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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/25 23:56:05」(JST)

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Reverse triiodothyronine (3,3’,5’-triiodothyronine, reverse T₃, or rT₃) is an isomer of triiodothyronine (3,5,3’ triiodothyronine, T₃). Reverse T₃ is the third-most common iodothyronine the thyroid gland releases into the bloodstream, of which 0.9% is rT₃; tetraiodothyronine (levothyroxine, T₄) constitutes 90% and T₃ is 9%. However, 95% of rT₃ in human blood is made elsewhere in the body, as enzymes remove a particular iodine atom from T₄.^[1]

The production of hormone by the thyroid gland is controlled by the hypothalamus and pituitary gland. The physiological activity of thyroid hormone is regulated by a system of enzymes that activate, inactivate or simply discard the prohormone T₄ and in turn functionally modify T₃ and rT₃. These enzymes operate under complex direction of systems including neurotransmitters, hormones, markers of metabolism and immunological signals.

The levels of rT3 increase in conditions such as sick euthyroid syndrome resulting from decreased clearance. It increases in sick euthyroid syndrome because its clearance decreases while its production stays the same. The decreased clearance is possibly from lower 5'-deiodinase activity in the peripheral tissue or decreased liver uptake of rT3. ^[2]

Reactions[edit]

Synthesis of Reverse T₃ from T₄ via deiodination. Synthesis of T₃ and T₂ is also shown.

References[edit]

^ Chopra IJ (July 1976). "An assessment of daily production and significance of thyroidal secretion of 3, 3', 5'-triiodothyronine (reverse T3) in man". J. Clin. Invest. 58 (1): 32–40. doi:10.1172/JCI108456. PMC 333152. PMID 932209.
^ http://emedicine.medscape.com/article/118651-overview#showall

External links[edit]

Triiodothyronine, Reverse at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. 非甲状腺疾患における甲状腺機能 thyroid function in nonthyroidal illness
2. 甲状腺ホルモンの合成および生理 thyroid hormone synthesis and physiology
3. 甲状腺ホルモンに対する感受性の低下 reduced sensitivity to thyroid hormone
4. 慢性腎疾患における甲状腺機能 thyroid function in chronic kidney disease
5. 甲状腺機能低下症の原因となる疾患 disorders that cause hypothyroidism

English Journal

Dosimetric and Late Radiation Toxicity Comparison Between Iodine-125 Brachytherapy and Stereotactic Radiation Therapy for Juxtapapillary Choroidal Melanoma.

Krema H, Heydarian M, Beiki-Ardakani A, Weisbrod D, Xu W, Laperriere NJ, Sahgal A.SourceDepartment of Ocular Oncology, Princess Margaret Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address: htmkrm19@yahoo.com.
International journal of radiation oncology, biology, physics.Int J Radiat Oncol Biol Phys.2013 Jul 1;86(3):510-515. doi: 10.1016/j.ijrobp.2013.02.005. Epub 2013 Mar 16.
PURPOSE: To compare the dose distributions and late radiation toxicities for 125I brachytherapy (IBT) and stereotactic radiation therapy (SRT) in the treatment of juxtapapillary choroidal melanoma.METHODS: Ninety-four consecutive patients with juxtapapillary melanoma were reviewed: 30 have been trea
PMID 23507292

Bioavailability of l-thyroxine and its metabolites after topical treatment with an emulsion containing 0.1% micronised l-thyroxine.

Certan D, Righini V, Oliva M, Fioravanti P, Bevilacqua M.SourceUnit of Endocrinology and Diabetology, Azienda Ospedaliera Luigi Sacco, Milan, Italy - righini.velella@hsacco.it.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia.G Ital Dermatol Venereol.2013 Jun;148(3):287-92.
Aim: Aim of the study was to assess systemic effects of a cycle of treatment with a topical formulation of l-T4 and escin (Somatoline®) in healthy women based on changes in bioavailability of FT4, FT3, rT3, and TSH. Methods: This study enrolled 20 healthy adult women with body mass index <30, no
PMID 23670065

Changes in Thyroid Status During Perinatal Development of MCT8-Deficient Male Mice.

