WordNet

a catecholamine secreted by the adrenal medulla in response to stress (trade name Adrenalin); stimulates autonomic nerve action (同)epinephrin, adrenaline, Adrenalin

PrepTutorEJDIC

=adrenalin[e]

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/17 14:51:14」(JST)

wiki en

Epinephrine (also known as adrenaline, adrenalin, or β,3,4-trihydroxy-N-methylphenethylamine) is a hormone and a neurotransmitter.^[1] Epinephrine and norepinephrine are two separate but related hormones secreted by the medulla of the adrenal glands. They are also produced at the ends of sympathetic nerve fibres, where they serve as chemical mediators for conveying the nerve impulses to effector organs.^[2] The investigation of the pharmacology of epinephrine made a major contribution to the understanding of the autonomic system and the function of the sympathetic system. Epinephrine remains a useful medicine for several emergency indications. This is despite its non-specific action on adrenoceptors and the subsequent development of multiple selective medicines that target subtypes of the adrenoceptors. The word adrenaline is used in common parlance to denote increased activation of the sympathetic system associated with the energy and excitement of the fight-or-flight response. ^[3]^[4] The influence of adrenaline is mainly limited to a metabolic effect and bronchodilation effect on organs devoid of direct sympathetic innervation.^[5]^[6]

In chemical terms, epinephrine is one of a group of monoamines called the catecholamines. It is produced in some neurons of the central nervous system, and in the chromaffin cells of the adrenal medulla from the amino acids phenylalanine and tyrosine.^[7]

1 Pathology
2 Medical uses
- 2.1 Cardiac arrest
- 2.2 Anaphylaxis
- 2.3 Asthma
- 2.4 Croup
- 2.5 Local anesthetics
- 2.6 Autoinjectors
- 2.7 Adverse effects
3 Terminology
4 Mechanism of action
5 Measurement in biological fluids
6 Biosynthesis and regulation
7 Physiology
- 7.1 Exercise
- 7.2 Psychology
8 Regulation
9 History
10 References
11 General references
12 External links

Pathology

Increased epinephrine secretion is observed in phaeochromocytoma, hypoglycaemia, myocardial infarction and to a lesser degree in benign essential familial tremor. A general increase in sympathetic neural activity is usually accompanied by increased adrenaline secretion, but there is selectivity during hypoxia and hypoglycaemia, when the ratio of adrenaline to noradrenaline is considerably increased.^[8]^[9]^[10] Therefore, there must be some autonomy of the adrenal medulla from the rest of the sympathetic system.

Myocardial infarction is associated with high levels of circulating epinephrine and norepinephrine, particularly in cardiogenic shock.^[11]^[12]

Benign familial tremor (BFT) is responsive to peripheral β-adrenergic blockers and beta 2 stimulation is known to cause tremor. Patients with BFT were found to have increased plasma epinephrine, but not norepinephrine.^[13]^[14]

Low, or absent, concentrations of epinephrine can be seen in autonomic neuropathy or following adrenalectomy. Failure of the adrenal cortex, as with Addisons disease, can suppress epinephrine secretion as the activity of the synthesing enzyme, phenylethanolamine-N-methyltransferase, depends on the high concentration of cortisol that drains from the cortex to the medulla.^[15]^[16]^[17]

Medical uses

Epinephrine vial 1mg (Adrenalin)

Adrenaline is used to treat a number of conditions including: cardiac arrest, anaphylaxis, and superficial bleeding.^[18] It has been used historically for bronchospasm and hypoglycemia, but newer treatments for these that are selective for beta2 adrenoceptors, such as salbutamol, a synthetic epinephrine derivative, are currently preferred. Currently the maximum recommended daily dosage for patients in a dental setting requiring local anesthesia with a peripheral vasoconstrictor is 10 mcg/lb of total body weight ^[18]

Cardiac arrest

Adrenaline is used as a drug to treat cardiac arrest and other cardiac dysrhythmias resulting in diminished or absent cardiac output. Its actions are to increase peripheral resistance via α₁receptor-dependent vasoconstriction and to increase cardiac output via its binding to β₁ receptors. The goal of reducing peripheral circulation is to increase coronary and cerebral perfusion pressures and therefore increase oxygen exchange at the cellular level. While epinephrine does increase aortic, cerebral, and carotid circulation pressure, it lowers carotid blood flow and end-tidal CO₂ or E_TCO₂ levels. It appears that epinephrine may be improving macrocirculation at the expense of the capillary beds where actual perfusion is taking place.^[19] E_TCO₂ levels have become the marker that predicts the effectiveness of CPR and return of spontaneous circulation.^[20] The ability of epinephrine to increase macrocirculatory pressures does not necessarily increase blood flow through end organs. E_TCO₂ levels might more accurately reflect tissue perfusion instead of perfusion pressure markers.^[21]

Epinephrine has not demonstrated its ability to improve tissue perfusion or positively impact long term survival,^[22]^[23] and could be reducing the survival rates of patients in cardiac arrest.^[24]^[25]

Anaphylaxis

Epinephrine/adrenaline is the drug of choice for treating anaphylaxis. Allergy^[26] patients undergoing immunotherapy may receive an adrenaline rinse before the allergen extract is administered, thus reducing the immune response to the administered allergen.

Different strengths, doses and routes of administration of epinephrine are used for several medical emergencies. The commonly used Epipen Auto-Injector delivers 0.3 mg epinephrine injection (0.3 mL, 1:1000) is indicated in the emergency treatment of allergic reactions (Type I) including anaphylaxis to stings, contrast agents, medicines or patients with a history of anaphylactic reactions to known triggers. A single dose is recommended for patients who weigh 30 kg or more, repeated if necessary. A lower strength product is available for paediatric use^[27] This dose causes vasoconstriction at the site of subcutaneous injection, delaying absorption. The pharmacokinetic profile produces plasma concentrations in the region of 2 nmol/l, a concentration that be also be achieved with the repeated use of an epinephrine inhaler. This concentration is similar to that achieved during intense exercise and is too low to have significant beta 1 adrenoceptor, or alpha vasoconstrictor activity, but has marked beta 2 adrenceptor activity causing a fall in plasma potassium, an elevation in plasma glucose and enhanced finger tremor with additional bronchodilation and bronchoprotection.^[28]

The allergic reaction dose of epinephrine (0.1ml/kg 1/1000 Epinephrine with a max single dose of 0.3ml SQ or IM with IM being preferred in a low perfusion state) suppresses the experimentally induced wheal of the wheal and flare response to intradermally injected antigen.^[29] This suppression of the wheal is mediated by beta 2 adrenoceptors.^[30] The mechanism of the suppression of the edema is to reduce the vascular leak of fluid through the inter-endothelial junction of post capillary venules via beta receptor stimulation on the endothelial surface.^[31] Repeated doses, or higher doses, may cause additional microvascular constriction via alpha receptor stimulation, which also suppresses inflammatory edema.^[32]

When given intravenously (iv), instraosseous (IO) or intra-muscularly (im), the potency of epinephrine is greatly enhanced. For this reason for refractory anaphylactic shock or cardiac arrest a dilute epinephrine preparation is used of 1/10,000, the iv or im route being used for faster onset of action.^[33]^[34]^[35] The adult dose for refractory anaphylactic shock is usually 1 mg (1:10,000) IV/IO over 5 min and for cardiac arrest 1 mg (1:10,000) as an IV/IO push. When given IV/IO a major mechanism is via alpha adrenoceptor mediated vasoconstriction, increasing central blood pressure, making more selective alpha adrenoceptor agonists an alternative treatment^[36]^[37] Intramuscular injection can be complicated in that the depth of subcutaneous fat varies and may result in subcutaneous injection, or may be injected intravenously in error, or the wrong strength used.^[38] Intramuscular injection does give a faster and higher pharmacokinetic profile when compared to SC injection ^[39]

Because of various expressions of α₁ or β₂ receptors, depending on the patient, administration of adrenaline may raise or lower blood pressure, depending on whether or not the net increase or decrease in peripheral resistance can balance the positive inotropic and chronotropic effects of adrenaline on the heart, effects that increase the contractility and rate, respectively, of the heart.^{[citation needed]}

The usual concentration for SC or IM injection is 0.15- 0.3 ml of 1:1,000. It is available in the trade as epipen

Asthma

Adrenaline is also used as a bronchodilator for asthma if specific β₂ agonists are unavailable or ineffective.^[40]

When given by the subcutaneous or intramuscular routes for asthma, an appropriate dose is 300-500 mcg.^[41]^[42]

Croup

Racemic epinephrine has historically been used for the treatment of croup.^[43]^[44] Racemic adrenaline is a 1:1 mixture of the dextrorotatory (d) and levorotatory (l) isomers of adrenaline.^[45] The l- form is the active component.^[45] Racemic adrenaline works by stimulation of the α-adrenergic receptors in the airway, with resultant mucosal vasoconstriction and decreased subglottic edema, and by stimulation of the β-adrenergic receptors, with resultant relaxation of the bronchial smooth muscle.^[44]

Local anesthetics

Adrenaline is added to injectable forms of a number of local anesthetics, such as bupivacaine and lidocaine, as a vasoconstrictor to slow the absorption and, therefore, prolong the action of the anesthetic agent. Due to epinephrine's vasoconstricting abilities, the use of epinephrine in localized anesthetics also helps to diminish the total blood loss the patient sustains during minor surgical procedures. Some of the adverse effects of local anesthetic use, such as apprehension, tachycardia, and tremor, may be caused by adrenaline. Epinephrine/adrenalin is frequently combined with dental and spinal anesthetics and can cause panic attacks in susceptible patients at a time when they may be unable to move or speak due to twilight anesthesia.^[46]

Autoinjectors

Adrenaline is available in an autoinjector delivery system. Auvi-Qs, Jexts, EpiPens, Emerade, Anapens, and Twinjects all use adrenaline as their active ingredient. Twinject, which is now discontinued, contained a second dose of adrenaline in a separate syringe and needle delivery system contained within the body of the autoinjector. Though both EpiPen and Twinject are trademark names, common usage of the terms is drifting toward the generic context of any adrenaline autoinjector.^{[citation needed]}

Adverse effects

Adverse reactions to adrenaline include palpitations, tachycardia, arrhythmia, anxiety, panic attack, headache, tremor, hypertension, and acute pulmonary edema.^[47]

Use is contraindicated in people on nonselective β-blockers, because severe hypertension and even cerebral hemorrhage may result.^[48] Although commonly believed that administration of adrenaline may cause heart failure by constricting coronary arteries, this is not the case. Coronary arteries have only β₂ receptors, which cause vasodilation in the presence of adrenaline.^[49] Even so, administering high-dose adrenaline has not been definitively proven to improve survival or neurologic outcomes in adult victims of cardiac arrest.^[50]

Terminology

Epinephrine is the hormone's United States Adopted Name and International Nonproprietary Name, though the more generic name adrenaline is frequently used. The term Epinephrine was coined by the pharmacologist John Abel (from the Greek for "on top of the kidneys"), who used the name to describe the extracts he prepared from the adrenal glands as early as 1897.^[51] In 1901, Jokichi Takamine patented a purified adrenal extract, and called it "adrenalin" (from the Latin for "on top of the kidneys"), which was trademarked by Parke, Davis & Co in the U.S.^[51] In the belief that Abel's extract was the same as Takamine's, a belief since disputed, epinephrine became the generic name in the U.S.^[51] The British Approved Name and European Pharmacopoeia term for this chemical is adrenaline and is indeed now one of the few differences between the INN and BAN systems of names.^[52]

Among American health professionals and scientists, the term epinephrine is used over adrenaline. However, pharmaceuticals that mimic the effects of epinephrine are often called adrenergics, and receptors for epinephrine are called adrenergic receptors or adrenoceptors.

