リンパ性白血病、リンパ様白血病
- 関
- lymphoblastic leukemia、lymphocytic leukaemia、lymphocytic leukemia
WordNet
- malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
- resembling lymph or lymphatic tissues
PrepTutorEJDIC
- 白血病
- リンパ状(液)の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/11/27 23:28:05」(JST)
[Wiki en表示]
| Lymphoid leukemia |
| Classification and external resources |
| ICD-10 |
C91 |
| ICD-9 |
204 |
| MeSH |
D007945 |
Lymphoid leukemia or lymphocytic leukemia is a type of leukemia affecting circulating lymphocyte cells. This is in contrast to lymphoma, which is a solid tumor of the same type of cells.[1]
Lymphocytes are a subtype of white blood cells. Most lymphoid leukemias involve a particular subtype of lymphocytes, the B cell.
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Contents
- 1 Classification
- 1.1 B-cell leukemias
- 1.2 T-cell leukemias
- 2 References
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Classification
Historically, they have been most commonly divided by the stage of maturation at which the clonal (neoplastic) lymphoid population stopped maturing:
- Acute lymphoblastic leukemia
- Chronic lymphocytic leukemia
However, the influential WHO Classification (published in 2001) emphasized a greater emphasis on cell lineage. To this end, lymphoid leukemias can also be divided by the type of cells affected:
- B-cell leukemia
- T-cell leukemia
- NK-cell leukemia
The most common type of lymphoid leukemia is B-cell chronic lymphocytic leukemia.
B-cell leukemias
| Lymphoid leukemia |
| Classification and external resources |
| MeSH |
D015448 |
B-cell leukemia describes several different types of lymphoid leukemia which affect B cells.
| Comparison of most common B-cell leukemias |
Incidence |
Histopathology |
Cell markers |
Comments |
B-cell chronic lymphocytic leukemia
(ICD-O: 9823/3) |
30% of all leukemias. Also 3 to 4% of lymphomas in adults[2] |
Small resting lymphocytes mixed with variable number of large activated cells. Lymph nodes are diffusely effaced[2] |
CD5, surface immunoglobulin[2] |
Occurs in older adults. Usually involves lymph nodes, bone marrow and spleen. Most patients have peripheral blood involvement. Indolent.[2] |
Precursor B-cell lymphoblastic leukemia
(ICD-O: 9835/3-9836/3) |
85% of acute leukemias in childhood,[2] Less common in adults[2] |
Lymphoblasts with irregular nuclear contours, condensed chromatin, small nucleoli and scant cytoplasm without granules.[2] |
TdT, CD19[2] |
Usually presents as acute leukemia[2] |
Other types include (with ICD-O code):
- 9826/3 - Acute lymphoblastic leukemia, mature B-cell type
- 9833/3 - B-cell prolymphocytic leukemia
- 9940/3 - Hairy cell leukemia
T-cell leukemias
| T-cell leukemia |
| Classification and external resources |
| MeSH |
D015458 |
T-cell leukemia describes several different types of lymphoid leukemias which affect T cells.
The most common T-cell leukemia is precursor T-cell lymphoblastic leukemia.[2] It causes 15% of acute leukemias in childhood, and also 40% of lymphomas in childhood.[2] It is most common in adolescent males.[2] Its morphology is identical to that of precursor B-cell lymphoblastic leukemia.[2] Cell markers include TdT, CD2, CD7.[2] It often presents as a mediastinal mass because of involvement of the thymus.[2] It is highly associated with NOTCH1 mutations.[2]
Other types include:
- Large granular lymphocytic leukemia
- Adult T-cell leukemia/lymphoma
- T-cell prolymphocytic leukemia
In practice, it can be hard to distinguish T-cell leukemia from T-cell lymphoma, and they are often grouped together.
References
- ^ Parham, Peter (2005). The immune system. New York: Garland Science. p. 414. ISBN 0-8153-4093-1.
- ^ a b c d e f g h i j k l m n o p Table 12-8 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.
