腫瘍壊死因子受容体
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- the localized death of living cells (as from infection or the interruption of blood supply) (同)mortification, gangrene, sphacelus
- an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- =sense organ / 受信装置
- 壊疽(えそ)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/19 00:31:45」(JST)
[Wiki en表示]
| TNFR/NGFR cysteine-rich region |
|
Structure of the soluble human 55 kd TNF receptor-human TNF beta complex.[1]
|
| Identifiers |
| Symbol |
TNFR_c6 |
| Pfam |
PF00020 |
| InterPro |
IPR011614 |
| PROSITE |
PDOC00561 |
| SCOP |
1tnr |
| SUPERFAMILY |
1tnr |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
|
The tumor necrosis factor receptor superfamily (TNFRSF) is a group of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain.[2][3] With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha.[4] In their active form, the majority of TNF receptors form trimeric complexes in the plasma membrame. Accordingly, most TNF receptors contain transmembrane domains (TMDs), although some can be cleaved into soluble forms (e.g. TNFR1), and some lack a TMD entirely (e.g. DcR3). In addition, most TNF receptors require specific adaptor protein such as TRADD, TRAF, RIP and FADD for downstream signalling. TNF receptors are primarily involved in apoptosis and inflammation, but they can also take part in other signal transduction pathways, such as proliferation, survival, and differentiation. TNF receptors are expressed in a wide variety of tissues in mammals, especially in leukocytes.[4]
The term death receptor refers to those members of the TNF receptor superfamily that contain a death domain, such as TNFR1, Fas receptor, DR4 and DR5.[4] They were named after the fact that they seemed to play an important role in apoptosis (programmed cell death), although they are now known to play other roles as well.[5]
In the strict sense, the term TNF receptor is often used to refer to the archetypal members of the superfamily, namely TNFR1 and TNFR2, which recognize TNF-alpha.
Contents
- 1 Members
- 2 References
- 3 Further reading
- 4 External links
Members
There are 27 family members, numerically classified as TNFRSF#, where # denotes the member number, sometimes followed a letter.[2]
| Type |
Protein (member #) |
Synonyms |
Gene |
Ligand(s) |
| 1 |
Tumor necrosis factor receptor 1 (1A) |
CD120a |
TNFRSF1A |
TNF-alpha (cachectin) |
| Tumor necrosis factor receptor 2 (1B) |
CD120b |
TNFRSF1B |
| 3 |
Lymphotoxin beta receptor (3) |
CD18 |
LTBR |
Lymphotoxin beta (TNF-C) |
| 4 |
OX40 (4) |
CD134 |
TNFRSF4 |
OX40L |
| 5 |
CD40 (5) |
Bp50 |
CD40 |
CD154 |
| 6 |
Fas receptor (6) |
Apo-1, CD95 |
FAS |
FasL |
| Decoy receptor 3 (6B) |
TR6, M68 |
TNFRSF6B |
FasL, LIGHT, TL1A |
| 7 |
CD27 (7) |
S152, Tp55 |
CD27 |
CD70, Siva |
| 8 |
CD30 (8) |
Ki-1 |
TNFRSF8 |
CD153 |
| 9 |
4-1BB (9) |
CD137 |
TNFRSF9 |
4-1BB ligand |
| 10 |
Death receptor 4 (10A) |
TRAILR1, Apo-2, CD261 |
TNFRSF10A |
TRAIL |
| Death receptor 5 (10B) |
TRAILR2, CD262 |
TNFRSF10B |
| Decoy receptor 1 (10C) |
TRAILR3, LIT, TRID, CD263 |
TNFRSF10C |
| Decoy receptor 2 (10D) |
TRAILR4, TRUNDD, CD264 |
TNFRSF10D |
| 11 |
RANK (11A) |
CD265 |
TNFRSF11A |