Mechanism of action

Physiologic responses to epinephrine by organ
Organ	Effects
Heart	Increases heart rate
Lungs	Increases respiratory rate
Systemic	Vasoconstriction and vasodilation
Liver	Stimulates glycogenolysis
Systemic	Triggers lipolysis
Systemic	Muscle contraction

Play media

7x speed timelapse video of fish melanophores responding to 200uM adrenaline.

As a hormone and neurotransmitter, epinephrine acts on nearly all body tissues. Its actions vary by tissue type and tissue expression of adrenergic receptors. For example, high levels of epinephrine causes smooth muscle relaxation in the airways but causes contraction of the smooth muscle that lines most arterioles.

Epinephrine acts by binding to a variety of adrenergic receptors. Epinephrine is a nonselective agonist of all adrenergic receptors, including the major subtypes α₁, α₂, β₁, β₂, and β₃.^[48] Epinephrine's binding to these receptors triggers a number of metabolic changes. Binding to α-adrenergic receptors inhibits insulin secretion by the pancreas, stimulates glycogenolysis in the liver and muscle, and stimulates glycolysis in muscle.^[53] β-Adrenergic receptor binding triggers glucagon secretion in the pancreas, increased adrenocorticotropic hormone (ACTH) secretion by the pituitary gland, and increased lipolysis by adipose tissue. Together, these effects lead to increased blood glucose and fatty acids, providing substrates for energy production within cells throughout the body.^[53]

Measurement in biological fluids

Epinephrine may be quantified in blood, plasma, or serum as a diagnostic aid, to monitor therapeutic administration, or to identify the causative agent in a potential poisoning victim. Endogenous plasma epinephrine concentrations in resting adults are normally less than 10 ng/L, but may increase by 10-fold during exercise and by 50-fold or more during times of stress. Pheochromocytoma patients often have plasma adrenaline levels of 1000-10,000 ng/L. Parenteral administration of epinephrine to acute-care cardiac patients can produce plasma concentrations of 10,000 to 100,000 ng/L.^[54]^[55]

Biosynthesis and regulation

Epinephrine is synthesized in the medulla of the adrenal gland in an enzymatic pathway that converts the amino acid tyrosine into a series of intermediates and, ultimately, epinephrine. Tyrosine is first oxidized to L-DOPA, which is subsequently decarboxylated to give dopamine. Oxidation gives norepinephrine. The final step in epinephrine biosynthesis is the methylation of the primary amine of noradrenaline. This reaction is catalyzed by the enzyme phenylethanolamine N-methyltransferase (PNMT) which utilizes S-adenosylmethionine (SAMe) as the methyl donor.^[56] While PNMT is found primarily in the cytosol of the endocrine cells of the adrenal medulla (also known as chromaffin cells), it has been detected at low levels in both the heart and brain.^[57]

Physiology

The adrenal medulla is a minor contributor to total circulating catecholamines, though it contributes over 90% of circulating epinephrine. Little epinephrine is found in other tissues, mostly in scattered chromaffin cells. Following adrenalectomy, epinephrine disappears below the detection limit in the blood stream.^[58]

The adrenals contribute about 7% of circulating norepinephrine, most of which is a spill over from neurotransmission with little activity as a hormone.^[59]^[60]^[61] Pharmacological doses of epinephrine stimulate α1, α2, β1, β2, and β3 adrenoceptors of the sympathetic nervous system. Sympathetic nerve receptors are classified as adrenergic, based on their responsiveness to adrenaline.^[62]

The term “adrenergic” is often misinterpreted in that the main sympathetic neurotransmitter is norepinephrine (noradrenaline), rather than epinephrine, as discovered by Ulf von Euler in 1946.^[63]^[64]

Epinephrine does have a β2 adrenoceptor mediated effect on metabolism and the airway, there being no direct neural connection from the sympathetic ganglia to the airway.^[65]^[66]^[67]

The concept of the adrenal medulla and the sympathetic nervous system being involved in the flight, fight and fright response was originally proposed by Cannon.^[68] But the adrenal medulla, in contrast to the adrenal cortex, is not required for survival. In adrenalectomized patients haemodynamic and metabolic responses to stimuli such as hypoglycaemia and exercise remain normal.^[69]^[70]

Epinephrine is important as a central neurotransmitter. In the periphery circulating epinephrine can stimulate the facilitatory noradrenaline pre-synaptic β receptor, though the significance of this is not clear.^[71] Beta blockade in man and adrenalectomy in animals show that endogenous epinephrine has significant metabolic effects.^[72]

Exercise

The main physiological stimulus to epinephrine secretion is exercise. This was first demonstrated using the dennervated pupil of a cat as an assay,^[73] later confirmed using a biological assay on urine samples.^[74] Biochemical methods for measuring catecholamines in plasma were published from 1950 onwards.^[75] Although much valuable work has been published using fluorimetric assays to measure total catecholamine concentrations, the method is too non-specific and insensitive to accurately determine the very small quantities of epinephrine in plasma. The development of extraction methods and enzyme-isotope derivate radio-enzymatic assays (REA) transformed the analysis down to a sensitivity of 1 pg for epinephrine.^[76] Early REA plasma assays indicated that epinephrine and total catecholamines rise late in exercise, mostly when anaerobic metabolism commences.^[77]^[78]^[79]

During exercise the epinephrine blood concentration rises partially from increased secretion from the adrenal medulla and partly from decreased metabolism because of reduced hepatic blood flow.^[80] Infusion of epinephrine to reproduce exercise circulating concentrations of epinephrine in subjects at rest has little haemodynamic effect, other than a small β2 mediated fall in diastolic blood pressure.^[81]^[82] Infusion of epinephrine well within the physiological range suppresses human airway hyper-reactivity sufficiently to antagonize the constrictor effects of inhaled histamine.^[83]

A link between what we now know as the sympathetic system and the lung was shown in 1887 when Grossman showed that stimulation of cardiac accelerator nerves reversed muscarine induced airway constriction.^[84] In elegant experiments in the dog, where the sympathetic chain was cut at the level of the diaphragm, Jackson showed that there was no direct sympathetic innervation to the lung, but that bronchoconstriction was reversed by release of epinephrine from the adrenal medulla.^[85] An increased incidence of asthma has not been reported for adrenalectomized patients; those with a predisposition to asthma will have some protection from airway hyper-reactivity from their corticosteroid replacement therapy. Exercise induces progressive airway dilation in normal subjects that correlates with work load and is not prevented by beta blockade.^[86] The progressive dilation of the airway with increasing exercise is mediated by a progressive reduction in resting vagal tone. Beta blockade with propranolol causes a rebound in airway resistance after exercise in normal subjects over the same time course as the bronchoconstriction seen with exercise induced asthma.^[87] The reduction in airway resistance during exercise reduces the work of breathing.^[88]

Psychology

Emotional response

Every emotional response has a behavioral component, an autonomic component, and a hormonal component. The hormonal component includes the release of epinephrine, an adrenomedullary response that occurs in response to stress and that is controlled by the sympathetic nervous system. The major emotion studied in relation to epinephrine is fear. In an experiment, subjects who were injected with epinephrine expressed more negative and fewer positive facial expressions to fear films compared to a control group. These subjects also reported a more intense fear from the films and greater mean intensity of negative memories than control subjects.^[89] The findings from this study demonstrate that there are learned associations between negative feelings and levels of epinephrine. Overall, the greater amount of epinephrine is positively correlated with an arousal state of negative feelings. These findings can be an effect in part that epinephrine elicits physiological sympathetic responses including an increased heart rate and knee shaking, which can be attributed to the feeling of fear regardless of the actual level of fear elicited from the video. Although studies have found a definite relation between epinephrine and fear, other emotions have not had such results. In the same study, subjects did not express a greater amusement to an amusement film nor greater anger to an anger film.^[89] Similar findings were also supported in a study that involved rodent subjects that either were able or unable to produce epinephrine. Findings support the idea that epinephrine does have a role in facilitating the encoding of emotionally arousing events, contributing to higher levels of arousal due to fear.^[90]

Memory

It has been found that adrenergic hormones, such as epinephrine, can produce retrograde enhancement of long-term memory in humans. The release of epinephrine due to emotionally stressful events, which is endogenous epinephrine, can modulate memory consolidation of the events, ensuring memory strength that is proportional to memory importance. Post-learning epinephrine activity also interacts with the degree of arousal associated with the initial coding.^[91] There is evidence that suggests epinephrine does have a role in long-term stress adaptation and emotional memory encoding specifically. Epinephrine may also play a role in elevating arousal and fear memory under particular pathological conditions including post-traumatic stress disorder.^[90] Overall, the general findings through most studies supports that “endogenous epinephrine released during learning modulate the formation of long-lasting memories for arousing events”.^[92] Studies have also found that recognition memory involving epinephrine depends on a mechanism that depends on B-adrenoceptors.^[92] Epinephrine does not readily cross the blood-brain barrier, so its effects on memory consolidation are at least partly initiated by B-adrenoceptors in the periphery. Studies have found that sotalol, a B-adrenoceptor antagonist that also does not readily enter the brain, blocks the enhancing effects of peripherally administered epinephrine on memory.^[93] These findings suggest that B-adrenoceptors are necessary for epinephrine to have an effect on memory consolidation.

