WordNet
- malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
PrepTutorEJDIC
- 白血病
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/11 16:25:29」(JST)
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For the journal, see Leukemia (journal). For animal diseases, see Leucosis.
| Leukemia | |
|---|---|
| Classification and external resources | |
A Wright's stained bone marrow aspirate smear from a patient with precursor B-cell acute lymphoblastic leukemia. |
|
| ICD-10 | C91-C95 |
| ICD-9 | 208.9 |
| ICD-O: | 9800-9940 |
| DiseasesDB | 7431 |
| MedlinePlus | 001299 |
| MeSH | D007938 |
Leukemia (American English) or leukaemia (British English) (from the Greek leukos λευκός "white", and haima αἷμα "blood"[1]) is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases. In turn, it is part of the even broader group of diseases affecting the blood, bone marrow, and lymphoid system, which are all known as hematological neoplasms.
In 2000, approximately 256,000 children and adults around the world developed some form of leukemia, and 209,000 died from it.[2] About 90% of all leukemias are diagnosed in adults.[3]
Contents
|
Classification
| Cell type | Acute | Chronic |
|---|---|---|
| Lymphocytic leukemia (or "lymphoblastic") |
Acute lymphoblastic leukemia (ALL) | Chronic lymphocytic leukemia (CLL) |
| Myelogenous leukemia (also "myeloid" or "nonlymphocytic") |
Acute myelogenous leukemia (AML) (or myeloblastic) |
Chronic myelogenous leukemia (CML) |
Clinically and pathologically, leukemia is subdivided into a variety of large groups. The first division is between its acute and chronic forms:
- Acute leukemia is characterized by a rapid increase in the number of immature blood cells. Crowding due to such cells makes the bone marrow unable to produce healthy blood cells. Immediate treatment is required in acute leukemia due to the rapid progression and accumulation of the malignant cells, which then spill over into the bloodstream and spread to other organs of the body. Acute forms of leukemia are the most common forms of leukemia in children
- Chronic leukemia is characterized by the excessive build up of relatively mature, but still abnormal, white blood cells. Typically taking months or years to progress, the cells are produced at a much higher rate than normal, resulting in many abnormal white blood cells. Whereas acute leukemia must be treated immediately, chronic forms are sometimes monitored for some time before treatment to ensure maximum effectiveness of therapy. Chronic leukemia mostly occurs in older people, but can theoretically occur in any age group.
Additionally, the diseases are subdivided according to which kind of blood cell is affected. This split divides leukemias into lymphoblastic or lymphocytic leukemias and myeloid or myelogenous leukemias:
- In lymphoblastic or lymphocytic leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. Most lymphocytic leukemias involve a specific subtype of lymphocyte, the B cell.
- In myeloid or myelogenous leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets.
Combining these two classifications provides a total of four main categories. Within each of these four main categories, there are typically several subcategories. Finally, some rarer types are usually considered to be outside of this classification scheme.
- Acute lymphoblastic leukemia (ALL) is the most common type of leukemia in young children. This disease also affects adults, especially those age 65 and older. Standard treatments involve chemotherapy and radiotherapy. The survival rates vary by age: 85% in children and 50% in adults.[4] Subtypes include precursor B acute lymphoblastic leukemia, precursor T acute lymphoblastic leukemia, Burkitt's leukemia, and acute biphenotypic leukemia.
- Chronic lymphocytic leukemia (CLL) most often affects adults over the age of 55. It sometimes occurs in younger adults, but it almost never affects children. Two-thirds of affected people are men. The five-year survival rate is 75%.[5] It is incurable, but there are many effective treatments. One subtype is B-cell prolymphocytic leukemia, a more aggressive disease.
- Acute myelogenous leukemia (AML) occurs more commonly in adults than in children, and more commonly in men than women. AML is treated with chemotherapy. The five-year survival rate is 40%.[6] Subtypes of AML include acute promyelocytic leukemia, acute myeloblastic leukemia, and acute megakaryoblastic leukemia.
- Chronic myelogenous leukemia (CML) occurs mainly in adults; a very small number of children also develop this disease. Treatment is with imatinib (Gleevec in US, Glivec in Europe) [7] or other drugs. The five-year survival rate is 90%.[8][9] One subtype is chronic monocytic leukemia.