Ferrara AM, Liao XH, Gil-Ibáñez P, Marcinkowski T, Bernal J, Weiss RE, Dumitrescu AM, Refetoff S.SourceDepartments of Medicine (A.M.F., X.-H.L., P.G.-I., T.M., R.E.W., A.S.R.) and Pediatrics (R.E.W., S.R.) and the Committee on Genetics (S.R.), The University of Chicago, Chicago, Illinois 60637; and Instituto de Investigaciones Biomédicas and Center for Biomedical Research on Rare Diseases (P.G-I., J.B.), Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, 28029 Madrid, Spain.
Endocrinology.Endocrinology.2013 May 21. [Epub ahead of print]
Patients with the monocarboxylate transporter 8 (MCT8) deficiency syndrome presents with a severe psychomotor retardation and abnormal serum thyroid hormone (TH) levels, consisting of high T3 and low T4 and rT3. Mice deficient in Mct8 replicate the thyroid phenotype of patients with the MCT8 gene mu
PMID 23696569

Japanese Journal

Normal Values of Real-Time 3-Dimensional Echocardiographic Parameters in a Healthy Japanese Population : The JAMP-3D Study

FUKUDA Shota,WATANABE Hiroyuki,DAIMON Masao,ABE Yukio,HIRASHIKI Akihiro,HIRATA Kumiko,ITO Hiroshi,IWAI TAKANO Masumi,IWAKURA Katsuomi,IZUMI Chisato,HIDAKA Takayuki,YUASA Toshinori,MURATA Kazuya,NAKATANI Satoshi,NEGISHI Kazuaki,NISHIGAMI Kazuhiro,NISHIKAGE Tomoko,OTA Takahiro,HAYASHIDA Akihiro,SAKATA Konomi,TANAKA Nobuhiro,YAMADA Satoshi,YAMAMOTO Kazuhiro,YOSHIKAWA Junichi
Circulation journal : official journal of the Japanese Circulation Society 76(5), 1177-1181, 2012-04-25
… Background: The recently developed real-time 3-dimensional echocardiography (RT3DE) is a promising imaging method to quantify cardiac chamber volumes and their functions in clinical practice. … However, normal reference values of RT3DE parameters have not been fully investigated in a large, healthy Japanese population. … Methods and Results: This study consisted of 410 healthy subjects aged from 20 to 69 years who had a RT3DE at one of the 23 collaborating institutions. …
NAID 10030132612

High-risk transseptal puncture in a patient with a "pancake" deformity in the left atrium caused by descending aorta displacement

Nishimura Takuro,Fukamizu Seiji,Matsushita Noriko,Hojo Rintaro,Hayashi Takekuni,Abe Tomomi,Komiyama Kota,Tanabe Yasuhiro,Tejima Tamotsu,Sakurada Harumizu,Nishizaki Mitsuhiro,Hiraoka Masayasu
Journal of Arrhythmia 28(4), 250-253, 2012
… We performed a transseptal puncture by using real-time three-dimensional transesophageal echocardiography (RT3D-TEE) in combination with fluoroscopic imaging, without any complications. … Although transseptal puncture can be performed without echocardiographic guidance in most patients, in our patient, RT3D-TEE proved to be a very helpful imaging technique to access the LA. …
NAID 130002129489

工場モニタリングおよびコントロールシステム : 製造装置組み込みから装置監視まで適用範囲を広げるコントローラ"e-RT3" (特集:半導体製造工程での計測機器・装置)

佐藤智義
計測技術 39(13), 1-5, 2011-12
NAID 40019084926

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Reverse triiodothyronine
	IUPAC name (2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid
Identifiers
CAS number	5817-39-0
PubChem	22069
MeSH	Reverse+triiodothyronine
Jmol-3D images	Image 1
	SMILES C1=CC(=C(C=C1C[C@@H](C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I ;
Properties
Molecular formula	C15H12I3NO4
Molar mass	650.974
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references