The biosynthesis of adrenaline involves a series of enzymatic reactions.

For noradrenaline to be acted upon by PNMT in the cytosol, it must first be shipped out of granules of the chromaffin cells. This may occur via the catecholamine-H⁺ exchanger VMAT1. VMAT1 is also responsible for transporting newly synthesized adrenaline from the cytosol back into chromaffin granules in preparation for release.^{[citation needed]}

In liver cells, adrenaline binds to the β-adrenergic receptor, which changes conformation and helps Gs, a G protein, exchange GDP to GTP. This trimeric G protein dissociates to Gs alpha and Gs beta/gamma subunits. Gs alpha binds to adenyl cyclase, thus converting ATP into cyclic AMP. Cyclic AMP binds to the regulatory subunit of protein kinase A: Protein kinase A phosphorylates phosphorylase kinase. Meanwhile, Gs beta/gamma binds to the calcium channel and allows calcium ions to enter the cytoplasm. Calcium ions bind to calmodulin proteins, a protein present in all eukaryotic cells, which then binds to phosphorylase kinase and finishes its activation. Phosphorylase kinase phosphorylates glycogen phosphorylase, which then phosphorylates glycogen and converts it to glucose-6-phosphate.^{[citation needed]}

Regulation

The major physiologic triggers of adrenaline release center upon stresses, such as physical threat, excitement, noise, bright lights, and high ambient temperature. All of these stimuli are processed in the central nervous system.^[94]

Adrenocorticotropic hormone (ACTH) and the sympathetic nervous system stimulate the synthesis of adrenaline precursors by enhancing the activity of tyrosine hydroxylase and dopamine-β-hydroxylase, two key enzymes involved in catecholamine synthesis.^{[citation needed]} ACTH also stimulates the adrenal cortex to release cortisol, which increases the expression of PNMT in chromaffin cells, enhancing adrenaline synthesis. This is most often done in response to stress.^{[citation needed]} The sympathetic nervous system, acting via splanchnic nerves to the adrenal medulla, stimulates the release of adrenaline. Acetylcholine released by preganglionic sympathetic fibers of these nerves acts on nicotinic acetylcholine receptors, causing cell depolarization and an influx of calcium through voltage-gated calcium channels. Calcium triggers the exocytosis of chromaffin granules and, thus, the release of adrenaline (and noradrenaline) into the bloodstream.^{[citation needed]}

Unlike many other hormones adrenaline (as with other catecholamines) does not exert negative feedback to down-regulate its own synthesis.^[95] Abnormally elevated levels of adrenaline can occur in a variety of conditions, such as surreptitious epinephrine administration, pheochromocytoma, and other tumors of the sympathetic ganglia.

Its action is terminated with reuptake into nerve terminal endings, some minute dilution, and metabolism by monoamine oxidase and catechol-O-methyl transferase.

History

Extracts of the adrenal gland were first obtained by Polish physiologist Napoleon Cybulski in 1895. These extracts, which he called nadnerczyna, contained adrenaline and other catecholamines.^[96] American ophthalmologist William H. Bates discovered adrenaline's usage for eye surgeries prior to April 20, 1896.^[97] Japanese chemist Jokichi Takamine and his assistant Keizo Uenaka independently discovered adrenaline in 1900.^[98]^[99] In 1901, Takamine successfully isolated and purified the hormone from the adrenal glands of sheep and oxen.^[100] Adrenaline was first synthesized in the laboratory by Friedrich Stolz and Henry Drysdale Dakin, independently, in 1904.^[99]

