- 関
- TNF receptor-associated factor 3、TRAF-3
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/26 15:34:57」(JST)
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| TNF receptor-associated factor 3 |
PDB rendering based on 1flk. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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1FLK, 1FLL, 1KZZ, 1L0A, 1RF3, 1ZMS, 2ECY, 2GKW
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| Identifiers |
| Symbols |
TRAF3; CAP-1; CD40bp; CRAF1; LAP1 |
| External IDs |
OMIM: 601896 MGI: 108041 HomoloGene: 7981 GeneCards: TRAF3 Gene |
| Gene Ontology |
| Molecular function |
• ubiquitin-protein ligase activity
• signal transducer activity
• protein binding
• zinc ion binding
• ubiquitin protein ligase binding
• thioesterase binding
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| Cellular component |
• mitochondrion
• endosome
• cytosol
• internal side of plasma membrane
• CD40 receptor complex
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| Biological process |
• regulation of cytokine production
• toll-like receptor signaling pathway
• apoptotic process
• induction of apoptosis
• signal transduction
• regulation of proteolysis
• negative regulation of NF-kappaB transcription factor activity
• negative regulation of type I interferon production
• regulation of interferon-beta production
• tumor necrosis factor-mediated signaling pathway
• innate immune response
• regulation of defense response to virus
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| Sources: Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
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| Entrez |
7187 |
22031 |
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| Ensembl |
ENSG00000131323 |
ENSMUSG00000021277 |
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| UniProt |
Q13114 |
Q60803 |
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| RefSeq (mRNA) |
NM_001199427.1 |
NM_001048206.1 |
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| RefSeq (protein) |
NP_001186356.1 |
NP_001041671.1 |
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| Location (UCSC) |
Chr 14:
103.24 – 103.38 Mb |
Chr 12:
111.17 – 111.27 Mb |
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| PubMed search |
[1] |
[2] |
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TNF receptor-associated factor 3 is a protein that in humans is encoded by the TRAF3 gene.[1][2]
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.[3]
Interactions
TRAF3 has been shown to interact with CD30,[4] CD27,[5][6] Lymphotoxin beta receptor,[7][8][9] Nucleoporin 62,[10] CD40,[11][12][13][14] TNFSF14,[15] RANK,[16][17] Caspase 3[18][19] and TANK.[20][21]
References
- ^ Sato T, Irie S, Reed JC (February 1995). "A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40". FEBS Lett 358 (2): 113–8. doi:10.1016/0014-5793(94)01406-Q. PMID 7530216.
- ^ Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E (March 1995). "The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family". Cell 80 (3): 389–99. doi:10.1016/0092-8674(95)90489-1. PMID 7859281.
- ^ "Entrez Gene: TRAF3 TNF receptor-associated factor 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7187.
- ^ Ansieau, S; Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff E, Herrmann F, Leutz A, Gruss H J (November 1996). "Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (24): 14053–8. doi:10.1073/pnas.93.24.14053. ISSN 0027-8424. PMC 19493. PMID 8943059. //www.ncbi.nlm.nih.gov/pmc/articles/PMC19493/. (Retracted. If this is intentional, please replace
{{Retracted}} with {{Retracted|intentional=yes}}.)
- ^ Yamamoto, H; Kishimoto T, Minamoto S (November 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27". J. Immunol. (UNITED STATES) 161 (9): 4753–9. ISSN 0022-1767. PMID 9794406.
- ^ Akiba, H; Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware C F, Malinin N L, Wallach D, Yagita H, Okumura K (May 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". J. Biol. Chem. (UNITED STATES) 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. ISSN 0021-9258. PMID 9582383.
- ^ VanArsdale, T L; VanArsdale S L, Force W R, Walter B N, Mosialos G, Kieff E, Reed J C, Ware C F (March 1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (6): 2460–5. doi:10.1073/pnas.94.6.2460. ISSN 0027-8424. PMC 20110. PMID 9122217. //www.ncbi.nlm.nih.gov/pmc/articles/PMC20110/.