- Hairy cell leukemia (HCL) is sometimes considered a subset of chronic lymphocytic leukemia, but does not fit neatly into this pattern. About 80% of affected people are adult men. No cases in children have been reported. HCL is incurable, but easily treatable. Survival is 96% to 100% at ten years.[10]
- T-cell prolymphocytic leukemia (T-PLL) is a very rare and aggressive leukemia affecting adults; somewhat more men than women are diagnosed with this disease.[11] Despite its overall rarity, it is also the most common type of mature T cell leukemia;[12] nearly all other leukemias involve B cells. It is difficult to treat, and the median survival is measured in months.
- Large granular lymphocytic leukemia may involve either T-cells or NK cells; like hairy cell leukemia, which involves solely B cells, it is a rare and indolent (not aggressive) leukemia.[13]
- Adult T-cell leukemia is caused by human T-lymphotropic virus (HTLV), a virus similar to HIV. Like HIV, HTLV infects CD4+ T-cells and replicates within them; however, unlike HIV, it does not destroy them. Instead, HTLV "immortalizes" the infected T-cells, giving them the ability to proliferate abnormally. Human T cell lymphotropic virus types I and II (HTLV-I/II) are endemic in certain areas of the world.
Signs and symptoms
Common symptoms of chronic or acute leukemia[14]
Damage to the bone marrow, by way of displacing the normal bone marrow cells with higher numbers of immature white blood cells, results in a lack of blood platelets, which are important in the blood clotting process. This means people with leukemia may easily become bruised, bleed excessively, or develop pinprick bleeds (petechiae).
White blood cells, which are involved in fighting pathogens, may be suppressed or dysfunctional. This could cause the patient's immune system to be unable to fight off a simple infection or to start attacking other body cells. Because leukemia prevents the immune system from working normally, some patients experience frequent infection, ranging from infected tonsils, sores in the mouth, or diarrhea to life-threatening pneumonia or opportunistic infections.
Finally, the red blood cell deficiency leads to anemia, which may cause dyspnea and pallor.
Some patients experience other symptoms, such as feeling sick, having fevers, chills, night sweats, feeling fatigued and other flu-like symptoms. Some patients experience nausea or a feeling of fullness due to an enlarged liver and spleen; this can result in unintentional weight loss. Blasts affected by the disease may come together and become swollen in the liver or in the lymph nodes causing pain and leading to nausea. [15]
If the leukemic cells invade the central nervous system, then neurological symptoms (notably headaches) can occur. All symptoms associated with leukemia can be attributed to other diseases. Consequently, leukemia is always diagnosed through medical tests.
The word leukemia, which means 'white blood', is derived from the disease's namesake high white blood cell counts that most leukemia patients have before treatment. The high number of white blood cells are apparent when a blood sample is viewed under a microscope. Frequently, these extra white blood cells are immature or dysfunctional. The excessive number of cells can also interfere with the level of other cells, causing a harmful imbalance in the blood count.
Some leukemia patients do not have high white blood cell counts visible during a regular blood count. This less-common condition is called aleukemia. The bone marrow still contains cancerous white blood cells which disrupt the normal production of blood cells, but they remain in the marrow instead of entering the bloodstream, where they would be visible in a blood test. For an aleukemic patient, the white blood cell counts in the bloodstream can be normal or low. Aleukemia can occur in any of the four major types of leukemia, and is particularly common in hairy cell leukemia.[16]
Causes
No single known cause for any of the different types of leukemia exists. The known causes, which are not generally factors within the control of the average person, account for relatively few cases.[17] The different leukemias likely have different causes.