References

^ Berecek Kh, B. M.; Brody, M. J. (1982). "Evidence for a neurotransmitter role for epinephrine derived from the adrenal medulla". Am J Physiol 242 (4): H593–H601. PMID 6278965. edit
^ epinephrine and norepinephrine. (2009). Encyclopædia Britannica. Encyclopædia Britannica 2009 Deluxe Edition. Chicago: Encyclopædia Britannica.
^ Editorial (1982). "Stress, hypertension, and the heart: the adrenaline trilogy". Lancet 2: 1440–1441.
^ Pearce., JMS (2009). "Links between nerves and glands: the story of adrenaline". Advances in Clinical Neuroscience & Rehabilitation 9: 22–28.
^ Celander, O (1954). "Celander O. The range of control exercised by the "sympathico-adrenal system"". Acta Physiol Scand 32: uppl 16.
^ Warren, JB (1986). "The adrenal medulla and the airway". Br J Dis Chest 80 (1): 1–6. doi:10.1016/0007-0971(86)90002-1. PMID 3004549.
^ von Bohlen und Halbach, O; Dermietzel, R (2006). Neurotransmitters and neuromodulators: handbook of receptors and biological effects. Wiley-VCH. p. 125. ISBN 978-3-527-31307-5.
^ Feldberg, W; Minz B (1934). "The mechanism of the nervous discharge of adrenaline". J Physiol 1934;81: 81: 286–304.
^ Burn, JH; Hutcheon DE; Parker RHO. (1950). "Adrenaline and noradrenaline in the suprarenal medulla after insulin". Br J Pharmacol Chemotherap 5 (3): 417–423. doi:10.1111/j.1476-5381.1950.tb00591.x.
^ Outshoorn, AS (1952). "The hormones of the adrenal medulla and their release". Br J Pharmacol Chemotherap 7 (4): 605–615. doi:10.1111/j.1476-5381.1952.tb00728.x.
^ Benedict, CR; DG Grahame-Smith (1979). "Plasma adrenaline and noradrenaline and dopamine B-hydroxylase activity in myocardial infarction with or without cardiogenic shock". Br Heart J. 1979;42:214–220 42 (2): 214–220. doi:10.1136/hrt.42.2.214.
^ Nadeau, RA; DeCamplain J (1979). "Plasma catecholamines in acute myocardial infarction". Am Heart J 98 (5): 548–554. doi:10.1016/0002-8703(79)90278-3. PMID 495400.
^ Larsson, S; Svedmyr N (1977). "Tremor caused by sympathomimetics is mediated by beta 2-adrenoceptors". Scand J Resp Dis 1977; 58: 5–10.
^ Warren, JB; O'Brien M; Dalton N; Turner CT (1984). "Sympathetic activity in benign familial tremor". Lancet 1 (8374): 461–2. doi:10.1016/S0140-6736(84)91804-X. PMID 6142198.
^ Wurtman, RJ; Pohorecky LA; Baliga BS. (1972). "Adrenocortical control of the biosynthesis of epinephrine and proteins in the adrenal medulla". Pharmacol Rev 24 (2): 411–426. PMID 4117970.
^ Jones, A; Jones IC (1955). "Chromaffin tissue in the lizard adrenal gland". Nature 1955:: 175 (4466): 1001–2. Bibcode:1955Natur.175.1001W. doi:10.1038/1751001b0.
^ Coupland, RE (1953). "On the morphology and adrenaline-noradrenaline content of chromaffin tissue" 9. pp. 194–203.
^ ^a ^b "Epinephrine". The American Society of Health-System Pharmacists. Retrieved 3 April 2011.
^ Burnett, Aaron M.; Segal, Nicolas; Salzman, Joshua G.; McKnite, M. Scott; Frascone, Ralph J. (August 2012). "Potential negative effects of epinephrine on carotid blood flow and E_TCO₂ during active compression–decompression CPR utilizing an impedance threshold device". Resuscitation 83 (8): 1021–1024. doi:10.1016/j.resuscitation.2012.03.018. PMID 22445865.
^ Trevino, RP; Bisera, J; Weil, MH; Rackow, EC; Grundler, WG (November 1985). "End-tidal CO2 as a guide to successful cardiopulmonary resuscitation: a preliminary report". Critical Care Medicine 13 (11): 910–1. doi:10.1097/00003246-198511000-00012. PMID 3931980.
^ Sanders, AB; Atlas, M; Ewy, GA; Kern, KB; Bragg, S (March 1985). "Expired PCO2 as an index of coronary perfusion pressure". The American journal of emergency medicine 3 (2): 147–9. doi:10.1016/0735-6757(85)90039-7. PMID 3918548.
^ Olasveengen, Theresa M.; Sunde, Kjetil; Brunborg, Cathrine; Thowsen, Jon; Steen, Petter A.; Wik, Lars (25 November 2009). "Intravenous Drug Administration During Out-of-Hospital Cardiac Arrest". JAMA 302 (20): 2222–2229. doi:10.1001/jama.2009.1729. PMID 19934423.
^ Jacobs, Ian G.; Finn, Judith C.; Jelinek, George A.; Oxer, Harry F.; Thompson, Peter L. (September 2011). "Effect of adrenaline on survival in out-of-hospital cardiac arrest: A randomised double-blind placebo-controlled trial". Resuscitation 82 (9): 1138–1143. doi:10.1016/j.resuscitation.2011.06.029. PMID 21745533.
^ Roberts, Daniel; Landalfo, Kevin; Light, R. Bruce; Dobson, Karen (1 February 1990). "Early predictors of mortality for hospitalized patients suffering cardiopulmonary arrest". Chest 97 (2): 413–419. doi:10.1378/chest.97.2.413. PMID 2298069.
^ McCaul, Conán L.; McNamara, Patrick J.; Engelberts, Doreen; Wilson, Gregory J.; Romaschin, Alex; Redington, Andrew N.; Kavanagh, Brian P. (February 2006). "Epinephrine Increases Mortality after Brief Asphyxial Cardiac Arrest in an In Vivo Rat Model". Anesthesia & Analgesia 102 (2): 542–548. doi:10.1213/01.ane.0000195231.81076.88.
^ Sicherer, Scott H. (2006). Understanding and Managing Your Child's Food Allergy. Baltimore: The Johns Hopkins University Press. ISBN 0-8018-8491-8.
^ Mylan Specialty L.P.,. "EPIPEN®- epinephrine injection, EPIPEN Jr®- epinephrine injection". FDA Product Label. Retrieved 22 January 2014.
^ Warren, JB; Doble N; Dalton N; Ewan PW (1986). "The systemic absorption of inhaled epinephrine". Clin Pharmacol Ther 40 (6): 673–678. doi:10.1038/clpt.1986.243. PMID 3780129.
^ Warren, JB; McCusker M; Fuller RW (1988). "Systemic adrenaline attenuates the skin response to antigen and histamine". Clin Allergy 18 (2): 197–199. doi:10.1111/j.1365-2222.1988.tb02859.x. PMID 2896554.
^ Warren, JB; Pixely FJ; Dollery CT (1989). "Importance of beta2-adrenoceptor stimulation in the suppression of intradermal antigen challenge by adrenaline". Br J Clin Pharmacol 27 (2): 173–177. doi:10.1111/j.1365-2125.1989.tb05348.x. PMC 1379777. PMID 2565729.
^ Warren, JB (1993). "Vascular control of inflammatory oedema". Clinical Science 84 (6): 581–584. PMID 8334803.
^ Warren, JB; Wilson AJ; Coughlan ML; Loi RK (1993). "Opposing roles of intracellular cAMP in the vascular control of edema formation". FASEB Journal 7 (14): 1394–1400. PMID 7693536.
^ ECC Committee, Subcommittees and Task Forces of the American Heart Association (2005). "2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 10.6: Anaphylaxis". Circulation 112 (24 suppl): IV–143–IV–145. doi:10.1161/circulationaha.105.166568.
^ Neumar, RW; Otto CW; Link MS; et al (2010). "Part 8: adult advanced cardiovascular life support: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care". Circulation 122 (18 suppl 3): S729–S767. doi:10.1161/CIRCULATIONAHA.110.970988. PMID 20956224.
^ Lieberman, P; Nicklas RA, Oppenheimer J, et al. (2010). "The diagnosis and management of anaphylaxis practice parameter: 2010 update". J Allergy Clin Immunol;. 126(3): (3): 477–480. doi:10.1016/j.jaci.2010.06.022.
^ Higgins, DJ; Gayatri P (1999). "Methoxamine in the management of severe anaphylaxis". Anaesthesia 54 (11): 1126. doi:10.1046/j.1365-2044.1999.01197.x.
^ McBrien, ME; Breslin DS; Atkinson S; Johnston JR. (2001). "Use of methoxamine in the resuscitation of epinephrine-resistant electromechanical dissociation". Anaesthesia 56 (11): 1085–89. doi:10.1046/j.1365-2044.2001.02268-2.x.
^ Pensylvannia Patient Advisory. "Let's Stop this "Epi"demic!—Preventing Errors with Epinephrine. .". Retrieved 22 January 2014.
^ McLean-Tooke, AP; Bethune CA; Fay AC; Spickett GP (2003). "Adrenaline in the treatment of anaphylaxis: what is the evidence?". BMJ 327 (7427): 1332–5. doi:10.1136/bmj.327.7427.1332. PMC 286326. PMID 14656845.
^ "Asthma Causes, Types, Symptoms, Treatment, Medication, Facts and the Link to Allergies by MedicineNet.com".
^ Soar, Perkins, et al (2010) European Resuscitation Council Guidelines for Resuscitation 2010 Section 8. Cardiac arrest in special circumstances: Electrolyte abnormalities, poisoning, drowning, accidental hypothermia, hyperthermia, asthma, anaphylaxis, cardiac surgery, trauma, pregnancy, electrocution. Resuscitation. Oct. pp.1400-1433
^ Fisher, Brown, Cooke (Eds) (2006) Joint Royal Colleges Ambulance Liaison Committee. UK Ambulance Clinical Practice Guidelines.
^ Bjornson CL, Johnson DW; Johnson (2008). "Croup". The Lancet 371 (9609): 329–339. doi:10.1016/S0140-6736(08)60170-1. PMID 18295000.
^ ^a ^b Thomas LP, Friedland LR; Friedland (1998). "The cost-effective use of nebulized racemic adrenaline in the treatment of croup". American Journal of Emergency Medicine 16 (1): 87–89. doi:10.1016/S0735-6757(98)90073-0. PMID 9451322.
^ ^a ^b Malhotra A, Krilov LR; Krilov (2001). "Viral Croup". Pediatrics in Review 22 (1): 5–12. doi:10.1542/pir.22-1-5. PMID 11139641.
^ R. Rahn and B. Ball. Local Anesthesia in Dentistry, 3M ESPE AG, ESPE Platz, Seefeld, Germany, 2001, 44 pp.
^ About.com - "The Definition of Epinephrine"
^ ^a ^b Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. p. 4. ISBN 1-59541-101-1.
^ Sun, D.; Huang, A.; Mital, S.; Kichuk, M. R.; Marboe, C. C.; Addonizio, L. J.; Michler, R. E.; Koller, A.; Hintze, T. H.; Kaley, G. (2002). "Norepinephrine elicits beta2-receptor-mediated dilation of isolated human coronary arterioles". Circulation 106 (5): 550–555. doi:10.1161/01.CIR.0000023896.70583.9F. PMID 12147535. edit
^ Stiell, I. G.; Hebert, P. C.; Weitzman, B. N.; Wells, G. A.; Raman, S.; Stark, R. M.; Higginson, L. A. J.; Ahuja, J.; Dickinson, G. E. (1992). "High-Dose Epinephrine in Adult Cardiac Arrest". New England Journal of Medicine 327 (15): 1045–1050. doi:10.1056/NEJM199210083271502. PMID 1522840. edit
^ ^a ^b ^c Aronson, Jeffrey K (19 February 2000). ""Where name and image meet"—the argument for "adrenaline"". British Medical Journal 320 (2733): 506–509. doi:10.1136/bmj.320.7233.506. PMC 1127537. PMID 10678871.
^ Changes to medicines names: BANs to rINNs, Medicines and Healthcare products Regulatory Agency
^ ^a ^b Sabyasachi Sircar (2007). Medical Physiology. Thieme Publishing Group. p. 536. ISBN 3-13-144061-9.
^ Raymondos, K.; Panning, B.; Leuwer, M.; Brechelt, G.; Korte, T.; Niehaus, M.; Tebbenjohanns, J.; Piepenbrock, S. (2000). "Absorption and hemodynamic effects of airway administration of adrenaline in patients with severe cardiac disease". Ann. Intern. Med. 132 (10): 800–803. doi:10.7326/0003-4819-132-10-200005160-00007. PMID 10819703.
^ Baselt, R. (2008). Disposition of Toxic Drugs and Chemicals in Man (8th ed.). Foster City, CA: Biomedical Publications. pp. 545–547. ISBN 0-9626523-7-7.
^ Kirshner, Norman; Goodall, McC. (1957). "The Formation of Adrenaline From Noradrenaline". Biochimica et Biophysica Acta 24 (3): 658–659. doi:10.1016/0006-3002(57)90271-8. PMID 13436503.
^ Axelrod, Julius (May 1962). "Purification and Properties of Phenylethanolamine-N-methyl Transferase". The Journal of Biological Chemistry 237 (5): 1657–1660.
^ Cryer, PE; Moore, Mary Jean; Cryer, Philip E. (1980). "Physiology and pathophysiology of the human sympathoadrenal neuroendocrine system". Nejm 1980 303 (8): 436–444. doi:10.1056/nejm198008213030806.
^ Cryer, PE (1976). "Isotope-derivative measurements of plasma norepinephrine and epinephrine in man". Diabetes 25 (11): 1071–1082. doi:10.2337/diab.25.11.1071. PMID 825406.
^ "Gerich J, et al. Hormonal mechanisms of recovery from insulin-induced hypoglycaemia in man". Am J Physiol 1979 236: 380–385. 1979.
^ Pacak, Karel (2007). Catecholamines and adrenergic receptors. In: Pheochromocytoma Diagnosis, Localization, and Treatment. Chapter 6: Blackwell Publishing Ltd, Oxford. p. 62.
^ Barger, G; Dale HH (1910). "Chemical structure and sympathetic action of amines". J Physiol 41 (1–2): 19–59. PMC 1513032. PMID 16993040.
^ Von Euler, US (1946). "A specific sympathomimetic ergone in adrenergic nerve fibres (sympathin) and its relations to adrenaline and nor adrenaline". Acta Physiol Scand 12: 73–97. doi:10.1111/j.1748-1716.1946.tb00368.x.
^ Von Euler, US; Hillarp NA (1956). "Evidence for the presence of noradrenaline in submicroscopic structures of adrenergic axons". Nature 177 (4497): 44–45. Bibcode:1956Natur.177...44E. doi:10.1038/177044b0. PMID 13288591.
^ Warren, JB. (1986). "The adrenal medulla and the airway". Br J Dis Chest 80 (1): 1–6. doi:10.1016/0007-0971(86)90002-1. PMID 3004549.
^ Twentyman, OP; Disley, A; Gribbin, HR; Alberti, KG; Tattersfield, AE (1981). "Effect of B-blockade on respiratory and metabolic responses to exercise". J Appl Physiol 51 (4): 788–793. PMID 6795164.
^ Richter, EA; Galbo, H; Christensen, NJ (1981). "Richter EA et al. Control of exercise-induced muscular glycogenolysis by adrenomedullary hormones in rats". J Appl Physiol 50 (1): 21–26. PMID 7009527.
^ Canon, WB. (1931). "Studies on the conditions of activity in endocrine organs xxvii. Evidence that medulliadrenal secretion is not continuous". Am J Physiol 98: 447–453.
^ Cryer, PE; Tse TF, Clutter WE, Shah SD ( (1984). "Roles of glucagon and epinephrine in hypoglycemic and nonhypoglycemic glucose counterregulation in humans". Am J Physiol 247: 247: E198–E205.
^ Hoelzer, DR; Dalsky GP; Schwartz NS; Clutter WE; Shah SD; Holloszy JO; Cryer PE (1986). "Epinephrine is not critical to prevention of hypoglycemia during exercise in humans". Am J Physiol 251 (1 Pt 1): E104–E110. PMID 3524257.
^ Langer, SZ (1981). "Presynapatic regulation of the release of catecholamines". Pharm Rev 32 (4): 337–362. PMID 6267618.
^ Lunborg, P; et al (1981). "Effect of B-adrenoceptor blockade on exercise performance and metabolism". Clin Sci 1981;61: 61: 299–305.
^ Hartman, FA; Waite RH; McCordock HA. (1922). "The liberation of epinephrine during muscular exercise". Am J Physiol 62: 225–241.
^ Von Euler, US; Hellner S (1952). "Excretion of noradrenaline and adrenaline in muscular work". Acta Phys Scand 26 (2–3): 183–191. doi:10.1111/j.1748-1716.1952.tb00900.x.
^ Lund, A (1950). "Simultaneous fluorimetric determinations of adrenaline and noradrenaline in blood". Acta Pharmac Tox;: 137–146.
^ Johnson, GA; Kupiecki RM; Baker CA. (1980). "Single isotope derivatice (radioenzymatic) methods in the measurement of catecholamines". Metabolism 1980;29:suppl:. 29suppl: 1106–1112.
^ Galbo, HJ; Holst, JJ; Christensen, NJ (1975). "Glucagon and catecholamine responses to graded and prolonged exercise in man". J Appl Physiol 38 (1): 70–76. PMID 1110246.
^ Winder, WW; et al (1978). "Time course of sympathoadrenal adaptation to endurance exercise training in man. J". Apply Physiol 45: 370–374.
^ Kindermann, W; et al; Schmitt, W. M.; Biro, G.; Hippchen, M. (1982). "Catecholamines, GH, cortisol, glucagon, insulin and sex hormones in exercise and B-1 blockade". Klin Wochenschrift 1982;60: 60 (10): 505–512. doi:10.1007/bf01756096.
^ Warren, JB; Dalton N; Turner C; Clark TJH; Toseland PA. (1984). "Adrenaline secretion during exercise". Clin Sci 66: 47–51.
^ Fitzgerald, GA; Barnes P; Hamilton CA; Dollery CT. (1980). "Circulating adrenaline and blood pressure: the metabolic effects and kinetics of infused adrenaline in man". Eur J Clin Invest 1980 10 (5): 401–406. doi:10.1111/j.1365-2362.1980.tb00052.x.
^ Warren, JB; Dalton N (1983). "A comparison of the bronchodilator and vassopresser effects of exercise levels of adrenaline in man". Clin Sci 64 (5): 475–479. PMID 6831836.
^ Warren, JB; Dalton N; Turner C; Clark TJH. (1984). "Protective effect of circulating epinephrine within the physiological range on the airway response to inhaled histamine in non-asthmatic subjects". J Allergy Clin Immunol 74 (5): 683–686. doi:10.1016/0091-6749(84)90230-6. PMID 6389647.
^ Grossman, M (1887). "Das muscarin-lungen-odem". Ztschr f Klin Med 12: 550–591.
^ Jackson, DE (1912). "The pulmonary action of the adrenal glands". J Pharmac Exp Therap 4: 59–74.
^ Kagawa, J; Kerr HD. (1970). "Effects of brief graded exercise on specific airway conductance in normal subjects". J Appl Physiol 28 (2): 138–144. PMID 5413299.
^ Warren, JB; Jennings SJ; Clark TJH. (1984). "Effect of adrenergic and vagal blockade on the normal human airway response to exercise". Clin Sci 66 (1): 79–85. PMID 6228370.
^ Jennings, SJ; Warren JB; Pride NB (1987). "Airway caliber and the work of breathing in humans". J Appl Physiol 63 (1): 20–24. PMID 2957350.
^ ^a ^b Mezzacappa, E.S.; Katkin, E.S.; Palmer, S.N. (1999). "Epinephrine, arousal, and emotion: A new look at two-factor theory". Cognition and Emotion 13 (2): 181–199. doi:10.1080/026999399379320.
^ ^a ^b Mate, T. et al. (2013). "Impaired conditioned fear response and startle reactivity in epinephrine-deficient mice". Behavioural Pharmacology 24 (1): 1–9. doi:10.1097/FBP.0b013e32835cf408.
^ Cahill, L.; Alkire, M.T. (2002). "Epinephrine enhancement of human memory consolidation; Interaction with arousal at encoding". Neurobiology of Learning and Memory 79 (2): 194–198. doi:10.1016/S1074-7427(02)00036-9.
^ ^a ^b Dornelles, A. et al. (2007). "Adrenergic enhancement of consolidation of object recognition memory". Neurobiology of Learning and Memory 88 (1): 137–142. doi:10.1016/j.nlm.2007.01.005.
^ Roozendaal, B.; James, L.M. (2011). "Theoretical review: Memory Modulation". Behavioral Neuroscience 125 (6): 797–824. doi:10.1037/a0026187.
^ Nelson, L.; Cox, M. (2004). Lehninger Principles of Biochemstry (4th ed.). New York: Freeman. p. 908. ISBN 0-7167-4339-6.
^ http://www.worldofmolecules.com/emotions/adrenaline.htm
^ "Polish Thread in the History of Circulatory Physiology". Retrieved 24 April 2011.
^ New York Medical Journal, May 16, 1896, pp. 647-650. Read before the Section in Ophthalmology of the New York Academy of Medicine, April 20, 1896 http://www.central-fixation.com/bates-medical-articles/use-of-extract-of-suprarenal-capsule.php
^ Yamashima T (2003). "Jokichi Takamine (1854–1922), the samurai chemist, and his work on adrenalin". J Med Biogr 11 (2): 95–102. PMID 12717538.
^ ^a ^b Bennett M (1999). "One hundred years of adrenaline: the discovery of autoreceptors". Clin Auton Res 9 (3): 145–59. doi:10.1007/BF02281628. PMID 10454061.
^ Takamine J (1901). The isolation of the active principle of the suprarenal gland. The Journal of Physiology (Great Britain: Cambridge University Press). pp. xxix–xxx.