- ^ Wu, M Y; Wang P Y, Han S H, Hsieh S L (April 1999). "The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells". J. Biol. Chem. (UNITED STATES) 274 (17): 11868–73. doi:10.1074/jbc.274.17.11868. ISSN 0021-9258. PMID 10207006.
- ^ Marsters, S A; Ayres T M, Skubatch M, Gray C L, Rothe M, Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. (UNITED STATES) 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. ISSN 0021-9258. PMID 9162022.
- ^ Gamper, C; van Eyndhoven W G, Schweiger E, Mossbacher M, Koo B, Lederman S (2000). "TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes". Mol. Immunol. (ENGLAND) 37 (1–2): 73–84. doi:10.1016/S0161-5890(00)00015-8. ISSN 0161-5890. PMID 10781837.
- ^ Tsukamoto, N; Kobayashi N, Azuma S, Yamamoto T, Inoue J (February 1999). "Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (4): 1234–9. doi:10.1073/pnas.96.4.1234. ISSN 0027-8424. PMC 15446. PMID 9990007. //www.ncbi.nlm.nih.gov/pmc/articles/PMC15446/.
- ^ Hu, H M; O'Rourke K, Boguski M S, Dixit V M (December 1994). "A novel RING finger protein interacts with the cytoplasmic domain of CD40". J. Biol. Chem. (UNITED STATES) 269 (48): 30069–72. ISSN 0021-9258. PMID 7527023.
- ^ Ni, C Z; Welsh K, Leo E, Chiou C K, Wu H, Reed J C, Ely K R (September 2000). "Molecular basis for CD40 signaling mediated by TRAF3". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (19): 10395–9. doi:10.1073/pnas.97.19.10395. ISSN 0027-8424. PMC 27035. PMID 10984535. //www.ncbi.nlm.nih.gov/pmc/articles/PMC27035/.
- ^ Roy, N; Deveraux Q L, Takahashi R, Salvesen G S, Reed J C (December 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. (ENGLAND) 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. ISSN 0261-4189. PMC 1170295. PMID 9384571. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1170295/.
- ^ Kuai, Jun; Nickbarg Elliott, Wooters Joe, Qiu Yongchang, Wang Jack, Lin Lih-Ling (April 2003). "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". J. Biol. Chem. (United States) 278 (16): 14363–9. doi:10.1074/jbc.M208672200. ISSN 0021-9258. PMID 12571250.
- ^ Galibert, L; Tometsko M E, Anderson D M, Cosman D, Dougall W C (December 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". J. Biol. Chem. (UNITED STATES) 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. ISSN 0021-9258. PMID 9852070.
- ^ Kim, H H; Lee D E, Shin J N, Lee Y S, Jeon Y M, Chung C H, Ni J, Kwon B S, Lee Z H (January 1999). "Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase". FEBS Lett. (NETHERLANDS) 443 (3): 297–302. doi:10.1016/S0014-5793(98)01731-1. ISSN 0014-5793. PMID 10025951.
- ^ Lee, Z H; Lee S E, Kwack K, Yeo W, Lee T H, Bae S S, Suh P G, Kim H H (March 2001). "Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells". J. Leukoc. Biol. (United States) 69 (3): 490–6. ISSN 0741-5400. PMID 11261798.
- ^ Leo, E; Deveraux Q L, Buchholtz C, Welsh K, Matsuzawa S, Stennicke H R, Salvesen G S, Reed J C (March 2001). "TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis". J. Biol. Chem. (United States) 276 (11): 8087–93. doi:10.1074/jbc.M009450200. ISSN 0021-9258. PMID 11098060.
- ^ Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216.
- ^ Rothe, M; Xiong J, Shu H B, Williamson K, Goddard A, Goeddel D V (August 1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. ISSN 0027-8424. PMC 38654. PMID 8710854. //www.ncbi.nlm.nih.gov/pmc/articles/PMC38654/.
Further reading
- Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. Signal. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837.
- Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs)". Oncogene 20 (44): 6482–91. doi:10.1038/sj.onc.1204788. PMID 11607847.
- Saha SK, Cheng G (2006). "TRAF3: a new regulator of type I interferons". Cell Cycle 5 (8): 804–7. doi:10.4161/cc.5.8.2637. PMID 16582590.