RANKL |
| Osteoprotegerin (11B) |
OCIF, TR1 |
TNFRSF11B |
| 12 |
TWEAK receptor (12A) |
Fn14, CD266 |
TNFRSF12A |
TWEAK |
| 13 |
TACI (13B) |
IGAD2, CD267 |
TNFRSF13B |
APRIL, BAFF, CAMLG |
| BAFF receptor (13C) |
CD268 |
TNFRSF13C |
BAFF |
| 14 |
Herpesvirus entry mediator (14) |
ATAR, TR2, CD270 |
TNFRSF14 |
LIGHT |
| 16 |
Nerve growth factor receptor (16) |
p75NTR, CD271 |
NGFR |
NGF, BDNF, NT-3, NT-4 |
| 17 |
B-cell maturation antigen (17) |
TNFRSF13A, CD269 |
TNFRSF17 |
BAFF |
| 18 |
Glucocorticoid-induced TNFR-related (18) |
AITR, CD357 |
TNFRSF18 |
GITR ligand |
| 19 |
TROY (19) |
TAJ, TRADE |
TNFRSF19 |
unknown |
| 21 |
Death receptor 6 (21) |
CD358 |
TNFRSF21 |
| 25 |
Death receptor 3 (25) |
Apo-3, TRAMP, LARD, WS-1 |
TNFRSF25 |
TL1A |
| 27 |
Ectodysplasin A2 receptor (27) |
XEDAR |
EDA2R |
EDA-A2 |
References
- ^ Banner DW, D'Arcy A, Janes W, et al. (May 1993). "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation". Cell 73 (3): 431–45. doi:10.1016/0092-8674(93)90132-A. PMID 8387891.
- ^ a b Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407.
- ^ Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMC 1782125. PMID 15819693.
- ^ a b c Gravestein, LA; Borst, J (December 1998). "Tumor necrosis factor receptor family members in the immune system.". Seminars in immunology 10 (6): 423–34. PMID 9826575.
- ^ Ashkenazi, A.; Dixit, VM (1998). "Death Receptors: Signaling and Modulation". Science 281 (5381): 1305–8. doi:10.1126/science.281.5381.1305. PMID 9721089.
Further reading
- Kavurma MM, Tan NY, Bennett MR. (2008). "Death receptors and their ligands in atherosclerosis". Arterioscler Thromb Vasc Biol. 28 (10): 1694–702. doi:10.1161/ATVBAHA.107.155143. PMID 18669890.
- Hatano, E. (2007). "Tumor necrosis factor signaling in hepatocyte apoptosis". J Gastroenterol Hepatol. 22: S43–44. doi:10.1111/j.1440-1746.2006.04645.x. PMID 17567463.
External links
- Tumor Necrosis Factor Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Membrane proteins, receptors: cell surface receptors
|
|
| G protein-coupled receptor |
| Class A |
- Eicosanoid receptor (Prostaglandin receptor)
- Protease-activated receptor
- Neurotransmitter receptor
- Purinergic receptor
- Biogenic amine receptor
- Olfactory receptor
|
|
| Class B |
|
|
| Class C |
- Metabotropic glutamate receptor
|
|
| Class D |
|
|
| Class E |
|
|
| Class F |
|
|
|
| Ligand-gated ion channel |
|
|
| Enzyme-linked receptor |
- Serine/threonine-specific protein kinase
- Receptor tyrosine kinase
- Guanylate cyclase
|
|
| Other/ungrouped |
- Asialoglycoprotein receptor
- Tumor necrosis factor receptor
- Immunoglobulin superfamily
- N-Acetylglucosamine receptor
- Neuropilins
- Transferrin receptor
- EDAR
- Lipoprotein receptor-related protein
|
|
- See also
- cell surface receptor deficiencies
|
Index of signal transduction
|
|
| Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
|
|
|
|
Apoptosis signaling pathway
|
|
| Fas path |
|
Ligand
|
|
|
|
Receptor
|
|
|
|
Intracellular
|
- Death-inducing signaling complex
- Cytochrome c
- Caspase 9
- Caspase 3
- Pro-apoptotic:
- BAX
- BAK1/Bcl-2 homologous antagonist killer
- Bcl-2-associated death promoter
- Anti-apoptotic:
- Bcl-2
- Bcl-xL
|
|
