal glucosuria, pregnant women with pseudo-diabetes and with diabetes, respectively, and each of these pregnant women was examined, in accordance with the months of pregnancy, in regard to <SUP>131</SUP>I-triodothyronine resin sponge uptake (RSU), estrogen values in the urine,17KS values in the urine,170H-CS values in the urine and serum insulin. …
- NAID 130004625174
Related Links
- Definitions and translations of triodothyronine, tetraiodothyronine 25 Apr 00:25 GMT See also: ProZ.com - Translators & translator resources Home My Wikiwords Add/import Stats FAQ About Username Password Register Search ...
- The effects of triodothyronine and thymulin on avian NK cytolytic activity James A. Marsh, a, , Patricia G. Merlino a, Peter Staeheli b a Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University ...
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- 英
- thyroid hormone, thyroid hormones
- 関
- 甲状腺、サイログロブリン、カルシトニン、甲状腺ホルモン製剤
- 胎児の発育・新生児の生理と適応
種類
分類
性状
産生組織
標的組織
受容体
- 核内甲状腺受容体(甲状腺ホルモン受容体ファミリー)
- ステロイドレセプタースーパーファミリーに属する → 核内受容体スーパーファミリー
作用
代謝系別
- 脳、脾臓、睾丸をのぞくすべての組織で酸素消費を高める ← 甲状腺クリーゼによる発熱の原因
- カテコラミンの作用を増強する
心筋細胞のカテコールアミン受容体を増加 ←証明されていない?
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- →甲状腺ホルモンの投与によりコルチゾールが減少し副腎クリーゼを誘発
- エリスロポエチン産生促進 → 赤血球増加
- ヘモグロビンからの酸素解離を促進 → 末梢組織での酸素利用↑
- 骨代謝回転を高め、骨形成・骨吸収を促進 (閉経後女性で甲状腺ホルモン多 → 骨塩量減少 → 骨粗鬆症
- グレーブス病では筋肉蛋白の代謝亢進、筋肉量の減少、筋力低下、筋脱力、四肢麻痺
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- 肝臓におけるコレステロール産生を促進
- 肝臓のトリグリセリドリパーゼ活性を亢進し、コレステロールの代謝を促進
- コレステロールが減少 ← 総じて分解系の法が作用が強い
薬理学的作用 (SPC.321)
- 全ての生体の活動に関わる-(不足)→成長停止、身体的・精神的発育停止
- 組織の酸素消費を高め、基礎代謝を亢進させる。Na+,K+-ATApaseの活性刺激や、核内クロマチンに作用してDNA転写を促進する作用による
- 上記の通り
- ネガティブフィードバック
分泌の調節
- 視床下部--(甲状腺刺激ホルモン放出ホルモン)-→下垂体前葉--(甲状腺刺激ホルモン)-→甲状腺濾胞細胞-→T3, T4-→T3, T4は下垂体前葉・視床下部に作用し甲状腺刺激ホルモンの分泌を抑制
分子機構
臨床関連
過多
欠乏
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- 低栄養、外傷、感染症、手術、腎不全、肝不全、心不全、悪性腫瘍
- エネルギー消費を減らすための適応かもしれない
- 以上2007後期生理学授業プリント内分泌(3)
生合成 (SP.916)