- Hu HM, O'Rourke K, Boguski MS, Dixit VM (1994). "A novel RING finger protein interacts with the cytoplasmic domain of CD40". J. Biol. Chem. 269 (48): 30069–72. PMID 7527023.
- Cheng G, Cleary AM, Ye ZS et al. (1995). "Involvement of CRAF1, a relative of TRAF, in CD40 signaling". Science 267 (5203): 1494–8. doi:10.1126/science.7533327. PMID 7533327.
- Hsu H, Shu HB, Pan MG, Goeddel DV (1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways". Cell 84 (2): 299–308. doi:10.1016/S0092-8674(00)80984-8. PMID 8565075.
- Hsu H, Huang J, Shu HB et al. (1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity 4 (4): 387–96. doi:10.1016/S1074-7613(00)80252-6. PMID 8612133.
- Butch ER, Guan KL (1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2". J. Biol. Chem. 271 (8): 4230–5. doi:10.1074/jbc.271.8.4230. PMID 8626767.
- Gedrich RW, Gilfillan MC, Duckett CS et al. (1996). "CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins". J. Biol. Chem. 271 (22): 12852–8. doi:10.1074/jbc.271.22.12852. PMID 8662842.
- Nakano H, Oshima H, Chung W et al. (1996). "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor". J. Biol. Chem. 271 (25): 14661–4. doi:10.1074/jbc.271.25.14661. PMID 8663299.
- Rothe M, Xiong J, Shu HB et al. (1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. PMC 38654. PMID 8710854. //www.ncbi.nlm.nih.gov/pmc/articles/PMC38654/.
- Hubberstey A, Yu G, Loewith R et al. (1997). "Mammalian CAP interacts with CAP, CAP2, and actin". J. Cell. Biochem. 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID 8761950.
- Ansieau S, Scheffrahn I, Mosialos G et al. (1997). "Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14053–8. doi:10.1073/pnas.93.24.14053. PMC 19493. PMID 8943059. //www.ncbi.nlm.nih.gov/pmc/articles/PMC19493/. (Retracted. If this is intentional, please replace
{{Retracted}} with {{Retracted|intentional=yes}}.)
- VanArsdale TL, VanArsdale SL, Force WR et al. (1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2460–5. doi:10.1073/pnas.94.6.2460. PMC 20110. PMID 9122217. //www.ncbi.nlm.nih.gov/pmc/articles/PMC20110/.
- Marsters SA, Ayres TM, Skubatch M et al. (1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. PMID 9162022.
- Boucher LM, Marengère LE, Lu Y et al. (1997). "Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily". Biochem. Biophys. Res. Commun. 233 (3): 592–600. doi:10.1006/bbrc.1997.6509. PMID 9168896.
- Song HY, Régnier CH, Kirschning CJ et al. (1997). "Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9792–6. doi:10.1073/pnas.94.18.9792. PMC 23270. PMID 9275204. //www.ncbi.nlm.nih.gov/pmc/articles/PMC23270/.
- Force WR, Cheung TC, Ware CF (1998). "Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor". J. Biol. Chem. 272 (49): 30835–40. doi:10.1074/jbc.272.49.30835. PMID 9388227.
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PDB gallery
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1flk: MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3
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1fll: MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3
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1kzz: DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3
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1l0a: DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3
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1rf3: Structurally Distinct Recognition Motifs in Lymphotoxin-B Receptor and CD40 for TRAF-mediated Signaling
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1zms: LMP1 Protein binds to TRAF3 as a structural CD40
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2gkw: Key contacts promote recongnito of BAFF-R by TRAF3
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Cell signaling: carrier proteins: signal transducing adaptor proteins
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| JAK-STAT |
see JAK-STAT signaling pathway
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| Growth factor receptor-bound protein |
GRB2 · GRB7 · GRB10
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| Other |
14-3-3 (YWHAE, YWHAZ) · Caveolin · Cortactin · Death-inducing signaling complex · Paxillin · Myd88 · SMAD · TRAF (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6) · BIN1 · SH3BP2 · LDB3
CHM · CHML
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
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English Journal
- Molecular cloning, characterization and expression analysis of tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster Pinctada fucata.