Leukemia, like other cancers, results from mutations in the DNA. Certain mutations can trigger leukemia by activating oncogenes or deactivating tumor suppressor genes, and thereby disrupting the regulation of cell death, differentiation or division. These mutations may occur spontaneously or as a result of exposure to radiation or carcinogenic substances.[18]
Among adults, the known causes are natural and artificial ionizing radiation, a few viruses such as human T-lymphotropic virus, and some chemicals, notably benzene and alkylating chemotherapy agents for previous malignancies.[19][20][21] Use of tobacco is associated with a small increase in the risk of developing acute myeloid leukemia in adults.[19] Cohort and case-control studies have linked exposure to some petrochemicals and hair dyes to the development of some forms of leukemia. A few cases of maternal-fetal transmission have been reported.[19] Diet has very limited or no effect, although eating more vegetables may confer a small protective benefit.[17]
Viruses have also been linked to some forms of leukemia. Experiments on mice and other mammals have demonstrated the relevance of retroviruses in leukemia, and human retroviruses have also been identified. The first human retrovirus identified was human T-lymphotropic virus, or HTLV-1, which is known to cause adult T-cell leukemia.[22]
Some people have a genetic predisposition towards developing leukemia. This predisposition is demonstrated by family histories and twin studies.[19] The affected people may have a single gene or multiple genes in common. In some cases, families tend to develop the same kinds of leukemia as other members; in other families, affected people may develop different forms of leukemia or related blood cancers.[19]
In addition to these genetic issues, people with chromosomal abnormalities or certain other genetic conditions have a greater risk of leukemia.[20] For example, people with Down syndrome have a significantly increased risk of developing forms of acute leukemia (especially acute myeloid leukemia), and Fanconi anemia is a risk factor for developing acute myeloid leukemia.[19]
Whether non-ionizing radiation causes leukemia has been studied for several decades. The International Agency for Research on Cancer expert working group undertook a detailed review of all data on static and extremely low frequency electromagnetic energy, which occurs naturally and in association with the generation, transmission, and use of electrical power.[23] They concluded that there is limited evidence that high levels of ELF magnetic (but not electric) fields might cause childhood leukemia. Exposure to significant ELF magnetic fields might result in twofold excess risk for leukemia for children exposed to these high levels of magnetic fields.[23] However, the report also says that methodological weaknesses and biases in these studies have likely caused the risk to be overstated.[23] No evidence for a relationship to leukemia or another form of malignancy in adults has been demonstrated.[23] Since exposure to such levels of ELFs is relatively uncommon, the World Health Organization concludes that ELF exposure, if later proven to be causative, would account for just 100 to 2400 cases worldwide each year, representing 0.2 to 4.9% of the total incidence of childhood leukemia for that year (about 0.03 to 0.9% of all leukemias).[24]
According to a study conducted at the Center for Research in Epidemiology and Population Health in France, children born to mothers who use fertility drugs to induce ovulation are more than twice as likely to develop leukemia during their childhoods than other children.[25]
Race is known to play a role, with some racial groups being more at risk than others. Hispanics, especially those under the age of 20, are at the highest risk for leukemia, while whites, Native Americans, Asians, and Alaska Natives are at higher risk than blacks.[26]
Diagnosis
Diagnosis is usually based on repeated complete blood counts and a bone marrow examination following observations of the symptoms, however, in rare cases blood tests may not show if a patient has leukemia, usually this is because the leukemia is in the early stages or has entered remission. A lymph node biopsy can be performed as well in order to diagnose certain types of leukemia in certain situations.
Following diagnosis, blood chemistry tests can be used to determine the degree of liver and kidney damage or the effects of chemotherapy on the patient. When concerns arise about visible damage due to leukemia, doctors may use an X-ray, MRI, or ultrasound. These can potentially view leukemia's effects on such body parts as bones (X-ray), the brain (MRI), or the kidneys, spleen, and liver (ultrasound). Finally, CT scans are rarely used to check lymph nodes in the chest.
Despite the use of these methods to diagnose whether or not a patient has leukemia, many people have not been diagnosed because many of the symptoms are vague, unspecific, and can refer to other diseases. For this reason, the American Cancer Society predicts that at least one-fifth of the people with leukemia have not yet been diagnosed.[16]
Mutation in SPRED1 gene has been associated with a predisposition to childhood leukemia.[27] SPRED1 gene mutations can be diagnosed with genetic sequencing.
Treatment
Most forms of leukemia are treated with pharmaceutical medication, typically combined into a multi-drug chemotherapy regimen. Some are also treated with radiation therapy. In some cases, a bone marrow transplant is useful.
Acute lymphoblastic
Further information: Acute lymphoblastic leukemia#Treatment
Management of ALL focuses on control of bone marrow and systemic (whole-body) disease. Additionally, treatment must prevent leukemic cells from spreading to other sites, particularly the central nervous system (CNS) e.g. monthly lumbar punctures. In general, ALL treatment is divided into several phases:
- Induction chemotherapy to bring about bone marrow remission. For adults, standard induction plans include prednisone, vincristine, and an anthracycline drug; other drug plans may include L-asparaginase or cyclophosphamide. For children with low-risk ALL, standard therapy usually consists of three drugs (prednisone, L-asparaginase, and vincristine) for the first month of treatment.
