関: ERK1、mitogen-activated protein kinase 3

WordNet

place signs, as along a road; "sign an intersection"; "This road has been signed"
(medicine) any objective evidence of the presence of a disorder or disease; "there were no signs of asphyxiation"
a perceptible indication of something not immediately apparent (as a visible clue that something has happened); "he showed signs of strain"; "they welcomed the signs of spring" (同)mark
a character indicating a relation between quantities; "dont forget the minus sign"
a fundamental linguistic unit linking a signifier to that which is signified; "The bond between the signifier and the signified is arbitrary"--de Saussure
a gesture that is part of a sign language
a public display of a message; "he posted signs in all the shop windows"
engage by written agreement; "They signed two new pitchers for the next season" (同)contract, sign on, sign_up
approve and express assent, responsibility, or obligation; "All parties ratified the peace treaty"; "Have you signed your contract yet?" (同)ratify
communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" (同)signal, signalize, signalise
mark with ones signature; write ones name (on); "She signed the letter and sent it off"; "Please sign here" (同)subscribe
be engaged by a written agreement; "He signed to play the casino on Dec. 18"; "The soprano signed to sing the new opera"
communicate in sign language; "I dont know how to sign, so I could not communicate with my deaf cousin"
notably out of the ordinary; "the year saw one signal triumph for the Labour party"
an electric quantity (voltage or current or field strength) whose modulation represents coded information about the source from which it comes
any nonverbal action or gesture that encodes a message; "signals from the boat suddenly stopped" (同)signaling, sign
any incitement to action; "he awaited the signal to start"; "the victory was a signal for wild celebration"
bring into conformity with rules or principles or usage; impose regulations; "We cannot regulate the way people dress"; "This town likes to regulate" (同)regularize, regularise, order, govern
fix or adjust the time, amount, degree, or rate of; "regulate the temperature"; "modulate the pitch" (同)modulate
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
located or occurring outside a cell or cells; "extracellular fluid"

PrepTutorEJDIC

(ある事実・状態・感情などの)『表れ』,印,気配,徴侯(indication);(…の)こん跡,計跡《+『of』+『名』》・『身ぶり』,手まね,合図 / 『標識』,看板 / (数学・音楽などの)記号 / (…の)『象徴』,シンボル(symbol)《+『of』+『名』》・《文》(…の)『前兆』,きざし《+『of』+『名』》・宮(きゅう)(黄道12区分の一つ) ・〈手紙・書類・作品など〉‘に'『署名する』・(…に)〈名前など〉‘を'書く《+『名』+『on』(『to』)+『名』》 / …‘を'雇う契約に署名する・…‘を'合図する,知らせる;…に合図する・署名する・契約書に署名して雇われる
(警告・指示・情報などを伝える)『信号』,合図 / (…の)きっかけ,動機,導火線《+『for』+『名』》 / 〈人・車など〉‘に'『合図する』,信号を送る / …‘を'『合図』(信号)『で知らせる』 / 『合図する』,信号する / 合図の,信号の / めざましい,顕著な
(規則などで)…‘を'『規制する』,『統制する』 / 〈機械など〉‘を'『調整する』 / 〈量や率など〉‘を'ある限度内におさえる

UpToDate Contents

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1. 黒色腫（メラノーマ）の分子生物学 the molecular biology of melanoma
2. 進行性肝細胞癌に対する全身治療 systemic treatment for advanced hepatocellular carcinoma
3. 結節性硬化症：遺伝学、臨床的特徴、および診断 tuberous sclerosis complex genetics clinical features and diagnosis
4. 薬物誘発性ループス drug induced lupus
5. 微細欠失症候群（12番～22番染色体） microdeletion syndromes chromosomes 12 to 22

English Journal

Connexin 32 and its derived homotypic gap junctional intercellular communication inhibit the migration and invasion of transfected HeLa cells via enhancement of intercellular adhesion.

Yang J, Liu B, Wang Q, Yuan D, Hong X, Yang Y, Tao L.SourceDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, P.R. China.
Molecular medicine reports.Mol Med Report.2011 Sep-Oct;4(5):971-9. doi: 10.3892/mmr.2011.509. Epub 2011 Jun 16.
The effects of connexin (Cx) and its derived homotypic gap junctional intercellular communication (GJIC) between tumor cells on the invasion of metastatic cancers and the underlying mechanisms remain unclear. In this study, we investigated the influence of Cx32 and the homotypic GJIC mediated by thi
PMID 21687945

Ceramide 1-phosphate induces neointimal formation via cell proliferation and cell cycle progression upstream of ERK1/2 in vascular smooth muscle cells.

Kim TJ, Kang YJ, Lim Y, Lee HW, Bae K, Lee YS, Yoo JM, Yoo HS, Yun YP.SourceDivision of Biological Science and Technology, College of Science and Technology, Yonsei University, Wonju 220-710, Republic of Korea.
Experimental cell research.Exp Cell Res.2011 Aug 15;317(14):2041-51. Epub 2011 May 20.
Ceramide 1-phosphate (C1P) is a novel bioactive sphingolipid formed by ceramide kinase (CERK)-catalyzed phosphorylation of ceramide. It has been implicated in the regulation of such vital pathophysiological functions as phagocytosis and inflammation, but there have been no reports ascribing a biolog
PMID 21624361

Japanese Journal

Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling

Kitajima Shunsuke,Miki T.,Takegami Yujiro,Kido Y.,Noda M.,Hara Eiji,Shamma Awad,Takahashi Chiaki
Oncogene 30(6), 737-750, 2011-02-10
… Within 2 days of RECK depletion, we observed a transient increase in protein kinase B (AKT) and extracellular signal-regulated kinase (ERK) phosphorylation associated with an upregulated expression of cyclin D1, p19Arf, Trp53, p21Cdkn1a and Sprouty 2. …
NAID 120002907445

Role of plasma membrane localization of the scaffold protein JSAP1 during differentiation of cerebellar granule cell precursors

Sato Tokiharu,Enkhbat Anir,Yoshioka Katsuji
Genes to Cells 16(1), 58-68, 2011-01
… We previously reported that the scaffold protein c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1) functions in cerebellar granule cell precursors (GCPs) to promote their cell-cycle exit and differentiation. …
NAID 120003141429