- Huang XD, Liu WG, Guan YY, Shi Y, Wang Q, Zhao M, Wu SZ, He MX.SourceKey Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China.
- Fish & shellfish immunology.Fish Shellfish Immunol.2012 Sep;33(3):652-8. Epub 2012 Jul 13.
- TRAF3 is a highly versatile regulator that negatively regulates JNK and alternative nuclear factor-κB signalling, but positively controls type I interferon production. To investigate TRAF3 function in innate immune responses among invertebrate especially mollusk, we characterized TRAF3 (PfTRAF3) fr
- PMID 22796485
- TRAF3 negatively regulates calcineurin-NFAT pathway by targeting calcineurin B subunit for degradation.
- Wang X, Huang Y, Li L, Wei Q.SourceDepartment of Biochemistry and Molecular Biology, College of Life Sciences, Beijing Normal University, Beijing Key Laboratory, Beijing, People's Republic of China; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, People's Republic of China.
- IUBMB life.IUBMB Life.2012 Sep;64(9):748-56. doi: 10.1002/iub.1060. Epub 2012 Jun 20.
- Calcineurin (CN) is the only serine/threonine specific protein phosphatase regulated by Ca(2+) /calmodulin (CaM), which is composed of catalytic A subunit (CNA) and regulatory B subunit (CNB). Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is an essential component in the Toll like
- PMID 22715070
Japanese Journal
- M12-Tet-Off pTRE2pur FLAG mTRAF3細胞株の樹立
- 田邊 香野,坂本 瞳,乾 誠治,タナベ カノ,サカモト ヒトミ,イヌイ セイジ,Tanabe Kano,Sakamoto Hitomi,Inui Seiji
- 熊本大学医学部保健学科紀要 9, 27-38, 2013-03-30
- … TRAF3 is the key molecule to keep the alternative pathway in an inactive state. … TRAF3 is also regulated by the constant degradation by ubiquitin-proteasome system. … To elucidate the mechanism of the TRAF3 degradation, we prepared Tet-Off gene expression system in M12 to inducibly express TRAF3 which was toxic when overexpressed in cells. …
- NAID 110009555909
- An MD simulation of the decoy action of Epstein–Barr virus LMP1 protein mimicking the CD40 interaction with TRAF3
- Chung Wilfredo Credo,Ishida Toshimasa
- Theoretical Chemistry Accounts 130(2-3), 401-410, 2011-10-00
- … In this paper, the dynamics of the interaction of EBV-expressed latent membrane protein 1 (LMP1) with cellular signaling intermediate tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3) is simulated using standard classical molecular dynamics (MD) protocols. … For comparison, the dynamics of the interaction of TRAF3 with CD40, a TNFR mimicked by LMP1 to effect EBV infection is also calculated under similar conditions. …
- NAID 120003644395
- BS69 cooperates with TRAF3 in the regulation of Epstein–Barr virus-derived LMP1/CTAR1-induced NF-κB activation
- Ikeda Osamu,Miyasaka Yuto,Yoshida Ryuji,Mizushima Akihiro,Oritani Kenji,Sekine Yuichi,Kuroda Makoto,Yasui Teruhito,Fujimuro Masahiro,Muromoto Ryuta,Nanbo Asuka,Matsuda Tadashi
- FEBS Letters 584(5), 865-872, 2010-03-05
- … Regarding the mechanisms involved, we found that BS69 directly interacted with TRAF3, a negative regulator of NF-κB activation. … Furthermore, small-interfering RNA-mediated knockdown experiments revealed that TRAF3 was involved in the BS69-mediated suppression of LMP1/CTAR1-induced NF-κB activation. …
- NAID 120001875432
Related Links
- TNF receptor-associated factor 3 is a protein that in humans is encoded by the TRAF3 gene. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and ...
Related Pictures
★リンクテーブル★
[★]
TNF受容体関連因子3
- 関
- TRAF-3、TRAF3
[★]
- 英
- TNF receptor-associated factor 3、TRAF3
[★]
- 関
- TNF receptor-associated factor、tumor necrosis factor receptor-associated factor