- Consolidation therapy or intensification therapy to eliminate any remaining leukemia cells. There are many different approaches to consolidation, but it is typically a high-dose, multi-drug treatment that is undertaken for a few months. Patients with low- to average-risk ALL receive therapy with antimetabolite drugs such as methotrexate and 6-mercaptopurine (6-MP). High-risk patients receive higher drug doses of these drugs, plus additional drugs.
- CNS prophylaxis (preventive therapy) to stop the cancer from spreading to the brain and nervous system in high-risk patients. Standard prophylaxis may include radiation of the head and/or drugs delivered directly into the spine.
- Maintenance treatments with chemotherapeutic drugs to prevent disease recurrence once remission has been achieved. Maintenance therapy usually involves lower drug doses, and may continue for up to three years.
- Alternatively, allogeneic bone marrow transplantation may be appropriate for high-risk or relapsed patients.[28]
Chronic lymphocytic
Further information: Chronic lymphocytic leukemia#Treatment
Decision to treat
Hematologists base CLL treatment on both the stage and symptoms of the individual patient. A large group of CLL patients have low-grade disease, which does not benefit from treatment. Individuals with CLL-related complications or more advanced disease often benefit from treatment. In general, the indications for treatment are:
- Falling hemoglobin or platelet count
- Progression to a later stage of disease
- Painful, disease-related overgrowth of lymph nodes or spleen
- An increase in the rate of lymphocyte production [29]
Typical treatment approach
CLL is probably incurable by present treatments. The primary chemotherapeutic plan is combination chemotherapy with chlorambucil or cyclophosphamide, plus a corticosteroid such as prednisone or prednisolone. The use of a corticosteroid has the additional benefit of suppressing some related autoimmune diseases, such as immunohemolytic anemia or immune-mediated thrombocytopenia. In resistant cases, single-agent treatments with nucleoside drugs such as fludarabine,[30] pentostatin, or cladribine may be successful. Younger patients may consider allogeneic or autologous bone marrow transplantation.[31]
Acute myelogenous
Further information: Acute myeloid leukemia#Treatment
Many different anti-cancer drugs are effective for the treatment of AML. Treatments vary somewhat according to the age of the patient and according to the specific subtype of AML. Overall, the strategy is to control bone marrow and systemic (whole-body) disease, while offering specific treatment for the central nervous system (CNS), if involved.
In general, most oncologists rely on combinations of drugs for the initial, induction phase of chemotherapy. Such combination chemotherapy usually offers the benefits of early remission and a lower risk of disease resistance. Consolidation and maintenance treatments are intended to prevent disease recurrence. Consolidation treatment often entails a repetition of induction chemotherapy or the intensification chemotherapy with additional drugs. By contrast, maintenance treatment involves drug doses that are lower than those administered during the induction phase.[32]
Chronic myelogenous
Further information: Chronic myelogenous leukemia#Treatment
There are many possible treatments for CML, but the standard of care for newly diagnosed patients is imatinib (Gleevec) therapy.[33] Compared to most anti-cancer drugs, it has relatively few side effects and can be taken orally at home. With this drug, more than 90% of patients will be able to keep the disease in check for at least five years,[33] so that CML becomes a chronic, manageable condition.
In a more advanced, uncontrolled state, when the patient cannot tolerate imatinib, or if the patient wishes to attempt a permanent cure, then an allogeneic bone marrow transplantation may be performed. This procedure involves high-dose chemotherapy and radiation followed by infusion of bone marrow from a compatible donor. Approximately 30% of patients die from this procedure.[33]
Hairy cell
Further information: Hairy cell leukemia#Treatment
Decision to treat
Patients with hairy cell leukemia who are symptom-free typically do not receive immediate treatment. Treatment is generally considered necessary when the patient shows signs and symptoms such as low blood cell counts (e.g., infection-fighting neutrophil count below 1.0 K/µL), frequent infections, unexplained bruises, anemia, or fatigue that is significant enough to disrupt the patient's everyday life.
