急性リンパ性白血病
WordNet
- of critical importance and consequence; "an acute (or critical) lack of research funds"
- having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
- extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
- having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
- of an angle; less than 90 degrees
- malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
- resembling lymph or lymphatic tissues
PrepTutorEJDIC
- (先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
- 白血病
- リンパ状(液)の
UpToDate Contents
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English Journal
- Redefining clinical risk classification in children with precursor B cell acute lymphoblastic leukemia using pre-treatment absolute lymphocyte count.
- Fungpipat P1, Sophonphan J2, Sosothikul D1, Suppipat K1.
- Leukemia & lymphoma.Leuk Lymphoma.2016 Apr;57(4):953-6. doi: 10.3109/10428194.2015.1081194. Epub 2015 Oct 12.
- PMID 26292611
- Loss of Mismatched HLA on the Leukemic Blasts of Patients With Relapsed Lymphoid Malignancies Following Bone Marrow Transplantation From Related Donors With HLA Class II Mismatches in the Graft Versus Host Direction.
- Hirabayashi K1, Kurata T1, Horiuchi K2, Saito S1, Shigemura T1, Tanaka M1, Yanagisawa R1, Matsuda K2, Sakashita K1, Koike K1, Nakazawa Y1.
- Pediatric blood & cancer.Pediatr Blood Cancer.2016 Apr;63(4):709-11. doi: 10.1002/pbc.25819. Epub 2015 Nov 6.
- Mechanisms of relapse of acute lymphoblastic leukemia (ALL) after human leukocyte antigen (HLA) class II mismatched hematopoietic stem cell transplantation (HSCT) remain unclear. We report two children with relapsed ALL after HSCT from related donors with HLA-DRB1 and -DQB1 mismatches in the graft v
- PMID 26544669
- Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.
- Madeen EP1,2,3, Löhr CV2,3,4, You H2, Siddens LK1,2, Krueger SK2,3, Dashwood RH5, Gonzalez FJ6, Baird WM1,3, Ho E2,7, Bramer L3,8, Waters KM3,8, Williams DE1,2,3.
- Molecular carcinogenesis.Mol Carcinog.2016 Mar 17. doi: 10.1002/mc.22480. [Epub ahead of print]
- The cytochrome P450 (CYP) 1 family is active toward numerous environmental pollutants, including polycyclic aromatic hydrocarbons (PAHs). Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, we tested the hypothesis that hCYP1B1 is important for dibenzo[def,p]chrysene (DBC) transpla
- PMID 26990437
Japanese Journal
- 新規抗体/薬物複合体によるリンパ系腫瘍の治療 : イノツズマブ・オゾガマイシンとブレンツキシマブ・ベドチン (特集 新規ターゲットおよび医薬品による血液がん治療の新たな展開)
- 小児ALL治療におけるCD19キメラ抗原受容体(CAR)発現T細胞療法の可能性
- Distinct Global DNA Methylation Status in B-Cell Lymphomas : Immunohistochemical Study of 5-Methylcytosine and 5-Hydroxymethylcytosine
- Matsuda Ikuo,Imai Yukihiro,Hirota Seiichi
- Journal of Clinical and Experimental Hematopathology 54(1), 67-73, 2014
- … Lymphomas are malignant neoplasms composed of lymphoid cells at various developmental stages and lineages. … Recent advances in comprehensive genomic analyses in acute myeloid leukemia have revealed prevalent mutations in regulators of epigenetic phenomena including global DNA methylation status. …
- NAID 130004886478
Related Links
- Bayard L. Powell, M.D. talks about Acute Myeloid and Lymphoid Leukemia. Dr. Powell is Section Chief of Hematology and Oncology at Wake Forest Baptist Health.
- acute lymphoid leukemia (ALL). See acute childhood leukemia. Patient discussion about acute lymphoid leukemia Q. What is the best treatment for Acute Lymphocytic Leukemia? What is the best treatment for Acute Lymphocytic ...
