inhibiting

• 抑制性の、阻害性の

関

inhibitory、suppressive

WordNet

1. tending to suppress; "the government used suppressive measures to control the protest"
2. restrictive of action; "a repressive regime"; "an overly strict and inhibiting discipline" (同)repressive, repressing

PrepTutorEJDIC

1. 抑圧する,抑制する;禁止する

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/10 02:42:09」(JST)

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[Wiki en表示]

Inhibitor or inhibition may refer to:

In biology

• Enzyme inhibitor, a substance that binds to an enzyme and decreases the enzyme's activity

In chemistry

• Corrosion inhibitor, a substance that decreases the rate of metal oxidation
• Reaction inhibitor, a substance that prevents or decreases the rate of a chemical reaction

In psychology and neurology

• Cognitive inhibition, the mind's ability to tune out irrelevant stimuli
• Reuptake inhibitor, a substance that increases neurotransmission by blocking the reuptake of a neurotransmitter
• Inhibition of return, a feature of attention
• Inhibition theory, a theory pertaining to the performance of a mental task
• Latent inhibition, a term used in classical conditioning
• Lateral inhibition, a neural mechanism that increases contrast between active and (neighbouring) inactive neurons
• Memory inhibition, processes that suppress or interfere with specific memories
• Sexual inhibition, reservations relating to sexual practices
• Social inhibition, a conditioned fear reaction to social marginalization or isolation
• Inhibitory postsynaptic potential, a synaptic potential that decreases the firing of a neuron

In popular culture

• Inhibitors (Revelation Space), machines in Alastair Reynolds's Revelation Space novels
• "Inhibitions", a 2008 single by Swedish band Alcazar

See also

• Preservative, a substance that inhibits spoilage
  • Embalming, the preservation of human remains
  • Food preservation, the inhibition of microbial growth in food
• Nuclear poison, an inhibitor of nuclear reactions

UpToDate Contents

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• 1. 女性の不妊評価 evaluation of female infertility
• 2. 思春期における多嚢胞性卵巣症候群の診断的評価 diagnostic evaluation of polycystic ovary syndrome in adolescents
• 3. 健常女性における卵巣の発達および機能不全（閉経） ovarian development and failure menopause in normal women
• 4. 正常な性的発育 normal sexual development
• 5. 抗癌剤および放射線療法による卵巣機能不全 ovarian failure due to anticancer drugs and radiation

English Journal

• Fatty Acid synthase inhibitor c75 ameliorates experimental colitis.

• Matsuo S1, Yang WL2, Aziz M2, Kameoka S3, Wang P2.Author information 1Department of Surgery, Hofstra North Shore-Long Island Jewish School of Medicine, and The Feinstein Institute for Medical Research, Manhasset, New York, United States of America Department of Surgery II, Tokyo Women's Medical University, Tokyo, Japan.2Department of Surgery, Hofstra North Shore-Long Island Jewish School of Medicine, and The Feinstein Institute for Medical Research, Manhasset, New York, United States of America.3Department of Surgery II, Tokyo Women's Medical University, Tokyo, Japan.AbstractAbnormalities of lipid metabolism through overexpression of fatty acid synthase (FASN), which catalyzes the formation of long-chain fatty acids, are associated with the development of inflammatory bowel disease (IBD). C75 is a synthetic α-methylene-γ-butyrolactone compound that inhibits FASN activity. We hypothesized that C75 treatment could effectively reduce the severity of experimental colitis. Male C57BL/6 mice were fed 4% dextran sodium sulfate (DSS) for 7 d. C75 (5 mg/kg body weight) or dimethyl sulfoxide (DMSO) (vehicle) was administered intraperitoneally from d 2 to 6. Clinical parameters were monitored daily. Mice were euthanized on d 8 for histological evaluation and measurements of colon length, chemokine, cytokine and inflammatory mediator expression. C75 significantly reduced body weight loss from 23% to 15% on d 8, compared with the vehicle group. The fecal bleeding, diarrhea and colon histological damage scores in the C75-treated group were significantly lower than scores in the vehicle animals. Colon shortening was significantly improved after C75 treatment. C75 protected colon tissues from DSS-induced apoptosis by inhibiting caspase-3 activity. Macrophage inflammatory protein 2, keratinocyte-derived chemokine, myeloperoxidase activity and proinflammatory cytokines (tumor necrosis factor-α, interleukin [IL]-1β and IL-6) in the colon were significantly downregulated in the C75-treated group, compared with the vehicle group. Treatment with C75 in colitis mice inhibited the elevation of FASN, cyclooxygenase-2 and inducible nitric oxide synthase expression as well as IκB degradation in colon tissues. C75 administration alleviates the severity of colon damage and inhibits the activation of inflammatory pathways in DSS-induced colitis. Thus, inhibition of FASN may represent an attractive therapeutic potential for treating IBD.
• Molecular medicine (Cambridge, Mass.).Mol Med.2014 Dec 24;20(1):1-9. doi: 10.2119/molmed.2013.00113.
• Abnormalities of lipid metabolism through overexpression of fatty acid synthase (FASN), which catalyzes the formation of long-chain fatty acids, are associated with the development of inflammatory bowel disease (IBD). C75 is a synthetic α-methylene-γ-butyrolactone compound that inhibits FASN activ
• PMID 24306512