Typical treatment approach
Patients who need treatment usually receive either one week of cladribine, given daily by intravenous infusion or a simple injection under the skin, or six months of pentostatin, given every four weeks by intravenous infusion. In most cases, one round of treatment will produce a prolonged remission.[34]
Other treatments include rituximab infusion or self-injection with Interferon-alpha. In limited cases, the patient may benefit from splenectomy (removal of the spleen). These treatments are not typically given as the first treatment because their success rates are lower than cladribine or pentostatin.[35]
T-cell prolymphocytic
Further information: T-cell prolymphocytic leukemia#Treatment
Most patients with T-cell prolymphocytic leukemia, a rare and aggressive leukemia with a median survival of less than one year, require immediate treatment.[36]
T-cell prolymphocytic leukemia is difficult to treat, and it does not respond to most available chemotherapeutic drugs.[36] Many different treatments have been attempted, with limited success in certain patients: purine analogues (pentostatin, fludarabine, cladribine), chlorambucil, and various forms of combination chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone CHOP, cyclophosphamide, vincristine, prednisone [COP], vincristine, doxorubicin, prednisone, etoposide, cyclophosphamide, bleomycin VAPEC-B). Alemtuzumab (Campath), a monoclonal antibody that attacks white blood cells, has been used in treatment with greater success than previous options.[36]
Some patients who successfully respond to treatment also undergo stem cell transplantation to consolidate the response.[36]
Juvenile myelomonocytic
Further information: Juvenile myelomonocytic leukemia#Treatment
Treatment for juvenile myelomonocytic leukemia can include splenectomy, chemotherapy, and bone marrow transplantation.[37]
Epidemiology
Age-standardized death from leukemia per 100,000 inhabitants in 2004.[38]
no data
less than 1
1-2
2-3
3-4
4-5
5-6
6-7
7-8
8-9
9-10
10-11
more than 11
In 2000, approximately 256,000 children and adults around the world developed a form of leukemia, and 209,000 died from it.[2] This represents about 3% of the almost seven million deaths due to cancer that year, and about 0.35% of all deaths from any cause.[2] Of the sixteen separate sites the body compared, leukemia was the 12th most common class of neoplastic disease, and the 11th most common cause of cancer-related death.[2]
About 245,000 people in the United States are affected with some form of leukemia, including those that have achieved remission or cure. Approximately 44,270 new cases of leukemia were diagnosed in the year of 2008 in the US.[39] This represents 2.9% of all cancers (excluding simple basal cell and squamous cell skin cancers) in the United States, and 30.4% of all blood cancers.[40]
Among children with some form of cancer, about a third have a type of leukemia, most commonly acute lymphoblastic leukemia.[39] A type of leukemia is the second most common form of cancer in infants (under the age of 12 months) and the most common form of cancer in older children.[41] Boys are somewhat more likely to develop leukemia than girls, and white American children are almost twice as likely to develop leukemia than black American children.[41] Only about 3% cancer diagnoses among adults are for leukemias, but because cancer is much more common among adults, more than 90% of all leukemias are diagnosed in adults.[39]
History
Rudolf Virchow
Leukemia was first observed by pathologist Rudolf Virchow in 1845. Observing an abnormally large number of white blood cells in a blood sample from a patient, Virchow called the condition Leukämie in German, which he formed from the two Greek words leukos (λευκός), meaning "white", and aima (αίμα), meaning "blood". Around ten years after Virchow's findings, pathologist Franz Ernst Christian Neumann found that one deceased leukemia patient's bone marrow was colored "dirty green-yellow" as opposed to the normal red. This finding allowed Neumann to conclude that a bone marrow problem was responsible for the abnormal blood of leukemia patients.
By 1900 leukemia was viewed as a family of diseases as opposed to a single disease. By 1947 Boston pathologist Sydney Farber believed from past experiments that aminopterin, a folic acid mimic, could potentially cure leukemia in children. The majority of the children with ALL who were tested showed signs of improvement in their bone marrow, but none of them were actually cured. This, however, led to further experiments.
In 1962, researchers Emil J. Freireich Jr. and Emil Frei III used combination chemotherapy to attempt to cure leukemia. The tests were successful with some patients surviving long after the tests.[42]
Research directions
Significant research into the causes, prevalence, diagnosis, treatment, and prognosis of leukemia is being performed. Hundreds of clinical trials are being planned or conducted at any given time.[43] Studies may focus on effective means of treatment, better ways of treating the disease, improving the quality of life for patients, or appropriate care in remission or after cures.
