関: TRAF-3、TRAF3

WordNet

having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
the 20th letter of the Roman alphabet (同)t
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
tritiumの化学記号
=sense organ / 受信装置

UpToDate Contents

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1. 腫瘍壊死因子受容体-1関連周期性発熱症候群（TRAPS） tumor necrosis factor receptor 1 associated periodic syndrome traps
2. 周期性発熱症候群およびその他の自己炎症性疾患：概要 periodic fever syndromes and other autoinflammatory diseases an overview
3. 複合免疫不全 combined immunodeficiencies
4. 全身性自己免疫疾患における心膜病変 pericardial involvement in systemic autoimmune diseases
5. 腫瘍壊死因子α阻害剤および抗酸菌感染 tumor necrosis factor alpha inhibitors and mycobacterial infections

English Journal

TRAF3 negatively regulates calcineurin-NFAT pathway by targeting calcineurin B subunit for degradation.

Wang X, Huang Y, Li L, Wei Q.SourceDepartment of Biochemistry and Molecular Biology, College of Life Sciences, Beijing Normal University, Beijing Key Laboratory, Beijing, People's Republic of China; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, People's Republic of China.
IUBMB life.IUBMB Life.2012 Sep;64(9):748-56. doi: 10.1002/iub.1060. Epub 2012 Jun 20.
Calcineurin (CN) is the only serine/threonine specific protein phosphatase regulated by Ca(2+) /calmodulin (CaM), which is composed of catalytic A subunit (CNA) and regulatory B subunit (CNB). Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is an essential component in the Toll like
PMID 22715070

Activation of the noncanonical NF-κB pathway by HIV controls a dendritic cell immunoregulatory phenotype.

Manches O, Fernandez MV, Plumas J, Chaperot L, Bhardwaj N.SourceCancer Institute, N ew York University Langone Medical Center, New York, NY 10016.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2012 Aug 28;109(35):14122-7. Epub 2012 Aug 9.
HIV modulates plasmacytoid dendritic cell (pDC) activation via Toll-like receptor 7, inducing type I IFN and inflammatory cytokines. Simultaneously, pDCs up-regulate the expression of indoleamine 2,3 dioxygenase (IDO), which is essential for the induction of regulatory T cells (Tregs), which functio
PMID 22879398

Japanese Journal

原発性マクログロブリン血症の診断と治療 (造血器腫瘍学 : 基礎と臨床の最新研究動向) -- (リンパ系腫瘍の臨床)

三輪哲義
日本臨床 70(1018 増刊2), 642-662, 2012-04
NAID 40019283025

自己抗体産生RP105陰性B細胞上に発現する B-cell maturation antigen は, 全身性エリテマトーデスの治療標的となりうるか

小荒田秀一,田代知子,末松梨絵,井上久子,大田明英,多田芳史
日本臨床免疫学会会誌 = Japanese journal of clinical immunology 35(1), 38-45, 2012-02-28
… RP105（CD180）はTLR（toll-like receptor）関連分子であるが，SLEにおいてRP105を欠損するB細胞（RP105（−）B細胞）が出現し，自己抗体を産生する．したがって，同細胞は，SLE治療の有力な標的となりうると考えられる．そのために，同細胞に特異的に発現する抗原の網羅的検索をDNAマイクロアレイ法とフローサイトメトリーで行った．マイクロアレイの結果，BCMA（B-cell maturation antigen）の発現が特異的に高いことが示唆され …
NAID 10030465586

W9-5 TRAF6は制御性T細胞のTh2型炎症の抑制に関与する

武藤剛,新倉芹菜,森田林平,小林隆志,吉村昭彦
日本臨床免疫学会会誌 35(4), 320b-320b, 2012
… アダプター分子TRAF6（TNF receptor-associated factor 6）はNF-kBの活性化に関与し，自然免疫反応の制御において重要な役割を果たすが，近年T細胞における機能が注目されている．今回我々は，制御性T細胞特異的にTRAF6を欠損させたマウスは，著明な全身リンパ節腫脹・皮膚炎・関節炎を自然発症することを発見した．このマウスでは末梢リンパ組織におけるTreg数の …
NAID 130003364032