• Persistent infectious diseases say - IDO. Role of indoleamine-2,3-dioxygenase in disease pathogenesis and implications for therapy.

• Barth H, Raghuraman S.Author information Inserm , U748, Strasbourg , France .AbstractIndoleamine-2,3-dioxygenase (IDO) is an enzyme that catabolises tryptophan - an essential amino acid critical for T cell proliferation. Initially recognized as a first line of host defense against infectious pathogens, IDO has been subsequently identified as an important immune-regulator inhibiting T-cell responses and promoting immune tolerance. Research over the past few years has demonstrated a crucial role for IDO in the pathogenesis of persistent infections that place an enormous burden on public health. In this review, we summarize current knowledge about IDO's role in causing pathogen persistence and progression to clinical disease. We conclude with a perspective on the potential benefits and risks of therapeutic IDO manipulation.
• Critical reviews in microbiology.Crit Rev Microbiol.2014 Nov;40(4):360-8. doi: 10.3109/1040841X.2012.742037. Epub 2012 Nov 23.
• Indoleamine-2,3-dioxygenase (IDO) is an enzyme that catabolises tryptophan - an essential amino acid critical for T cell proliferation. Initially recognized as a first line of host defense against infectious pathogens, IDO has been subsequently identified as an important immune-regulator inhibiting
• PMID 23174025

• Expression and Purification of Optimized rolGLP-1, A Novel GLP-1 Analog, in Escherichia Coli BL21(DE3) and its Good Glucoregulatory Effect on Type 2 Diabetic Mice.