General references

Boron WF, Boulpaep EL (2005). Medical Physiology: A Cellular And Molecular Approach. Philadelphia, PA: Elsevier/Saunders. ISBN 1-4160-2328-3. OCLC 56191776.
Voet D, Voet J (2004). Biochemistry (3rd ed.). USA: Wiley. ISBN 0-471-19350-X. OCLC 154657578.

External links

Look up adrenaline junkie in Wiktionary, the free dictionary.

U.S. National Library of Medicine: Drug Information Portal - Epinephrine

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. アナフィラキシー：迅速な認識および治療 anaphylaxis rapid recognition and treatment
2. アナフィラキシー自己治療のためのエピネフリン処方 prescribing epinephrine for anaphylaxis self treatment
3. 精漿に対するアレルギー反応 allergic reactions to seminal plasma
4. 昇圧剤および強心剤の使用 use of vasopressors and inotropes
5. 敗血症性ショック：小児における迅速な覚知および初期蘇生 septic shock rapid recognition and initial resuscitation in children

English Journal

Multiwalled carbon nanotubes bearing 'terminal monomeric unit' for the fabrication of epinephrine imprinted polymer-based electrochemical sensor.

Prasad BB, Prasad A, Tiwari MP, Madhuri R.SourceAnalytical Division, Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India. prof.bbpd@yahoo.com
Biosensors & bioelectronics.Biosens Bioelectron.2013 Jul 15;45:114-22. doi: 10.1016/j.bios.2013.01.042. Epub 2013 Feb 9.
Carbon-nanotubes play a pivotal role in molecularly imprinted polymer technology for inculcating conducting property, high surface to volume ratio, and maximum porosity in the film texture. Contrary to the non-covalent heterogeneous dispersion of pure (unmodified) multiwalled carbon nanotubes in the
PMID 23455050

A novel composite of SiO2-coated graphene oxide and molecularly imprinted polymers for electrochemical sensing dopamine.

Zeng Y, Zhou Y, Kong L, Zhou T, Shi G.SourceDepartment of Chemistry and Shanghai Key Laboratory of Green Chemistry and Chemical Process, East China Normal University, 500 Dongchuan Road Shanghai 200241, PR China.
Biosensors & bioelectronics.Biosens Bioelectron.2013 Jul 15;45:25-33. doi: 10.1016/j.bios.2013.01.036. Epub 2013 Jan 31.
A novel imprinting route based on graphene oxide (GO) was proposed for preparing a composite of SiO2-coated GO and molecularly imprinted polymers (GO/SiO2-MIPs). In this route, SiO2-coated GO sheets were synthesized in a water-alcohol mixture with sol-gel technique. Prior to polymerization, the viny
PMID 23454339

Effect of voluntary physical exercise and post-training epinephrine on acquisition of a spatial task in the barnes maze.

Jacotte-Simancas A, Costa-Miserachs D, Torras-Garcia M, Coll-Andreu M, Portell-Cortés I.SourceDepartament de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, Edifici B, E-08193 Bellaterra, Barcelona, Spain.
Behavioural brain research.Behav Brain Res.2013 Jun 15;247:178-81. doi: 10.1016/j.bbr.2013.03.038. Epub 2013 Apr 1.
A number of experiments have shown that physical exercise improves acquisition and retention for a variety of learning tasks in rodents. Most of these works have been conducted with tasks associated with a considerable level of stress, physical effort and/or food deprivation that might interact with
PMID 23557692

Japanese Journal

秋田県内小中学生における食物アレルギーの実態 : 2009年と2011年アンケート調査の比較

小松真紀,小泉ひろみ,石田明 [他]
秋田県医師会雑誌 63(2), 80-87, 2012-09
NAID 40019437605

Impact of Early Intravenous Epinephrine Administration on Outcomes Following Out-of-Hospital Cardiac Arrest

HAYASHI Yasuyuki,IWAMI Taku,KITAMURA Tetsuhisa,NISHIUCHI Tatsuya,KAJINO Kentaro,SAKAI Tomohiko,NISHIYAMA Chika,NITTA Masahiko,HIRAIDE Atsushi,KAI Tatsuro
Circulation journal : official journal of the Japanese Circulation Society 76(7), 1639-1645, 2012-06-25
NAID 10030503308

Selective Determination of Epinephrine in the Presence of Ascorbic Acid Using a Glassy Carbon Electrode Modified with Graphene

LI Xia,CHEN Meifeng,MA Xinying
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 28(2), 147-151, 2012-02-10
NAID 10030446689

Related Pictures

★リンクテーブル★

リンク元	「カテコールアミン」「アドレナリン」「アドレナリン製剤」「エピネフリン製剤」「エピ」
拡張検索	「epinephrine bitartrate」「epinephrine hydrochloride」「norepinephrine hydrochloride」「norepinephrine」