|
| TNF path |
|
Ligand
|
- Tumor necrosis factor alpha
|
|
|
Receptor
|
- Tumor necrosis factor receptor 1
- Tumor necrosis factor receptor 2
|
|
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Intracellular
|
- FADD
- Caspase 8
- Caspase 3
- BID
- TRAF2
- ASK-1
- MEKK1
- IKK
- IκBα
- MKK7
- JNK
- NF-κB
|
|
|
| Other |
|
Intracellular
|
- IAPs
- XIAP
- NAIP
- Survivin
- c-IAP-1
- c-IAP-2
- Apoptosis-inducing factor
|
|
|
|
Index of signal transduction
|
|
| Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
|
|
|
UpToDate Contents
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- 1. 腫瘍壊死因子受容体-1関連周期性発熱症候群（TRAPS）tumor necrosis factor receptor 1 associated periodic syndrome traps [show details]
…necrosis factor (TNF) receptor-1 associated periodic syndrome (TRAPS) is a rare, autosomal dominant autoinflammatory syndrome resulting from mutations in the tumor necrosis factor receptor 1 (TNFR1) gene …
- 2. 周期性発熱症候群およびその他の自己炎症性疾患：概要periodic fever syndromes and other autoinflammatory diseases an overview [show details]
…fever, which is shortest in FMF (mean two to three days) and longest in tumor necrosis factor (TNF) alpha receptor-1 associated syndrome (TRAPS, mean 15 days in severe disease and five to nine days in mild …
- 3. 全身性自己免疫疾患における心膜病変pericardial involvement in systemic autoimmune diseases [show details]
…adulthood. The most common autoinflammatory syndromes are familial Mediterranean fever and tumor necrosis factor receptor-1 associated periodic syndrome (TRAPS) . Familial Mediterranean Fever (FMF) is a disorder …
- 4. ホジキンリンパ腫の発症機序pathogenesis of hodgkin lymphoma [show details]
…of HRS cells from apoptotic destruction in germinal centers (GC). LMP1 resembles CD40 (tumor necrosis factor receptor) and may function like a constitutively activated CD40 molecule . Signaling through CD40 …
- 5. 高IgD症候群：臨床症状および診断hyperimmunoglobulin d syndrome clinical manifestations and diagnosis [show details]
…periodic fever syndromes. As an example, one case report highlights a 10-year-old boy with tumor necrosis factor receptor 1 associated periodic syndrome (TRAPS) who also had some features suggestive of HIDS …
English Journal
- Acetylcholine Inhibits Tumor Necrosis Factor α Activated Endoplasmic Reticulum Apoptotic Pathway via EGFR-PI3K Signaling in Cardiomyocytes.
- Miao Y1, Bi XY, Zhao M, Jiang HK, Liu JJ, Li DL, Yu XJ, Yang YH, Huang N, Zang WJ.
- Journal of cellular physiology.J Cell Physiol.2015 Apr;230(4):767-74. doi: 10.1002/jcp.24800.
- Previous findings have shown that acetylcholine (ACh) decreased hypoxia-induced tumor necrosis factor alpha (TNF α) production, thus protected against cardiomyocyte injury. However, whether and how ACh affects TNF α-induced endoplasmic reticulum (ER) stress and cell apoptosis remain poorly defined
- PMID 25201632
- Behavioral alterations in rat offspring following maternal immune activation and ELR-CXC chemokine receptor antagonism during pregnancy: Implications for neurodevelopmental psychiatric disorders.
- Ballendine SA1, Greba Q1, Dawicki W2, Zhang X2, Gordon JR2, Howland JG3.
- Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2015 Mar 3;57:155-65. doi: 10.1016/j.pnpbp.2014.11.002. Epub 2014 Nov 12.