• Ma B, Tu P, Zhao X, Zhang Y, Wang Y, Ma C, Ji Y, Li X, Abbas SA, Li M.Author information Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, Tianjin 300071, P.R. China. mgl@nankai.edu.cn.AbstractGlucagon-like peptide-1 (GLP-1) is an incretin hormone that decreases postprandial glycemic excursions by enhancing insulin secretion but with short half-life due to rapid inactivation by enzymatic N-terminal truncation. Therefore, efforts are being made to improve the stability of GLP-1 via modifying its structure or inhibiting dipeptidylpeptidase IV (DPP IV), which is responsible for its degradation. GLP-M, consisting of 10 tandem repeated rolGLP-1 (GLP-1 analog), has been expressed in Pichia pastoris by our laboratory. Although it had a long effect of maintaining glucose homeostasis, redundant amino acids and purification tag limited its application. Here, optimized rolGLP-1(GLPO) with no redundant amino acids and purification tag was constructed by molecular cloning and site-directed mutagenesis, which was expressed efficiently in Escherichia coli BL21(DE3) with the production of 81.5 mg/L, and confirmed by the results of SDS-PAGE electrophoresis and Western Blotting. Then GLP-O was purified via ion exchange chromatography and gel filtration chromatography. The purity of GLP-O was close to 100%. GLP-O could be cut into single rolGLP-1 by trypsin in vitro, and rolGLP-1 had anti-trypsin activity. After oral administration of GLP-O for 4 weeks, the level of blood glucose in type 2 diabetic mice was lowered effectively, and the oral glucose tolerance of mice was improved significantly. These results settled the foundation for further clinical application of GLP-O.
• Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2014 Nov;14(11):985-94.
• Glucagon-like peptide-1 (GLP-1) is an incretin hormone that decreases postprandial glycemic excursions by enhancing insulin secretion but with short half-life due to rapid inactivation by enzymatic N-terminal truncation. Therefore, efforts are being made to improve the stability of GLP-1 via modifyi
• PMID 24372241

Japanese Journal

• Inhibition of Automatic Semantic Processing in Children With High-Functioning Pervasive Developmental Disorders Having Reading Difficulty

• Yanai Tomonori,Maekawa Hisao
• Journal of Special Education Research 2(1), 25-33, 2018
• … The above results indicate that students with HF-PDD and reading difficulty have problems in conducting bottom-up processing while inhibiting top-down processing, when automatically generated semantic processing interferes with the processing conducted through the phonological route. …
• NAID 130004673117

• Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma

• Tuzova Marina,Jean Jyh-Chang,Hughey Rebecca P.,Brown Lou Ann S.,Cruikshank William W.,Hiratake Jun,Joyce-Brady Martin
• Frontiers in Pharmacology 5, 2014-07-31
• Asthma is characterized by airway inflammation. Inflammation is associated with oxidant stress. Airway epithelial cells are shielded from this stress by a thin layer of lung lining fluid (LLF) which c …
• NAID 120005462595

• IM塩酸溶液中におけるC38炭素鋼の腐食抑制 : 環境に優しい腐食抑制剤によるアプローチ

• ZHANG Shi Hong,QI Zhen Wei,KUANG Fei [他]
• 電気化学および工業物理化学 82(7), 584-590, 2014-07
• NAID 40020109104

Related Links

• Inhibiting | Define Inhibiting at Dictionary.com

British Dictionary definitions for inhibiting Expand inhibit / ɪnˈhɪbɪt / verb (transitive) -its, -iting, -ited 1. to restrain or hinder (an impulse, a desire, etc) 2. to prohibit; forbid 3. to stop, prevent, or decrease the rate of (a chemical 4. ...

• inhibiting - definition of inhibiting by The Free Dictionary

Translations of inhibiting. inhibiting synonyms, inhibiting antonyms. Information about inhibiting in the free online English dictionary and encyclopedia. inhibiting - definition of inhibiting by The Free Dictionary http://www Search / ? ...

Related Pictures

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★リンクテーブル★

リンク元	「inhibitory」「抑制性」「阻害性」「suppressive」
拡張検索	「muellerian inhibiting factor」「muellerian-inhibiting substance」「mullerian inhibiting substance」

「inhibitory」

　　[★]

• 抑制性の、抑制的な、阻害性の

関

inhibiting、suppressive

　

「抑制性」

　　[★]

英

inhibitory、inhibiting、suppressive

関

阻害性、抑制的

「阻害性」

　　[★]

英

inhibitory、inhibiting

関

抑制性、抑制的

「suppressive」

　　[★]

• 抑制性の

関

inhibiting、inhibitory

　 　

「muellerian inhibiting factor」

　　[★] 抗ミュラー管ホルモン

「muellerian-inhibiting substance」

　　[★] 抗ミュラー管ホルモン

「mullerian inhibiting substance」

　　[★] 抗ミュラー管ホルモン