「カテコールアミン」

Epinephrine
Systematic (IUPAC) name
	(R)-4-(1-Hydroxy-2-(methylamino)ethyl)benzene-1,2-diol
Clinical data
Pregnancy; category	US: C;
Legal status	AU: Prescription Only (S4); UK: POM; US: OTC;
Addiction; liability	None
Routes	IV, IM, endotracheal, IC, Nasal Ophthalmic
Pharmacokinetic data
Metabolism	adrenergic synapse (MAO and COMT)
Half-life	2 minutes
Excretion	Urine
Identifiers
CAS number	51-43-4
ATC code	A01AD01 B02BC09 C01CA24 R01AA14 R03AA01 S01EA01
PubChem	CID 5816
IUPHAR ligand	479
DrugBank	DB00668
ChemSpider	5611
UNII	YKH834O4BH
KEGG	D00095
ChEBI	CHEBI:28918
ChEMBL	CHEMBL679
PDB ligand ID	ALE (PDBe, RCSB PDB)
Chemical data
Formula	C9H13NO3
Molecular mass	183.204 g/mol
	SMILES Oc1ccc(cc1O)[C@@H](O)CNC;
	InChI InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1 ; Key:UCTWMZQNUQWSLP-VIFPVBQESA-N ;
(what is this?) (verify)

　　[★]

英: catecholamine catecholamines CA
同: カテコラミン
関: 副腎髄質ホルモン

カテコールでかつアミンを持つ構造

Wikipedia

ドーパミン、ノルアドレナリン、アドレナリン

生合成

チロシン tyrosine
 (フェニル基の3位にOHを導入) ：律速酵素
 -チロシン 3-モノオキシゲナーゼ tyrosine 3-monooxygenase, チロシン水酸化酵素 tyrosine hydroxylase
 ←{H₄・biopterin}
 →{H₂・biopterin}
L-ドーパ L-dopa
 (アミノ酸から脱炭酸)
 -芳香族アミノ酸デカルボキシラーゼ dopa decarboxylase + {ピリドキサル5-リン酸(VB₆)}
 →CO₂
ドパミン dopamine
 (β位の炭素にOHを導入)
 -ドーパミン β-モノオキシゲナーゼ dopamine β-monoxygenase, dopamine β-odidase
 ←O₂ + ビタミンC(アスコルビン酸)
 →H₂O + デヒドロアスコルビン酸
ノルアドレナリン norepinephrine
 (アミノ基にメチル基を転移)
 -フェニルエタノールアミン N-メチルトランスフェラーゼ phenylethanolamine N-methyl transferase
 ←S-アデノシルメチオニン S-adenosylmethionine
 →S-アデノシルホモシステイン S-adenosylhemocysteine
アドレナリン epinephrine

分解

ドパミン、ノルアドレナリン、アドレナリンはいずれも以下の酵素により分解される

分解産物

ドパミン dopamine	－－－→	ジヒドロキシフェニル酢酸 3,4-dihydroxyphenylacetic acid DOPAC	－－－→	ホモバニリン酸 homovanillic acid HVA
｜｜	MAO COMT
｜｜ ↓
ノルエピネフリン norepinephrine	－－－→	バニリルマンデリン酸 vanillylmandelic acid VMA 　　　　　　　・メトキシヒドロキシフェニルグリコール methoxyhydroxyphenylglycol MHPG
｜｜ ↓	MAO COMT
エピネフリン epinephrine	－－－→
	MAO COMT

薬理作用

昇圧作用

(ドパミン、ドブタミン)アシドーシス存在下で効力低下

臨床検査

褐色細胞腫、神経芽腫の診断に用いられる。

基準値

カテコールアミン３分画(血漿)(BML)

アドレナリン：≦0.10 ng/mL
ノルアドレナリン：0.10～0.50 ng/mL
ドパミン：≦0.03 ng/mL

「アドレナリン」

　　[★]

英: adrenarine
同: (国試)エピネフリン epinephrine、エピレナミン epirenamine、スプラレニン suprarenin
化: 酒石酸水素エピネフリン
商: Adrenalin, EpiPen、ボスミン、エピペン
関: カテコールアミン、ノルアドレナリン、アドレナリン受容体

SPC. 61,68,86,142
GOO. 244

副腎髄質のクロム親和性細胞で合成・分泌される
MAOやCOMTによって代謝される

作用機序

薬理作用

血管作用

小動脈、前毛細血管括約筋？収縮
アドレナリン反転 epinephreine reversal

アドレナリン投与下にα受容体阻害薬を投与すると末梢血管抵抗が低下し血圧が低下する現象。α受容体を介した末梢血管収縮が抑制され、β2受容体を介した末梢血管平滑筋が弛緩することによる。

動態

適応

効能又は効果

(エピネフリン注０．１％シリンジ「テルモ」添付文書)

下記疾患に基づく気管支痙攣の緩解

気管支喘息，百日咳
各種疾患もしくは状態に伴う急性低血圧またはショック時の補助治療
心停止の補助治療

用量

心肺蘇生

ACLS：静注1mg　　←　　プレフィルのシリンジは大抵1mg/1mlで調製されている。
PALS：静注・骨髄 0.01mg/kg　気管内投与 0.1mg/kg

アナフィラキシーショック：皮下注～筋注で0.3mg

注意

本剤は心筋酸素需要を増加させるため、心原性ショックや出血性・外傷性ショック時の使用は避けること(エピネフリン注０．１％シリンジ「テルモ」添付文書)

禁忌

副作用

「アドレナリン製剤」

　　[★]

英: adrenaline
同: エピネフリン製剤 epinephrine
商: ボスミン

「エピネフリン製剤」

　　[★]

英: epinephrine
関: アドレナリン製剤

「エピ」

　　[★]

英: epi
関: 上

epinephrine

「epinephrine bitartrate」

　　[★]

酒石酸水素エピネフリン、重酒石酸エピネフリン

関: adrenaline、epinephrine、epinephrine hydrochloride

「epinephrine hydrochloride」

　　[★]

塩酸エピネフリン

関: epinephrine、epinephrine bitartrate

「norepinephrine hydrochloride」

　　[★]

塩酸ノルエピネフリン

関: noradrenaline、norepinephrine

「norepinephrine」

　　[★] ノルエピネフリン NE、ノルアドレナリン NA

[1] Berecek Kh, B. M.; Brody, M. J. (1982). "Evidence for a neurotransmitter role for epinephrine derived from the adrenal medulla". Am J Physiol 242 (4): H593–H601. PMID 6278965. edit

[2] rine and norepinephrine. (2009). Encyclopædia Britannica. Encyclopædia Britannica 2009 Deluxe Edition. Chicago: Encyclopædia Britannica.

[3] Editorial (1982). "Stress, hypertension, and the heart: the adrenaline trilogy". Lancet 2: 1440–1441.

[4] Pearce., JMS (2009). "Links between nerves and glands: the story of adrenaline". Advances in Clinical Neuroscience & Rehabilitation 9: 22–28.

[5] Celander, O (1954). "Celander O. The range of control exercised by the "sympathico-adrenal system"". Acta Physiol Scand 32: uppl 16.

[6] Warren, JB (1986). "The adrenal medulla and the airway". Br J Dis Chest 80 (1): 1–6. doi:10.1016/0007-0971(86)90002-1. PMID 3004549.

[HalbachDermietzel2006-7] von Bohlen und Halbach, O; Dermietzel, R (2006). Neurotransmitters and neuromodulators: handbook of receptors and biological effects. Wiley-VCH. p. 125. ISBN 978-3-527-31307-5.

[8] Feldberg, W; Minz B (1934). "The mechanism of the nervous discharge of adrenaline". J Physiol 1934;81: 81: 286–304.

[9] Burn, JH; Hutcheon DE; Parker RHO. (1950). "Adrenaline and noradrenaline in the suprarenal medulla after insulin". Br J Pharmacol Chemotherap 5 (3): 417–423. doi:10.1111/j.1476-5381.1950.tb00591.x.

[10] Outshoorn, AS (1952). "The hormones of the adrenal medulla and their release". Br J Pharmacol Chemotherap 7 (4): 605–615. doi:10.1111/j.1476-5381.1952.tb00728.x.

[11] Benedict, CR; DG Grahame-Smith (1979). "Plasma adrenaline and noradrenaline and dopamine B-hydroxylase activity in myocardial infarction with or without cardiogenic shock". Br Heart J. 1979;42:214–220 42 (2): 214–220. doi:10.1136/hrt.42.2.214.

[12] Nadeau, RA; DeCamplain J (1979). "Plasma catecholamines in acute myocardial infarction". Am Heart J 98 (5): 548–554. doi:10.1016/0002-8703(79)90278-3. PMID 495400.

[13] Larsson, S; Svedmyr N (1977). "Tremor caused by sympathomimetics is mediated by beta 2-adrenoceptors". Scand J Resp Dis 1977; 58: 5–10.

[14] Warren, JB; O'Brien M; Dalton N; Turner CT (1984). "Sympathetic activity in benign familial tremor". Lancet 1 (8374): 461–2. doi:10.1016/S0140-6736(84)91804-X. PMID 6142198.

[15] Wurtman, RJ; Pohorecky LA; Baliga BS. (1972). "Adrenocortical control of the biosynthesis of epinephrine and proteins in the adrenal medulla". Pharmacol Rev 24 (2): 411–426. PMID 4117970.

[16] Jones, A; Jones IC (1955). "Chromaffin tissue in the lizard adrenal gland". Nature 1955:: 175 (4466): 1001–2. Bibcode:1955Natur.175.1001W. doi:10.1038/1751001b0.

[17] Coupland, RE (1953). "On the morphology and adrenaline-noradrenaline content of chromaffin tissue" 9. pp. 194–203.

[AHFS-18] "Epinephrine". The American Society of Health-System Pharmacists. Retrieved 3 April 2011.

[19] Burnett, Aaron M.; Segal, Nicolas; Salzman, Joshua G.; McKnite, M. Scott; Frascone, Ralph J. (August 2012). "Potential negative effects of epinephrine on carotid blood flow and E_TCO₂ during active compression–decompression CPR utilizing an impedance threshold device". Resuscitation 83 (8): 1021–1024. doi:10.1016/j.resuscitation.2012.03.018. PMID 22445865.

[20] Trevino, RP; Bisera, J; Weil, MH; Rackow, EC; Grundler, WG (November 1985). "End-tidal CO2 as a guide to successful cardiopulmonary resuscitation: a preliminary report". Critical Care Medicine 13 (11): 910–1. doi:10.1097/00003246-198511000-00012. PMID 3931980.