In general, there are two types of leukemia research: clinical/translational research and basic science research. Clinical/translational research focuses on studying the disease in a defined and generally immediately patient-applicable way, whereas basic science research studies the disease process at a distance and the results from such studies are generally less immediately useful to patients with the disease.[44]
Treatment through gene therapy is currently being pursued. One such approach turns T cells into cancer-targeting attackers. As of August 2011, a year after treatment, two of the three patients are cancer-free.[45]
Society and culture
Leukemias are often romanticized in 20th century fiction. It is presented as a pure, clean disease, whose innocent, beautiful, and spiritually sensitive victims tragically die young. As such, it is the cultural successor to tuberculosis.[46]
In pregnancy
Leukemia is rarely associated with pregnancy, affecting only about 1 in 10,000 pregnant women.[47] How it is handled depends primarily on the type of leukemia. Nearly all leukemias appearing in pregnant women are acute leukemias.[48] Acute leukemias normally require prompt, aggressive treatment, despite significant risks of pregnancy loss and birth defects, especially if chemotherapy is given during the developmentally sensitive first trimester.[47] Chronic myelogenous leukemia can be treated with relative safety at any time during pregnancy with Interferon-alpha hormones.[47] Treatment for chronic lymphocytic leukemias, which are rare in pregnant women, can often be postponed until after the end of the pregnancy.[48][47]
See also
- Acute erythroid leukemia
- Antileukemic drugs, medications used to kill leukemia cells
- Hematologic diseases, the large class of blood-related disorders, including leukemia
- Cancer-related fatigue
References
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- ^ a b c d Non-Ionizing Radiation, Part 1: Static and Extremely Low-Frequency (ELF) Electric and Magnetic Fields (IARC Monographs on the Evaluation of the Carcinogenic Risks). Geneva: World Health Organisation. 2002. pp. 332–333, 338. ISBN 92-832-1280-0. http://monographs.iarc.fr/ENG/Monographs/vol80/index.php.
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- ^ Gribben JG (January 2008). "Stem cell transplantation in chronic lymphocytic leukemia". Biol. Blood Marrow Transplant. 15 (1 Suppl): 53–8. doi:10.1016/j.bbmt.2008.10.022. PMC 2668540. PMID 19147079. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2668540/.
- ^ American Cancer Society (6 July 2009). "Typical Treatment of Acute Myeloid Leukemia". Detailed Guide: Leukemia - Acute Myeloid (AML). American Cancer Society. http://www.cancer.org/docroot/CRI/content/CRI_2_4_4x_Treatment_of_Acute_Myeloid_Leukemia_AML.asp. Retrieved 4 May 2010. [dead link]
- ^ a b c Fausel C (October 2007). "Targeted chronic myeloid leukemia therapy: seeking a cure". J Manag Care Pharm 13 (8 Suppl A): 8–12. PMID 17970609. http://www.amcp.org/data/jmcp/pages%208-12.pdf.
- ^ "Cladribine in a weekly versus daily schedule for untreated active hairy cell leukemia: final report from the Polish Adult Leukemia Group (PALG) of a prospective, randomized, multicenter trial -- Robak et al. 109 (9): 3672 -- Blood". http://bloodjournal.hematologylibrary.org/cgi/content/abstract/bloodjournal;109/9/3672. Retrieved 2007-09-10.
- ^ "Filgrastim for Cladribine-Induced Neutropenic Fever in Patients With Hairy Cell Leukemia -- Saven et al. 93 (8): 2471 -- Blood". http://bloodjournal.hematologylibrary.org/cgi/content/full/93/8/2471. Retrieved 2007-09-10.
- ^ a b c d Dearden CE, Matutes E, Cazin B (September 2001). "High remission rate in T-cell prolymphocytic leukemia with CAMPATH-1H". Blood 98 (6): 1721–6. doi:10.1182/blood.V98.6.1721. PMID 11535503. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=11535503.
- ^ "JMMLfoundation.org". JMMLfoundation.org. http://www.jmmlfoundation.org/modules.php?name=Content&pa=showpage&pid=8/. Retrieved 2010-08-29. [dead link]
- ^ "WHO Disease and injury country estimates". World Health Organization. 2009. http://www.who.int/healthinfo/global_burden_disease/estimates_country/en/index.html. Retrieved 2009-11-11.
