WordNet

any localized abnormal structural change in a bodily part

PrepTutorEJDIC

傷害,傷 / (体の組織や機能の)障害

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1. 小児における核上性注視異常 supranuclear disorders of gaze in children
2. 核間性眼筋麻痺 internuclear ophthalmoparesis
3. 複視の概要 overview of diplopia
4. 症候性（二次性）ミオクローヌス symptomatic secondary myoclonus
5. 進行性核上性麻痺（PSP）：臨床的特徴および診断 progressive supranuclear palsy psp clinical features and diagnosis

English Journal

Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology.

Ling H1,2,3, Kovacs GG4, Vonsattel JP5, Davey K1,2, Mok KY3,6, Hardy J3, Morris HR7, Warner TT1,2,3, Holton JL1,2,3, Revesz T8,2,3.
Brain : a journal of neurology.Brain.2016 Dec;139(Pt 12):3237-3252. Epub 2016 Oct 25.
SEE KOBYLECKI AND MANN DOI101093/AWW267 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Animal models have shown that tau seeding and propagation are strain- and neural network-specific. The study of preclinical cases is valuable to gain insights into early pathological features of corticobasal degener
PMID 27797812

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.

McKee AC1,2,3,4,5, Cairns NJ6, Dickson DW7, Folkerth RD8, Keene CD9, Litvan I10, Perl DP11, Stein TD12,13,14,15, Vonsattel JP16, Stewart W17, Tripodis Y13,18, Crary JF19, Bieniek KF7, Dams-O'Connor K20, Alvarez VE21,12,13,14, Gordon WA20; TBI/CTE group.
Acta neuropathologica.Acta Neuropathol.2016 Jan;131(1):75-86. doi: 10.1007/s00401-015-1515-z. Epub 2015 Dec 14.
Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE can only be definitively diagnosed by post-mortem examination of brain tissue. A
PMID 26667418
PMID 25853693

Japanese Journal

Widespread spinal cord involvement in progressive supranuclear palsy

IWASAKI Yasushi,YOSHIDA Mari,HASHIZUME Yoshio,HATTORI Manabu,AIBA Ikuko,SOBUE Gen
Neuropathology : official journal the Japanese Society of Neuropathology 27(4), 331-340, 2007-08-01
NAID 10021236009

Supranuclear Horizontal Gaze Palsy in Thalamomesencephalic Vascular Lesions

横田淳一
Equilibrium research 64(3), 151-156, 2005-06-01
… Two patients presenting supranuclear gaze palsy with thalamomesencephalic vascular lesions were reported on. … It is postulated that the present cases of supranuclear horizontal gaze palsy were due to the interruption of cortico-bulber pathways to the paramedian pontine reticular formation (PPRF), or output from the PPRF to control horizontal gaze passing near the thalamic lesion extending to the rostral part of the mesencephalon. …
NAID 10017269286

両眼核上性水平・垂直注視障害を呈した両側視床梗塞例

横田淳一,小坂健二,天草大陸
Equilibrium research 58(3), 238-246, 1999-06-01
… The saggital view of MRI disclosed that the lesion extended from the thalamus toward the rostral portion of the mesencephalon, in the territory of the paramedian thalamic arteries.<BR>Occlusion of these arteries may cause bilateral paramedian thalamic infarction, because these arteries arise from a common trunk of the basilar communicating artery which then bifurcates. …
NAID 10009387545

Related Links

Supranuclear Lesions - Multiple Sclerosis - Mussen Healthcare

Supranuclear Lesions. Lesions above the oculomotor nucleus tend to cause bilateral pupillary dysfunction; the most common cause is dorsal compression of the midbrain ( Parinaud syndrome; p. 358).

Supranuclear pathways and lesions - SlideShare

SUPRANUCLEAR PATHWAYS AND LESIONS Moderator: Dr. Seema Bhosale Presenter : Shruti Chandra Jain 2. Overview of the Presentation A. Fundamentals of Extra-ocular movements B. Anatomy of cortical and brainstem centers C. Basic binocular eye movements and their pathways D. Step-wise evaluation of EOMs E. Lesions of Supranuclear Pathways

Supranuclear lesion | definition of supranuclear lesion by ...

Neurological damage to the corticospinal or pyramidal tract in the brain or spinal cord. This lesion results in hemiplegia, paraplegia, or quadriplegia, depending on its location and extent. Clinical signs include loss of voluntary movement, spasticity, sensory loss, and pathological reflexes. See also: lesion.