[21] Sanders, AB; Atlas, M; Ewy, GA; Kern, KB; Bragg, S (March 1985). "Expired PCO2 as an index of coronary perfusion pressure". The American journal of emergency medicine 3 (2): 147–9. doi:10.1016/0735-6757(85)90039-7. PMID 3918548.

[22] Olasveengen, Theresa M.; Sunde, Kjetil; Brunborg, Cathrine; Thowsen, Jon; Steen, Petter A.; Wik, Lars (25 November 2009). "Intravenous Drug Administration During Out-of-Hospital Cardiac Arrest". JAMA 302 (20): 2222–2229. doi:10.1001/jama.2009.1729. PMID 19934423.

[23] Jacobs, Ian G.; Finn, Judith C.; Jelinek, George A.; Oxer, Harry F.; Thompson, Peter L. (September 2011). "Effect of adrenaline on survival in out-of-hospital cardiac arrest: A randomised double-blind placebo-controlled trial". Resuscitation 82 (9): 1138–1143. doi:10.1016/j.resuscitation.2011.06.029. PMID 21745533.

[24] Roberts, Daniel; Landalfo, Kevin; Light, R. Bruce; Dobson, Karen (1 February 1990). "Early predictors of mortality for hospitalized patients suffering cardiopulmonary arrest". Chest 97 (2): 413–419. doi:10.1378/chest.97.2.413. PMID 2298069.

[25] McCaul, Conán L.; McNamara, Patrick J.; Engelberts, Doreen; Wilson, Gregory J.; Romaschin, Alex; Redington, Andrew N.; Kavanagh, Brian P. (February 2006). "Epinephrine Increases Mortality after Brief Asphyxial Cardiac Arrest in an In Vivo Rat Model". Anesthesia & Analgesia 102 (2): 542–548. doi:10.1213/01.ane.0000195231.81076.88.

[26] Sicherer, Scott H. (2006). Understanding and Managing Your Child's Food Allergy. Baltimore: The Johns Hopkins University Press. ISBN 0-8018-8491-8.

[27] Mylan Specialty L.P.,. "EPIPEN®- epinephrine injection, EPIPEN Jr®- epinephrine injection". FDA Product Label. Retrieved 22 January 2014.

[28] Warren, JB; Doble N; Dalton N; Ewan PW (1986). "The systemic absorption of inhaled epinephrine". Clin Pharmacol Ther 40 (6): 673–678. doi:10.1038/clpt.1986.243. PMID 3780129.

[29] Warren, JB; McCusker M; Fuller RW (1988). "Systemic adrenaline attenuates the skin response to antigen and histamine". Clin Allergy 18 (2): 197–199. doi:10.1111/j.1365-2222.1988.tb02859.x. PMID 2896554.

[30] Warren, JB; Pixely FJ; Dollery CT (1989). "Importance of beta2-adrenoceptor stimulation in the suppression of intradermal antigen challenge by adrenaline". Br J Clin Pharmacol 27 (2): 173–177. doi:10.1111/j.1365-2125.1989.tb05348.x. PMC 1379777. PMID 2565729.

[31] Warren, JB (1993). "Vascular control of inflammatory oedema". Clinical Science 84 (6): 581–584. PMID 8334803.

[32] Warren, JB; Wilson AJ; Coughlan ML; Loi RK (1993). "Opposing roles of intracellular cAMP in the vascular control of edema formation". FASEB Journal 7 (14): 1394–1400. PMID 7693536.

[33] ECC Committee, Subcommittees and Task Forces of the American Heart Association (2005). "2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 10.6: Anaphylaxis". Circulation 112 (24 suppl): IV–143–IV–145. doi:10.1161/circulationaha.105.166568.

[34] Neumar, RW; Otto CW; Link MS; et al (2010). "Part 8: adult advanced cardiovascular life support: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care". Circulation 122 (18 suppl 3): S729–S767. doi:10.1161/CIRCULATIONAHA.110.970988. PMID 20956224.

[35] Lieberman, P; Nicklas RA, Oppenheimer J, et al. (2010). "The diagnosis and management of anaphylaxis practice parameter: 2010 update". J Allergy Clin Immunol;. 126(3): (3): 477–480. doi:10.1016/j.jaci.2010.06.022.

[36] Higgins, DJ; Gayatri P (1999). "Methoxamine in the management of severe anaphylaxis". Anaesthesia 54 (11): 1126. doi:10.1046/j.1365-2044.1999.01197.x.

[37] McBrien, ME; Breslin DS; Atkinson S; Johnston JR. (2001). "Use of methoxamine in the resuscitation of epinephrine-resistant electromechanical dissociation". Anaesthesia 56 (11): 1085–89. doi:10.1046/j.1365-2044.2001.02268-2.x.

[38] Pensylvannia Patient Advisory. "Let's Stop this "Epi"demic!—Preventing Errors with Epinephrine. .". Retrieved 22 January 2014.

[39] McLean-Tooke, AP; Bethune CA; Fay AC; Spickett GP (2003). "Adrenaline in the treatment of anaphylaxis: what is the evidence?". BMJ 327 (7427): 1332–5. doi:10.1136/bmj.327.7427.1332. PMC 286326. PMID 14656845.

[40] "Asthma Causes, Types, Symptoms, Treatment, Medication, Facts and the Link to Allergies by MedicineNet.com".

[41] Soar, Perkins, et al (2010) European Resuscitation Council Guidelines for Resuscitation 2010 Section 8. Cardiac arrest in special circumstances: Electrolyte abnormalities, poisoning, drowning, accidental hypothermia, hyperthermia, asthma, anaphylaxis, cardiac surgery, trauma, pregnancy, electrocution. Resuscitation. Oct. pp.1400-1433

[42] Fisher, Brown, Cooke (Eds) (2006) Joint Royal Colleges Ambulance Liaison Committee. UK Ambulance Clinical Practice Guidelines.

[43] Bjornson CL, Johnson DW; Johnson (2008). "Croup". The Lancet 371 (9609): 329–339. doi:10.1016/S0140-6736(08)60170-1. PMID 18295000.

[Thomas-44] Thomas LP, Friedland LR; Friedland (1998). "The cost-effective use of nebulized racemic adrenaline in the treatment of croup". American Journal of Emergency Medicine 16 (1): 87–89. doi:10.1016/S0735-6757(98)90073-0. PMID 9451322.

[Malhotra-45] Malhotra A, Krilov LR; Krilov (2001). "Viral Croup". Pediatrics in Review 22 (1): 5–12. doi:10.1542/pir.22-1-5. PMID 11139641.

[46] R. Rahn and B. Ball. Local Anesthesia in Dentistry, 3M ESPE AG, ESPE Platz, Seefeld, Germany, 2001, 44 pp.

[47] About.com - "The Definition of Epinephrine"

[pharmnemonics-48] Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. p. 4. ISBN 1-59541-101-1.

[EpiCoronaryB2-49] Sun, D.; Huang, A.; Mital, S.; Kichuk, M. R.; Marboe, C. C.; Addonizio, L. J.; Michler, R. E.; Koller, A.; Hintze, T. H.; Kaley, G. (2002). "Norepinephrine elicits beta2-receptor-mediated dilation of isolated human coronary arterioles". Circulation 106 (5): 550–555. doi:10.1161/01.CIR.0000023896.70583.9F. PMID 12147535. edit

[EpiHighDose-50] Stiell, I. G.; Hebert, P. C.; Weitzman, B. N.; Wells, G. A.; Raman, S.; Stark, R. M.; Higginson, L. A. J.; Ahuja, J.; Dickinson, G. E. (1992). "High-Dose Epinephrine in Adult Cardiac Arrest". New England Journal of Medicine 327 (15): 1045–1050. doi:10.1056/NEJM199210083271502. PMID 1522840. edit

[BMJ-51] Aronson, Jeffrey K (19 February 2000). ""Where name and image meet"—the argument for "adrenaline"". British Medical Journal 320 (2733): 506–509. doi:10.1136/bmj.320.7233.506. PMC 1127537. PMID 10678871.

[52] Changes to medicines names: BANs to rINNs, Medicines and Healthcare products Regulatory Agency

[sabyasachi-53] Sabyasachi Sircar (2007). Medical Physiology. Thieme Publishing Group. p. 536. ISBN 3-13-144061-9.

[54] Raymondos, K.; Panning, B.; Leuwer, M.; Brechelt, G.; Korte, T.; Niehaus, M.; Tebbenjohanns, J.; Piepenbrock, S. (2000). "Absorption and hemodynamic effects of airway administration of adrenaline in patients with severe cardiac disease". Ann. Intern. Med. 132 (10): 800–803. doi:10.7326/0003-4819-132-10-200005160-00007. PMID 10819703.

[55] Baselt, R. (2008). Disposition of Toxic Drugs and Chemicals in Man (8th ed.). Foster City, CA: Biomedical Publications. pp. 545–547. ISBN 0-9626523-7-7.

[56] Kirshner, Norman; Goodall, McC. (1957). "The Formation of Adrenaline From Noradrenaline". Biochimica et Biophysica Acta 24 (3): 658–659. doi:10.1016/0006-3002(57)90271-8. PMID 13436503.

[Axelrod-57] Axelrod, Julius (May 1962). "Purification and Properties of Phenylethanolamine-N-methyl Transferase". The Journal of Biological Chemistry 237 (5): 1657–1660.

[58] Cryer, PE; Moore, Mary Jean; Cryer, Philip E. (1980). "Physiology and pathophysiology of the human sympathoadrenal neuroendocrine system". Nejm 1980 303 (8): 436–444. doi:10.1056/nejm198008213030806.

[59] Cryer, PE (1976). "Isotope-derivative measurements of plasma norepinephrine and epinephrine in man". Diabetes 25 (11): 1071–1082. doi:10.2337/diab.25.11.1071. PMID 825406.

[60] "Gerich J, et al. Hormonal mechanisms of recovery from insulin-induced hypoglycaemia in man". Am J Physiol 1979 236: 380–385. 1979.

[61] Pacak, Karel (2007). Catecholamines and adrenergic receptors. In: Pheochromocytoma Diagnosis, Localization, and Treatment. Chapter 6: Blackwell Publishing Ltd, Oxford. p. 62.

[62] Barger, G; Dale HH (1910). "Chemical structure and sympathetic action of amines". J Physiol 41 (1–2): 19–59. PMC 1513032. PMID 16993040.