- Research suggests that maternal immune activation (MIA) during pregnancy increases the risk of neurodevelopmental disorders including schizophrenia and autism in the offspring. Current theories suggest that inflammatory mediators including cytokines and chemokines may underlie the increased risk of
- PMID 25445065
- Molecular characterization and functional analysis of duck TRAF6.
- Zhai Y1, Luo F1, Chen Y1, Zhou S1, Li Z1, Liu M1, Bi D1, Jin H2.
- Developmental and comparative immunology.Dev Comp Immunol.2015 Mar;49(1):1-6. doi: 10.1016/j.dci.2014.11.006. Epub 2014 Nov 11.
- Tumor necrosis factor receptor-associated factor 6 (TRAF6) plays a pivotal role in activating various signaling cascades as an intracellular signal transducer. Although significant progress has been made clarifying TRAF6 function in mammals, the role of TRAF6 in ducks (duTRAF6) remains poorly unders
- PMID 25445905
Japanese Journal
- Peroxisome Proliferator-activated Receptor-γ agonists Prevent Tumor Necrosis Factor-α-mediated Inhibition of FSH-induced Follicle Development and Estradiol Production in A Preantral Follicle Culture System (Mini-Symposium : New insights from basic and clinical studies of PCOS)
- Hara Shuichiro,Takahashi Toshifumi,Igarashi Hideki [他]
- Journal of mammalian ova research = 日本卵子学会誌 31(1), 2-11, 2014-04
- NAID 40020087135
- Prevotella intermedia Induces Severe Bacteremic Pneumococcal Pneumonia in Mice with Upregulated Platelet-Activating Factor Receptor Expression
- Nagaoka Kentaro,Yanagihara Katsunori,Morinaga Yoshitomo,Nakamura Shigeki,Harada Tatsuhiko,Hasegawa Hiroo,Izumikawa Koichi,Ishimatsu Yuji,Kakeya Hiroshi,Nishimura Masaharu,Kohno Shigeru
- Infection and Immunity 82(2), 587-593, 2014-02
- … Although oral hygiene has been considered a risk factor for developing pneumonia, the relationship between oral bacteria and pneumococcal infection is unknown. … The effects of PiSup on platelet-activating factor receptor (PAFR) transcript levels in vitro and in vivo were analyzed by quantitative real-time PCR, and the differences between the effects of pneumococcal infection induced by various periodontopathic bacterial species were verified in mice. …
- NAID 120005439024
- 堀中 真野
- 日本衛生学雑誌 69(1), 8-14, 2014
- … As the molecular target of our model, we focused on the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor. … First, we searched for food factors inducing the expression of death receptor 5 (DR5), one of the TRAIL receptors. …
- NAID 130003394517
Related Links
- Tumor necrosis factor receptor-associated periodic syndrome (commonly known as TRAPS) is a condition characterized by recurrent episodes of fever. These fevers typically last about 3 weeks but can last from a few ...
- Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an inherited condition characterized by recurrent episodes of fever. Episodes can begin at any age but most often begin in early childhood. Fevers ...
★リンクテーブル★
[★]
- 英
- tumor necrosis factor receptor、TNF receptor, TNFR
- 同
- 腫瘍壊死因子レセプター、TNF受容体、TNFレセプター
- 関
- 腫瘍壊死因子 tumor necrosis factor TNF
[show details]
[★]
- 関
- TNFR、tumor necrosis factor receptor
[★]
- 英
- tumor necrosis factor receptor、TNF receptor
- 関
- 腫瘍壊死因子受容体、TNF受容体、TNFレセプター
[★]
- 関
- TNFR1、tumor necrosis factor receptor、type I tumor necrosis factor receptor
[★]
- 関
- TNF receptor-associated factor、TRAF、tumor necrosis factor receptor-associated peptides and proteins
[★]
腫瘍壊死因子I型受容体
- 関
- TNFR-I、TNFR1、tumor necrosis factor receptor
[★]
腫瘍壊死因子II型受容体
- 関
- TNF-R2、TNF-RII、TNFR-II、TNFR2
[★]
腫瘍壊死因子受容体メンバー14
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter
[★]