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English Journal

Diffusion tensor MRI contributes to differentiate Richardson's syndrome from PSP-parkinsonism.

Agosta F, Pievani M, Svetel M, Ječmenica Lukić M, Copetti M, Tomić A, Scarale A, Longoni G, Comi G, Kostić VS, Filippi M.SourceNeuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Neurobiology of aging.Neurobiol Aging.2012 Dec;33(12):2817-26. doi: 10.1016/j.neurobiolaging.2012.02.002. Epub 2012 Mar 13.
This study investigated the regional distribution of white matter (WM) damage in Richardson's syndrome (PSP-RS) and progressive supranuclear palsy-Parkinsonism (PSP-P) using diffusion tensor (DT) magnetic resonance imaging (MRI). The DT MRI classificatory ability in diagnosing progressive supranucle
PMID 22418735

Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy.

Schaeffer V, Goedert M.SourceMRC Laboratory of Molecular Biology; Cambridge UK.
Autophagy.Autophagy.2012 Nov 1;8(11). [Epub ahead of print]
The most common neurodegenerative diseases are characterized by the accumulation of misfolded proteins. Tauopathies, which include Alzheimer disease, progressive supranuclear palsy, corticobasal degeneration, Pick disease and cases of frontotemporal dementia and parkinsonism linked to chromosome 17,
PMID 22874558