- ^ a b c "Leukemia Facts & Statistics." The Leukemia & Lymphoma Society. Retrieved 2009-07-02.
- ^ Horner MJ, Ries LAG, Krapcho M, Neyman N, et al. (eds).. "SEER Cancer Statistics Review, 1975–2006". Surveillance Epidemiology and End Results (SEER). Bethesda, MD: National Cancer Institute. http://seer.cancer.gov/csr/1975_2006/. Retrieved 2009-11-03. "Table 1.4: Age-Adjusted SEER Incidence and U.S. Death Rates and 5-Year Relative Survival Rates By Primary Cancer Site, Sex and Time Period"
- ^ a b James G. Gurney, Malcolm A. Smith, Julie A. Ross (1999) Cancer Incidence and Survival among Children and Adolescents, United States SEER program 1975-1995, chapter on Leukemia Cancer Statistics Branch, National Cancer Institute, available online from the SEER web site
- ^ Patlak, Margie. "Targeting Leukemia: From Bench to Bedside". Breakthroughs in Bioscience. The Federation of American Societies for Experimental Biology. http://opa1.faseb.org/pdf/leukemia.pdf. Retrieved 20 May 2010.
- ^ http://www.clinicaltrials.gov/ct2/results?term=leukemia
- ^ "Understanding Clinical Trials for Blood Cancers". Leukemia and Lymphoma Society. http://www.leukemia-lymphoma.org/attachments/National/br_1162487596.pdf. Retrieved 19 May 2010.
- ^ Jaslow, Ryan. "New Leukemia Therapy Destroys Cancer by Turning Blood Cells into "Assassins"". CBSnews.com HealthPop section. http://www.cbsnews.com/8301-504763_162-20091135-10391704.html. Retrieved 11 August 2011.
- ^ Sontag, Susan (1978). Illness as Metaphor. New York: Farrar, Straus and Giroux. pp. 18. ISBN 0-374-17443-1.
- ^ a b c d Shapira T, Pereg D, Lishner M (September 2008). "How I treat acute and chronic leukemia in pregnancy". Blood Rev. 22 (5): 247–59. doi:10.1016/j.blre.2008.03.006. PMID 18472198.
- ^ a b Koren G, Lishner M (2010). "Pregnancy and commonly used drugs in hematology practice". Hematology Am Soc Hematol Educ Program 2010: 160–5. doi:10.1182/asheducation-2010.1.160. PMID 21239787.
External links
- Images of leukemia cells (click "Leukemias" in menu on left)
- Leukemia at the Open Directory Project
- Leukaemia information for patients, from Cancer Research UK
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UpToDate Contents
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- 1. 急性骨髄性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of acute myeloid leukemia
- 2. 小児および思春期における急性リンパ芽球性白血病の症状および診断の概要 overview of the presentation and diagnosis of acute lymphoblastic leukemia in children and adolescents
- 3. 慢性リンパ性白血病に対する治療の概要 overview of the treatment of chronic lymphocytic leukemia
- 4. 急性骨髄性白血病の合併症の概要 overview of the complications of acute myeloid leukemia
- 5. 小児および思春期における急性リンパ芽球性白血病の治療の概要 overview of the treatment of acute lymphoblastic leukemia in children and adolescents
English Journal
- Cytotoxicity of (-)-vitisin B in human leukemia cells.
- Wu SS, Chen LG, Lin RJ, Lin SY, Lo YE, Liang YC.SourceDepartment of Orthopedics, Shuang Ho Hospital, Taipei Medical University , Taipei , Taiwan.
- Drug and chemical toxicology.Drug Chem Toxicol.2013 Jul;36(3):313-9. doi: 10.3109/01480545.2012.720990. Epub 2012 Oct 3.
- Vitis thunbergii var. taiwaniana (VTT) is an indigenous Taiwanese wild grape and is used as a folk medicine in Taiwan. VTT is rich in polyphenols, especially quercetin and resveratrol derivatives, which were demonstrated to exhibit inhibitory activities against carcinogenesis and prevent some neurod
- PMID 23030068
- Chemical composition, antimicrobial, cytotoxic and antioxidant activities of the essential oil of Artemisia indica Willd.
- Rashid S, Rather MA, Shah WA, Bhat BA.SourceMedicinal Chemistry Division, Indian Institute of Integrative Medicine, Srinagar 190005, India.
