WordNet

the means of connection between things linked in series (同)nexus
a unit of length equal to 1/100 of a chain
an interconnecting circuit between two or more locations for the purpose of transmitting and receiving data (同)data link
a fastener that serves to join or connect; "the walls are held together with metal links placed in the wet mortar during construction" (同)linkup, tie, tie-in
(computing) an instruction that connects one part of a program or an element on a list to another program or list
used to express refusal or denial or disagreement etc or especially to emphasize a negative statement; "no, you are wrong"
a negative; "his no was loud and clear"
referring to the degree to which a certain quality is present; "he was no heavier than a child" (同)no more
not in any degree or manner; not at all; "he is no better today"
quantifier; used with either mass nouns or plural count nouns for indicating a complete or almost complete lack or zero quantity of; "we have no bananas"; "no eggs left and no money to buy any"; "have you no decency?"; "did it with no help"; "Ill get you there in no time"
a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"
the 9th letter of the Roman alphabet (同)i
publicize in an exaggerated and often misleading manner

PrepTutorEJDIC

(鎖の)『輪』,環 / 鎖のようにつながったソーセージの一節 / (…と)つなぐ物(人),(…との)きずな,つながり《+『with』(『to』)+『名』》 / 《複数形で》=cuff links / …‘を'『つなぎ合わせる』,連結する;(…と)…‘を'つなぐ《+『名』+『with』(『to』)+『名』》 / (…と)結合する,つながる《+[『up』(『together』)]『with』+『名』》
たいまつ
《名詞の前に置いて》『一つも』(『一人も,少しも』)・・・『ない』 / 《補語につけて》『決して・・・でない』 / 《省略文で》・・・なし;・・・お断り / 《話》少ししか(あまり)・・・ない / (肯定の問いに対して)『いいえ』;(否定の問いに対して)はい,ええ / 《not, norの前に挿入して》『いや』,否 / 《形容詞の前に置その形容詞を否定して》…どころではない / 《比較級の前に置いて》ちっとも…でない,…と全く同じ / 《… or no の形で》…であってもなくても / 《驚き・困惑・不信などを表して》とんでもない / 《単数形で》『拒否』,「『いいえ』」という返事 / 《複数形で》反対[投]票
(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
『私は』私が
iodineの化学記号
…‘を'刺激する,駆り立てる / (不正な手段で)〈評判など〉‘を'高める,強化する / 不正な手段 / (皮下注射による)麻薬中毒者

UpToDate Contents

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1. 高IgM症候群 hyperimmunoglobulin m syndromes
2. 原発性免疫不全症の肺合併症 pulmonary complications of primary immunodeficiencies
3. 複合免疫不全 combined immunodeficiencies
4. 原発性免疫不全症の診断のためのフローサイトメトリー flow cytometry for the diagnosis of primary immunodeficiencies
5. 移植免疫 transplantation immunobiology

English Journal

Hyper IgM Syndrome: a Report from the USIDNET Registry.

Leven EA1, Maffucci P1, Ochs HD2, Scholl PR3, Buckley RH4, Fuleihan RL5, Geha RS6, Cunningham CK4, Bonilla FA6, Conley ME7, Ferdman RM8, Hernandez-Trujillo V9, Puck JM10, Sullivan K11, Secord EA12, Ramesh M13, Cunningham-Rundles C14.
Journal of clinical immunology.J Clin Immunol.2016 Jul;36(5):490-501. doi: 10.1007/s10875-016-0291-4. Epub 2016 May 17.
PURPOSE: The United States Immunodeficiency Network (USIDNET) patient registry was used to characterize the presentation, genetics, phenotypes, and treatment of patients with Hyper IgM Syndrome (HIGM).METHODS: The USIDNET Registry was queried for HIGM patient data collected from October 1992 to July
PMID 27189378

c-Rel plays a key role in deficient activation of B cells from a non-X-linked hyper-IgM patient.

Lu KT1, Sinquett FL, Dryer RL, Song C, Covey LR.
Blood.Blood.2006 Dec 1;108(12):3769-76. Epub 2006 Aug 8.
Our previous results demonstrated that B cells from a patient (pt1) with non-X-linked hyper-IgM syndrome (HIGM) possess an atypical CD23(lo) phenotype that is unaffected by CD40-mediated activation. To investigate the molecular mechanism underlying defective CD23 expression in pt1 B cells, we used l
PMID 16896156

Maintenance of the CD40-related immunodeficient response in hyper-IgM B cells immortalized with a LMP1-regulated mini-EBV.

Lu KT1, Dryer RL, Song C, Covey LR.
Journal of leukocyte biology.J Leukoc Biol.2005 Sep;78(3):620-9. Epub 2005 Jun 16.
Our previous investigation of a patient (pt1) with non-X-linked hyper-immunoglobulin M syndrome revealed a CD40-mediated defect in B cell activation that resulted in low CD23 expression and absence of germ-line transcription and class-switch recombination. These deficiencies were complemented in vit
PMID 15961576