[63] Von Euler, US (1946). "A specific sympathomimetic ergone in adrenergic nerve fibres (sympathin) and its relations to adrenaline and nor adrenaline". Acta Physiol Scand 12: 73–97. doi:10.1111/j.1748-1716.1946.tb00368.x.

[64] Von Euler, US; Hillarp NA (1956). "Evidence for the presence of noradrenaline in submicroscopic structures of adrenergic axons". Nature 177 (4497): 44–45. Bibcode:1956Natur.177...44E. doi:10.1038/177044b0. PMID 13288591.

[65] Warren, JB. (1986). "The adrenal medulla and the airway". Br J Dis Chest 80 (1): 1–6. doi:10.1016/0007-0971(86)90002-1. PMID 3004549.

[66] Twentyman, OP; Disley, A; Gribbin, HR; Alberti, KG; Tattersfield, AE (1981). "Effect of B-blockade on respiratory and metabolic responses to exercise". J Appl Physiol 51 (4): 788–793. PMID 6795164.

[67] Richter, EA; Galbo, H; Christensen, NJ (1981). "Richter EA et al. Control of exercise-induced muscular glycogenolysis by adrenomedullary hormones in rats". J Appl Physiol 50 (1): 21–26. PMID 7009527.

[68] Canon, WB. (1931). "Studies on the conditions of activity in endocrine organs xxvii. Evidence that medulliadrenal secretion is not continuous". Am J Physiol 98: 447–453.

[69] Cryer, PE; Tse TF, Clutter WE, Shah SD ( (1984). "Roles of glucagon and epinephrine in hypoglycemic and nonhypoglycemic glucose counterregulation in humans". Am J Physiol 247: 247: E198–E205.

[70] Hoelzer, DR; Dalsky GP; Schwartz NS; Clutter WE; Shah SD; Holloszy JO; Cryer PE (1986). "Epinephrine is not critical to prevention of hypoglycemia during exercise in humans". Am J Physiol 251 (1 Pt 1): E104–E110. PMID 3524257.

[71] Langer, SZ (1981). "Presynapatic regulation of the release of catecholamines". Pharm Rev 32 (4): 337–362. PMID 6267618.

[72] Lunborg, P; et al (1981). "Effect of B-adrenoceptor blockade on exercise performance and metabolism". Clin Sci 1981;61: 61: 299–305.

[73] Hartman, FA; Waite RH; McCordock HA. (1922). "The liberation of epinephrine during muscular exercise". Am J Physiol 62: 225–241.

[74] Von Euler, US; Hellner S (1952). "Excretion of noradrenaline and adrenaline in muscular work". Acta Phys Scand 26 (2–3): 183–191. doi:10.1111/j.1748-1716.1952.tb00900.x.

[75] Lund, A (1950). "Simultaneous fluorimetric determinations of adrenaline and noradrenaline in blood". Acta Pharmac Tox;: 137–146.

[76] Johnson, GA; Kupiecki RM; Baker CA. (1980). "Single isotope derivatice (radioenzymatic) methods in the measurement of catecholamines". Metabolism 1980;29:suppl:. 29suppl: 1106–1112.

[77] Galbo, HJ; Holst, JJ; Christensen, NJ (1975). "Glucagon and catecholamine responses to graded and prolonged exercise in man". J Appl Physiol 38 (1): 70–76. PMID 1110246.

[78] Winder, WW; et al (1978). "Time course of sympathoadrenal adaptation to endurance exercise training in man. J". Apply Physiol 45: 370–374.

[79] Kindermann, W; et al; Schmitt, W. M.; Biro, G.; Hippchen, M. (1982). "Catecholamines, GH, cortisol, glucagon, insulin and sex hormones in exercise and B-1 blockade". Klin Wochenschrift 1982;60: 60 (10): 505–512. doi:10.1007/bf01756096.

[80] Warren, JB; Dalton N; Turner C; Clark TJH; Toseland PA. (1984). "Adrenaline secretion during exercise". Clin Sci 66: 47–51.

[81] Fitzgerald, GA; Barnes P; Hamilton CA; Dollery CT. (1980). "Circulating adrenaline and blood pressure: the metabolic effects and kinetics of infused adrenaline in man". Eur J Clin Invest 1980 10 (5): 401–406. doi:10.1111/j.1365-2362.1980.tb00052.x.

[82] Warren, JB; Dalton N (1983). "A comparison of the bronchodilator and vassopresser effects of exercise levels of adrenaline in man". Clin Sci 64 (5): 475–479. PMID 6831836.

[83] Warren, JB; Dalton N; Turner C; Clark TJH. (1984). "Protective effect of circulating epinephrine within the physiological range on the airway response to inhaled histamine in non-asthmatic subjects". J Allergy Clin Immunol 74 (5): 683–686. doi:10.1016/0091-6749(84)90230-6. PMID 6389647.

[84] Grossman, M (1887). "Das muscarin-lungen-odem". Ztschr f Klin Med 12: 550–591.

[85] Jackson, DE (1912). "The pulmonary action of the adrenal glands". J Pharmac Exp Therap 4: 59–74.

[86] Kagawa, J; Kerr HD. (1970). "Effects of brief graded exercise on specific airway conductance in normal subjects". J Appl Physiol 28 (2): 138–144. PMID 5413299.

[87] Warren, JB; Jennings SJ; Clark TJH. (1984). "Effect of adrenergic and vagal blockade on the normal human airway response to exercise". Clin Sci 66 (1): 79–85. PMID 6228370.

[88] Jennings, SJ; Warren JB; Pride NB (1987). "Airway caliber and the work of breathing in humans". J Appl Physiol 63 (1): 20–24. PMID 2957350.

[Mezzacappa.2C_E.S._1999-89] Mezzacappa, E.S.; Katkin, E.S.; Palmer, S.N. (1999). "Epinephrine, arousal, and emotion: A new look at two-factor theory". Cognition and Emotion 13 (2): 181–199. doi:10.1080/026999399379320.

[Mate.2C_T._2013-90] Mate, T. et al. (2013). "Impaired conditioned fear response and startle reactivity in epinephrine-deficient mice". Behavioural Pharmacology 24 (1): 1–9. doi:10.1097/FBP.0b013e32835cf408.

[91] Cahill, L.; Alkire, M.T. (2002). "Epinephrine enhancement of human memory consolidation; Interaction with arousal at encoding". Neurobiology of Learning and Memory 79 (2): 194–198. doi:10.1016/S1074-7427(02)00036-9.

[Dornelles.2C_A._2007-92] Dornelles, A. et al. (2007). "Adrenergic enhancement of consolidation of object recognition memory". Neurobiology of Learning and Memory 88 (1): 137–142. doi:10.1016/j.nlm.2007.01.005.

[93] Roozendaal, B.; James, L.M. (2011). "Theoretical review: Memory Modulation". Behavioral Neuroscience 125 (6): 797–824. doi:10.1037/a0026187.

[94] Nelson, L.; Cox, M. (2004). Lehninger Principles of Biochemstry (4th ed.). New York: Freeman. p. 908. ISBN 0-7167-4339-6.

[95] ttp://www.worldofmolecules.com/emotions/adrenaline.htm

[96] "Polish Thread in the History of Circulatory Physiology". Retrieved 24 April 2011.

[97] New York Medical Journal, May 16, 1896, pp. 647-650. Read before the Section in Ophthalmology of the New York Academy of Medicine, April 20, 1896 http://www.central-fixation.com/bates-medical-articles/use-of-extract-of-suprarenal-capsule.php

[98] Yamashima T (2003). "Jokichi Takamine (1854–1922), the samurai chemist, and his work on adrenalin". J Med Biogr 11 (2): 95–102. PMID 12717538.

[pmid10454061-99] Bennett M (1999). "One hundred years of adrenaline: the discovery of autoreceptors". Clin Auton Res 9 (3): 145–59. doi:10.1007/BF02281628. PMID 10454061.

[100] Takamine J (1901). The isolation of the active principle of the suprarenal gland. The Journal of Physiology (Great Britain: Cambridge University Press). pp. xxix–xxx.

Systematic (IUPAC) name

(R)-4-(1-Hydroxy-2-(methylamino)ethyl)benzene-1,2-diol
Clinical data
Pregnancy category	US: C
Legal status	AU: Prescription Only (S4) UK: POM US: OTC
Addiction liability	None
Routes	IV, IM, endotracheal, IC, Nasal Ophthalmic
Pharmacokinetic data
Metabolism	adrenergic synapse (MAO and COMT)
Half-life	2 minutes
Excretion	Urine
Identifiers
CAS number	51-43-4^Y
ATC code	A01AD01 B02BC09 C01CA24 R01AA14 R03AA01 S01EA01
PubChem	CID 5816
IUPHAR ligand	479
DrugBank	DB00668
ChemSpider	5611^Y
UNII	YKH834O4BH^Y
KEGG	D00095^Y
ChEBI	CHEBI:28918^Y
ChEMBL	CHEMBL679^Y
PDB ligand ID	ALE (PDBe, RCSB PDB)
Chemical data
Formula	C₉H₁₃NO₃
Molecular mass	183.204 g/mol
SMILES Oc1ccc(cc1O)[C@@H](O)CNC
InChI InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1^Y Key:UCTWMZQNUQWSLP-VIFPVBQESA-N^Y
Y (what is this?) (verify)

匿名

検索

案内

epinephrine

WordNet

PrepTutorEJDIC

Wikipedia preview

wiki en

Contents

Pathology

Medical uses

Cardiac arrest

Anaphylaxis

Asthma

Croup

Local anesthetics

Autoinjectors

Adverse effects

Terminology

Mechanism of action

Measurement in biological fluids

Biosynthesis and regulation

Physiology

Exercise

Psychology

Regulation

History

References

General references

External links

UpToDate Contents

English Journal

Japanese Journal

Related Links

Related Pictures

★リンクテーブル★

「カテコールアミン」

生合成

分解

分解産物

薬理作用

昇圧作用

臨床検査

基準値

カテコールアミン３分画(血漿)(BML)

「アドレナリン」

作用機序

薬理作用

血管作用

動態

適応

効能又は効果

(エピネフリン注０．１％シリンジ「テルモ」添付文書)

用量

注意

禁忌

副作用

「アドレナリン製剤」

「エピネフリン製剤」

「エピ」

「epinephrine bitartrate」

「epinephrine hydrochloride」

「norepinephrine hydrochloride」

「norepinephrine」