Related Pictures
![Acute Lymphoblastic Leukemia](https://1mg.info/0/3/w/0696.jpg)
![Acute Lymphoblastic Leukemia](https://1mg.info/0/3/w/0697.jpg)
![Acute lymphoblastic leukemia: Acute](https://1mg.info/0/3/w/0698.jpg)
![Leukemia, Lymphocytic, Acute](https://1mg.info/0/3/w/0699.jpg)
![Acute lymphoblastic leukemia, B-cell](https://1mg.info/0/3/w/0700.jpg)
★リンクテーブル★
[★]
- 英
- acute lymphoblastic leukemia, acute lymphocytic leukemia, acute lymphoid leukemia, ALL
- 同
- 急性リンパ球性白血病
- 関
- 急性白血病、急性骨髄性白血病 AML
疫学
- 小児ALL:B前駆細胞系ALLは75-80%、T前駆細胞系ALLは10-15%
分類
リンパ球の種類
[show details]
FAB分類
- FAB分類L1:小型で均一なリンパ芽球。クロマチン構造繊細。 → 小児型。予後良好
- FAB分類L2:大小不同で大型のリンパ芽球。クロマチン構造粗造。 → 成人型。予後やや不良
- FAB分類L3:大型で塩基性の細胞質を有する。クロマチンは細やかな点状で密。細胞質、核に空胞。 → 予後不良
病態
- リンパ球系の細胞に分化障害が起こり腫瘍性に増殖して、骨髄における異常リンパ球の占拠や臓器への浸潤がみられ
、末梢血中にも認められるようになる。
- この結果として造血障害や臓器浸潤による症状が認められるようになる。
症状
- 貧血、易感染性、出血傾向
- 異常リンパ球の浸潤(肝臓、脾臓、リンパ節、髄膜、精巣、皮膚、歯肉
検査
- 血算:赤血球減少、血小板減少、白血球減少~増加
- 骨髄穿刺:20%以上の芽球
- 免疫染色:PAS染色陽性、MPO染色陰性。
予後
- SPE.535改変
|
予後良好群
|
予後不良群
|
初診末梢血白血球数
|
1万/μl未満
|
10万/μl以上
|
年齢
|
1歳~10歳
|
1歳未満。10歳以上
|
免疫学的細胞形質
|
B細胞前駆性
|
T細胞性、 B細胞性、 mixed lineage
|
胸腺腫大
|
無
|
有
|
初診時中枢神経系/精巣浸潤
|
無
|
有
|
著明な肝脾腫
|
無
|
有
|
著明なリンパ節腫大
|
無
|
有
|
染色体
|
高2倍体、t(12;21)
|
低2倍体、t(9;22), t(4;11)
|
治療14日目の骨髄中の芽球
|
5%未満
|
25%以上
|
ステロイドに対する感受性
|
良好
|
不良
|
- 参考5
|
染色体異常
|
遺伝子異常
|
予後
|
B前駆細胞型ALL
|
t(9;22)
|
BCR/ABL融合
|
不良
|
t(4;11)
|
MLL/AF4融合
|
不良
|
染色体数45本未満
|
|
不良
|
t(12;21)
|
TEL/AML1融合
|
良好
|
t(1;19)
|
E2A/PBX1融合
|
良好
|
染色体数50本以上
|
|
良好
|
T細胞型ALL
|
t(11;19)
|
TAL1変異
|
不良
|
MLL/ENL
|
良好
|
HOX11高発現
|
良好
|
NOTCH1変異
|
不明
|
メモ
参考
- 1. 急性リンパ性白血病 (ALL) - 血液腫瘍画像データベース
- http://www.midb.jp/blood_db/db.php?module=FAB&action=Index&id=2
- http://ganjoho.jp/public/cancer/data/ALL.html
- http://ja.wikipedia.org/wiki/%E6%80%A5%E6%80%A7%E3%83%AA%E3%83%B3%E3%83%91%E6%80%A7%E7%99%BD%E8%A1%80%E7%97%85
- http://www.gan-pro.com/public/cancer/hemat/acute-lymphoid-leukemia.html
- 5. 小児の白血病 受診から診断、治療、経過観察への流れ - がん情報サービス
- http://ganjoho.jp/public/qa_links/brochure/odjrh3000000puq6-att/leukemia01.pdf
http://www.news-medical.net/health/Acute-Lymphoblastic-Leukemia-Prognosis-(Japanese).aspx
- 7. [charged] Risk group stratification and prognosis for acute lymphoblastic leukemia in children - uptodate [1]
国試
[★]
成人急性リンパ性白血病、成人急性リンパ芽球性白血病
- 関
- acute lymphoblastic leukemia、acute lymphocytic leukemia、acute lymphoid leukemia、adult acute lymphocytic leukemia、childhood acute lymphoblastic leukemia、childhood ALL、L1 acute lymphocytic leukemia、L2 acute lymphoblastic leukemia、L2 acute lymphocytic leukemia、lymphoblastic leukemia、lymphoblastic lymphoma、precursor cell lymphoblastic leukemia-lymphoma
[★]
小児急性リンパ性白血病
- 関
- acute lymphoblastic leukemia、acute lymphocytic leukemia、acute lymphoid leukemia、adult acute lymphoblastic leukemia、childhood acute lymphoblastic leukemia、L1 acute lymphocytic leukemia、L2 acute lymphoblastic leukemia、L2 acute lymphocytic leukemia、lymphoblastic leukemia、lymphoblastic lymphoma、precursor cell lymphoblastic leukemia-lymphoma
[★]
L1型急性リンパ性白血病
- 関
- acute lymphoblastic leukemia、acute lymphocytic leukemia、acute lymphoid leukemia、adult acute lymphoblastic leukemia、childhood acute lymphoblastic leukemia、childhood ALL、L2 acute lymphoblastic leukemia、L2 acute lymphocytic leukemia、lymphoblastic leukemia、lymphoblastic lymphoma、precursor cell lymphoblastic leukemia-lymphoma
[★]
L2型急性リンパ性白血病
- 関
- acute lymphoblastic leukemia、acute lymphocytic leukemia、acute lymphoid leukemia、adult acute lymphoblastic leukemia、childhood acute lymphoblastic leukemia、childhood ALL、L1 acute lymphocytic leukemia、L2 acute lymphoblastic leukemia、lymphoblastic leukemia、lymphoblastic lymphoma、precursor cell lymphoblastic leukemia-lymphoma
[★]
- (疾患)急性の、急性型の、急性的な。(形状が)鋭い、鋭角の。(感覚、才知などが)鋭い。明敏な、鋭い眼識のある。
- 関
- acutely、quick、sharp
[★]
リンパ性白血病、リンパ様白血病
- 関
- lymphoblastic leukemia、lymphocytic leukaemia、lymphocytic leukemia
[★]
- 関
- lymphatic system