- Food chemistry.Food Chem.2013 May 1;138(1):693-700. doi: 10.1016/j.foodchem.2012.10.102. Epub 2012 Nov 10.
- Essential oil from the aerial parts of Artemisia indica was analysed by GC-FID and GC-MS. A total of 43 compounds representing 96.8% of the oil were identified and the major components were found to be artemisia ketone (42.1%), germacrene B (8.6%), borneol (6.1%) and cis-chrysanthenyl acetate (4.8%)
- PMID 23265542
Japanese Journal
- 医療ネグレクトにより急性リンパ性白血病で死亡した1部検例
- 臼元 洋介,鮫島 直美,辻 彰子 [他]
- 福岡医学雑誌 = Fukuoka acta medica 105(12), 234-240, 2014-12-25
- NAID 40020401827
- 医療ネグレクトにより急性リンパ性白血病で死亡した1剖検例
- Usumoto Yosuke,Sameshima Naomi,Tsuji Akiko,Kudo Keiko,Nishida Naoki,Ikeda Noriaki
- Fukuoka Acta Medica 105(12), 234-240, 2014-12-25
- … ている．しかしながら，死者の両親は西洋医学より補完代替療法（自然療法）を好んでおり，死者が産まれてから健康診断や予防接種で病院に連れて行ったことがなかった．死者が通常の医療を受けていれば，5年生存率は60％を超えていたと考えられ，両親の動機によらず，本事例は医療ネグレクトと考えられた．We report the case of 2-year-old girl who died of precursor B-cell acute lymphoblastic leukaemia(ALL), the most common cancer in …
- NAID 120005553596
- 20(S)-Ginsenoside Rh2 Induces Apoptosis in Human Leukaemia Reh Cells through Mitochondrial Signaling Pathways
- Xia Ting,Wang Jian-Cheng,Xu Wei [他]
- Biological & pharmaceutical bulletin 37(2), 248-254, 2014-02
- NAID 40019957084
Related Links
- Leukemia (American English) or leukaemia (British English) (from the Ancient Greek λευκός leukos "white", and αἷμα haima "blood") is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white ...
- 30 Sep 2011 ... There are many different types of leukaemia and the treatment varies for different types. There are links on this page to our main leukaemia sections on CancerHelp UK.
Related Pictures
★リンクテーブル★
| リンク元 | 「ロス斑」「leukemic」「leukaemic」 |
| 拡張検索 | 「lymphocytic leukaemia」「myeloid leukaemia」「acute myeloid leukaemia」 |
「ロス斑」
- 英
- Roth spot, Roth spots, Roth's spots
- 同
- Roth斑
概念
- ロス斑は白斑を中心と中心とする出血像を示す。ロス斑は綿花状白斑の周りを出血が取り囲んでいる。綿花用白斑は虚血に陥った軸索の膨化(破裂?, bursting)により生じている。毛細血管に入る前の細動脈が虚血により破裂することにより生じている。多くの病態でロス斑が起こるのであって、細菌性心内膜炎に特異的なわけではない。(参考(1))
原因
- 参考3
- 亜急性細菌性心内膜炎 subacute bacterial endocarditis
- 白血病 leukaemias
- 貧血 anaemia
- 無酸素症 anoxia
- 一酸化炭素中毒 carbon monoxide poisoning
- prolonged intubation during anaesthesia
- 高血圧網膜症 hypertensive retinopathy
- 妊娠高血圧腎症 pre-eclampsia
- 糖尿病性網膜症 diabetic retinopathy
- 新生児分娩時損傷 neonatal birth trauma
- 外傷伴う出産 mothers who have undergone traumatic deliveries
- 被虐待児症候群/揺さぶられっ子症候群 battered children / shaken baby syndrome
- 動静脈奇形に起因する頭蓋内出血 intracranial hemorrhage from arteriovenous malformation
- 線維柱帯切除術後の眼球内圧の減圧 ocular decompression following trabeculectomy
参考
- 1.
- 2.
- 3. Roland Ling, Bruce James White-centred retinal haemorrhages(Roth spots). Postgrad Med Ja 1998;74:581-582
- 4
- 5.写真
「leukemic」
- adj.
- 白血病性の、白血病の
「leukaemic」
- adj.
- 白血病の