- 同
- rS-SCID
- 同
- rS-SCID
WordNet
- very bad in degree or extent; "a severe worldwide depression"; "the house suffered severe damage"
- unsparing and uncompromising in discipline or judgment; "a parent severe to the pitch of hostility"- H.G.Wells; "a hefty six-footer with a rather severe mien"; "a strict disciplinarian"; "a Spartan upbringing" (同)spartan
- intensely or extremely bad or unpleasant in degree or quality; "severe pain"; "a severe case of flu"; "a terrible cough"; "under wicked fire from the enemys guns"; "a wicked cough" (同)terrible, wicked
- join for a common purpose or in a common action; "These forces combined with others"
- harvester that heads and threshes and cleans grain while moving across the field
- add together from different sources; "combine resources"
- responsive to physical stimuli; "a mimosas leaves are sensitive to touch"; "a sensitive voltmeter"; "sensitive skin"; "sensitive to light"
- hurting; "the tender spot on his jaw" (同)sore, raw, tender
- being susceptible to the attitudes, feelings, or circumstances of others; "sensitive to the local community and its needs"
- of or pertaining to classified information or matters affecting national security
- the spontaneous emission of a stream of particles or electromagnetic rays in nuclear decay (同)radioactivity
- energy that is radiated or transmitted in the form of rays or waves or particles
- the act of spreading outward from a central source
- a radial arrangement of nerve fibers connecting different parts of the brain
- the spread of a group of organisms into new habitats
- set or keep apart; "sever a relationship" (同)break_up
PrepTutorEJDIC
- (人・法律などが)『厳しい』,厳格な / (態度・表情が)厳粛な,いかめしい / (病気などが)『重い』,危険な / (様式・趣味などが)簡素な,じみな,飾りのない / (人の体に)厳しくこたえる,激しい / (試験などが)難しい,厳しい
- …'を'『結合する』,合同する / …'を'兼ね備える;(…と)…'を'兼ね合わさせる《+『名』+『with』+『名』》 / …'を'化合させる;(…と)…'を'化合させる《+『名』+『with』+『名』》 / 『結合する』,連合する,合同する / (…と)化合する《+『with』+『名』》 / 連合,合同;(特に)企業合同,政治連合 / (また『combine harvester』)(刈り取りと脱穀が同時にできる)複式収穫機,コンバイン
- (五感が)『敏感な』,感じやすい / 物事を非常に気にする,神経過敏な / 感光性の;(器械などが)感度のよい
- 〈U〉(光・熱・放射能などの)発散,放射 / 〈C〉放射物;放射線;輻射(ふくしゃ)熱 / 〈C〉(喜び・幸福感などの)発散《+『of』+『名』》 / =radioactivity
- (全体から)…‘を'切断する《+『名』+『from』+『名』》 / (いくつかの部分に)…‘を'分ける《+『名』+『in』(『into』)+『名』》 / 〈関係など〉‘を'断つ / 切れる,分かれる,分裂する
UpToDate Contents
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- 1. 重度複合型免疫不全（SCID）：概要 severe combined immunodeficiency scid an overview
- 2. 重度複合型免疫不全（SCID）：特定の欠損 severe combined immunodeficiency scid specific defects
- 3. T-B-NK+ SCID：臨床症状、診断、および治療 t b nk scid clinical manifestations diagnosis and treatment
- 4. T-B-NK+ SCID：病因および遺伝学 t b nk scid pathogenesis and genetics
- 5. X連鎖重度複合型免疫不全（SCID） x linked severe combined immunodeficiency scid
English Journal
- Radiation-sensitive severe combined immunodeficiency: The arguments for and against conditioning before hematopoietic cell transplantation-what to do?
- Cowan MJ1, Gennery AR2.
- The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2015 Jun 5. pii: S0091-6749(15)00589-8. doi: 10.1016/j.jaci.2015.04.027. [Epub ahead of print]
- Defects in DNA cross-link repair 1C (DCLRE1C), protein kinase DNA activated catalytic polypeptide (PRKDC), ligase 4 (LIG4), NHEJ1, and NBS1 involving the nonhomologous end-joining (NHEJ) DNA repair pathway result in radiation-sensitive severe combined immunodeficiency (SCID). Results of hematopoieti
- PMID 26055221
- Role of transgene regulation in ex vivo lentiviral correction of artemis deficiency.
- Multhaup MM1, Podetz-Pedersen KM, Karlen AD, Olson ER, Gunther R, Somia NV, Blazar BR, Cowan MJ, McIvor RS.
- Human gene therapy.Hum Gene Ther.2015 Apr;26(4):232-43. doi: 10.1089/hum.2014.062. Epub 2015 Apr 13.
- Artemis is a single-stranded endonuclease, deficiency of which results in a radiation-sensitive form of severe combined immunodeficiency (SCID-A) most effectively treated by allogeneic hematopoietic stem cell (HSC) transplantation and potentially treatable by administration of genetically corrected
- PMID 25738323
- Cytotoxicity associated with artemis overexpression after lentiviral vector-mediated gene transfer.
- Multhaup M1, Karlen AD, Swanson DL, Wilber A, Somia NV, Cowan MJ, McIvor RS.
- Human gene therapy.Hum Gene Ther.2010 Jul;21(7):865-75. doi: 10.1089/hum.2009.162.
- Artemis is a hairpin-opening endonuclease involved in nonhomologous end-joining and V(D)J recombination. Deficiency of Artemis results in radiation-sensitive severe combined immunodeficiency (SCID) characterized by complete absence of T and B cells due to an arrest at the receptor recombination stag
- PMID 20163250
Related Links
- increased sensitivity to ionising radiation in bone marrow and fibroblast cells. Also known as Artemis, DNA cross-link repair protein 1C, T cell-negative (T-) B cell-negative (B-) natural killer cell-positive (NK+) severe Request a test ...
- Version 4.5 (October 2011) NE THAMES REGIONAL MOLECULAR GENETICS SERVICE Radiation-sensitive severe combined immunodeficiency (RS-SCID) Contact details Molecular Genetics GOSH NHS Trust Level 6 York ...
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★リンクテーブル★
| 関連記事 | 「combine」「severe」「sensitive」「sever」「radiation」 |
「combine」
- v.
- 併用する、組み合わせる、結合する、合併する
- 関
- ally、associate、bind、binding、bond、bonding、combination、combined application、complicate、concomitant、concurrent、conjoin、conjugate、conjugation、conjunction、connect、connection、couple、dock、engage、engagement、join、ligate、linkage、merge、merger、symphysial、union
「severe」
- adj.
- 重篤な、重症の、重度の、激しい、苛酷な
- 1.
- 厳しい、厳格な。厳密な(⇔mild)。容赦しない、血も涙もない、痛烈な
- ひどい、猛烈な。骨の折れる。過酷な
- 2
- 簡素な、地味な、渋い。厳粛な
- 関
- critically ill、grave、heavily、intense、life-threatening、rampant、serious、seriously、severe disease、severely、strenuous、severeness
「sensitive」
- adj.
- 感受性の、感応性の、敏感な、鋭敏な
「sever」
- v.
- 切断する
- 関
- ablate、ablation、amputate、amputation、break、breakage、cleavage、cleave、scission、transection、truncate、truncation
「radiation」
- n.
- 放射、放射線
- 放射物
- 輻射、放熱