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Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
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B cell
(lymphoma,
leukemia)
(most CD19
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By development/
marker
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TdT+
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- ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
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CD5+
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mantle zone (Mantle cell)
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CD22+
|
- Prolymphocytic
- CD11c+ (Hairy cell leukemia)
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CD79a+
|
- germinal center/follicular B cell (Follicular
- Burkitt's
- GCB DLBCL
- Primary cutaneous follicular lymphoma)
marginal zone/marginal-zone B cell (Splenic marginal zone
- MALT
- Nodal marginal zone
- Primary cutaneous marginal zone lymphoma)
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RS (CD15+, CD30+)
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- Classic Hodgkin's lymphoma (Nodular sclerosis)
- CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)
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PCDs/PP
(CD38+/CD138+)
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- see immunoproliferative immunoglobulin disorders
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By infection
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- KSHV (Primary effusion)
- EBV (Lymphomatoid granulomatosis
- Post-transplant lymphoproliferative disorder)
- HIV (AIDS-related lymphoma)
- Helicobacter pylori (MALT lymphoma)
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Cutaneous
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- Diffuse large B-cell lymphoma
- Intravascular large B-cell lymphoma
- Primary cutaneous marginal zone lymphoma
- Primary cutaneous immunocytoma
- Plasmacytoma
- Plasmacytosis
- Primary cutaneous follicular lymphoma
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T/NK
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T cell
(lymphoma,
leukemia)
(most CD3
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By development/
marker
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- TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
- prolymphocyte (Prolymphocytic)
- CD30+ (Anaplastic large-cell lymphoma
- Lymphomatoid papulosis type A)
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Cutaneous
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MF+variants
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- indolent: Mycosis fungoides
- Pagetoid reticulosis
- Granulomatous slack skin
aggressive: Sézary's disease
- Adult T-cell leukemia/lymphoma
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Non-MF
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- CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
- Pleomorphic T-cell lymphoma
- Lymphomatoid papulosis type B
CD30+: CD30+ cutaneous T-cell lymphoma
- Secondary cutaneous CD30+ large cell lymphoma
- Lymphomatoid papulosis type A
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Other peripheral
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- Hepatosplenic
- Angioimmunoblastic
- Enteropathy-associated T-cell lymphoma
- Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma)
- Subcutaneous T-cell lymphoma
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By infection
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- HTLV-1 (Adult T-cell leukemia/lymphoma)
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NK cell/
(most CD56)
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- Aggressive NK-cell leukemia
- Blastic NK cell lymphoma
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T or NK
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- EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma)
- Large granular lymphocytic leukemia
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Lymphoid+myeloid
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- Acute biphenotypic leukaemia
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Lymphocytosis
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- Lymphoproliferative disorders (X-linked lymphoproliferative disease
- Autoimmune lymphoproliferative syndrome)
- Leukemoid reaction
- Diffuse infiltrative lymphocytosis syndrome
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| Cutaneous lymphoid hyperplasia |
- Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns
- Cutaneous lymphoid hyperplasia with nodular pattern
- Jessner lymphocytic infiltrate of the skin
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cell/phys/auag/auab/comp, igrc
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UpToDate Contents
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English Journal
- Evaluation of ETV6/RUNX1 Fusion and Additional Abnormalities Involving ETV6 and/or RUNX1 Genes Using FISH Technique in Patients with Childhood Acute Lymphoblastic Leukemia.
- Aydin C1, Cetin Z2, Manguoglu AE3, Tayfun F4, Clark OA5, Kupesiz A4, Akkaya B6, Karauzum SB3.
- Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion.Indian J Hematol Blood Transfus.2016 Jun;32(2):154-61. doi: 10.1007/s12288-015-0557-7. Epub 2015 Jun 2.
- Childhood acute lymphoblastic leukemia (ALL) is the most common type of childhood leukemia. Specifically, ALL is a malignant disorder of the lymphoid progenitor cells, with a peak incidence among children aged 2-5 years. The t(12;21)(p13;q22) translocation occurs in 25 % of childhood B cell precur
- PMID 27065576
- Intracellular Signaling Pathways Involved in Childhood Acute Lymphoblastic Leukemia; Molecular Targets.
- Layton Tovar CF1, Mendieta Zerón H2.
- Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion.Indian J Hematol Blood Transfus.2016 Jun;32(2):141-53. doi: 10.1007/s12288-015-0609-z. Epub 2015 Oct 20.
- Acute lymphoblastic leukemia (ALL) is a malignant disease characterized by an uncontrolled proliferation of immature lymphoid cells. ALL is the most common hematologic malignancy in early childhood, and it reaches peak incidence between the ages of 2 and 3 years. The prognosis of ALL is associated
- PMID 27065575
- Synchronous gastric and ampullary adenocarcinomas in a hairy cell leukemia patient treated with pentostatin eight years prior.
- Senatore FJ1, Dasanu CA2.
- Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.J Oncol Pharm Pract.2016 Jun;22(3):543-7. doi: 10.1177/1078155215574140. Epub 2015 Feb 23.
- Hairy cell leukemia patients are at increased risk for second malignancies, including both solid and lymphoid neoplasms. Along with other factors, multiple immune defects present in hairy cell leukemia likely contribute to subsequent carcinogenesis. We report herein a case of synchronous high-grade
- PMID 25712625
Japanese Journal
- Monoclonal gammopathy of undetermined significance (MGUS)の長期予後
- 小児ALL治療におけるCD19キメラ抗原受容体(CAR)発現T細胞療法の可能性
- リンパ性白血病における分子標的治療 (特集 血液疾患の分子標的薬 : 進化する血液疾患治療研究の最新動向) -- (治療研究)
Related Links
- leukemia [loo-ke´me-ah] a progressive, malignant neoplasm of the blood-forming organs, marked by diffuse replacement of the bone marrow development of ... Her medical history revealed the diagnosis for chronic lymphoid leukemia ...
- ... Leukemias that start in immature forms of lymphocytes are called lymphocytic leukemias (also known as lymphoid or lymphoblastic leukemias). The rest of this document focuses on acute lymphocytic leukemia (ALL) in see . ...
★リンクテーブル★
[★]
リンパ性白血病
- 関
- lymphoblastic leukemia、lymphocytic leukemia、lymphoid leukemia
[★]
- 英
- lymphoid leukemia
- 関
- リンパ性白血病
[★]
急性非リンパ性白血病、急性非リンパ球性白血病
- 関
- acute nonlymphoblastic leukemia、acute nonlymphocytic leukemia、ANLL
[★]
骨髄性リンパ性白血病タンパク質
[★]
プレBリンパ球性白血病
[★]
プレTリンパ球性白血病
[★]
- 関
- lymphatic system